SBK1 Gene
protein-coding GIFtS: 49
GCID: GC16P028211
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|
SH3-binding domain kinase 1
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Aliases
for SBK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SH3-Binding Domain Kinase 11 2 | | Serine/Threonine-Protein Kinase SBK12 | | EC 2.7.11.13 8 | | SH3-Binding Kinase 13 | | Sbk1 | | EC 2.7.118 | | SBK2 | | |
Export aliases for SBK1 gene to outside databasesPrevious GC identifers: GC16P028160 GC16P026395 |
Summaries
for SBK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2Function: May be involved in signal-transduction pathways related to the control of brain development (By similarity)
|
Genomic Views
for SBK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SBK1 gene promoter:
NRSF form 1 CUTL1 MIF-1 NRSF form 2 c-Ets-1 Chx10 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for SBK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SBK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2SBK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P028211: view genomic region
(about GC identifiers)
Start:
|
28,303,840 bp from pter |
End:
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28,335,170 bp from pter |
Size:
|
31,331 bases |
Orientation:
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plus strand |
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Proteins
for SBK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase SBK1 Size: 424 amino acids; 46252 Da
Subcellular location: Cytoplasm (By similarity)Explore the universe of human proteins at neXtProt for SBK1: NX_Q52WX2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q52WX2
4/7 DME Specific Peptides for SBK1 (Q52WX2) (see all 7)
SBK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001019572.1
ENSEMBL proteins: ENSP00000343248
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
SBK1 for ontologies About GeneDecksing
SBK1 Antibody Products:
Assay Products for SBK1: |
Protein
Domains /
Families
for SBK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SBK1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q52WX2ProtoNet protein and cluster: Q52WX2 UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for SBK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SBK1_HUMAN, Q52WX2Function: May be involved in signal-transduction pathways related to the control of brain development (By similarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SBK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SBK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SBK1 (NM_001024401) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SBK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
SBK1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SBK1:
|
Pathways & Interactions
for SBK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SBK1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for SBK1 (Q52WX23 ENSP000003432484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007420 | brain development |
-- | -- | | GO:0018105 | peptidyl-serine phosphorylation |
-- | -- | | GO:0018107 | peptidyl-threonine phosphorylation |
-- | -- |
SBK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SBK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SBK1
2 HMDB Compounds for SBK1 About this table
Search CenterWatch for drugs/clinical trials and news about SBK1
|
Transcripts
for SBK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SBK1 gene: NM_001024401.2 Unigene Cluster for SBK1: SH3-binding domain kinase 1 Hs.97837 [show with all ESTs]Unigene Representative Sequence: AY8748621 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000341901(uc002dpd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SBK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SBK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SBK1 (NM_001024401) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SBK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1 |
Additional cDNA sequence: AL390134.1 AY874862.2 6 DOTS entries: DT.209792 DT.120728348 DT.97814144 DT.101970720 DT.120728376 DT.97811723 1 AceView cDNA sequence: BQ071837
GeneLoc Exon Structure
|
Expression
for SBK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SBK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGATTGCTA
About this image
See SBK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SBK1
SOURCE GeneReport for Unigene cluster: Hs.97837
SABiosciences Custom PCR Arrays for SBK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SBK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SBK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SBK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SBK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1 |
Orthologs
for SBK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SBK1 gene from 6/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SBK11 |
SH3-binding domain kinase 1 |
81.62(n)
79.49(a) |
|
426442 XM_424086.3 XP_424086.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SBK16 |
-- |
78(a) |
1 ↔ 1 |
GL344795.1(2114-5154) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.123672 |
Transcribed sequence with weak similarity to protein more |
74.87(n) |
|
BX709019.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5597921 |
serine/threonine-protein kinase SBK1-like |
64.16(n)
65.59(a) |
|
559792 XM_683164.4 XP_688256.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG112216CG49456 |
-- |
23(a)19(a) |
many ↔ manymany ↔ many |
2L(6742508-6755686) 2R(12453552-12457625) |
worm
(Caenorhabditis elegans) |
Secernentea |
C01C4.36 |
Putative serine/threonine-protein kinase C01C4.3 |
24(a) |
1 → many |
X(3706729-3713318) |
ENSEMBL Gene Tree for SBK1 (if available)
TreeFam Gene Tree for SBK1 (if available) |
Paralogs
for SBK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SBK1 gene
- SBK22 SGK1102
8 SIMAP similar genes for SBK1 using alignment to 1 protein entry: SBK1_HUMAN:KIN27 PRKACB SBK2 STK17A PRKAA1 SGK110
CDK4 NUAK1
SBK1 for paralogs About GeneDecksing
|
Genomic Variants
for SBK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SBK1 (28303840 - 28335170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SBK1
4 CNVs: 49687 49686 49685 3999 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SBK1 |
|
Disorders
/ Diseases
for SBK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SBK1 for disorders About GeneDecksing
3  diseases for SBK1: About MalaCardsesophagus squamous cell carcinoma squamous cell carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for SBK1:Esophagus squamous cell carcinoma Human Genome Epidemiology (HuGE) Navigator: SBK1 (1 document)
Export disorders for SBK1 gene to outside databases
|
Publications
for SBK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SBK1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SBK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human SBK1 is dysregulated in multiple cancers and pr omotes survival of ovary cancer SK-OV-3 cells. (PubMed id 21104019)1 Wang P....Ma D. (2011)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. (PubMed id 19041431)1 Linkermann A....Janssen O. (2009)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
- Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. (PubMed id 11322885)1 Nara K....Nagai Y. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for SBK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SBK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SBK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SBK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SBK1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SBK1 gene:
Search GeneIP for patents involving SBK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SBK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SBK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SBK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SBK1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SBK1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SBK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SBK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SBK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SBK1 | | OriGene Custom Protein Services for SBK1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SBK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SBK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SBK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SBK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SBK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SBK1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SBK1 |
| |  |  |  |  | | | | |
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 | | | SBK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SBK1 |
|  |  |  | | | | ThermoFisher Antibodies for SBK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SBK1 |
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