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Aliases for SBK3 Gene

Aliases for SBK3 Gene

  • SH3 Domain Binding Kinase Family Member 3 2 3 5
  • SH3-Binding Domain Kinase Family Member 3 3 4
  • Sugen Kinase 110 3 4
  • SGK110 3 4
  • Uncharacterized Serine/Threonine-Protein Kinase SBK3 3
  • SH3 Domain Binding Kinase Family, Member 3 2
  • EC 2.7.11.1 4

External Ids for SBK3 Gene

Previous GeneCards Identifiers for SBK3 Gene

  • GC19M056055

Summaries for SBK3 Gene

GeneCards Summary for SBK3 Gene

SBK3 (SH3 Domain Binding Kinase Family Member 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SBK2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK3 Gene

Genomics for SBK3 Gene

Regulatory Elements for SBK3 Gene

Enhancers for SBK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 14.3 +25.3 25334 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G055516 1.5 Ensembl ENCODE dbSUPER 12.4 +28.4 28377 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ZNF143 FOS KLF13 SBK2 SBK3 SSC5D NAT14 ZNF628 ZNF580 ZNF581 CCDC106 FIZ1 ZNF524
GH19G055544 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -2.4 -2439 6.2 FOXA2 CREB3L1 ARID4B SIN3A ZNF143 FOS KLF13 SP5 JUNB SMARCB1 SBK3 SBK2 LOC646709 KIR2DS4 SSC5D ZNF471 GC19P055562
GH19G055619 1 Ensembl ENCODE 11.7 -75.5 -75480 3.6 HDGF PKNOX1 AGO1 MAX CEBPG TEAD3 POLR2A KDM5B PAF1 ZNF362 ZNF524 SBK3 SBK2 ENSG00000268593 ZNF580 GC19M055621 ENSG00000276488
GH19G055521 0.6 ENCODE dbSUPER 13.3 +23.7 23660 0.7 ZSCAN4 SBK3 ZNF524 FIZ1 SSC5D NAT14 SYT5 RDH13 EPS8L1 TMEM86B SBK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SBK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SBK3 Gene

Chromosome:
19
Start:
55,540,559 bp from pter
End:
55,545,543 bp from pter
Size:
4,985 bases
Orientation:
Minus strand

Genomic View for SBK3 Gene

Genes around SBK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK3 Gene

Proteins for SBK3 Gene

  • Protein details for SBK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C264-SBK3_HUMAN
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SBK3
    Protein Accession:
    P0C264

    Protein attributes for SBK3 Gene

    Size:
    359 amino acids
    Molecular mass:
    38488 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK3 Gene

Post-translational modifications for SBK3 Gene

No Post-translational modifications

Other Protein References for SBK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SBK3 Gene

Domains & Families for SBK3 Gene

Protein Domains for SBK3 Gene

Suggested Antigen Peptide Sequences for SBK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C264

UniProtKB/Swiss-Prot:

SBK3_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK3: view

No data available for Gene Families for SBK3 Gene

Function for SBK3 Gene

Molecular function for SBK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for SBK3 Gene

Gene Ontology (GO) - Molecular Function for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SBK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SBK3

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SBK3 Gene

Localization for SBK3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SBK3 Gene

Pathways & Interactions for SBK3 Gene

No Data Available

Interacting Proteins for SBK3 Gene

Gene Ontology (GO) - Biological Process for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SBK3: view

No data available for Pathways by source and SIGNOR curated interactions for SBK3 Gene

Transcripts for SBK3 Gene

mRNA/cDNA for SBK3 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SBK3 Gene

No ASD Table

Relevant External Links for SBK3 Gene

GeneLoc Exon Structure for
SBK3
ECgene alternative splicing isoforms for
SBK3

Expression for SBK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SBK3 Gene

mRNA differential expression in normal tissues according to GTEx for SBK3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x30.8), Muscle - Skeletal (x6.7), and Heart - Left Ventricle (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of SBK3 Gene:

SBK3
genes like me logo Genes that share expression patterns with SBK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBK3 Gene

Orthologs for SBK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SBK3 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SBK3 34
  • 82.96 (n)
dog
(Canis familiaris)
Mammalia SGK110 34
  • 82.82 (n)
SBK3 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sbk3 34 16
  • 81.05 (n)
Gm1078 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sbk3 34
  • 81.05 (n)
oppossum
(Monodelphis domestica)
Mammalia SBK3 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SBK3 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101748417 34
  • 57.59 (n)
SBK3 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SBK3 35
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135243 34
  • 48.73 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:172086 35
  • 31 (a)
ManyToMany
si:ch211-171h4.3 35
  • 28 (a)
ManyToMany
CABZ01038514.1 35
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11221 35
  • 19 (a)
ManyToMany
CG4945 35
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C01C4.3 35
  • 18 (a)
OneToMany
Species where no ortholog for SBK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK3 Gene

ENSEMBL:
Gene Tree for SBK3 (if available)
TreeFam:
Gene Tree for SBK3 (if available)

Paralogs for SBK3 Gene

Paralogs for SBK3 Gene

(5) SIMAP similar genes for SBK3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SBK3: view

Variants for SBK3 Gene

Sequence variations from dbSNP and Humsavar for SBK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000103830 -- 55,540,166(+) GGAGG(C/G)TGAGG downstream-variant-500B
rs1000361849 -- 55,546,949(+) TCCCT(C/T)ACACC upstream-variant-2KB
rs1000462783 -- 55,544,683(+) AGTAC(C/G)CCCAC intron-variant
rs1000522810 -- 55,544,502(+) CACAG(C/T)CGCCT intron-variant
rs1002015009 -- 55,544,934(+) GAGGG(C/T)TGTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SBK3 Gene

Variant ID Type Subtype PubMed ID
esv2661748 CNV deletion 23128226
esv3893252 CNV loss 25118596
nsv1071950 CNV deletion 25765185
nsv953624 CNV deletion 24416366

Variation tolerance for SBK3 Gene

Gene Damage Index Score: 3.81; 58.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SBK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SBK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBK3 Gene

Disorders for SBK3 Gene

Relevant External Links for SBK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SBK3

No disorders were found for SBK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBK3 Gene

Publications for SBK3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for SBK3 Gene

Sources for SBK3 Gene

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