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Aliases for SBNO2 Gene

Aliases for SBNO2 Gene

  • Strawberry Notch Homolog 2 (Drosophila) 2 3
  • KIAA0963 2 3 4
  • STNO 3
  • SNO 3

External Ids for SBNO2 Gene

Previous HGNC Symbols for SBNO2 Gene

  • KIAA0963

Previous GeneCards Identifiers for SBNO2 Gene

  • GC19M001059
  • GC19M000881

Summaries for SBNO2 Gene

GeneCards Summary for SBNO2 Gene

SBNO2 (Strawberry Notch Homolog 2 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is SBNO1.

UniProtKB/Swiss-Prot for SBNO2 Gene

  • Seems to have transcriptional repression activity in macrophages.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBNO2 Gene

Genomics for SBNO2 Gene

Regulatory Elements for SBNO2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SBNO2 Gene

1,107,634 bp from pter
1,174,283 bp from pter
66,650 bases
Minus strand

Genomic View for SBNO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SBNO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBNO2 Gene

Proteins for SBNO2 Gene

  • Protein details for SBNO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein strawberry notch homolog 2
    Protein Accession:
    Secondary Accessions:
    • A8K8P2
    • B3KWJ1
    • O75257
    • Q3KQX0
    • Q8TEM0

    Protein attributes for SBNO2 Gene

    1366 amino acids
    Molecular mass:
    150275 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC28919.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA76807.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84928.1; Type=Frameshift; Positions=1236; Evidence={ECO:0000305};

    Alternative splice isoforms for SBNO2 Gene


neXtProt entry for SBNO2 Gene

Proteomics data for SBNO2 Gene at MOPED

Post-translational modifications for SBNO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SBNO2 Gene

No data available for DME Specific Peptides for SBNO2 Gene

Domains & Families for SBNO2 Gene

Protein Domains for SBNO2 Gene

Suggested Antigen Peptide Sequences for SBNO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SBNO family.
  • Belongs to the SBNO family.
genes like me logo Genes that share domains with SBNO2: view

No data available for Gene Families for SBNO2 Gene

Function for SBNO2 Gene

Molecular function for SBNO2 Gene

UniProtKB/Swiss-Prot Function:
Seems to have transcriptional repression activity in macrophages.

Gene Ontology (GO) - Molecular Function for SBNO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SBNO2: view
genes like me logo Genes that share phenotypes with SBNO2: view

Animal Models for SBNO2 Gene

MGI Knock Outs for SBNO2:

Animal Model Products

miRNA for SBNO2 Gene

miRTarBase miRNAs that target SBNO2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SBNO2 Gene

Localization for SBNO2 Gene

Subcellular locations from

Jensen Localization Image for SBNO2 Gene COMPARTMENTS Subcellular localization image for SBNO2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SBNO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SBNO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SBNO2 Gene

Pathways & Interactions for SBNO2 Gene

SuperPathways for SBNO2 Gene

No Data Available

Interacting Proteins for SBNO2 Gene

Gene Ontology (GO) - Biological Process for SBNO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IMP 18025162
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0030282 bone mineralization IEA --
GO:0030316 osteoclast differentiation --
genes like me logo Genes that share ontologies with SBNO2: view

No data available for Pathways by source and SIGNOR curated interactions for SBNO2 Gene

Drugs & Compounds for SBNO2 Gene

No Compound Related Data Available

Transcripts for SBNO2 Gene

Unigene Clusters for SBNO2 Gene

Strawberry notch homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SBNO2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^
SP2: -
SP5: -
SP6: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31
SP1: -
SP9: -

Relevant External Links for SBNO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SBNO2 Gene

mRNA expression in normal human tissues for SBNO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SBNO2 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for SBNO2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.1), Spleen (15.0), and Cervix (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SBNO2 Gene

SOURCE GeneReport for Unigene cluster for SBNO2 Gene Hs.408708

mRNA Expression by UniProt/SwissProt for SBNO2 Gene

Tissue specificity: Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.
genes like me logo Genes that share expression patterns with SBNO2: view

