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Aliases for SBNO1 Gene

Aliases for SBNO1 Gene

  • Strawberry Notch Homolog 1 2 3 5
  • Monocyte Protein 3 3 4
  • MOP3 3 4
  • Sno, Strawberry Notch Homolog 1 (Drosophila) 2
  • Protein Strawberry Notch Homolog 1 3
  • MOP-3 4
  • Sno 3

External Ids for SBNO1 Gene

Previous GeneCards Identifiers for SBNO1 Gene

  • GC12M123587
  • GC12M122216
  • GC12M122217
  • GC12M122305
  • GC12M123780
  • GC12M120734
  • GC12M123774

Summaries for SBNO1 Gene

GeneCards Summary for SBNO1 Gene

SBNO1 (Strawberry Notch Homolog 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and hydrolase activity. An important paralog of this gene is SBNO2.

Additional gene information for SBNO1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBNO1 Gene

Genomics for SBNO1 Gene

Regulatory Elements for SBNO1 Gene

Enhancers for SBNO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H123265 1.3 ENCODE dbSUPER 21.7 +96.2 96183 7 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YY1 GLIS2 ZNF143 SP3 ZHX2 DDX55 CDK2AP1 C12orf65 EIF2B1 SBNO1 MPHOSPH9 TCTN2 RSRC2 ZCCHC8 ENSG00000239215
GH12H123600 1.2 ENCODE 18 -236.6 -236622 2 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A ZFP41 SSRP1 LOC101927415 C12orf65 DDX55 EIF2B1 TCTN2 SBNO1 ENSG00000239215 DNAH10OS KMT5A ENSG00000270130
GH12H123277 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +87.1 87103 1 PKNOX1 TBL1XR1 JUN BATF RELA EED ATF7 PRDM10 ETV6 RUNX3 CDK2AP1 MPHOSPH9 ENSG00000256092 ENSG00000207189 SBNO1 C12orf65 SNORA9B DDX55 RILPL1 EIF2B1
GH12H122419 1.8 FANTOM5 ENCODE dbSUPER 9.7 +943.4 943417 4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 SLC30A9 ZNF766 ZNF143 REST ZNF592 RSRC2 ZCCHC8 PSMD9 KNTC1 LINC01089 ENSG00000252192 ENSG00000272849 CLIP1 KDM2B C12orf65
GH12H123362 1.4 ENCODE dbSUPER 10.7 +0.7 702 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 DDX55 RSRC2 ZCCHC8 EIF2B1 CDK2AP1 LOC101927415 ENSG00000256092 ENSG00000239215 ENSG00000235423 ATP6V0A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SBNO1 on UCSC Golden Path with GeneCards custom track

Promoters for SBNO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058733 725 2801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for SBNO1 Gene

Chromosome:
12
Start:
123,289,109 bp from pter
End:
123,365,525 bp from pter
Size:
76,417 bases
Orientation:
Minus strand

Genomic View for SBNO1 Gene

Genes around SBNO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBNO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBNO1 Gene

Proteins for SBNO1 Gene

  • Protein details for SBNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A3KN83-SBNO1_HUMAN
    Recommended name:
    Protein strawberry notch homolog 1
    Protein Accession:
    A3KN83
    Secondary Accessions:
    • Q05C06
    • Q3ZTS3
    • Q9H3T8
    • Q9NVB2

    Protein attributes for SBNO1 Gene

    Size:
    1393 amino acids
    Molecular mass:
    154312 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ76814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SBNO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SBNO1 Gene

Post-translational modifications for SBNO1 Gene

  • Ubiquitination at isoforms=2, 3, 4155 and Lys378
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SBNO1 Gene

Domains & Families for SBNO1 Gene

Gene Families for SBNO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SBNO1 Gene

Suggested Antigen Peptide Sequences for SBNO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A3KN83

UniProtKB/Swiss-Prot:

SBNO1_HUMAN :
  • Belongs to the SBNO family.
Family:
  • Belongs to the SBNO family.
genes like me logo Genes that share domains with SBNO1: view

Function for SBNO1 Gene

Phenotypes From GWAS Catalog for SBNO1 Gene

Gene Ontology (GO) - Molecular Function for SBNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SBNO1: view
genes like me logo Genes that share phenotypes with SBNO1: view

Animal Model Products

CRISPR Products

miRNA for SBNO1 Gene

miRTarBase miRNAs that target SBNO1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SBNO1 Gene

