Aliases for SAXO2 Gene
Aliases for SAXO2 Gene
External Ids for SAXO2 Gene
- HGNC: 33727
- Entrez Gene: 283726
- Ensembl: ENSG00000188659
- UniProtKB: Q658L1
Previous HGNC Symbols for SAXO2 Gene
- FAM154B
Summaries for SAXO2 Gene
GeneCards Summary for SAXO2 Gene
SAXO2 (Stabilizer Of Axonemal Microtubules 2) is a Protein Coding gene. An important paralog of this gene is SAXO1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAXO2 Gene
Genomics for SAXO2 Gene
GeneHancer (GH) Regulatory Elements for SAXO2 Gene
Promoters and enhancers for SAXO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SAXO2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SAXO2 Gene
Genomic Locations for SAXO2 Gene
- chr15:82,262,810-82,284,930
- (GRCh38/hg38)
- Size:
- 22,121 bases
- Orientation:
- Plus strand
- chr15:82,555,151-82,577,271
- (GRCh37/hg19)
Genomic View for SAXO2 Gene
Genes around SAXO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q25.2 by Ensembl
- 15q25.2 by Entrez Gene
- 15q25.2 by HGNC
SAXO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SAXO2 Gene
Proteins for SAXO2 Gene
-
Protein details for SAXO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q658L1-SAXO2_HUMAN
- Recommended name:
- Stabilizer of axonemal microtubules 2
- Protein Accession:
- Q658L1
- B4E2M2
Protein attributes for SAXO2 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 45933 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for SAXO2 Gene
No Post-translational modifications
Other Protein References for SAXO2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SAXO2
- Novus Biologicals Antibodies for SAXO2
- Invitrogen Antibodies for SAXO2
- Search GeneTex for Antibodies for SAXO2
Protein Products
-
OriGene Purified Proteins for SAXO2
- Search Origene for MassSpec and Protein Over-expression Lysates for SAXO2
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- Search GeneTex for Proteins for SAXO2
Assay Products
No data available for DME Specific Peptides for SAXO2 Gene
Domains & Families for SAXO2 Gene
Gene Families for SAXO2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for SAXO2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q658L1- Family:
-
- Belongs to the FAM154 family.
Function for SAXO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008017 | microtubule binding | IEA | -- |
Phenotypes for SAXO2 Gene
- GenomeRNAi human phenotypes for SAXO2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SAXO2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SAXO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SAXO2 gene
- Search ViGene Biosciences for SAXO2
CRISPR Products
-
OriGene CRISPR knockouts for SAXO2
- genomics-online: gRNA clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
- Applied Biological Materials CRISPR for SAXO2
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for SAXO2
miRNA for SAXO2 Gene
- miRTarBase miRNAs that target SAXO2
miRNA Products
- Search ViGene Biosciences for SAXO2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SAXO2
- Browse OriGene Inhibitory RNA Products For SAXO2
- genomics-online: shRNA clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SAXO2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SAXO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SAXO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SAXO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SAXO2
-
ViGene Biosciences adenoviral particle packaged cDNA for SAXO2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SAXO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SAXO2 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAXO2 Gene
Localization for SAXO2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAXO2 Gene
Transcripts for SAXO2 Gene
mRNA/cDNA for SAXO2 Gene
- (9) REFSEQ mRNAs :
- (20) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for SAXO2
- genomics-online: gRNA clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
- Applied Biological Materials CRISPR for SAXO2
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for SAXO2
miRNA Products
- Search ViGene Biosciences for SAXO2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SAXO2
- Browse OriGene Inhibitory RNA Products For SAXO2
- genomics-online: shRNA clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SAXO2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SAXO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SAXO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SAXO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: | - | - |
Expression for SAXO2 Gene
NURSA nuclear receptor signaling pathways regulating expression of SAXO2 Gene:
SAXO2Evidence on tissue expression from TISSUES for SAXO2 Gene
- Stomach(4.1)
Primer Products
-
OriGene qPCR primer pairs for SAXO2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAXO2 Gene
Orthologs for SAXO2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM154B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FAM154B 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fam154b 33 34 |
|
||
| Saxo2 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Fam154b 33 |
|
||
| cow (Bos Taurus) |
Mammalia | FAM154B 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FAM154B 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM154B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM154B 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FAM154B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam154b 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam154b 33 34 |
|
||
| Dr.15468 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | T08G11.3 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for SAXO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SAXO2 Gene
Pseudogenes.org Pseudogenes for SAXO2 Gene
Variants for SAXO2 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022697 | -- | 82,271,137(+) | A/G | intron_variant | |
| rs1000113023 | -- | 82,268,175(+) | TTTTTTT/TTTTTT | intron_variant | |
| rs1000227961 | -- | 82,267,864(+) | C/G | intron_variant | |
| rs1000241321 | -- | 82,275,797(+) | A/G | intron_variant | |
| rs1000398392 | -- | 82,275,250(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv321n27 | CNV | gain | 19166990 |
| dgv457e214 | CNV | gain | 21293372 |
| dgv4682n54 | CNV | gain | 21841781 |
| esv2663603 | CNV | deletion | 23128226 |
| esv3552760 | CNV | deletion | 23714750 |
| esv3637056 | CNV | loss | 21293372 |
| esv3637057 | CNV | loss | 21293372 |
| nsv1041040 | CNV | gain | 25217958 |
| nsv1041506 | CNV | loss | 25217958 |
| nsv1120052 | OTHER | inversion | 24896259 |
| nsv977743 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
20.17;
99.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SAXO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SAXO2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAXO2 Gene
Disorders for SAXO2 Gene
Additional Disease Information for SAXO2
No disorders were found for SAXO2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAXO2 Gene
Publications for SAXO2 Gene
- Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures. (PMID: 25673876) Dacheux D … Bonhivers M (Journal of cell science 2015) 2 3 58
- The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
Products for SAXO2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for SAXO2
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- Novus Biologicals Antibodies for SAXO2
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for SAXO2
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- VectorBuilder custom plasmid, inducible vectors for SAXO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SAXO2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for SAXO2
- Search GeneTex for Proteins for SAXO2
- ViGene Biosciences adenoviral particle packaged cDNA for SAXO2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SAXO2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SAXO2 gene
- Search ViGene Biosciences for SAXO2
- Horizon Cell Lines for SAXO2
- genomics-online: cdna clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
- orf clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
- genomics-online: gRNA clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
- genomics-online: primer clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
- genomics-online: shRNA clones - Search results for 70 available FAM154B gene related products
- Overview of 70 available FAM154B gene related products
Sources for SAXO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
- (15) Blocks
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
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- (84) Vector BioLabs
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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- (114) diseasecard
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew