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Aliases for SBK3 Gene

Aliases for SBK3 Gene

  • SH3 Domain Binding Kinase Family, Member 3 2 3
  • SH3-Binding Domain Kinase Family Member 3 3 4
  • Sugen Kinase 110 3 4
  • SGK110 3 4
  • Uncharacterized Serine/Threonine-Protein Kinase SBK3 3
  • EC 4

External Ids for SBK3 Gene

Previous GeneCards Identifiers for SBK3 Gene

  • GC19M056055

Summaries for SBK3 Gene

GeneCards Summary for SBK3 Gene

SBK3 (SH3 Domain Binding Kinase Family, Member 3) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SBK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK3 Gene

Genomics for SBK3 Gene

Genomic Location for SBK3 Gene

55,540,656 bp from pter
55,545,543 bp from pter
4,888 bases
Minus strand

Genomic View for SBK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SBK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK3 Gene

No data available for Regulatory Elements for SBK3 Gene

Proteins for SBK3 Gene

  • Protein details for SBK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SBK3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SBK3 Gene

    359 amino acids
    Molecular mass:
    38488 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK3 Gene

Proteomics data for SBK3 Gene at MOPED

Post-translational modifications for SBK3 Gene

No Post-translational modifications

Other Protein References for SBK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SBK3 Gene

Domains for SBK3 Gene

Protein Domains for SBK3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SBK3 Gene

Function for SBK3 Gene

Molecular function for SBK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for SBK3 Gene

Gene Ontology (GO) - Molecular Function for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with SBK3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SBK3 Gene

Localization for SBK3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SBK3 Gene

Pathways for SBK3 Gene

SuperPathways for SBK3 Gene

No Data Available

Interacting Proteins for SBK3 Gene

Gene Ontology (GO) - Biological Process for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with SBK3: view

No data available for Pathways by source for SBK3 Gene

Transcripts for SBK3 Gene

mRNA/cDNA for SBK3 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SBK3 Gene

No ASD Table

Relevant External Links for SBK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SBK3 Gene

mRNA expression in normal human tissues for SBK3 Gene

mRNA differential expression in normal tissues according to GTEx for SBK3 Gene

This gene is overexpressed in Heart - Atrial Appendage (30.8), Muscle - Skeletal (6.7), and Heart - Left Ventricle (5.1).
genes like me logo Genes that share expressions with SBK3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SBK3 Gene

Orthologs for SBK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SBK3 35
  • 82.96 (n)
  • 83.52 (a)
(Canis familiaris)
Mammalia SGK110 35
  • 82.82 (n)
  • 83.01 (a)
SBK3 36
  • 78 (a)
(Mus musculus)
Mammalia Sbk3 35
  • 81.05 (n)
  • 86.93 (a)
Gm1078 16
Gm1078 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Sbk3 35
  • 81.05 (n)
  • 84.87 (a)
(Monodelphis domestica)
Mammalia SBK3 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SBK3 36
  • 52 (a)
(Pan troglodytes)
Mammalia SBK3 36
  • 100 (a)
(Gallus gallus)
Aves LOC101748417 35
  • 57.59 (n)
  • 48.17 (a)
SBK3 36
  • 47 (a)
(Anolis carolinensis)
Reptilia SBK3 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135243 35
  • 48.73 (n)
  • 38.24 (a)
(Danio rerio)
Actinopterygii CABZ01038514.1 36
  • 26 (a)
si:ch211-171h4.3 36
  • 28 (a)
zgc:172086 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11221 36
  • 19 (a)
CG4945 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C01C4.3 36
  • 18 (a)
Species with no ortholog for SBK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK3 Gene

Gene Tree for SBK3 (if available)
Gene Tree for SBK3 (if available)

Paralogs for SBK3 Gene

Paralogs for SBK3 Gene

(5) SIMAP similar genes for SBK3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SBK3: view

Variants for SBK3 Gene

Sequence variations from dbSNP and Humsavar for SBK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs491639 -- 55,544,818(-) CTCCT(C/T)GCCCA synonymous-codon, reference
rs571765 -- 55,545,805(-) GGGTG(C/T)GGGGA upstream-variant-2KB
rs595284 -- 55,545,310(-) GAGAA(A/C/T)TGGAC intron-variant
rs654439 -- 55,541,404(-) GACCC(A/G)GTCTG synonymous-codon, reference
rs673519 -- 55,547,270(-) AGGCG(C/G)GGAAC upstream-variant-2KB

Relevant External Links for SBK3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SBK3 Gene

Disorders for SBK3 Gene

No disorders were found for SBK3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SBK3 Gene

Publications for SBK3 Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SBK3 Gene

Sources for SBK3 Gene

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