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SBNO1 Gene

protein-coding   GIFtS: 51
GCID: GC12M123774

Strawberry Notch Homolog 1 (Drosophila)

(Previous names: sno, strawberry notch homolog 1 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Strawberry Notch Homolog 1 (Drosophila)1 2     Sno2
Monocyte Protein 32 3     Protein Strawberry Notch Homolog 12
MOP32 3     MOP-33
Sno, Strawberry Notch Homolog 1 (Drosophila)1     

External Ids:    HGNC: 229731   Entrez Gene: 552062   Ensembl: ENSG000001396977   OMIM: 6142745   UniProtKB: A3KN833   

Export aliases for SBNO1 gene to outside databases

Previous GC identifers: GC12M123587 GC12M122216 GC12M122217 GC12M122305 GC12M123780 GC12M120734


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SBNO1 Gene:
SBNO1 (strawberry notch homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with SBNO1 include barrett's esophagus, and breast and colorectal cancer. An important paralog of this gene is SBNO2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SBNO1 gene promoter:
         Oct-B1   USF1   oct-B3   Sp1   oct-B2   Egr-2   AREB6   SRY   POU2F1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSBNO1 promoter sequence
   Search Chromatin IP Primers for SBNO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SBNO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SBNO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SBNO1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M123774:  view genomic region     (about GC identifiers)

Start:
123,773,656 bp from pter      End:
123,849,390 bp from pter
Size:
75,735 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SBNO1_HUMAN, A3KN83 (See protein sequence)
Recommended Name: Protein strawberry notch homolog 1  
Size: 1393 amino acids; 154312 Da
Sequence caution: Sequence=AAQ76814.1; Type=Erroneous initiation;
Secondary accessions: Q05C06 Q3ZTS3 Q9H3T8 Q9NVB2
Alternative splicing: 4 isoforms:  A3KN83-1   A3KN83-2   A3KN83-3   A3KN83-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SBNO1: NX_A3KN83

Explore proteomics data for SBNO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys155, Lys378
  • Modification sites at PhosphoSitePlus

  • See SBNO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161328.1  NP_060653.3  

    ENSEMBL proteins: 
     ENSP00000473480   ENSP00000473665   ENSP00000387361   ENSP00000267176  

    SBNO1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SBNO1
    OriGene Custom MassSpec
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    Novus Biologicals SBNO1 Protein
    Novus Biologicals SBNO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SBNO1

    SBNO1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SBNO1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SBNO1
    Novus Biologicals SBNO1 Antibody
    Abcam antibodies for SBNO1
    Cloud-Clone Corp. Antibodies for SBNO1
    Search ThermoFisher Antibodies for SBNO1
    Search LSBio for Antibodies for SBNO1

    SBNO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SBNO1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SBNO1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SBNO1
    Cloud-Clone Corp. CLIAs for SBNO1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR026937 SBNO_Helicase_C_dom
     IPR026741 SNO
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry A3KN83

    ProtoNet protein and cluster: A3KN83

    UniProtKB/Swiss-Prot: SBNO1_HUMAN, A3KN83
    Similarity: Belongs to the SBNO family


    SBNO1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding ----
    GO:0003824catalytic activity ----
    GO:0005524ATP binding ----
    GO:0016491oxidoreductase activity ----
         
    SBNO1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SBNO1:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SBNO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SBNO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SBNO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SBNO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SBNO1:
    hsa-mir-188-5p (MIRT044901), hsa-mir-196a-5p (MIRT048283), hsa-mir-218-5p (MIRT046997)

    Block miRNA regulation of human, mouse, rat SBNO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SBNO1 (see all 206):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-26a-2* hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-1260b hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SBNO1
    Predesigned siRNA for gene silencing in human, mouse, rat SBNO1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SBNO1

    Clone
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    OriGene clones in human, mouse for SBNO1 (see all 12)
    OriGene ORF clones in mouse, rat for SBNO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SBNO1 (NM_018183)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SBNO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBNO1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SBNO1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SBNO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBNO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    SBNO1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SBNO1
    Interactions:

