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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SBK1 Gene

protein-coding   GIFtS: 50
GCID: GC16P028211

SH3 Domain Binding Kinase 1

(Previous name: SH3-binding domain kinase 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SH3 Domain Binding Kinase 11     Serine/Threonine-Protein Kinase SBK12
SH3-Binding Domain Kinase 11 2     SH3-Binding Kinase 13
EC 2.7.11.13 8     EC 2.7.118
SBK2     

External Ids:    HGNC: 176991   Entrez Gene: 3882282   Ensembl: ENSG000001883227   UniProtKB: Q52WX23   

Export aliases for SBK1 gene to outside databases

Previous GC identifers: GC16P028160 GC16P026395


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SBK1 Gene: 
SBK1 (SH3 domain binding kinase 1) is a protein-coding gene. Diseases associated with SBK1 include esophagus squamous cell carcinoma, and squamous cell carcinoma. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is SBK3.

UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2
Function: May be involved in signal-transduction pathways related to the control of brain development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SBK1 gene promoter:
         NRSF form 1   CUTL1   MIF-1   NRSF form 2   c-Ets-1   Chx10   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSBK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SBK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SBK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SBK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SBK1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028211:  view genomic region     (about GC identifiers)

Start:
28,303,840 bp from pter      End:
28,335,170 bp from pter
Size:
31,331 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SBK1  
Size: 424 amino acids; 46252 Da
Subcellular location: Cytoplasm (By similarity)

Explore the universe of human proteins at neXtProt for SBK1: NX_Q52WX2

Explore proteomics data for SBK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q52WX2

  • 4/7 DME Specific Peptides for SBK1 (Q52WX2) (see all 7)
     VKLADFG  EEFVRWQ  IPYTAPE  LTGNFPWE 

    SBK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SBK1 Protein Expression
    REFSEQ proteins: NP_001019572.1  
    ENSEMBL proteins: 
     ENSP00000343248  

    Human Recombinant Protein Products for SBK1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SBK1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SBK1 for ontologies           About GeneDecksing



    SBK1 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for SBK1 
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    LSBio Antibodies in human, mouse, rat for SBK1 

    Assay Products for SBK1: 
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    Cloud-Clone Corp. CLIAs for SBK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: SH3-binding domain kinase 1 
    NKF1 family

    5 InterPro protein domains:
     IPR016234 Ser/Thr_kinase_Sbk1
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q52WX2

    ProtoNet protein and cluster: Q52WX2

    UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    SBK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SBK1_HUMAN, Q52WX2
    Function: May be involved in signal-transduction pathways related to the control of brain development (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    SBK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SBK1:
     Decreased CYP1A1 activity afte 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SBK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SBK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SBK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SBK1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SBK1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate SBK1 (see all 79):
    hsa-miR-30d hsa-miR-3921 hsa-miR-4267 hsa-miR-30a hsa-miR-3649 hsa-miR-92b hsa-miR-1266 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSBK1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SBK1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SBK1 (Q52WX23 ENSP000003432484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCHSD1Q86WN13, ENSP000003992594I2D: score=1 STRING: ENSP00000399259
    PACSIN3Q9UKS63, ENSP000002988384I2D: score=1 STRING: ENSP00000298838
    PACSIN2Q9UNF03, ENSP000002632464I2D: score=1 STRING: ENSP00000263246
    TRIP10Q156423, ENSP000003204934I2D: score=1 STRING: ENSP00000320493
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    SBK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SBK1

    2 HMDB Compounds for SBK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about SBK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SBK1 gene: 
    NM_001024401.2  

    Unigene Cluster for SBK1:

    SH3-binding domain kinase 1
    Hs.97837  [show with all ESTs]
    Unigene Representative Sequence: AY874862
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341901(uc002dpd.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SBK1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate SBK1 (see all 79):
    hsa-miR-30d hsa-miR-3921 hsa-miR-4267 hsa-miR-30a hsa-miR-3649 hsa-miR-92b hsa-miR-1266 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSBK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SBK1
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SBK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1
    Sirion Biotech Customized lentivirus for stable overexpression of SBK1 
                         Customized lentivirus expression plasmids for stable overexpression of SBK1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SBK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SBK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SBK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SBK1

    Additional mRNA sequence: 

    AL390134.1 AY874862.2 

    6 DOTS entries:

    DT.209792  DT.120728348  DT.97814144  DT.101970720  DT.120728376  DT.97811723 

    1 AceView cDNA sequence:

    BQ071837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SBK1 expression in normal human tissues (normalized intensities)      SBK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGATTGCTA
    SBK1 Expression
    About this image


