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SAV1 Gene

protein-coding   GIFtS: 53
GCID: GC14M051100

Salvador Homolog 1 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Salvador Homolog 1 (Drosophila)1 2     1700040G09Rik2
WW452 3 5     WWP42
45 KDa WW Domain Protein2 3     Protein Salvador Homolog 12
hWW452 3     WW Domain-Containing2
SAV2 5     

External Ids:    HGNC: 177951   Entrez Gene: 604852   Ensembl: ENSG000001517487   OMIM: 6072035   UniProtKB: Q9H4B63   

Export aliases for SAV1 gene to outside databases

Previous GC identifers: GC14M044894 GC14M049088 GC14M049090 GC14M050170 GC14M031228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SAV1 Gene:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide
variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a
protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult
tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It
has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to
attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor
suppressor. (provided by RefSeq, Aug 2012)

GeneCards Summary for SAV1 Gene:
SAV1 (salvador homolog 1 (Drosophila)) is a protein-coding gene. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6
Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ
size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation
into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation
in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2
to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the
transcriptional activity of ESR1 through the modulation of its phosphorylation

Gene Wiki entry for SAV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAV1 gene promoter:
         p53   AML1a   Bach2   HTF   LCR-F1   FOXL1   CREB   Sox9   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAV1 promoter sequence
   Search Chromatin IP Primers for SAV1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13-q23   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q13-q23

SAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAV1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M051100:  view genomic region     (about GC identifiers)

Start:
51,098,776 bp from pter      End:
51,135,049 bp from pter
Size:
36,274 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6 (See protein sequence)
Recommended Name: Protein salvador homolog 1  
Size: 383 amino acids; 44634 Da
Subunit: Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with
isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA
Secondary accessions: A8K4B8 D3DSB6 Q6IA58 Q9H949 Q9HAK9

Explore the universe of human proteins at neXtProt for SAV1: NX_Q9H4B6

Explore proteomics data for SAV1 at MOPED

Post-translational modifications: 

  • Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the
    number of protein binding sites on the scaffold molecule1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAV1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068590.1  
    ENSEMBL proteins: 
     ENSP00000451492   ENSP00000324729   ENSP00000450571   ENSP00000452104   ENSP00000451596  
    Reactome Protein details: Q9H4B6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011524 SARAH_dom
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9H4B6

    ProtoNet protein and cluster: Q9H4B6

    UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6
    Similarity: Contains 1 SARAH domain
    Similarity: Contains 2 WW domains


    Find genes that share domains with SAV1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAV1_HUMAN, Q9H4B6
    Function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ
    size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
    is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1,
    phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates
    and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation
    into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
    SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation
    in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2
    to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the
    transcriptional activity of ESR1 through the modulation of its phosphorylation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16930133
         
    Find genes that share ontologies with SAV1           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sav1):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  integument  liver/biliary system  mortality/aging 
     respiratory system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with SAV1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sav1tm1Dlim for SAV1

       genOway: Develop your customized and physiologically relevant rodent model for SAV1

    miRNA
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    Block miRNA regulation of human, mouse, rat SAV1 using miScript Target Protectors
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    hsa-miR-3163 hsa-miR-203 hsa-miR-3685 hsa-miR-100* hsa-miR-409-3p hsa-miR-27a hsa-miR-513a-5p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidSAV1 3' UTR sequence
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    Addgene plasmids for SAV1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAV1_HUMAN, Q9H4B6: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19212654
    GO:0005737cytoplasm IDA19212654
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SAV1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SAV1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signal Transduction0.58
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Signaling by Hippo
    Signaling by Hippo
    4Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with SAV1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SAV1
        Wnt / Hedgehog / Notch


    1 Reactome Pathway for SAV1
        Signaling by Hippo


    1 Kegg Pathway  (Kegg details for SAV1):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAV1
    Interactions:

        GeneGlobe Interaction Network for SAV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for SAV1 (Q9H4B61, 2, 3 ENSP000003247294) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK3Q131881, 3, ENSP000003905004EBI-1017775,EBI-992580 I2D: score=5 STRING: ENSP00000390500
    STK4Q130431, 3, ENSP000003618924EBI-1017775,EBI-367376 I2D: score=4 STRING: ENSP00000361892
    SFNP319472, 3MINT-3976204 I2D: score=2 
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    RASSF3Q86WH23, ENSP000003366164I2D: score=1 STRING: ENSP00000336616
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0007165signal transduction ----
    GO:0030216keratinocyte differentiation IEA--
    GO:0035329hippo signaling TAS--
    GO:0043065positive regulation of apoptotic process IEA--

    Find genes that share ontologies with SAV1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for SAV1

    5 Novoseek inferred chemical compound relationships for SAV1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    streptavidin 84.5 58 17193589 (7), 10898581 (6), 18421386 (4), 19788308 (3) (see all 11)
    biotin 70.6 12 10898581 (4), 18421386 (2), 17193589 (1), 18461928 (1) (see all 6)
    beta-cyclodextrin 65.8 12 17193589 (6), 17511636 (1)
    threonine 58.5 3 17964162 (1), 16930133 (1), 17174922 (1)
    serine 46.5 3 17964162 (1), 16930133 (1), 17174922 (1)



    Find genes that share compounds with SAV1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SAV1 gene: 
    NM_021818.3  

    Unigene Cluster for SAV1:

    Salvador homolog 1 (Drosophila)
    Hs.642842  [show with all ESTs]
    Unigene Representative Sequence: NM_021818
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555720 ENST00000324679(uc001wyh.1 uc021rsy.1) ENST00000553731
    ENST00000557458 ENST00000602664 ENST00000556735
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    Additional mRNA sequence: 

    AF088000.1 AJ292969.1 AK021500.1 AK023071.1 AK095903.1 AK225896.1 AK290883.1 AL833378.1 
    BC006385.2 BC020537.1 CR457297.1 

    20 DOTS entries:

    DT.100794720  DT.213480  DT.100794722  DT.100689235  DT.99953322  DT.91724997  DT.120765507  DT.120765530 
    DT.120765653  DT.100816796  DT.441169  DT.91856820  DT.100024637  DT.100682667  DT.120765515  DT.86859702 
    DT.92432781  DT.95274536  DT.120765516  DT.120765519 

    Selected AceView cDNA sequences (see all 187):

    BC006385 AI093815 AA489498 CD679189 AI679905 AA993410 CD677516 BE349346 
    AA885057 AW290872 AI086040 BU620974 AU117370 AL833378 AW071550 AI125901 
    BQ573813 AA972007 BE378132 BC020537 AA829947 BX327906 BI489611 AI082128 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SAV1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:        -                                 
    SP2:                                          


    ECgene alternative splicing isoforms for SAV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SAV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGTAAAT
    SAV1 Expression
    About this image


    SAV1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    SAV1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAV1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642842

    UniProtKB/Swiss-Prot: SAV1_HUMAN, Q9H4B6
    Tissue specificity: Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and
    interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the
    adult heart. Expressed in various cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAV1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SAV1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sav11 , 5 salvador homolog 1 (Drosophila)1, 5 89.21(n)1
    94.26(a)1
      12 (28.94 cM)5
    640101  NM_022028.21  NP_071311.11 
     699650125 
    chicken
    (Gallus gallus)
    Aves SAV11 salvador homolog 1 (Drosophila) 75.47(n)
    85.23(a)
      423578  XM_421467.4  XP_421467.3 
    lizard
    (Anolis carolinensis)
    Reptilia SAV16
    salvador homolog 1 (Drosophila)
    80(a)
    1 ↔ 1
    AAWZ02037268(5300-17743)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163602 Xenopus laevis transcribed sequence with moderate similarity more 75.42(n)    BX842849.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sav11 salvador homolog 1 (Drosophila) 65.96(n)
    70.13(a)
      447821  NM_001004560.1  NP_001004560.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sav6
    salvador
    24(a)
    1 ↔ 1
    3R(18884331-18886991)
    worm
    (Caenorhabditis elegans)
    Secernentea sav-16
    Protein SAV-1 (sav-1) mRNA, complete cds
    19(a)
    1 ↔ 1
    X(2283994-2287188) WBGene00020427