        Search GeneGlobe Interaction Network for SBNO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SBNO1 (A3KN833 ENSP000002671764) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JAG2Q9Y2193, ENSP000003281694I2D: score=1 STRING: ENSP00000328169
    NOTCH2Q047213, ENSP000002566464I2D: score=1 STRING: ENSP00000256646
    DLL1O005483, ENSP000003557184I2D: score=1 STRING: ENSP00000355718
    TBL1XR1Q9BZK73, ENSP000004055744I2D: score=1 STRING: ENSP00000405574
    CUX1P398803I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--
    GO:0055114oxidation-reduction process ----

    SBNO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SBNO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SBNO1 gene (2 alternative transcripts): 
    NM_001167856.1  NM_018183.3  

    Unigene Cluster for SBNO1:

    Strawberry notch homolog 1 (Drosophila)
    Hs.7012  [show with all ESTs]
    Unigene Representative Sequence: NM_001167856
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602750 ENST00000602398 ENST00000420886(uc010tap.2 uc001uet.2 uc001uev.2 uc009zxy.1)
    ENST00000267176(uc009zxv.3 uc010tao.2 uc010taq.2 uc001ues.1 uc001ueu.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SBNO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SBNO1 (see all 206):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-26a-2* hsa-miR-361-5p hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-1260b hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SBNO1
    Predesigned siRNA for gene silencing in human, mouse, rat SBNO1
    Clone
    Products:
         
    OriGene clones in human, mouse for SBNO1 (see all 12)
    OriGene ORF clones in mouse, rat for SBNO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SBNO1 (NM_018183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SBNO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBNO1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SBNO1
    OriGene qSTAR qPCR primer pairs in human, mouse for SBNO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SBNO1
      QuantiTect SYBR Green Assays in human, mouse, rat SBNO1
      QuantiFast Probe-based Assays in human, mouse, rat SBNO1

    Additional mRNA sequence: 

    AB014772.1 AF086046.1 AK001563.1 AK001695.1 AK074256.1 AK092518.1 AK096864.1 AK122703.1 
    AK307488.1 AY364255.1 BC030544.1 BC041141.2 BC129949.1 BC133704.1 

    15 DOTS entries:

    DT.40308387  DT.443065  DT.121215356  DT.97846250  DT.100778044  DT.91849891  DT.92430330  DT.101973321 
    DT.101981693  DT.91961065  DT.95227815  DT.101961446  DT.70103309  DT.91858836  DT.97846248 

    Selected AceView cDNA sequences (see all 218):

    BM706248 AI289035 NM_018183 AI523075 BM541670 AL707616 AV649490 AB014772 
    AI240723 AI379498 AI273470 N94741 BU168017 BM564592 BM986913 N25754 
    AA984682 BU737013 AI670935 BQ773112 AW590416 AI151127 AL699426 BM706357 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SBNO1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:                                                      
    SP2:                                                      
    SP3:                          -                           
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SBNO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SBNO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTCTGGAG
    SBNO1 Expression
    About this image