    SBK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Thalamus
             Human Astrocytes   
             cerebellum   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             ESI-049   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Retina
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             Human Renal Epithelial Cells (HREpiC)   

    See SBK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SBK1

    SOURCE GeneReport for Unigene cluster: Hs.97837
        SABiosciences Custom PCR Arrays for SBK1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SBK1 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sbk11 , 5 SH3-binding kinase 11, 5 87.77(n)1
    95.68(a)1
      7 (69.01 cM)5
    1041751  NM_145587.21  NP_663562.11 
     1262726195 
    chicken
    (Gallus gallus)
    Aves SBK11 SH3-binding domain kinase 1 81.62(n)
    79.49(a)
      426442  XM_424086.3  XP_424086.2 
    lizard
    (Anolis carolinensis)
    Reptilia SBK16
    Serine/threonine-protein kinase SBK1
    78(a)
    1 ↔ 1
    GL344795.1(1957-8636)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.123672 Transcribed sequence with weak similarity to protein more 74.87(n)    BX709019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5597921 serine/threonine-protein kinase SBK1-like 64.16(n)
    65.59(a)
      559792  XM_683164.4  XP_688256.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112216
    CG49456
    --
    22(a)
    18(a)
    many ↔ many
    many ↔ many
    2L(6742508-6755686)
    2R(12453552-12457625)
    worm
    (Caenorhabditis elegans)
    Secernentea R02C2.66
    C01C4.36
    (see all 7)
    Putative serine/threonine-protein kinase C01C4.3
    (see all 7)
    24(a)
    23(a)
    (see all 7)
    possible ortholog
    1 ↔ many
    (see all 7)
    V(238963-240362)
    X(3706742-3713331)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CHK16
    Serine/threonine kinase and DNA damage checkpoint ...
    15(a)
    1 → many
    II(749594-751177)


    ENSEMBL Gene Tree for SBK1 (if available)
    TreeFam Gene Tree for SBK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SBK1 gene
    SBK32  SBK22  
    6 SIMAP similar genes for SBK1 using alignment to 1 protein entry:     SBK1_HUMAN:
    KIN27    PRKACB    SBK2    STK17A    PRKAA1    SGK110

    SBK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/551 SNPs in SBK1 are shown (see all 551)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410684
    An ovarian mucinous carcinoma sample4--see VAR_0410682 K E mis40--------
    VAR_0410704
    ----see VAR_0410702 A S mis40--------
    rs71949381,2
    C--28305495(+) CCCCAG/ACCTGG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1834791491,2
    --28305549(+) AAGCCA/GAGAGA 1 -- int10--------
    rs1403613541,2
    C--28305553(+) CGAGAC/GACCCT 1 -- int10--------
    rs559176721,2
    C,F--28305727(+) GGCTCG/AGGAAG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1866225771,2
    --28305816(+) ATGGAA/CCATGC 1 -- int10--------
    rs1914715321,2
    --28305906(+) TCCCAC/TTGGGC 1 -- int10--------
    rs1824694911,2
    --28306020(+) TGGCTA/GACTCC 1 -- int10--------
    rs1421244381,2
    --28306152(+) TGGCAA/GCCTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SBK1 (28303840 - 28335170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SBK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516054CNV Loss19592680
    nsv526174CNV Gain19592680
    dgv843e1CNV Complex17122850
    dgv842e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SBK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SBK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SBK1:    About MalaCards
    esophagus squamous cell carcinoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for SBK1:
    Esophagus squamous cell carcinoma

    SBK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SBK1
    Human Genome Epidemiology (HuGE) Navigator: SBK1 (1 document)

    Export disorders for SBK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SBK1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SBK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    2. Human SBK1 is dysregulated in multiple cancers and pr omotes survival of ovary cancer SK-OV-3 cells. (PubMed id 21104019)1 Wang P....Ma D. (2011)
    3. Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. (PubMed id 19041431)1 Linkermann A....Janssen O. (2009)
    4. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    6. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. (PubMed id 11322885)1 Nara K....Nagai Y. (2001)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388228 HGNC: 17699 AceView: LOC388228 Ensembl:ENSG00000188322 euGenes: HUgn388228
    ECgene: SBK1 H-InvDB: SBK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SBK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SBK1 gene:
    Search GeneIP for patents involving SBK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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