SAV1 Gene
protein-coding GIFtS: 50
GCID: GC14M051100
|
|
salvador homolog 1 (Drosophila)
| |
Aliases
for SAV1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Salvador Homolog 1 (Drosophila)1 2 | | SAV2 5 | | WW451 2 3 5 | | Salvador1 | | WWP41 2 | | 1700040G09Rik2 | | 45 KDa WW Domain Protein2 3 | | Protein Salvador Homolog 12 | | HWW451 | | WW Domain-Containing2 |
Export aliases for SAV1 gene to outside databasesPrevious GC identifers: GC14M044894 GC14M049088 GC14M049090 GC14M050170 GC14M031228 |
Summaries
for SAV1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SAV1:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a widevariety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes aprotein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues.This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also beenshown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate theanti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. (provided byRefSeq, Aug 2012)
UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ sizecontrol and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into thenucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is requiredfor STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developingepithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, andits ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activityof ESR1 through the modulation of its phosphorylation
Gene Wiki entry for SAV1
|
Genomic Views
for SAV1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SAV1 gene promoter:
p53 AML1a Bach2 HTF LCR-F1 FOXL1 CREB Sox9 Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SAV1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAV1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q13-q23 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q13-q23SAV1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M051100: view genomic region
(about GC identifiers)
Start:
|
51,098,776 bp from pter |
End:
|
51,135,049 bp from pter |
Size:
|
36,274 bases |
Orientation:
|
minus strand |
|
Proteins
for SAV1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6 (See
protein sequence)Recommended Name: Protein salvador homolog 1 Size: 383 amino acids; 44634 Da
Subunit: Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) withisoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: A8K4B8 D3DSB6 Q6IA58 Q9H949 Q9HAK9Explore the universe of human proteins at neXtProt for SAV1: NX_Q9H4B6
Post-translational modifications:
Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase thenumber of protein binding sites on the scaffold molecule1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4B6
SAV1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068590.1
ENSEMBL proteins: ENSP00000451492 ENSP00000324729 ENSP00000450571 ENSP00000452104 ENSP00000451596 Reactome Protein details: Q9H4B6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SAV1 for ontologies About GeneDecksing
SAV1 Antibody Products:
Assay Products for SAV1: |
Protein
Domains /
Families
for SAV1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SAV1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H4B6ProtoNet protein and cluster: Q9H4B6 UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6Similarity: Contains 1 SARAH domainSimilarity: Contains 2 WW domains |
Function
for SAV1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ sizecontrol and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway iscomposed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into thenucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is requiredfor STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developingepithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, andits ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activityof ESR1 through the modulation of its phosphorylation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAV1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript Custom all cDNA clones Services for SAV1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAV1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAV1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SAV1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Sav1tm1Dlim for SAV1
13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Sav1):
SAV1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SAV1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by Hippo | | | 2 | Wnt / Hedgehog / Notch | | | 3 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for SAV1
2 
Reactome Pathways for SAV1
SAV1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAV1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/21 Interacting proteins for SAV1 (Q9H4B61, 2, 3 ENSP000003247294) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001942 | hair follicle development |
IEA | -- | | GO:0007165 | signal transduction |
-- | -- | | GO:0030216 | keratinocyte differentiation |
IEA | -- | | GO:0035329 | hippo signaling cascade |
TAS | -- | | GO:0043065 | positive regulation of apoptotic process |
IEA | -- |
SAV1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SAV1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SAV1 for compounds About GeneDecksing
 Browse Tocris compounds for SAV1
5 Novoseek chemical compound relationships for SAV1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| streptavidin |
84.5 |
58 |
17193589 (7), 10898581 (6), 18421386 (4), 19788308 (3) (see all 11) |
| biotin |
70.6 |
12 |
10898581 (4), 18421386 (2), 17193589 (1), 18461928 (1) (see all 6) |
| beta-cyclodextrin |
65.8 |
12 |
17193589 (6), 17511636 (1) |
| threonine |
58.5 |
3 |
17964162 (1), 16930133 (1), 17174922 (1) |
| serine |
46.5 |
3 |
17964162 (1), 16930133 (1), 17174922 (1) |
Search CenterWatch for drugs/clinical trials and news about SAV1
|
Transcripts
