Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAV1 Gene

protein-coding   GIFtS: 53
GCID: GC14M051100

Salvador Homolog 1 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Salvador Homolog 1 (Drosophila)1 2     1700040G09Rik2
WW452 3 5     WWP42
45 KDa WW Domain Protein2 3     Protein Salvador Homolog 12
hWW452 3     WW Domain-Containing2
SAV2 5     

External Ids:    HGNC: 177951   Entrez Gene: 604852   Ensembl: ENSG000001517487   OMIM: 6072035   UniProtKB: Q9H4B63   

Export aliases for SAV1 gene to outside databases

Previous GC identifers: GC14M044894 GC14M049088 GC14M049090 GC14M050170 GC14M031228


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SAV1 Gene:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide
variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a
protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult
tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It
has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to
attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor
suppressor. (provided by RefSeq, Aug 2012)

GeneCards Summary for SAV1 Gene: 
SAV1 (salvador homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with SAV1 include soft tissue sarcoma, and conjunctivitis, and among its related super-pathways are Signaling by GPCR. GO annotations related to this gene include protein binding. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6
Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ
size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation
into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation
in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2
to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the
transcriptional activity of ESR1 through the modulation of its phosphorylation

Gene Wiki entry for SAV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAV1 gene promoter:
         p53   AML1a   Bach2   HTF   LCR-F1   FOXL1   CREB   Sox9   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAV1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SAV1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13-q23   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q13-q23

SAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAV1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M051100:  view genomic region     (about GC identifiers)

Start:
51,098,776 bp from pter      End:
51,135,049 bp from pter
Size:
36,274 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6 (See protein sequence)
Recommended Name: Protein salvador homolog 1  
Size: 383 amino acids; 44634 Da
Subunit: Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with
isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: A8K4B8 D3DSB6 Q6IA58 Q9H949 Q9HAK9

Explore the universe of human proteins at neXtProt for SAV1: NX_Q9H4B6

Explore proteomics data for SAV1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the
    number of protein binding sites on the scaffold molecule
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H4B6

  • SAV1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SAV1 Protein Expression
    REFSEQ proteins: NP_068590.1  
    ENSEMBL proteins: 
     ENSP00000451492   ENSP00000324729   ENSP00000450571   ENSP00000452104   ENSP00000451596  
    Reactome Protein details: Q9H4B6
    Human Recombinant Protein Products for SAV1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SAV1
    OriGene Protein Over-expression Lysate for SAV1
    OriGene MassSpec for SAV1 
    OriGene Custom Protein Services for SAV1
    GenScript Custom Purified and Recombinant Proteins Services for SAV1
    Novus Biologicals SAV1 Protein
    Novus Biologicals SAV1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SAV1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19212654
    GO:0005737cytoplasm IDA19212654
    GO:0005829cytosol TAS--

    SAV1 for ontologies           About GeneDecksing



    SAV1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SAV1 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SAV1
    GenScript Superior Antibodies for SAV1
    Novus Biologicals SAV1 Antibodies
    Abcam antibodies for SAV1
    Cloud-Clone Corp. Antibodies for SAV1 
    Search ThermoFisher Antibodies for SAV1
    LSBio Antibodies in human, mouse, rat for SAV1 

    Assay Products for SAV1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAV1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAV1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAV1 
    Cloud-Clone Corp. CLIAs for SAV1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011524 SARAH_dom
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9H4B6

    ProtoNet protein and cluster: Q9H4B6

    UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6
    Similarity: Contains 1 SARAH domain
    Similarity: Contains 2 WW domains


    SAV1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAV1_HUMAN, Q9H4B6
    Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ
    size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
    is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
    phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
    and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation
    into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
    SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation
    in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2
    to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the
    transcriptional activity of ESR1 through the modulation of its phosphorylation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16930133
         
    SAV1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sav1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  integument  liver/biliary system  mortality/aging 
     respiratory system  tumorigenesis  vision/eye 