Protein tissue co-expression partners for SBNO2 Gene

Primer Products

In Situ Assay Products

Orthologs for SBNO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SBNO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SBNO2 35
  • 85.69 (n)
  • 86.38 (a)
SBNO2 36
  • 84 (a)
(Canis familiaris)
Mammalia SBNO2 35
  • 86.36 (n)
  • 86.73 (a)
SBNO2 36
  • 85 (a)
(Mus musculus)
Mammalia Sbno2 35
  • 80.59 (n)
  • 82.53 (a)
Sbno2 16
Sbno2 36
  • 80 (a)
(Pan troglodytes)
Mammalia SBNO2 35
  • 99.14 (n)
  • 99.31 (a)
SBNO2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sbno2 35
  • 82.16 (n)
  • 85.09 (a)
(Monodelphis domestica)
Mammalia SBNO2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SBNO2 36
  • 67 (a)
(Gallus gallus)
Aves SBNO2 35
SBNO2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia SBNO2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sbno2 35
  • 63.24 (n)
  • 68.07 (a)
(Danio rerio)
Actinopterygii LOC100002292 35
  • 65.28 (n)
  • 67.42 (a)
SBNO2 (2 of 2) 36
  • 54 (a)
sbno2a 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3491 36
  • 29 (a)
sno 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea let-765 36
  • 28 (a)
(Triticum aestivum)
Liliopsida Ta.17075 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5085 36
  • 42 (a)
Species with no ortholog for SBNO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SBNO2 Gene

Gene Tree for SBNO2 (if available)
Gene Tree for SBNO2 (if available)

Paralogs for SBNO2 Gene

Paralogs for SBNO2 Gene

(1) SIMAP similar genes for SBNO2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SBNO2: view

Variants for SBNO2 Gene

Sequence variations from dbSNP and Humsavar for SBNO2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs873289 -- 1,175,397(-) AACTC(C/T)AGTTT upstream-variant-2KB
rs2075711 -- 1,107,336(+) ATGGG(A/G)CCCGG downstream-variant-500B
rs4807599 -- 1,147,168(+) CCCAC(C/T)GTAAA intron-variant
rs4807644 -- 1,175,842(+) CAGGA(A/G)GAACA upstream-variant-2KB
rs4807645 -- 1,175,888(+) ATGGT(A/G)AAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SBNO2 Gene

Variant ID Type Subtype PubMed ID
dgv3513n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv9662 CNV Gain 18304495
nsv469845 CNV Loss 16826518
essv258 CNV CNV 17122850
nsv833704 CNV Gain 17160897
dgv1055e1 CNV Complex 17122850
dgv3569n71 CNV Loss 21882294
dgv3575n71 CNV Loss 21882294
nsv470102 CNV Loss 18288195
dgv3579n71 CNV Loss 21882294
nsv910412 CNV Loss 21882294
nsv910413 CNV Gain 21882294
dgv3580n71 CNV Loss 21882294
nsv470103 CNV Gain 18288195
dgv3581n71 CNV Loss 21882294
dgv3582n71 CNV Loss 21882294
nsv910420 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3584n71 CNV Loss 21882294
nsv828367 CNV Gain 20364138
nsv516646 CNV Loss 19592680
dgv3585n71 CNV Loss 21882294
nsv910429 CNV Loss 21882294
nsv910432 CNV Loss 21882294
nsv2386 CNV Insertion 18451855
nsv526080 CNV Loss 19592680
esv2663150 CNV Deletion 23128226
esv27094 CNV Gain 19812545
esv2717826 CNV Deletion 23290073
esv2616658 CNV Insertion 19546169
esv1210673 CNV Insertion 17803354
esv29901 CNV Gain 19812545
esv1785958 CNV Deletion 17803354
esv2717827 CNV Deletion 23290073
esv2717828 CNV Deletion 23290073
nsv910433 CNV Loss 21882294
esv1002029 CNV Insertion 20482838
esv2640042 CNV Loss 19546169
esv1649795 CNV Insertion 17803354
esv2538063 CNV Insertion 19546169
nsv138169 CNV Loss 16902084
esv2717830 CNV Deletion 23290073
esv1428489 CNV Insertion 17803354
dgv3586n71 CNV Loss 21882294
nsv470104 CNV Loss 18288195

Variation tolerance for SBNO2 Gene

Gene Damage Index Score: 5.78; 73.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SBNO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBNO2 Gene

Disorders for SBNO2 Gene

Relevant External Links for SBNO2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SBNO2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBNO2 Gene

Publications for SBNO2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 67
  2. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. (PMID: 25903009) Grill M. … Campbell I.L. (Glia 2015) 67
  3. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for SBNO2 Gene

Sources for SBNO2 Gene

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