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Aliases for SAXO1 Gene

Aliases for SAXO1 Gene

  • Stabilizer Of Axonemal Microtubules 1 2 3
  • Family With Sequence Similarity 154, Member A 2 3
  • C9orf138 3 4
  • FAM154A 3 4
  • Chromosome 9 Open Reading Frame 138 2
  • Protein FAM154A 3
  • 4930500O09Rik 3

External Ids for SAXO1 Gene

Previous HGNC Symbols for SAXO1 Gene

  • C9orf138
  • FAM154A

Summaries for SAXO1 Gene

GeneCards Summary for SAXO1 Gene

SAXO1 (Stabilizer Of Axonemal Microtubules 1) is a Protein Coding gene. An important paralog of this gene is SAXO2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAXO1 Gene

Genomics for SAXO1 Gene

Genomic Location for SAXO1 Gene

Start:
18,927,658 bp from pter
End:
19,049,354 bp from pter
Size:
121,697 bases
Orientation:
Minus strand

Genomic View for SAXO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAXO1 Gene

No data available for Regulatory Elements for SAXO1 Gene

Proteins for SAXO1 Gene

  • Protein details for SAXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX7-F154A_HUMAN
    Recommended name:
    Protein FAM154A
    Protein Accession:
    Q8IYX7
    Secondary Accessions:
    • Q5VY58

    Protein attributes for SAXO1 Gene

    Size:
    474 amino acids
    Molecular mass:
    54621 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAXO1 Gene

Proteomics data for SAXO1 Gene at MOPED

Post-translational modifications for SAXO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAXO1 Gene

No data available for DME Specific Peptides for SAXO1 Gene

Domains for SAXO1 Gene

Protein Domains for SAXO1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IYX7

UniProtKB/Swiss-Prot:

F154A_HUMAN :
  • Q8IYX7
Family:
  • Belongs to the FAM154 family.
genes like me logo Genes that share domains with SAXO1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SAXO1 Gene

Function for SAXO1 Gene

Gene Ontology (GO) - Molecular Function for SAXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23088713
GO:0008017 microtubule binding IDA 25673876
genes like me logo Genes that share ontologies with SAXO1: view

Phenotypes for SAXO1 Gene

GenomeRNAi human phenotypes for SAXO1:
genes like me logo Genes that share phenotypes with SAXO1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SAXO1 Gene

Localization for SAXO1 Gene

Gene Ontology (GO) - Cellular Components for SAXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 25673876
GO:0005879 axonemal microtubule IDA 25673876
GO:0031512 motile primary cilium IDA 25673876
GO:0036064 ciliary basal body IDA 25673876
GO:0036126 sperm flagellum IDA 25673876
genes like me logo Genes that share ontologies with SAXO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SAXO1 Gene

Pathways for SAXO1 Gene

SuperPathways for SAXO1 Gene

No Data Available

Interacting Proteins for SAXO1 Gene

Gene Ontology (GO) - Biological Process for SAXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009631 cold acclimation IDA 25673876
GO:0045724 positive regulation of cilium assembly IMP 25673876
GO:0070417 cellular response to cold IDA 25673876
GO:1903994 positive regulation of protein stabilization IDA 25673876
genes like me logo Genes that share ontologies with SAXO1: view

No data available for Pathways by source for SAXO1 Gene

Transcripts for SAXO1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAXO1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SAXO1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAXO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - -
SP2:
SP3: - - - -
SP4: - -

Relevant External Links for SAXO1 Gene

GeneLoc Exon Structure for
SAXO1
ECgene alternative splicing isoforms for
SAXO1

Expression for SAXO1 Gene

mRNA expression in normal human tissues for SAXO1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SAXO1 Gene

genes like me logo Genes that share expressions with SAXO1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SAXO1 Gene

Orthologs for SAXO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAXO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM154A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM154A 35
  • 84.71 (n)
  • 81.82 (a)
FAM154A 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM154A 35
  • 86.92 (n)
  • 83.33 (a)
FAM154A 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam154a 35
  • 76.39 (n)
  • 66.17 (a)
Fam154a 16
Fam154a 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM154A 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fam154a 35
  • 75.65 (n)
  • 66.03 (a)
chicken
(Gallus gallus)
Aves FAM154A 35
  • 58.56 (n)
  • 47.75 (a)
FAM154A 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T08G11.3 35
  • 39.94 (n)
  • 26.09 (a)
T08G11.3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for SAXO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SAXO1 Gene

ENSEMBL:
Gene Tree for SAXO1 (if available)
TreeFam:
Gene Tree for SAXO1 (if available)

Paralogs for SAXO1 Gene

Paralogs for SAXO1 Gene

genes like me logo Genes that share paralogs with SAXO1: view

Variants for SAXO1 Gene

Sequence variations from dbSNP and Humsavar for SAXO1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs755168 -- 18,927,466(+) TTGCT(C/G/T)GTATG downstream-variant-500B
rs883439 -- 19,008,761(+) ACAGG(A/G)CAAAT intron-variant
rs883440 -- 19,008,825(+) CAGGT(A/C)CAGGA intron-variant
rs945442 -- 18,927,770(+) AGAAA(A/C)CCTCA utr-variant-3-prime
rs945443 -- 18,927,820(+) TGAAA(A/C/T)GGGGT utr-variant-3-prime

Relevant External Links for SAXO1 Gene

HapMap Linkage Disequilibrium report
SAXO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAXO1 Gene

Disorders for SAXO1 Gene

No disorders were found for SAXO1 Gene.

No data available for UniProtKB/Swiss-Prot for SAXO1 Gene

Publications for SAXO1 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures. (PMID: 25673876) Dacheux D. … Bonhivers M. (J. Cell. Sci. 2015) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SAXO1 Gene

Sources for SAXO1 Gene

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