Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SBK1 Gene

protein-coding   GIFtS: 51
GCID: GC16P028211

SH3 Domain Binding Kinase 1

(Previous name: SH3-binding domain kinase 1)
  See SBK1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SH3 Domain Binding Kinase 11 2     Serine/Threonine-Protein Kinase SBK12
SH3-Binding Domain Kinase 11 2     SH3-Binding Kinase 13
EC 2.7.11.13 8     EC 2.7.118
SBK2     

External Ids:    HGNC: 176991   Entrez Gene: 3882282   Ensembl: ENSG000001883227   UniProtKB: Q52WX23   

Export aliases for SBK1 gene to outside databases

Previous GC identifers: GC16P028160 GC16P026395


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SBK1 Gene:
SBK1 (SH3 domain binding kinase 1) is a protein-coding gene. Diseases associated with SBK1 include esophagus squamous cell carcinoma. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is SBK3.

UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2
Function: May be involved in signal-transduction pathways related to the control of brain development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SBK1 gene promoter:
         NRSF form 1   CUTL1   MIF-1   NRSF form 2   c-Ets-1   Chx10   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSBK1 promoter sequence
   Search Chromatin IP Primers for SBK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SBK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SBK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SBK1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P028211:  view genomic region     (about GC identifiers)

Start:
28,303,840 bp from pter      End:
28,335,170 bp from pter
Size:
31,331 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase SBK1  
Size: 424 amino acids; 46252 Da

Explore the universe of human proteins at neXtProt for SBK1: NX_Q52WX2

Explore proteomics data for SBK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys176
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SBK1 (Q52WX2) (see all 7)
     VKLADFG  EEFVRWQ  IPYTAPE  LTGNFPWE 


    See SBK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001019572.1  
    ENSEMBL proteins: 
     ENSP00000343248  

    SBK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SBK1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for SBK1
    OriGene Custom Protein Services for SBK1
    GenScript Custom Purified and Recombinant Proteins Services for SBK1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SBK1

     
    Search eBioscience for Proteins for SBK1 

    SBK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SBK1
    Novus Biologicals SBK1 Antibody
    Abcam antibodies for SBK1
    Cloud-Clone Corp. Antibodies for SBK1
    Search ThermoFisher Antibodies for SBK1
    Search LSBio for Antibodies for SBK1

    SBK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SBK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SBK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SBK1
    Cloud-Clone Corp. CLIAs for SBK1
    Search eBioscience for ELISAs for SBK1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: SH3-binding domain kinase 1
    NKF1 family

    5 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR016234 Ser/Thr_kinase_Sbk1

    Graphical View of Domain Structure for InterPro Entry Q52WX2

    ProtoNet protein and cluster: Q52WX2

    UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with SBK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SBK1_HUMAN, Q52WX2
    Function: May be involved in signal-transduction pathways related to the control of brain development (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with SBK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SBK1:
     Decreased CYP1A1 activity afte 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SBK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SBK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SBK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SBK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SBK1:
    hsa-mir-532-3p (MIRT037917)

    Block miRNA regulation of human, mouse, rat SBK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SBK1 (see all 79):
    hsa-miR-30d hsa-miR-3921 hsa-miR-4267 hsa-miR-30a hsa-miR-3649 hsa-miR-92b hsa-miR-1266 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSBK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SBK1
    Predesigned siRNA for gene silencing in human, mouse, rat SBK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SBK1

    Clone
    Products:
         
    OriGene clones in human, mouse for SBK1 (see all 6)
    OriGene ORF clones in mouse, rat for SBK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SBK1 (NM_001024401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SBK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SBK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SBK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SBK1_HUMAN, Q52WX2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SBK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SBK1
    Interactions:

        Search GeneGlobe Interaction Network for SBK1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SBK1 (Q52WX23 ENSP000003432484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCHSD1Q86WN13, ENSP000003992594I2D: score=1 STRING: ENSP00000399259
    PACSIN3Q9UKS63, ENSP000002988384I2D: score=1 STRING: ENSP00000298838
    PACSIN2Q9UNF03, ENSP000002632464I2D: score=1 STRING: ENSP00000263246
    TRIP10Q156423, ENSP000003204934I2D: score=1 STRING: ENSP00000320493
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with SBK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SBK1

    2 HMDB Compounds for SBK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SBK1 gene: 
    NM_001024401.2  

    Unigene Cluster for SBK1:

    SH3-binding domain kinase 1
    Hs.97837  [show with all ESTs]
    Unigene Representative Sequence: AY874862
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341901(uc002dpd.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SBK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SBK1 (see all 79):
    hsa-miR-30d hsa-miR-3921 hsa-miR-4267 hsa-miR-30a hsa-miR-3649 hsa-miR-92b hsa-miR-1266 hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidSBK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SBK1
    Predesigned siRNA for gene silencing in human, mouse, rat SBK1
    Clone
    Products:
         
    OriGene clones in human, mouse for SBK1 (see all 6)
    OriGene ORF clones in mouse, rat for SBK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SBK1 (NM_001024401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SBK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SBK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SBK1
      QuantiTect SYBR Green Assays in human, mouse, rat SBK1
      QuantiFast Probe-based Assays in human, mouse, rat SBK1

    Additional mRNA sequence: 

    AL390134.1 AY874862.2 

    6 DOTS entries:

    DT.209792  DT.120728348  DT.97814144  DT.101970720  DT.120728376  DT.97811723 

    1 AceView cDNA sequence:

    BQ071837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SBK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGATTGCTA
    SBK1 Expression
    About this image


    SBK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neurons
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
     
