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Aliases for SBK3 Gene

Aliases for SBK3 Gene

  • SH3 Domain Binding Kinase Family Member 3 2 3 5
  • SH3-Binding Domain Kinase Family Member 3 3 4
  • Sugen Kinase 110 3 4
  • SGK110 3 4
  • Uncharacterized Serine/Threonine-Protein Kinase SBK3 3
  • SH3 Domain Binding Kinase Family, Member 3 2
  • EC 4

External Ids for SBK3 Gene

Previous GeneCards Identifiers for SBK3 Gene

  • GC19M056055

Summaries for SBK3 Gene

GeneCards Summary for SBK3 Gene

SBK3 (SH3 Domain Binding Kinase Family Member 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SBK2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK3 Gene

Genomics for SBK3 Gene

Regulatory Elements for SBK3 Gene

Enhancers for SBK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055519 1.6 FANTOM5 Ensembl ENCODE 14.3 +25.3 25334 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055516 1.3 Ensembl ENCODE 12.4 +28.4 28377 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ZNF143 FOS KLF13 SBK2 SBK3 SSC5D NAT14 ZNF580 ZNF581 CCDC106 ZNF628 FIZ1 ZNF524
GH19F055246 1.2 ENCODE 11.1 +291.7 291685 14.5 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 HSPBP1 TMEM86B ZNF628 RFPL4AP1 RPL13P13 PPP6R1 BRSK1 MIR6805 RPL28 TMEM238
GH19F054747 1.2 Ensembl 11.1 +797.7 797654 1.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D ZNF628 LENG1 LENG8-AS1 MIR519A2 PRPF31 ZNF784 SBK3 ENSG00000269275 ENSG00000235681 KIR2DL3
GH19F055544 1.4 FANTOM5 ENCODE 8.7 -2.4 -2439 6.2 ARID4B ZNF48 ZNF143 FOS SP5 JUNB NCOA1 PPARG SMARCB1 KAT8 ZNF784 ZNF865 ZNF581 ZNF628 SBK3 SBK2 LOC646709 KIR2DS4 ZNF471 SSC5D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SBK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SBK3 Gene

55,540,559 bp from pter
55,545,543 bp from pter
4,985 bases
Minus strand

Genomic View for SBK3 Gene

Genes around SBK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK3 Gene

Proteins for SBK3 Gene

  • Protein details for SBK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SBK3
    Protein Accession:

    Protein attributes for SBK3 Gene

    359 amino acids
    Molecular mass:
    38488 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK3 Gene

Post-translational modifications for SBK3 Gene

No Post-translational modifications

Other Protein References for SBK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SBK3 Gene

Domains & Families for SBK3 Gene

Protein Domains for SBK3 Gene

Suggested Antigen Peptide Sequences for SBK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK3: view

No data available for Gene Families for SBK3 Gene

Function for SBK3 Gene

Molecular function for SBK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for SBK3 Gene

Gene Ontology (GO) - Molecular Function for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SBK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SBK3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SBK3 Gene

Localization for SBK3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SBK3 Gene

Pathways & Interactions for SBK3 Gene

No Data Available

Interacting Proteins for SBK3 Gene

Gene Ontology (GO) - Biological Process for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SBK3: view

No data available for Pathways by source and SIGNOR curated interactions for SBK3 Gene

Transcripts for SBK3 Gene

mRNA/cDNA for SBK3 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBK3 Gene

No ASD Table

Relevant External Links for SBK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SBK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SBK3 Gene

mRNA differential expression in normal tissues according to GTEx for SBK3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x30.8), Muscle - Skeletal (x6.7), and Heart - Left Ventricle (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of SBK3 Gene:

genes like me logo Genes that share expression patterns with SBK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SBK3 Gene

Orthologs for SBK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SBK3 35
  • 100 (a)
(Bos Taurus)
Mammalia SBK3 34
  • 82.96 (n)
(Canis familiaris)
Mammalia SGK110 34
  • 82.82 (n)
SBK3 35
  • 78 (a)
(Mus musculus)
Mammalia Sbk3 34 16
  • 81.05 (n)
Gm1078 35
  • 76 (a)
(Rattus norvegicus)
Mammalia Sbk3 34
  • 81.05 (n)
(Monodelphis domestica)
Mammalia SBK3 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SBK3 35
  • 52 (a)
(Gallus gallus)
Aves LOC101748417 34
  • 57.59 (n)
SBK3 35
  • 47 (a)
(Anolis carolinensis)
Reptilia SBK3 35
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135243 34
  • 48.73 (n)
(Danio rerio)
Actinopterygii zgc:172086 35
  • 31 (a)
si:ch211-171h4.3 35
  • 28 (a)
CABZ01038514.1 35
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11221 35
  • 19 (a)
CG4945 35
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C01C4.3 35
  • 18 (a)
Species where no ortholog for SBK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK3 Gene

Gene Tree for SBK3 (if available)
Gene Tree for SBK3 (if available)

Paralogs for SBK3 Gene

Paralogs for SBK3 Gene

(5) SIMAP similar genes for SBK3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SBK3: view

Variants for SBK3 Gene

Sequence variations from dbSNP and Humsavar for SBK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404541 -- 55,541,990(+) TTCTT(A/G)TATAT intron-variant
rs10415647 -- 55,547,041(+) caggc(C/T)ccagc upstream-variant-2KB
rs10415827 -- 55,547,071(+) ggagt(A/C)caggc upstream-variant-2KB
rs10415837 -- 55,547,085(+) cagcc(C/T)cttct upstream-variant-2KB
rs10415839 -- 55,547,091(+) cttct(C/T)cctca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SBK3 Gene

Variant ID Type Subtype PubMed ID
esv2661748 CNV deletion 23128226
esv3893252 CNV loss 25118596
nsv1071950 CNV deletion 25765185
nsv953624 CNV deletion 24416366

Variation tolerance for SBK3 Gene

Gene Damage Index Score: 3.81; 58.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SBK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBK3 Gene

Disorders for SBK3 Gene

Relevant External Links for SBK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SBK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBK3 Gene

Publications for SBK3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for SBK3 Gene

Sources for SBK3 Gene

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