Localization for SBNO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SBNO1 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SBNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SBNO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SBNO1 Gene

Pathways & Interactions for SBNO1 Gene

SuperPathways for SBNO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SBNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SBNO1: view

No data available for Pathways by source and SIGNOR curated interactions for SBNO1 Gene

Drugs & Compounds for SBNO1 Gene

No Compound Related Data Available

Transcripts for SBNO1 Gene

Unigene Clusters for SBNO1 Gene

Strawberry notch homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBNO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SBNO1 Gene

GeneLoc Exon Structure for
SBNO1
ECgene alternative splicing isoforms for
SBNO1

Expression for SBNO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SBNO1 Gene

Protein differential expression in normal tissues from HIPED for SBNO1 Gene

This gene is overexpressed in Testis (28.8), Peripheral blood mononuclear cells (8.7), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SBNO1 Gene



Protein tissue co-expression partners for SBNO1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SBNO1 Gene:

SBNO1

SOURCE GeneReport for Unigene cluster for SBNO1 Gene:

Hs.7012

Evidence on tissue expression from TISSUES for SBNO1 Gene

  • Blood(4.1)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with SBNO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBNO1 Gene

Orthologs for SBNO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SBNO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SBNO1 33 34
  • 99.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SBNO1 33 34
  • 94.09 (n)
cow
(Bos Taurus)
Mammalia SBNO1 33 34
  • 93.41 (n)
rat
(Rattus norvegicus)
Mammalia Sbno1 33
  • 89.58 (n)
mouse
(Mus musculus)
Mammalia Sbno1 33 16 34
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia SBNO1 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SBNO1 33 34
  • 82.33 (n)
lizard
(Anolis carolinensis)
Reptilia SBNO1 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sbno1 33
  • 76.74 (n)
Str.16725 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19331 33
zebrafish
(Danio rerio)
Actinopterygii sbno1 33
  • 70.25 (n)
SBNO1 34
  • 19 (a)
OneToOne
Dr.25585 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13697 33
fruit fly
(Drosophila melanogaster)
Insecta sno 33 34
  • 58.24 (n)
CG3491 34
  • 33 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011199 33
  • 26.36 (n)
worm
(Caenorhabditis elegans)
Secernentea let-765 33 34
  • 59.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB1135 33
  • 52.06 (n)
rice
(Oryza sativa)
Liliopsida Os08g0223700 33
  • 53.25 (n)
Os.14486 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5085 34
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5929 33
Species where no ortholog for SBNO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBNO1 Gene

ENSEMBL:
Gene Tree for SBNO1 (if available)
TreeFam:
Gene Tree for SBNO1 (if available)

Paralogs for SBNO1 Gene

Paralogs for SBNO1 Gene

(1) SIMAP similar genes for SBNO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SBNO1: view

Variants for SBNO1 Gene

Sequence variations from dbSNP and Humsavar for SBNO1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_037910 A breast cancer sample
VAR_037912 A breast cancer sample
VAR_037913 A breast cancer sample
rs193920847 Uncertain significance 123,350,306(-) AGGTA(A/C)GAGTT intron-variant
rs1000032716 -- 123,298,038(+) TGTGC(C/T)ACTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SBNO1 Gene

Variant ID Type Subtype PubMed ID
esv2746502 CNV deletion 23290073
esv2746503 CNV deletion 23290073
esv2746504 CNV deletion 23290073
esv3549920 CNV deletion 23714750
nsv1127301 CNV deletion 24896259
nsv1144662 CNV deletion 24896259
nsv477316 CNV novel sequence insertion 20440878

Variation tolerance for SBNO1 Gene

Residual Variation Intolerance Score: 1.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SBNO1 Gene

Human Gene Mutation Database (HGMD)
SBNO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SBNO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBNO1 Gene

Disorders for SBNO1 Gene

Relevant External Links for SBNO1

Genetic Association Database (GAD)
SBNO1
Human Genome Epidemiology (HuGE) Navigator
SBNO1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SBNO1

No disorders were found for SBNO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBNO1 Gene

Publications for SBNO1 Gene

  1. Common variants at 12q15 and 12q24 are associated with infant head circumference. (PMID: 22504419) Taal HR … Early Growth Genetics Consortium (Nature genetics 2012) 3 45 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 45 60
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for SBNO1 Gene

Sources for SBNO1 Gene

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