     Kidney (Urinary System)
             Metanephros
    SBK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SBK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97837
        Custom PCR Arrays for SBK1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SBK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SBK1
    QuantiTect SYBR Green Assays in human, mouse, rat SBK1
    QuantiFast Probe-based Assays in human, mouse, rat SBK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SBK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sbk11 , 5 SH3-binding kinase 11, 5 87.61(n)1
    95.44(a)1
      7 (69.01 cM)5
    1041751  NM_145587.21  NP_663562.11 
     1262726195 
    chicken
    (Gallus gallus)
    Aves SBK11 SH3-binding domain kinase 1 82.26(n)
    80.1(a)
      426442  XM_004945399.1  XP_004945456.1 
    lizard
    (Anolis carolinensis)
    Reptilia SBK16
    SH3 domain binding kinase 1
    74(a)
    1 ↔ 1
    GL344795.1(1957-8636)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.123672 Transcribed sequence with weak similarity to protein more 74.87(n)    BX709019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-183d21.31 si:ch211-183d21.3 65.74(n)
    68.31(a)
      559792  XM_683164.5  XP_688256.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112216
    CG49456
    --
    23(a)
    19(a)
    many ↔ many
    many ↔ many
    2L(6742508-6755686)
    2R(12453552-12457625)
    worm
    (Caenorhabditis elegans)
    Secernentea C01C4.36
    Protein C01C4.3, isoform b (C01C4.3) mRNA, complet...
    23(a)
    1 → many
    X(3706742-3713331) WBGene00015293


    ENSEMBL Gene Tree for SBK1 (if available)
    TreeFam Gene Tree for SBK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SBK1 gene
    SBK32  SBK22  
    6 SIMAP similar genes for SBK1 using alignment to 1 protein entry:     SBK1_HUMAN:
    KIN27    PRKACB    SBK2    STK17A    PRKAA1    SBK3

    Find genes that share paralogs with SBK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SBK1 (see all 551)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410684
    An ovarian mucinous carcinoma sample4--see VAR_0410682 K E mis40--------
    rs71949381,2
    C--28305495(+) CCCCAG/ACCTGG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1834791491,2
    --28305549(+) AAGCCA/GAGAGA 1 -- int10--------
    rs1403613541,2
    C--28305553(+) CGAGAC/GACCCT 1 -- int10--------
    rs559176721,2
    C,F--28305727(+) GGCTCG/AGGAAG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1866225771,2
    --28305816(+) ATGGAA/CCATGC 1 -- int10--------
    rs1914715321,2
    --28305906(+) TCCCAC/TTGGGC 1 -- int10--------
    rs1824694911,2
    --28306020(+) TGGCTA/GACTCC 1 -- int10--------
    rs1421244381,2
    --28306152(+) TGGCAA/GCCTCT 1 -- int10--------
    rs1511368411,2
    --28306250(+) AAGCAC/TGTGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SBK1 (28303840 - 28335170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SBK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516054CNV Loss19592680
    nsv526174CNV Gain19592680
    dgv843e1CNV Complex17122850
    dgv842e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SBK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SBK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for SBK1:    
    About MalaCards
    esophagus squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for SBK1:
    Esophagus squamous cell carcinoma

    Find genes that share disorders with SBK1           About GenesLikeMe

    Genetic Association Database (GAD): SBK1
    Human Genome Epidemiology (HuGE) Navigator: SBK1 (1 document)

    Export disorders for SBK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SBK1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SBK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    2. Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells. (PubMed id 21104019)1 Wang P....Ma D. (Mol. Biol. Rep. 2011)
    3. Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. (PubMed id 19041431)1 Linkermann A....Janssen O. (Biochim. Biophys. Acta 2009)
    4. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    6. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. (PubMed id 11322885)1 Nara K....Nagai Y. (Eur. J. Biochem. 2001)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 388228 HGNC: 17699 AceView: LOC388228 Ensembl:ENSG00000188322 euGenes: HUgn388228
    ECgene: SBK1 H-InvDB: SBK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SBK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SBK1 gene:
    Search GeneIP for patents involving SBK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SBK1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for SBK1   OriGene clones in human, mouse for SBK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SBK1   OriGene Purified Protein for SBK1  
     OriGene ORF clones in mouse, rat for SBK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SBK1   OriGene Custom Protein Services for SBK1  

     
     
     Block miRNA regulation of human, mouse, rat SBK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SBK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SBK1 Predesigned siRNA for gene silencing in human, mouse, rat SBK1
     QuantiFast Probe-based Assays in human, mouse, rat SBK1 QuantiTect SYBR Green Assays in human, mouse, rat SBK1
     Custom PCR Arrays for SBK1 Search Chromatin IP Primers for SBK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SBK1  Search GeneGlobe Interaction Network for SBK1
     Regulatory tfbs in SBK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SBK1 GenScript cDNA clones with any tag delivered in your preferred vector for SBK1
     GenScript Custom Assay Services for SBK1 GenScript Custom overexpressing Cell Line Services for SBK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SBK1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SBK1 antibodies
     Antibodies for SBK1
     See all of Abcam's Antibodies, Kits and Proteins for SBK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SBK1
     Antibodies for SBK1
     ELISAs for SBK1
     CLIAs for SBK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SBK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1
     SwitchGear 3'UTR luciferase reporter plasmids for SBK1
     SwitchGear Promoter luciferase reporter plasmids for SBK1
     Search ThermoFisher Antibodies for SBK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SBK1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SBK1
     Search LSBio for Antibodies for SBK1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SBK1
      Search eBioscience for proteins for SBK1
      Search eBioscience for elisas for SBK1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SBK1 gene at Home site.
    Version: 3.12.210 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4