SBK2 Gene
protein-coding GIFtS: 34
GCID: GC19M056041
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SH3-binding domain kinase family, member 2
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Aliases
for SBK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3-Binding Domain Kinase Family, Member 21 2 | | Serine/Threonine-Protein Kinase SBK22 | | SGK0691 2 3 | | SgK0693 | | Sugen Kinase 692 3 | | SH3-Binding Domain Kinase Family Member 23 | | EC 2.7.11.13 8 | | EC 2.7.118 |
Export aliases for SBK2 gene to outside databasesPrevious GC identifers: GC19M060736 GC19M052354 |
Summaries
for SBK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SBK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SBK2 gene promoter:
SRF MAZR SRF (504 AA) HSF1 (long) PPAR-gamma1 FOXJ2 (long isoform) HSF1short PPAR-gamma2 ZID FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SBK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SBK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42SBK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M056041: view genomic region
(about GC identifiers)
Start:
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56,041,100 bp from pter |
End:
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56,048,456 bp from pter |
Size:
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7,357 bases |
Orientation:
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minus strand |
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Proteins
for SBK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SBK2_HUMAN, P0C263 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase SBK2 Size: 348 amino acids; 38088 DaExplore the universe of human proteins at neXtProt for SBK2: NX_P0C263
2 DME Specific Peptides for SBK2 (P0C263)
SBK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001094871.2
ENSEMBL proteins: ENSP00000389015 ENSP00000345044
Human Recombinant Protein Products for SBK2:
SBK2 Antibody Products:
Assay Products for SBK2: |
Protein
Domains /
Families
for SBK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SBK2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C263ProtoNet protein and cluster: P0C263 UniProtKB/Swiss-Prot: SBK2_HUMAN, P0C263Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamilySimilarity: Contains 1 protein kinase domain |
Function
for SBK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/Swiss-Prot Summary: SBK2_HUMAN, P0C263Catalytic activity: ATP + a protein = ADP + a phosphoprotein Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
SBK2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SBK2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SBK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SBK2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SBK2 (NM_001101401) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SBK2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SBK2 |
|
Pathways & Interactions
for SBK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SBK2
|
Drugs & Compounds
for SBK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SBK2
Search CenterWatch for drugs/clinical trials and news about SBK2
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Transcripts
for SBK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SBK2 gene: NM_001101401.2 Unigene Cluster for SBK2: SH3-binding domain kinase family, member 2 Hs.532676 [show with all ESTs]Unigene Representative Sequence: NM_0011014012 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000413299(uc010ygc.2) ENST00000344158
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SBK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SBK2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SBK2 (NM_001101401) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SBK2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SBK2 |
1 DOTS entry: DT.102822142
GeneLoc Exon Structure
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Expression
for SBK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SBK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTCATCC
About this image
See SBK2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.532676
SABiosciences Custom PCR Arrays for SBK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SBK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SBK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SBK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SBK2 |
Orthologs
for SBK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for SBK2 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for SBK2 (if available)
TreeFam Gene Tree for SBK2 (if available) |
Paralogs
for SBK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SBK2 gene
- SBK12 SGK1102
4 SIMAP similar genes for SBK2 using alignment to 1 protein entry: SBK2_HUMAN:SBK1 SGK110 NUAK1 MARK4
SBK2 for paralogs About GeneDecksing
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Genomic Variants
for SBK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SBK2 (56041100 - 56048456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SBK2
5 Indels: 40293 61724 12040 26348 42747 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SBK2 |
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Disorders
/ Diseases
for SBK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SBK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SBK2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SBK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)1, 2 Greenman C.... Stratton M.R. (2007)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
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External Searches for SBK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SBK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing SBK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SBK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SBK2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SBK2 gene:
Search GeneIP for patents involving SBK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SBK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SBK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SBK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SBK2 | | | OriGene Protein Over-expression Lysate for SBK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SBK2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SBK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SBK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SBK2 | | OriGene Custom Protein Services for SBK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SBK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SBK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SBK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SBK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SBK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SBK2 |
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| | | | Search Tocris compounds for SBK2 |
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 | | | SBK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for SBK2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SBK2 |
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