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SAXO2 Gene(Protein Coding)

Stabilizer Of Axonemal Microtubules 2

GCID:
GC15P082262
GIFtS:
34
Genes Participants
UDN Logo

Aliases for SAXO2 Gene

Aliases for SAXO2 Gene

  • Stabilizer Of Axonemal Microtubules 2 2 3 5
  • Family With Sequence Similarity 154, Member B 2 3
  • FAM154B 3 4
  • Protein FAM154B 3

External Ids for SAXO2 Gene

Previous HGNC Symbols for SAXO2 Gene

  • FAM154B

Summaries for SAXO2 Gene

GeneCards Summary for SAXO2 Gene

SAXO2 (Stabilizer Of Axonemal Microtubules 2) is a Protein Coding gene. An important paralog of this gene is SAXO1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAXO2 Gene

Genomics for SAXO2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SAXO2 Gene

Enhancers for SAXO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G082260 1.4 ENCODE dbSUPER 48.5 -0.5 -457 3.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SAXO2 CSPG4P10 HDGFL3 CPEB1 AP3B2 EFL1 GC15M082251
GH15G082177 1.1 Ensembl ENCODE dbSUPER 47.9 -84.7 -84717 1.5 ZNF316 MAX EMSY PRDM1 MAFK SPI1 NFE2L2 SAXO2 GC15M082175 RNU1-77P GC15P082195
GH15G082159 0.8 ENCODE dbSUPER 47.8 -102.5 -102476 1.7 JUND BHLHE40 INSM2 SIN3A ZNF600 FOS SAXO2 CSPG4P10 AP3B2 PIR43496 GC15M082175 RNU1-77P
GH15G082708 1 ENCODE 23.9 +446.5 446522 2.0 HDGF PKNOX1 ZNF133 ARID4B SIN3A ZNF48 ZNF766 GLIS2 ELK1 ZNF143 AP3B2 SAXO2 SNHG21 CPEB1 C15orf40 CPEB1-AS1 HDGFL3 EFL1 PIR57194
GH15G082285 1.1 Ensembl ENCODE 19.1 +24.1 24067 2.0 HDGF PKNOX1 TBL1XR1 TAL1 BACH1 YBX1 EBF1 TCF12 ZNF316 ARID3A SAXO2 GC15P082290 GC15P082281
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAXO2 on UCSC Golden Path with GeneCards custom track

Promoters for SAXO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080177 -110 1801 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF143 ZNF207 FOS

Genomic Location for SAXO2 Gene

Chromosome:
15
Start:
82,262,810 bp from pter
End:
82,284,930 bp from pter
Size:
22,121 bases
Orientation:
Plus strand

Genomic View for SAXO2 Gene

Genes around SAXO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAXO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAXO2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SAXO2 Gene

Proteins for SAXO2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SAXO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q658L1-SAXO2_HUMAN
    Recommended name:
    Stabilizer of axonemal microtubules 2
    Protein Accession:
    Q658L1
    Secondary Accessions:
    • B4E2M2

    Protein attributes for SAXO2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAXO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAXO2 Gene

Post-translational modifications for SAXO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAXO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAXO2 Gene

Domains & Families for SAXO2 Gene

Protein Domains for SAXO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAXO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q658L1

UniProtKB/Swiss-Prot:

SAXO2_HUMAN :
  • Belongs to the FAM154 family.
Family:
  • Belongs to the FAM154 family.
genes like me logo Genes that share domains with SAXO2: view

No data available for Gene Families for SAXO2 Gene

Function for SAXO2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for SAXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with SAXO2: view

Phenotypes for SAXO2 Gene

GenomeRNAi human phenotypes for SAXO2:
genes like me logo Genes that share phenotypes with SAXO2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAXO2 Gene

Localization for SAXO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAXO2 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
golgi apparatus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAXO2 Gene

