External Ids for SBNO2 Gene
Previous HGNC Symbols for SBNO2 Gene
Previous GeneCards Identifiers for SBNO2 Gene
GeneCards Summary for SBNO2 Gene
SBNO2 (Strawberry Notch Homolog 2 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is SBNO1.
UniProtKB/Swiss-Prot for SBNO2 Gene
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).