    SBNO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SBNO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7012
        Custom PCR Arrays for SBNO1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SBNO1
    OriGene qSTAR qPCR primer pairs in human, mouse for SBNO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SBNO1
    QuantiTect SYBR Green Assays in human, mouse, rat SBNO1
    QuantiFast Probe-based Assays in human, mouse, rat SBNO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBNO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SBNO1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sbno11 , 5 sno, strawberry notch homolog 1 (Drosophila)1, 5 89.33(n)1
    97.19(a)1
      5 (63.54 cM)5
    2432721  NM_001081203.11  NP_001074672.11 
     1243687025 
    chicken
    (Gallus gallus)
    Aves SBNO11 strawberry notch homolog 1 (Drosophila) 82.33(n)
    92.66(a)
      427694  NM_001031469.1  NP_001026640.1 
    lizard
    (Anolis carolinensis)
    Reptilia SBNO16
    strawberry notch homolog 1 (Drosophila)
    79(a)
    1 ↔ 1
    LGb(1835711-1859967)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193312 Xenopus laevis transcribed sequence with weak similarity to protein pirT02748 (H.sapiens) T02748 hypothetical protein R31180_1 - human less 80.34(n)    BX844227.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.255852 Transcribed sequence with weak similarity to protein pirT02748 (H.sapiens) T02748 hypothetical protein R31180_1 - human less 75.06(n)    CF996685.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sno1 strawberry notch 58.24(n)
    62.51(a)
      32273  NM_001103497.1  NP_001096967.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-7651 let-765 59.86(n)
    61.06(a)
      175934  NM_066054.4  NP_498455.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB11351 EMB1135 52.06(n)
    47.02(a)
      844273  NM_106583.5  NP_178053.4 
    rice
    (Oryza sativa)
    Liliopsida Os.144862 Oryza sativa (japonica cultivar-group) cDNA cloneJ033064C18, full insert sequence less 71.24(n)    AK101763.1 


    ENSEMBL Gene Tree for SBNO1 (if available)
    TreeFam Gene Tree for SBNO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SBNO1 gene
    SBNO22  
    1 SIMAP similar gene for SBNO1 using alignment to 1 protein entry:     SBNO1_HUMAN:
    SBNO2

    SBNO1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SBNO1 (see all 1567)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0379104
    A breast cancer sample4--see VAR_0379102 T S mis40--------
    VAR_0379124
    A breast cancer sample4--see VAR_0379122 E K mis40--------
    VAR_0379134
    A breast cancer sample4--see VAR_0379132 S C mis40--------
    rs732319941,2
    C,F--123651771(+) ACCTGG/ATTAAT 2 -- us2k12Minor allele frequency- A:0.05NA 122
    rs110572441,2
    C,F,H--123773263(+) ATTCAG/CGAGGT 2 -- ds50019Minor allele frequency- C:0.02NS EA NA CSA 644
    rs1467725601,2
    C--123773280(+) CCCCC-/TAAACA 2 -- ds50010--------
    rs1128702311,2
    C,F--123773579(+) TGACAG/CCACTT 2 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1901875171,2
    --123773634(+) GACAGC/TGCGCA 2 -- ds50010--------
    rs1818449611,2
    --123773637(+) AGCGCA/GCAAAG 2 -- ds50010--------
    rs2001882921,2
    --123773695(+) AACAA-/AAAAC 
            
    AAAAC
    2 -- ut310--------

    HapMap Linkage Disequilibrium report for SBNO1 (123773656 - 123849390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SBNO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746504CNV Deletion23290073
    esv2746503CNV Deletion23290073
    esv2746502CNV Deletion23290073

    Human Gene Mutation Database (HGMD): SBNO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SBNO1
    DNA2.0 Custom Variant and Variant Library Synthesis for SBNO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614274    OMIM disorders: --

    5 diseases for SBNO1:    
    About MalaCards
    barrett's esophagus    breast and colorectal cancer    lung cancer    colorectal cancer
    malaria


    SBNO1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SBNO1
    Human Genome Epidemiology (HuGE) Navigator: SBNO1 (1 document)

    Export disorders for SBNO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SBNO1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SBNO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants at 12q15 and 12q24 are associated with infant head circumference. (PubMed id 22504419)1, 4 Taal H.R....Jaddoe V.W. (Nat. Genet. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    7. Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus. (PubMed id 22449796)1 Tamagawa Y....Kinoshita Y. ( a journal of technical methods and pathology 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55206 HGNC: 22973 AceView: SBNO1 Ensembl:ENSG00000139697 euGenes: HUgn55206
    ECgene: SBNO1 H-InvDB: SBNO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SBNO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SBNO1 gene:
    Search GeneIP for patents involving SBNO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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