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SBK3 Gene

protein-coding   GIFtS: 19
GCID: GC19M056055

SH3 Domain Binding Kinase Family, Member 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SH3 Domain Binding Kinase Family, Member 31 2
SGK1102 3
SH3-Binding Domain Kinase Family Member 32 3
Sugen Kinase 1102 3
Uncharacterized Serine/Threonine-Protein Kinase SBK32
EC 2.7.11.13

External Ids:    HGNC: 441211   Entrez Gene: 1001308272   Ensembl: ENSG000002312747   UniProtKB: P0C2643   

Export aliases for SBK3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SBK3 Gene:
SBK3 (SH3 domain binding kinase family, member 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SBK1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SBK3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SBK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

SBK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SBK3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056055:  view genomic region     (about GC identifiers)

Start:
56,052,023 bp from pter      End:
56,056,909 bp from pter
Size:
4,887 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SBK3_HUMAN, P0C264 (See protein sequence)
Recommended Name: Uncharacterized serine/threonine-protein kinase SBK3  
Size: 359 amino acids; 38488 Da

Explore the universe of human proteins at neXtProt for SBK3: NX_P0C264

Explore proteomics data for SBK3 at MOPED


See SBK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001186753.1  
ENSEMBL proteins: 
 ENSP00000388220   ENSP00000467263  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR017441 Protein_kinase_ATP_BS
 IPR011009 Kinase-like_dom
 IPR008271 Ser/Thr_kinase_AS
 IPR000719 Prot_kinase_dom

Graphical View of Domain Structure for InterPro Entry P0C264

ProtoNet protein and cluster: P0C264

UniProtKB/Swiss-Prot: SBK3_HUMAN, P0C264
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily
Similarity: Contains 1 protein kinase domain


Find genes that share domains with SBK3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SBK3_HUMAN, P0C264
Catalytic activity: ATP + a protein = ADP + a phosphoprotein

     Enzyme Number (IUBMB): EC 2.7.11.11

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004672protein kinase activity ----
GO:0004674protein serine/threonine kinase activity IEA--
GO:0004713protein tyrosine kinase activity ----
GO:0005524ATP binding IEA--
GO:0016772transferase activity, transferring phosphorus-containing groups ----
     
Find genes that share ontologies with SBK3           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SBK3
Interactions:

    Search GeneGlobe Interaction Network for SBK3

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006468protein phosphorylation ----

Find genes that share ontologies with SBK3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for SBK3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SBK3 gene: 
NM_001199824.2  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000420723(uc021vbx.1) ENST00000592464
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

SBK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SBK3 Protein Expression
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SBK3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm10785
Sbk31
predicted gene 10785
SH3 domain binding kinase family, member 31
81.05(n)1
86.93(a)1
  7 (2.87 cM)5
3818351  NM_001200041.11  NP_001186970.11 
 49652605 
chicken
(Gallus gallus)
Aves LOC1017484171 putative uncharacterized serine/threonine-protein kinase more 57.59(n)
48.17(a)
  101748417  XM_004949780.1  XP_004949837.1 
lizard
(Anolis carolinensis)
Reptilia SBK36
SH3 domain binding kinase family, member 3
30(a)
1 ↔ 1
GL343253.1(1279998-1304414)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1001352431 uncharacterized LOC100135243 48.73(n)
38.24(a)
  100135243  NM_001113933.2  NP_001107405.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1720866
si:ch211-171h4.36
(see all 3)
si:ch211-171h4.3
(see all 3)
31(a)
28(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
16(14462325-14475159) ENSDARG00000057687
19(11038020-11047676) ENSDARG00000020455
fruit fly
(Drosophila melanogaster)
Insecta CG112216
CG49456
--
19(a)
15(a)
many ↔ many
many ↔ many
2L(6742508-6755686)
2R(12453552-12457625)
worm
(Caenorhabditis elegans)
Secernentea C01C4.36
Protein C01C4.3, isoform b (C01C4.3) mRNA, complet...
18(a)
1 → many
X(3706742-3713331) WBGene00015293


ENSEMBL Gene Tree for SBK3 (if available)
TreeFam Gene Tree for SBK3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SBK3 gene
SBK12  SBK22  
5 SIMAP similar genes for SBK3 using alignment to 3 protein entries:     SBK3_HUMAN (see all proteins):
STK36    SBK2    BRSK2    SBK1    ULK1

Find genes that share paralogs with SBK3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SBK3 (see all 141)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1814279251,2
--56051649(+) CAGGCA/GTGGTG 1 -- ds50010--------
rs1860078081,2
--56051702(+) TGGATC/TATTTG 1 -- ds50010--------
rs1397369051,2
C--56051778(+) TTAGCC/TGGGTG 1 -- ds50010--------
rs730611131,2
C,F--56051946(+) AAGACA/GCTCTG 1 -- ds50014Minor allele frequency- G:0.21WA CSA EA 242
rs751809151,2
F--56051968(+) GAGGAA/TAGGTC 1 -- ds50010--------
rs348374141,2
C,F--56052008(+) TCCTGC/TGTCTG 1 -- ds50017Minor allele frequency- T:0.27NA WA EA 366
rs1138589531,2
C--56052031(+) CAGGAG/ACTGGG 1 -- ut311Minor allele frequency- A:0.50CSA 2
rs1510288711,2
--56052068(+) ATGCGC/TGTCCA 1 -- ut310--------
rs1397902141,2
--56052103(+) GCAATA/GTGTTC 1 -- ut310--------
rs1903078851,2
--56052132(+) TGCAGC/GTGTCT 1 -- ut310--------

HapMap Linkage Disequilibrium report for SBK3 (56052023 - 56056909 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SBK3: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SBK3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SBK3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SBK3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
  2. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (Science 2002)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100130827 HGNC: 44121 Ensembl:ENSG00000231274 euGenes: HUgn100130827 ECgene: SBK3
H-InvDB: SBK3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SBK3 gene:
Search GeneIP for patents involving SBK3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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