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Aliases for SBK2 Gene

Aliases for SBK2 Gene

  • SH3 Domain Binding Kinase Family, Member 2 2 3
  • SH3-Binding Domain Kinase Family, Member 2 2 3
  • Sugen Kinase 69 3 4
  • EC 2.7.11.1 4 63
  • SGK069 3 4
  • SH3-Binding Domain Kinase Family Member 2 4
  • Serine/Threonine-Protein Kinase SBK2 3
  • EC 2.7.11 63

External Ids for SBK2 Gene

Previous GeneCards Identifiers for SBK2 Gene

  • GC19M060736
  • GC19M056041
  • GC19M052354

Summaries for SBK2 Gene

GeneCards Summary for SBK2 Gene

SBK2 (SH3 Domain Binding Kinase Family, Member 2) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SBK1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK2 Gene

Genomics for SBK2 Gene

Genomic Location for SBK2 Gene

Start:
55,529,413 bp from pter
End:
55,537,089 bp from pter
Size:
7,677 bases
Orientation:
Minus strand

Genomic View for SBK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SBK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK2 Gene

Proteins for SBK2 Gene

  • Protein details for SBK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C263-SBK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SBK2
    Protein Accession:
    P0C263
    Secondary Accessions:

    Protein attributes for SBK2 Gene

    Size:
    348 amino acids
    Molecular mass:
    38088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK2 Gene

Proteomics data for SBK2 Gene at MOPED

Selected DME Specific Peptides for SBK2 Gene

Post-translational modifications for SBK2 Gene

No Post-translational modifications

Other Protein References for SBK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SBK2 Gene

Gene Families for SBK2 Gene

Protein Domains for SBK2 Gene

Suggested Antigen Peptide Sequences for SBK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C263

UniProtKB/Swiss-Prot:

SBK2_HUMAN :
  • P0C263
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK2: view

Function for SBK2 Gene

Molecular function for SBK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for SBK2 Gene

Gene Ontology (GO) - Molecular Function for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004708 MAP kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with SBK2: view

Phenotypes for SBK2 Gene

GenomeRNAi human phenotypes for SBK2:
genes like me logo Genes that share phenotypes with SBK2: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SBK2 Gene

Localization for SBK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SBK2 Gene COMPARTMENTS Subcellular localization image for SBK2 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SBK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SBK2 Gene

Pathways for SBK2 Gene

SuperPathways for SBK2 Gene

No Data Available

Interacting Proteins for SBK2 Gene

Gene Ontology (GO) - Biological Process for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000187 activation of MAPK activity IBA --
GO:0006468 protein phosphorylation IEA --
GO:0023014 signal transduction by protein phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with SBK2: view

No data available for Pathways by source for SBK2 Gene

Transcripts for SBK2 Gene

mRNA/cDNA for SBK2 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SBK2 Gene

SH3-binding domain kinase family, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SBK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBK2 Gene

No ASD Table

Relevant External Links for SBK2 Gene

GeneLoc Exon Structure for
SBK2
ECgene alternative splicing isoforms for
SBK2

Expression for SBK2 Gene

mRNA expression in normal human tissues for SBK2 Gene

mRNA differential expression in normal tissues according to GTEx for SBK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (48.7).

Protein differential expression in normal tissues for SBK2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SBK2 Gene

SOURCE GeneReport for Unigene cluster for SBK2 Gene Hs.532676

genes like me logo Genes that share expressions with SBK2: view

Expression partners for SBK2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SBK2 Gene

Orthologs for SBK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SBK2 35
  • 81.84 (n)
  • 78.26 (a)
SBK2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SBK2 35
  • 85.09 (n)
  • 84.08 (a)
SBK2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sbk2 35
  • 79.44 (n)
  • 81.84 (a)
Sbk2 16
Sbk2 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SBK2 35
  • 98.56 (n)
  • 97.41 (a)
SBK2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sbk2 35
  • 78.96 (n)
  • 80.98 (a)
oppossum
(Monodelphis domestica)
Mammalia SBK2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SBK2 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves SBK2 35
  • 61.63 (n)
  • 56.04 (a)
SBK2 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SBK2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492557 35
  • 55.37 (n)
  • 52.35 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-8e10.3 35
  • 53.55 (n)
  • 44.84 (a)
SBK2 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11221 36
  • 19 (a)
ManyToMany
CG4945 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C01C4.3 36
  • 19 (a)
OneToMany
Species with no ortholog for SBK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK2 Gene

ENSEMBL:
Gene Tree for SBK2 (if available)
TreeFam:
Gene Tree for SBK2 (if available)

Paralogs for SBK2 Gene

Paralogs for SBK2 Gene

Selected SIMAP similar genes for SBK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SBK2: view

Variants for SBK2 Gene

Sequence variations from dbSNP and Humsavar for SBK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs310452 -- 55,536,477(-) TGACC(A/T)GGGGC intron-variant
rs310453 -- 55,536,081(-) AGGGT(C/T)GCTAT missense, reference
rs310454 -- 55,535,797(-) AAGTG(A/T)TCCTC intron-variant
rs310455 -- 55,534,659(-) cacaa(C/T)catag intron-variant
rs310456 -- 55,534,155(-) cagca(A/C)tgggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SBK2 Gene

Variant ID Type Subtype PubMed ID
nsv912473 CNV Loss 21882294
nsv912478 CNV Loss 21882294
dgv4023n71 CNV Loss 21882294
nsv912486 CNV Loss 21882294
dgv4025n71 CNV Loss 21882294
nsv912493 CNV Loss 21882294
dgv4026n71 CNV Loss 21882294
esv4756 CNV Deletion 18987735
nsv138153 CNV Loss 16902084
esv997838 CNV Deletion 20482838
esv1510388 CNV Deletion 17803354
esv7136 CNV Loss 19470904
esv2718980 CNV Deletion 23290073

Relevant External Links for SBK2 Gene

HapMap Linkage Disequilibrium report
SBK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBK2 Gene

Disorders for SBK2 Gene

No disorders were found for SBK2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SBK2 Gene

Publications for SBK2 Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 3 4

Products for SBK2 Gene

Sources for SBK2 Gene

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