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Aliases for SBK1 Gene

Aliases for SBK1 Gene

  • SH3 Domain Binding Kinase 1 2 3
  • SH3-Binding Domain Kinase 1 2 3
  • EC 2.7.11.1 4 64
  • Serine/Threonine-Protein Kinase SBK1 3
  • SH3-Binding Kinase 1 4
  • EC 2.7.11 64
  • SBK 3

External Ids for SBK1 Gene

Summaries for SBK1 Gene

GeneCards Summary for SBK1 Gene

SBK1 (SH3 Domain Binding Kinase 1) is a Protein Coding gene. Diseases associated with SBK1 include esophagus squamous cell carcinoma. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SBK2.

UniProtKB/Swiss-Prot for SBK1 Gene

  • May be involved in signal-transduction pathways related to the control of brain development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK1 Gene

Genomics for SBK1 Gene

Genomic Location for SBK1 Gene

Start:
28,258,720 bp from pter
End:
28,323,849 bp from pter
Size:
65,130 bases
Orientation:
Plus strand

Genomic View for SBK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SBK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK1 Gene

Regulatory Elements for SBK1 Gene

Proteins for SBK1 Gene

  • Protein details for SBK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52WX2-SBK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SBK1
    Protein Accession:
    Q52WX2
    Secondary Accessions:

    Protein attributes for SBK1 Gene

    Size:
    424 amino acids
    Molecular mass:
    46252 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK1 Gene

Proteomics data for SBK1 Gene at MOPED

Selected DME Specific Peptides for SBK1 Gene

Post-translational modifications for SBK1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys176

Other Protein References for SBK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SBK1 Gene

Gene Families for SBK1 Gene

UniProtKB/Swiss-Prot:

SBK1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q52WX2
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • Q52WX2
genes like me logo Genes that share domains with SBK1: view

Function for SBK1 Gene

Molecular function for SBK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: May be involved in signal-transduction pathways related to the control of brain development.

Enzyme Numbers (IUBMB) for SBK1 Gene

Gene Ontology (GO) - Molecular Function for SBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with SBK1: view

Phenotypes for SBK1 Gene

GenomeRNAi human phenotypes for SBK1:
genes like me logo Genes that share phenotypes with SBK1: view

miRNA for SBK1 Gene

miRTarBase miRNAs that target SBK1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SBK1 Gene

Localization for SBK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SBK1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SBK1 Gene COMPARTMENTS Subcellular localization image for SBK1 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for SBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SBK1: view

Pathways for SBK1 Gene

SuperPathways for SBK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with SBK1: view

No data available for Pathways by source for SBK1 Gene

Compounds for SBK1 Gene

(2) HMDB Compounds for SBK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with SBK1: view

Transcripts for SBK1 Gene

mRNA/cDNA for SBK1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SBK1 Gene

SH3-binding domain kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SBK1 Gene

No ASD Table

Relevant External Links for SBK1 Gene

GeneLoc Exon Structure for
SBK1
ECgene alternative splicing isoforms for
SBK1

Expression for SBK1 Gene

mRNA expression in normal human tissues for SBK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SBK1 Gene

This gene is overexpressed in Brain - Cerebellum (9.0) and Brain - Cerebellar Hemisphere (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SBK1 Gene

SOURCE GeneReport for Unigene cluster for SBK1 Gene Hs.97837

genes like me logo Genes that share expressions with SBK1: view

Orthologs for SBK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SBK1 36
  • 99.11 (n)
  • 98.93 (a)
SBK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SBK1 36
  • 88.8 (n)
  • 93.89 (a)
SBK1 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SBK1 36
  • 94.03 (n)
  • 98.42 (a)
SBK1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sbk1 36
  • 87.61 (n)
  • 95.44 (a)
Sbk1 16
Sbk1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SBK1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SBK1 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sbk1 36
  • 87.37 (n)
  • 95.92 (a)
chicken
(Gallus gallus)
Aves SBK1 36
  • 82.26 (n)
  • 80.1 (a)
SBK1 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SBK1 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100125030 36
  • 69.61 (n)
  • 76.1 (a)
Str.12367 36
zebrafish
(Danio rerio)
Actinopterygii SBK1 37
  • 58 (a)
OneToOne
si:ch211-183d21.3 36
  • 65.74 (n)
  • 68.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11221 37
  • 23 (a)
ManyToMany
CG4945 37
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C01C4.3 37
  • 23 (a)
OneToMany
Species with no ortholog for SBK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK1 Gene

ENSEMBL:
Gene Tree for SBK1 (if available)
TreeFam:
Gene Tree for SBK1 (if available)

Paralogs for SBK1 Gene

Paralogs for SBK1 Gene

Selected SIMAP similar genes for SBK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SBK1: view

Variants for SBK1 Gene

Sequence variations from dbSNP and Humsavar for SBK1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1875219 -- 28,308,564(+) actat(A/G)ggcat intron-variant
rs2055390 -- 28,316,905(-) ACTGC(A/T)CCCGG intron-variant
rs2412052 -- 28,303,509(-) aaaaa(A/G)aaaaa intron-variant
rs2466825 -- 28,308,414(+) ccaaa(A/T)tgctg intron-variant
rs2650492 -- 28,322,090(+) CACCA(A/G)GGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SBK1 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv526174 CNV Gain 19592680
nsv516054 CNV Loss 19592680

Relevant External Links for SBK1 Gene

HapMap Linkage Disequilibrium report
SBK1

Disorders for SBK1 Gene

(1) University of Copenhagen DISEASES for SBK1 Gene

Relevant External Links for SBK1

Genetic Association Database (GAD)
SBK1
Human Genome Epidemiology (HuGE) Navigator
SBK1
genes like me logo Genes that share disorders with SBK1: view

No data available for UniProtKB/Swiss-Prot for SBK1 Gene

Publications for SBK1 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  2. Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells. (PMID: 21104019) Wang P. … Ma D. (Mol. Biol. Rep. 2011) 3
  3. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 4
  4. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. (PMID: 11322885) Nara K. … Nagai Y. (Eur. J. Biochem. 2001) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for SBK1 Gene

Sources for SBK1 Gene

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