for SAV1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SAV1 gene: NM_021818.3 Unigene Cluster for SAV1: Salvador homolog 1 (Drosophila) Hs.642842 [show with all ESTs]Unigene Representative Sequence: NM_0218186 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555720 ENST00000324679(uc001wyh.1 uc021rsy.1) ENST00000553731
ENST00000557458 ENST00000557668 ENST00000556735
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAV1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAV1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SAV1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAV1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAV1 |
Additional cDNA sequence: AF088000.1 AJ292969.1 AK021500.1 AK023071.1 AK095903.1 AK225896.1 AK290883.1 AL833378.1 BC006385.2 BC020537.1 CR457297.1 17 DOTS entries: DT.213480 DT.100794722 DT.100794720 DT.100689235 DT.99953322 DT.91724997 DT.120765507 DT.120765530 DT.120765653 DT.100816796 DT.91856820 DT.100024637 DT.100682667 DT.120765515 DT.92432781 DT.95274536 DT.120765516 24/187 AceView cDNA sequences (see all 187): AI093815 BC006385 BM546724 BQ446964 CA314657 AI005425 AI186417 BQ232211 R71224 N53743 AV658641 CA309185 NM_021818 AA489497 AA463189 AI082128 BI489611 BX327906 AA885057 BE378132 BQ573813 AA972007 AI125901 AU117370
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SAV1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SAV1
|
Expression
for SAV1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SAV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTGTAAAT
About this image
See SAV1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAV1
SOURCE GeneReport for Unigene cluster: Hs.642842
UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6Tissue specificity: Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta andinterventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adultheart. Expressed in various cell lines
SABiosciences Custom PCR Arrays for SAV1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SAV1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SAV1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAV1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAV1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1 |
Orthologs
for SAV1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SAV1 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for SAV1 (if available)
TreeFam Gene Tree for SAV1 (if available) |
Paralogs
for SAV1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SAV1 gene
- MAGI22 MAGIX2 MAGI12 MAGI32
SAV1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SAV1
PGOHUM00000245718
|
Genomic Variants
for SAV1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SAV1 (51098776 - 51135049 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SAV1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SAV1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SAV1 for disorders About GeneDecksing
OMIM gene information: 607203
OMIM disorders: --
6  diseases for SAV1: About MalaCardssoft tissue sarcoma conjunctivitis sarcoma ovarian carcinoma
breast cancer carcinoma
3 Novoseek disease relationships for SAV1 gene About this table
Export disorders for SAV1 gene to outside databases
|
Publications
for SAV1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SAV1 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with SAV1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. (PubMed id 12202036)1, 2, 3 Tapon N.... Hariharan I.K. (2002)
- Cloning, expression and mapping of hWW45, a novel WW-domain containing gene. (PubMed id 11027580)1, 2, 3 Valverde P. (2000)
- The human WW45 protein enhances MST1-mediated apoptosis in vivo. (PubMed id 19212654)1, 2, 9 Luo X....Gong J. (2009)
- Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. (PubMed id 16930133)1, 2, 9 Callus B.A.... Vaux D.L. (2006)
- Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand. (PubMed id 21104395)1, 2 Park Y.... Lee Y. (2011)
- Components of the Hippo pathway cooperate with Nek2 k inase to regulate centrosome disjunction. (PubMed id 21076410)1, 2 Mardin B.R....Schiebel E. (2010)
- The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2 Chan E.H.Y.... Sillje H.H.W. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutational analysis of salvador gene in human carcinomas. (PubMed id 12969014)1, 9 Yoo N.J....Lee S.H. (2003)
|
External Searches for SAV1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SAV1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SAV1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAV1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SAV1 gene:
Search GeneIP for patents involving SAV1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SAV1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SAV1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SAV1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SAV1 | | | OriGene Protein Over-expression Lysate for SAV1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SAV1 | | OriGene 3'-UTR Clone for SAV1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SAV1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAV1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SAV1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SAV1 | | OriGene Custom Protein Services for SAV1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAV1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SAV1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAV1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAV1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAV1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAV1 |
| |
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| | Antibodies & Assays for SAV1 |
| | | | Search Tocris compounds for SAV1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SAV1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SAV1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAV1 |
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