    ENSEMBL Gene Tree for SAV1 (if available)
    TreeFam Gene Tree for SAV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAV1 gene
    MAGI22  MAGIX2  MAGI12  MAGI32  

    Find genes that share paralogs with SAV1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SAV1
    PGOHUM00000245718


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SAV1 (see all 865)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0158804
    A colon cancer cell line4--see VAR_0158802 A D mis40--------
    rs1409963401,2
    C--31229961(+) TGTCA-/GTTTTTt 1 -- int10--------
    rs1814795421,2
    --51100585(+) AGTTAC/TAGTTT 1 -- ut310--------
    rs775380181,2
    C,F--51100617(+) GCAATC/TAAATG 1 -- ut311Minor allele frequency- T:0.03EA 120
    rs116230001,2
    C,F,H--51100648(+) ATGTTT/GTAACT 1 -- ut313Minor allele frequency- G:0.01NS NA 230
    rs1160611351,2
    C--51100750(+) CATTCA/GATTTA 1 -- ut310--------
    rs1856556741,2
    --51100909(+) GAAGAA/TGATGT 1 -- ut310--------
    rs1907125531,2
    --51100928(+) TTGAGA/TTTCAC 1 -- ut310--------
    rs1819673951,2
    --51101030(+) CTCAAC/TATGCT 1 -- ut310--------
    rs1414426351,2
    --51101054(+) TTATT-/TTGTTTTT 1 -- cds10--------

    HapMap Linkage Disequilibrium report for SAV1 (51098776 - 51135049 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SAV1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SAV1
    DNA2.0 Custom Variant and Variant Library Synthesis for SAV1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607203    OMIM disorders: --


    Find genes that share disorders with SAV1           About GenesLikeMe

    3 Novoseek inferred disease relationships for SAV1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warts 76.2 5 17964162 (2), 17538946 (1), 12941273 (1), 17174922 (1)
    cancer 14.9 6 12969014 (3)
    tumors 0 3 17538946 (1), 12941273 (1), 17379520 (1)


    Export disorders for SAV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAV1 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with SAV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. (PubMed id 12202036)1, 2, 3 Tapon N.... Hariharan I.K. (Cell 2002)
    2. Cloning, expression and mapping of hWW45, a novel WW-domain containing gene. (PubMed id 11027580)1, 2, 3 Valverde P. (Biochem. Biophys. Res. Commun. 2000)
    3. The human WW45 protein enhances MST1-mediated apoptosis in vivo. (PubMed id 19212654)1, 2, 9 Luo X.... Gong J. (Int. J. Mol. Med. 2009)
    4. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. (PubMed id 16930133)1, 2, 9 Callus B.A.... Vaux D.L. (FEBS J. 2006)
    5. Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand. (PubMed id 21104395)1, 2 Park Y.... Lee Y. (J. Mol. Med. 2011)
    6. Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction. (PubMed id 21076410)1, 2 Mardin B.R....Schiebel E. (Nat. Cell Biol. 2010)
    7. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. (PubMed id 15688006)1, 2 Chan E.H.Y.... Sillje H.H.W. (Oncogene 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Mutational analysis of salvador gene in human carcinomas. (PubMed id 12969014)1, 9 Yoo N.J....Lee S.H. (APMIS 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60485 HGNC: 17795 AceView: SAV1 Ensembl:ENSG00000151748 euGenes: HUgn60485
    ECgene: SAV1 Kegg: 60485 H-InvDB: SAV1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SAV1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SAV1 gene:
    Search GeneIP for patents involving SAV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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