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Aliases for SAYSD1 Gene

Aliases for SAYSD1 Gene

  • SAYSVFN Motif Domain Containing 1 2 3
  • C6orf64 3 4
  • Chromosome 6 Open Reading Frame 64 2

External Ids for SAYSD1 Gene

Previous HGNC Symbols for SAYSD1 Gene

  • C6orf64

Previous GeneCards Identifiers for SAYSD1 Gene

  • GC06M039072
  • GC06M039076
  • GC06M039183
  • GC06M039215
  • GC06M039259
  • GC06M039253

Summaries for SAYSD1 Gene

GeneCards Summary for SAYSD1 Gene

SAYSD1 (SAYSVFN Motif Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAYSD1 Gene

Genomics for SAYSD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAYSD1 Gene

Chromosome:
6
Start:
39,104,063 bp from pter
End:
39,115,189 bp from pter
Size:
11,127 bases
Orientation:
Minus strand

Genomic View for SAYSD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAYSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAYSD1 Gene

No data available for Regulatory Elements for SAYSD1 Gene

Proteins for SAYSD1 Gene

  • Protein details for SAYSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPB0-SMDC1_HUMAN
    Recommended name:
    SAYSvFN domain-containing protein 1
    Protein Accession:
    Q9NPB0
    Secondary Accessions:
    • Q9H0D8

    Protein attributes for SAYSD1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20163 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAYSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAYSD1 Gene

Proteomics data for SAYSD1 Gene at MOPED

Post-translational modifications for SAYSD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAYSD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAYSD1 Gene

Domains & Families for SAYSD1 Gene

Protein Domains for SAYSD1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAYSD1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SAYSD1 Gene

Function for SAYSD1 Gene

Phenotypes for SAYSD1 Gene

GenomeRNAi human phenotypes for SAYSD1:
genes like me logo Genes that share phenotypes with SAYSD1: view

Animal Model Products

CRISPR Products

miRNA for SAYSD1 Gene

miRTarBase miRNAs that target SAYSD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAYSD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SAYSD1 Gene

Localization for SAYSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAYSD1 Gene

Cytoplasmic vesicle membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SAYSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SAYSD1: view

No data available for Subcellular locations from COMPARTMENTS for SAYSD1 Gene

Pathways & Interactions for SAYSD1 Gene

SuperPathways for SAYSD1 Gene

No Data Available

Interacting Proteins for SAYSD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229903%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q9NPB0-SMDC1_HUMAN ENSP00000229903 for SAYSD1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SAYSD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAYSD1 Gene

Drugs & Compounds for SAYSD1 Gene

No Compound Related Data Available

Transcripts for SAYSD1 Gene

Unigene Clusters for SAYSD1 Gene

SAYSVFN motif domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAYSD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAYSD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
SP1: - - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SAYSD1 Gene

GeneLoc Exon Structure for
SAYSD1
ECgene alternative splicing isoforms for
SAYSD1

Expression for SAYSD1 Gene

mRNA expression in normal human tissues for SAYSD1 Gene

mRNA differential expression in normal tissues according to GTEx for SAYSD1 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for SAYSD1 Gene

This gene is overexpressed in Bone (48.8) and Fetal ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAYSD1 Gene



SOURCE GeneReport for Unigene cluster for SAYSD1 Gene Hs.58382

genes like me logo Genes that share expression patterns with SAYSD1: view

Protein tissue co-expression partners for SAYSD1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SAYSD1 Gene

Orthologs for SAYSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAYSD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAYSD1 35
  • 78.51 (n)
  • 77.05 (a)
SAYSD1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAYSD1 35
  • 87.25 (n)
  • 85.25 (a)
SAYSD1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Saysd1 35
  • 79.92 (n)
  • 78.41 (a)
Saysd1 16
Saysd1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAYSD1 35
  • 99.27 (n)
  • 98.91 (a)
SAYSD1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAYSD1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAYSD1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAYSD1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAYSD1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia saysd1 35
  • 54.8 (n)
  • 53.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30665 35
zebrafish
(Danio rerio)
Actinopterygii SAYSD1 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13663 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C13F10.5 36
  • 31 (a)
OneToOne
Species with no ortholog for SAYSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAYSD1 Gene

ENSEMBL:
Gene Tree for SAYSD1 (if available)
TreeFam:
Gene Tree for SAYSD1 (if available)

Paralogs for SAYSD1 Gene

No data available for Paralogs for SAYSD1 Gene

Variants for SAYSD1 Gene

Sequence variations from dbSNP and Humsavar for SAYSD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3840 -- 39,105,222(-) GGGTC(C/T)GACGC utr-variant-3-prime
rs7696 -- 39,104,905(+) TAAAG(A/G)TATTT utr-variant-3-prime
rs10023 -- 39,104,258(-) TGATA(C/T)GTGTT utr-variant-3-prime
rs170644 -- 39,113,088(-) AGTCT(A/G)CTTTC utr-variant-5-prime, intron-variant
rs172935 -- 39,107,858(-) AGCCC(C/T)GTCAT intron-variant

Variation tolerance for SAYSD1 Gene

Residual Variation Intolerance Score: 47.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAYSD1 Gene

HapMap Linkage Disequilibrium report
SAYSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAYSD1 Gene

Disorders for SAYSD1 Gene

Relevant External Links for SAYSD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAYSD1
genes like me logo Genes that share disorders with SAYSD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAYSD1 Gene

Publications for SAYSD1 Gene

  1. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PMID: 22361696) Stadler C. … Lundberg E. (J. Proteomics 2012) 67
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 67

Products for SAYSD1 Gene

Sources for SAYSD1 Gene

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