    SAV1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sav1tm1Dlim for SAV1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SAV1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAV1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAV1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAV1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAV1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SAV1 (see all 15):
    hsa-miR-3163 hsa-miR-203 hsa-miR-3685 hsa-miR-100* hsa-miR-409-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSAV1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAV1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAV1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAV1
    Sirion Biotech Customized adenovirus for overexpression of SAV1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SAV1 (see all 7)
    OriGene ORF clones in mouse, rat for SAV1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SAV1
    Sino Biological Human cDNA Clone for SAV1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAV1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAV1
    Sirion Biotech Customized lentivirus for stable overexpression of SAV1 
                         Customized lentivirus expression plasmids for stable overexpression of SAV1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAV1
    Search LifeMap BioReagents cell lines for SAV1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SAV1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.55
    2Signaling by Hippo
    Signaling by Hippo
    3Hippo signaling pathway
    Hippo signaling pathway
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SAV1
        Wnt / Hedgehog / Notch


    2        Reactome Pathways for SAV1
        Signaling by Hippo
    Signal Transduction


    1         Kegg Pathway  (Kegg details for SAV1):
        Hippo signaling pathway


    SAV1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for SAV1 (Q9H4B61, 2, 3 ENSP000003247294) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK3Q131881, 3, ENSP000003905004EBI-1017775,EBI-992580 I2D: score=5 STRING: ENSP00000390500
    STK4Q130431, 3, ENSP000003618924EBI-1017775,EBI-367376 I2D: score=4 STRING: ENSP00000361892
    SFNP319472, 3MINT-3976204 I2D: score=2 
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    RASSF3Q86WH23, ENSP000003366164I2D: score=1 STRING: ENSP00000336616
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0007165signal transduction ----
    GO:0030216keratinocyte differentiation IEA--
    GO:0035329hippo signaling cascade TAS--
    GO:0043065positive regulation of apoptotic process IEA--

    SAV1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SAV1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAV1

    5 Novoseek inferred chemical compound relationships for SAV1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    streptavidin 84.5 58 17193589 (7), 10898581 (6), 18421386 (4), 19788308 (3) (see all 11)
    biotin 70.6 12 10898581 (4), 18421386 (2), 17193589 (1), 18461928 (1) (see all 6)
    beta-cyclodextrin 65.8 12 17193589 (6), 17511636 (1)
    threonine 58.5 3 17964162 (1), 16930133 (1), 17174922 (1)
    serine 46.5 3 17964162 (1), 16930133 (1), 17174922 (1)

    Search CenterWatch for drugs/clinical trials and news about SAV1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SAV1 gene: 
    NM_021818.3  

    Unigene Cluster for SAV1:

    Salvador homolog 1 (Drosophila)
    Hs.642842  [show with all ESTs]
    Unigene Representative Sequence: NM_021818
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555720 ENST00000324679(uc001wyh.1 uc021rsy.1) ENST00000553731
    ENST00000557458 ENST00000602664 ENST00000556735
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAV1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SAV1 (see all 15):
    hsa-miR-3163 hsa-miR-203 hsa-miR-3685 hsa-miR-100* hsa-miR-409-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSAV1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAV1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAV1
    Clone
    Products:
         
    OriGene clones in human, mouse for SAV1 (see all 7)
    OriGene ORF clones in mouse, rat for SAV1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SAV1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAV1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAV1
    Sirion Biotech Customized lentivirus for stable overexpression of SAV1 
                         Customized lentivirus expression plasmids for stable overexpression of SAV1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SAV1
    OriGene qSTAR qPCR primer pairs in human, mouse for SAV1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SAV1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAV1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAV1

    Additional mRNA sequence: 

    AF088000.1 AJ292969.1 AK021500.1 AK023071.1 AK095903.1 AK225896.1 AK290883.1 AL833378.1 
    BC006385.2 BC020537.1 CR457297.1 

