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Aliases for SAYSD1 Gene

Aliases for SAYSD1 Gene

  • SAYSVFN Motif Domain Containing 1 2 3 5
  • C6orf64 3 4
  • SAYSvFN Domain-Containing Protein 1 3
  • Chromosome 6 Open Reading Frame 64 2

External Ids for SAYSD1 Gene

Previous HGNC Symbols for SAYSD1 Gene

  • C6orf64

Previous GeneCards Identifiers for SAYSD1 Gene

  • GC06M039072
  • GC06M039076
  • GC06M039183
  • GC06M039215
  • GC06M039259
  • GC06M039253
  • GC06M039331
  • GC06M039361
  • GC06M039382
  • GC06M039420

Summaries for SAYSD1 Gene

GeneCards Summary for SAYSD1 Gene

SAYSD1 (SAYSVFN Motif Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAYSD1 Gene

Genomics for SAYSD1 Gene

Regulatory Elements for SAYSD1 Gene

Enhancers for SAYSD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G039101 1.2 Ensembl ENCODE dbSUPER 13.2 +13.1 13066 1.1 CTCF PKNOX1 ATF1 RB1 ZFP64 HLF REST RAD21 JUND KLF16 SAYSD1 GLP1R KCNK17 KCNK5 GC06M039484 PIR34726 LOC105375046
GH06G039820 1.4 Ensembl ENCODE dbSUPER 10.8 -707.8 -707759 4.3 PKNOX1 ZFP64 FEZF1 RAD21 ZNF335 SCRT2 ZNF202 ZNF680 ZNF654 ZBTB11 ANKRD18EP DAAM2 SAYSD1 ENSG00000281969 LOC100505635
GH06G039082 0.6 dbSUPER 22.5 +31.9 31903 1.9 CTCF RFX1 ZFHX2 ZNF776 ZKSCAN8 GLIS1 KLF9 EGR2 EZH2 GLP1R SAYSD1 DAAM2 LOC105375046 GC06M039484 PIR34726
GH06G039084 0.6 dbSUPER 21.7 +30.3 30298 1.2 ZNF776 GLIS1 ZKSCAN8 TEAD4 MNT ZIC2 GLP1R SAYSD1 GLO1 LOC105375046 PIR34726 GC06M039484
GH06G039067 0.7 dbSUPER 16.8 +47.0 46966 1.9 HDAC1 ZNF175 CEBPG ZIC2 ZNF335 ZNF766 ZFHX2 EGR1 ELK1 ZNF547 SAYSD1 KCNK17 KCNK16 KCNK5 GLP1R LOC105375046
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAYSD1 on UCSC Golden Path with GeneCards custom track

Promoters for SAYSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196585 389 1201 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SAYSD1 Gene

Chromosome:
6
Start:
39,104,063 bp from pter
End:
39,115,189 bp from pter
Size:
11,127 bases
Orientation:
Minus strand

Genomic View for SAYSD1 Gene

Genes around SAYSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAYSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAYSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAYSD1 Gene

Proteins for SAYSD1 Gene

  • Protein details for SAYSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPB0-SMDC1_HUMAN
    Recommended name:
    SAYSvFN domain-containing protein 1
    Protein Accession:
    Q9NPB0
    Secondary Accessions:
    • Q9H0D8

    Protein attributes for SAYSD1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20163 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAYSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAYSD1 Gene

Post-translational modifications for SAYSD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAYSD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAYSD1 Gene

Domains & Families for SAYSD1 Gene

Protein Domains for SAYSD1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAYSD1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SAYSD1 Gene

Function for SAYSD1 Gene

Phenotypes for SAYSD1 Gene

genes like me logo Genes that share phenotypes with SAYSD1: view

Animal Model Products

CRISPR Products

miRNA for SAYSD1 Gene

miRTarBase miRNAs that target SAYSD1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAYSD1 Gene

Localization for SAYSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAYSD1 Gene

Cytoplasmic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAYSD1 gene
Compartment Confidence
mitochondrion 2
peroxisome 2
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SAYSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SAYSD1: view

Pathways & Interactions for SAYSD1 Gene

SuperPathways for SAYSD1 Gene

No Data Available

Interacting Proteins for SAYSD1 Gene

Selected Interacting proteins: Q9NPB0-SMDC1_HUMAN for SAYSD1 Gene via IID

Gene Ontology (GO) - Biological Process for SAYSD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAYSD1 Gene

Drugs & Compounds for SAYSD1 Gene

No Compound Related Data Available

Transcripts for SAYSD1 Gene

Unigene Clusters for SAYSD1 Gene

SAYSVFN motif domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAYSD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
SP1: - - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SAYSD1 Gene

GeneLoc Exon Structure for
SAYSD1
ECgene alternative splicing isoforms for
SAYSD1

Expression for SAYSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAYSD1 Gene

mRNA differential expression in normal tissues according to GTEx for SAYSD1 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for SAYSD1 Gene

This gene is overexpressed in Bone (48.8) and Fetal ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAYSD1 Gene



Protein tissue co-expression partners for SAYSD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAYSD1 Gene:

SAYSD1

SOURCE GeneReport for Unigene cluster for SAYSD1 Gene:

Hs.58382
genes like me logo Genes that share expression patterns with SAYSD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAYSD1 Gene

Orthologs for SAYSD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAYSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAYSD1 34 35
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia SAYSD1 34 35
  • 87.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SAYSD1 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAYSD1 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Saysd1 34 16 35
  • 79.92 (n)
cow
(Bos Taurus)
Mammalia SAYSD1 34 35
  • 78.51 (n)
chicken
(Gallus gallus)
Aves SAYSD1 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAYSD1 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia saysd1 34
  • 54.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30665 34
zebrafish
(Danio rerio)
Actinopterygii SAYSD1 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13663 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C13F10.5 35
  • 31 (a)
OneToOne
Species where no ortholog for SAYSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAYSD1 Gene

ENSEMBL:
Gene Tree for SAYSD1 (if available)
TreeFam:
Gene Tree for SAYSD1 (if available)

Paralogs for SAYSD1 Gene

No data available for Paralogs for SAYSD1 Gene

Variants for SAYSD1 Gene

Sequence variations from dbSNP and Humsavar for SAYSD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000276069 -- 39,107,890(+) GGGAG(A/C)CAGAT intron-variant
rs1000653880 -- 39,112,459(+) TTACA(A/G)AGAGC intron-variant, utr-variant-5-prime
rs1001129153 -- 39,106,234(+) CTTTT(C/T)ACGTT intron-variant
rs1001176104 -- 39,113,434(+) TGAAG(-/A)AAAAA intron-variant, utr-variant-5-prime
rs1001316555 -- 39,106,913(+) GGAAC(C/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAYSD1 Gene

Variant ID Type Subtype PubMed ID
esv2422109 CNV deletion 20811451
esv25413 CNV loss 19812545
esv2674697 CNV deletion 23128226
esv2761050 CNV loss 21179565
esv3378714 CNV insertion 20981092
esv3608754 CNV loss 21293372
nsv441994 CNV loss 18776908
nsv514357 CNV loss 21397061
nsv516974 CNV loss 19592680

Variation tolerance for SAYSD1 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAYSD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAYSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAYSD1 Gene

Disorders for SAYSD1 Gene

Relevant External Links for SAYSD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAYSD1

No disorders were found for SAYSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAYSD1 Gene

Publications for SAYSD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PMID: 22361696) Stadler C. … Lundberg E. (J. Proteomics 2012) 4 64

Products for SAYSD1 Gene

Sources for SAYSD1 Gene

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