Pathways & Interactions for SAXO2 Gene

SuperPathways for SAXO2 Gene

PathCards logo More details on SuperPathways for SAXO2
No Data Available

Interacting Proteins for SAXO2 Gene

Gene Ontology (GO) - Biological Process for SAXO2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAXO2 Gene

Drugs & Compounds for SAXO2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SAXO2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SAXO2 Gene

(9) REFSEQ mRNAs :
(20) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAXO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for SAXO2 Gene

GeneLoc Exon Structure for
SAXO2
ECgene alternative splicing isoforms for
SAXO2

Expression for SAXO2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAXO2 Gene

mRNA expression in normal human tissues for SAXO2 Gene
mRNA expression by GTEx for SAXO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAXO2 Gene:

SAXO2

Evidence on tissue expression from TISSUES for SAXO2 Gene

  • Stomach(4.1)
genes like me logo Genes that share expression patterns with SAXO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAXO2 Gene

Orthologs for SAXO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAXO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FAM154B 34 35
  • 98.58 (n)
dog
(Canis familiaris)
 Mammalia FAM154B 34 35
  • 87.1 (n)
mouse
(Mus musculus)
 Mammalia Fam154b 34 35
  • 86.68 (n)
Saxo2 16
rat
(Rattus norvegicus)
 Mammalia Fam154b 34
  • 86.6 (n)
cow
(Bos Taurus)
 Mammalia FAM154B 34 35
  • 79.91 (n)
oppossum
(Monodelphis domestica)
 Mammalia FAM154B 35
  • 48 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FAM154B 35
  • 24 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FAM154B 34 35
  • 67.28 (n)
lizard
(Anolis carolinensis)
 Reptilia FAM154B 35
  • 43 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fam154b 34
  • 65.54 (n)
zebrafish
(Danio rerio)
 Actinopterygii fam154b 34 35
  • 55.44 (n)
Dr.15468 34
worm
(Caenorhabditis elegans)
 Secernentea T08G11.3 35
  • 14 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 32 (a)
 ManyToMany
-- 35
  • 32 (a)
 ManyToMany
Species where no ortholog for SAXO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAXO2 Gene

ENSEMBL:
Gene Tree for SAXO2 (if available)
TreeFam:
Gene Tree for SAXO2 (if available)

Paralogs for SAXO2 Gene

Paralogs for SAXO2 Gene

Pseudogenes.org Pseudogenes for SAXO2 Gene

genes like me logo Genes that share paralogs with SAXO2: view

Variants for SAXO2 Gene

Sequence variations from dbSNP and Humsavar for SAXO2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000022697 -- 82,271,137(+) CGAGA(A/G)AACAG intron-variant
rs1000113023 -- 82,268,175(+) TAATA(-/T)TTTTT intron-variant
rs1000227961 -- 82,267,864(+) AAGAG(C/G)CAGTA intron-variant
rs1000241321 -- 82,275,797(+) CATCT(A/G)TGACA intron-variant
rs1000398392 -- 82,275,250(+) TAAGG(A/G)AATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAXO2 Gene

Variant ID Type Subtype PubMed ID
dgv321n27 CNV gain 19166990
dgv457e214 CNV gain 21293372
dgv4682n54 CNV gain 21841781
esv2663603 CNV deletion 23128226
esv3552760 CNV deletion 23714750
esv3637056 CNV loss 21293372
esv3637057 CNV loss 21293372
nsv1041040 CNV gain 25217958
nsv1041506 CNV loss 25217958
nsv1120052 OTHER inversion 24896259
nsv977743 CNV duplication 23825009

Variation tolerance for SAXO2 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.17; 99.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAXO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAXO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAXO2 Gene

Disorders for SAXO2 Gene

Relevant External Links for SAXO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAXO2

No disorders were found for SAXO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAXO2 Gene

Publications for SAXO2 Gene

  1. Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures. (PMID: 25673876) Dacheux D. … Bonhivers M. (J. Cell. Sci. 2015) 2 3 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for SAXO2 Gene

Sources for SAXO2 Gene

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