    20 DOTS entries:

    DT.100794720  DT.213480  DT.100794722  DT.100689235  DT.99953322  DT.91724997  DT.120765507  DT.120765530 
    DT.120765653  DT.100816796  DT.441169  DT.91856820  DT.100024637  DT.100682667  DT.120765515  DT.86859702 
    DT.92432781  DT.95274536  DT.120765516  DT.120765519 

    24/187 AceView cDNA sequences (see all 187):

    AI082128 AA972007 AW290872 CD679189 BX327906 AA489498 AA829947 AI679905 
    AL833378 BQ027432 AW071550 BE349346 BI489611 AI086040 AA885057 AU117370 
    AI125901 CD677516 BQ573813 AA993410 AI093815 AA463189 NM_021818 AA489497 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SAV1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:        -                                 
    SP2:                                          


    ECgene alternative splicing isoforms for SAV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGTAAAT
    SAV1 Expression
    About this image


    See SAV1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAV1

    SOURCE GeneReport for Unigene cluster: Hs.642842

    UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6
    Tissue specificity: Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and
    interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the
    adult heart. Expressed in various cell lines

        SABiosciences Custom PCR Arrays for SAV1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SAV1
    OriGene qSTAR qPCR primer pairs in human, mouse for SAV1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SAV1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAV1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAV1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SAV1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sav11 , 5 salvador homolog 1 (Drosophila)1, 5 89.21(n)1
    94.26(a)1
      12 (28.94 cM)5
    640101  NM_022028.21  NP_071311.11 
     699650125 
    chicken
    (Gallus gallus)
    Aves SAV11 salvador homolog 1 (Drosophila) 75.47(n)
    85.23(a)
      423578  XM_421467.3  XP_421467.3 
    lizard
    (Anolis carolinensis)
    Reptilia SAV16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    AAWZ02037268(5300-17743)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163602 Xenopus laevis transcribed sequence with moderate similarity more 75.42(n)    BX842849.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sav11 salvador homolog 1 (Drosophila) 66.04(n)
    70.13(a)
      447821  NM_001004560.1  NP_001004560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sav6
    salvador
    21(a)
    1 ↔ 1
    3R(18884331-18886991)
    worm
    (Caenorhabditis elegans)
    Secernentea sav-16
    Protein SAV-1
    23(a)
    1 ↔ 1
    X(2283994-2287188)


    ENSEMBL Gene Tree for SAV1 (if available)
    TreeFam Gene Tree for SAV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAV1 gene
    MAGI22  MAGIX2  MAGI12  MAGI32  

    SAV1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SAV1
    PGOHUM00000245718


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/865 SNPs in SAV1 are shown (see all 865)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0158804
    A colon cancer cell line4--see VAR_0158802 A D mis40--------
    rs1409963401,2
    C--31229961(+) TGTCA-/GTTTTTt 1 -- int10--------
    rs1814795421,2
    --51100585(+) AGTTAC/TAGTTT 1 -- ut310--------
    rs775380181,2
    C,F--51100617(+) GCAATC/TAAATG 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs116230001,2
    C,F,H--51100648(+) ATGTTT/GTAACT 1 -- ut313Minor allele frequency- G:0.01NS NA 230
    rs1160611351,2
    C--51100750(+) CATTCA/GATTTA 1 -- ut310--------
    rs1856556741,2
    --51100909(+) GAAGAA/TGATGT 1 -- ut310--------
    rs1907125531,2
    --51100928(+) TTGAGA/TTTCAC 1 -- ut310--------
    rs1819673951,2
    --51101030(+) CTCAAC/TATGCT 1 -- ut310--------
    rs1414426351,2
    --51101054(+) TTATT-/TTGTTTTT 1 -- cds10--------

    HapMap Linkage Disequilibrium report for SAV1 (51098776 - 51135049 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SAV1: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SAV1
    DNA2.0 Custom Variant and Variant Library Synthesis for SAV1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607203    OMIM disorders: --

    6 diseases for SAV1:    About MalaCards
    soft tissue sarcoma    conjunctivitis    clear cell renal cell carcinoma    sarcoma
    renal cell carcinoma    breast cancer


    SAV1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SAV1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warts 76.2 5 17964162 (2), 17538946 (1), 12941273 (1), 17174922 (1)
    cancer 14.9 6 12969014 (3)
    tumors 0 3 17538946 (1), 12941273 (1), 17379520 (1)


    Export disorders for SAV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAV1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SAV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. (PubMed id 12202036)1, 2, 3 Tapon N.... Hariharan I.K. (2002)
    2. Cloning, expression and mapping of hWW45, a novel WW-domain containing gene. (PubMed id 11027580)1, 2, 3 Valverde P. (2000)
    3. The human WW45 protein enhances MST1-mediated apoptosis in vivo. (PubMed id 19212654)1, 2, 9 Luo X....Gong J. (2009)
    4. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. (PubMed id 16930133)1, 2, 9 Callus B.A.... Vaux D.L. (2006)
    5. Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand. (PubMed id 21104395)1, 2 Park Y.... Lee Y. (2011)
    6. Components of the Hippo pathway cooperate with Nek2 k inase to regulate centrosome disjunction. (PubMed id 21076410)1, 2 Mardin B.R....Schiebel E. (2010)
    7. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2 Chan E.H.Y.... Sillje H.H.W. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Mutational analysis of salvador gene in human carcinomas. (PubMed id 12969014)1, 9 Yoo N.J....Lee S.H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60485 HGNC: 17795 AceView: SAV1 Ensembl:ENSG00000151748 euGenes: HUgn60485
    ECgene: SAV1 Kegg: 60485 H-InvDB: SAV1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAV1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SAV1 gene:
    Search GeneIP for patents involving SAV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SAV1  
     OriGene qPCR primer pairs and template standards for SAV1   OriGene Protein Over-expression Lysate for SAV1  
     OriGene MassSpec something-or-other for SAV1   OriGene clones in human, mouse for SAV1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SAV1   OriGene Purified Protein for SAV1  
     OriGene ORF clones in mouse, rat for SAV1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SAV1   OriGene Custom Protein Services for SAV1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAV1
     QIAGEN SeqTarget long-range PCR primers for resequencing SAV1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAV1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAV1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAV1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAV1
     GenScript Custom Purified and Recombinant Proteins Services for SAV1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SAV1
     GenScript Custom Assay Services for SAV1 GenScript Superior Antibodies for SAV1
     GenScript Custom overexpressing Cell Line Services for SAV1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SAV1 

     Regulatory tfbs in SAV1 promoter
     Search Chromatin IP Primers for SAV1
     RT2 qPCR Primer Assay in human, mouse / rat SAV1
     GNC Network for SAV1
     SABiosciences Custom PCR Arrays for SAV1
     Search Tocris compounds for SAV1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SAV1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SAV1 antibodies
     SAV1 proteins
     SAV1 lysates
     Antibodies for SAV1
     See all of Abcam's Antibodies, Kits and Proteins for SAV1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SAV1
     Antibodies for SAV1
     ELISAs for SAV1
     CLIAs for SAV1
     Search LifeMap BioReagents cell lines for SAV1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1
     SwitchGear 3'UTR luciferase reporter plasmids for SAV1
     SwitchGear Promoter luciferase reporter plasmids for SAV1
     Search ThermoFisher Antibodies for SAV1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAV1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SAV1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAV1
    Customized:
     lentivirus for stable overexpression of SAV1
     lentivirus expression plasmids for stable overexpression of SAV1
     adenovirus for overexpression of SAV1
     LSBio Antibodies in human, mouse, rat for SAV1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SAV1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4