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Aliases for SAV1 Gene

Aliases for SAV1 Gene

  • Salvador Family WW Domain Containing Protein 1 2 3
  • WW45 3 4 6
  • WW Domain-Containing Adaptor 45 2 3
  • 45 KDa WW Domain Protein 3 4
  • HWW45 3 4
  • SAV 3 6
  • Salvador Homolog 1 (Drosophila) 2
  • Protein Salvador Homolog 1 3
  • Salvador Homolog 1 3
  • 1700040G09Rik 3
  • WWP4 3

External Ids for SAV1 Gene

Previous GeneCards Identifiers for SAV1 Gene

  • GC14M044894
  • GC14M049088
  • GC14M049090
  • GC14M050170
  • GC14M051100
  • GC14M031228

Summaries for SAV1 Gene

Entrez Gene Summary for SAV1 Gene

  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

GeneCards Summary for SAV1 Gene

SAV1 (Salvador Family WW Domain Containing Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. An important paralog of this gene is MAGI3.

UniProtKB/Swiss-Prot for SAV1 Gene

  • Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Gene Wiki entry for SAV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAV1 Gene

Genomics for SAV1 Gene

Regulatory Elements for SAV1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAV1 Gene

Start:
50,632,058 bp from pter
End:
50,668,353 bp from pter
Size:
36,296 bases
Orientation:
Minus strand

Genomic View for SAV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAV1 Gene

Proteins for SAV1 Gene

  • Protein details for SAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4B6-SAV1_HUMAN
    Recommended name:
    Protein salvador homolog 1
    Protein Accession:
    Q9H4B6
    Secondary Accessions:
    • A8K4B8
    • D3DSB6
    • Q6IA58
    • Q9H949
    • Q9HAK9

    Protein attributes for SAV1 Gene

    Size:
    383 amino acids
    Molecular mass:
    44634 Da
    Quaternary structure:
    • Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA.

neXtProt entry for SAV1 Gene

Proteomics data for SAV1 Gene at MOPED

Post-translational modifications for SAV1 Gene

  • Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAV1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SAV1 (SAV1)

No data available for DME Specific Peptides for SAV1 Gene

Domains for SAV1 Gene

Protein Domains for SAV1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H4B6

UniProtKB/Swiss-Prot:

SAV1_HUMAN :
  • Q9H4B6
Domain:
  • Contains 1 SARAH domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with SAV1: view

No data available for Gene Families for SAV1 Gene

Function for SAV1 Gene

Molecular function for SAV1 Gene

UniProtKB/Swiss-Prot Function:
Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Gene Ontology (GO) - Molecular Function for SAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16930133
genes like me logo Genes that share ontologies with SAV1: view
genes like me logo Genes that share phenotypes with SAV1: view

Animal Models for SAV1 Gene

MGI Knock Outs for SAV1:

Animal Model Products

miRNA for SAV1 Gene

miRTarBase miRNAs that target SAV1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SAV1 Gene

Localization for SAV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAV1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAV1 Gene COMPARTMENTS Subcellular localization image for SAV1 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19212654
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SAV1: view

Pathways for SAV1 Gene

genes like me logo Genes that share pathways with SAV1: view

Pathways by source for SAV1 Gene

1 Cell Signaling Technology pathway for SAV1 Gene
2 Reactome pathways for SAV1 Gene
1 KEGG pathway for SAV1 Gene

Gene Ontology (GO) - Biological Process for SAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0007165 signal transduction --
GO:0030216 keratinocyte differentiation IEA --
GO:0035329 hippo signaling TAS --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with SAV1: view

Compounds for SAV1 Gene

(5) Novoseek inferred chemical compound relationships for SAV1 Gene

Compound -log(P) Hits PubMed IDs
streptavidin 84.5 36
biotin 70.6 10
beta-cyclodextrin 65.8 7
threonine 58.5 3
serine 46.5 3
genes like me logo Genes that share compounds with SAV1: view

Transcripts for SAV1 Gene

Unigene Clusters for SAV1 Gene

Salvador homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAV1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAV1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for SAV1 Gene

GeneLoc Exon Structure for
SAV1
ECgene alternative splicing isoforms for
SAV1

Expression for SAV1 Gene

mRNA expression in normal human tissues for SAV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SAV1 Gene

This gene is overexpressed in Lung (58.4) and Tlymphocyte (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAV1 Gene

SOURCE GeneReport for Unigene cluster for SAV1 Gene Hs.642842

mRNA Expression by UniProt/SwissProt for SAV1 Gene

Q9H4B6-SAV1_HUMAN
Tissue specificity: Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
genes like me logo Genes that share expressions with SAV1: view

Expression partners for SAV1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SAV1 Gene

Orthologs for SAV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAV1 35
  • 93.56 (n)
  • 96.61 (a)
SAV1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAV1 35
  • 95.04 (n)
  • 97.65 (a)
SAV1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sav1 35
  • 89.21 (n)
  • 94.26 (a)
Sav1 16
Sav1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAV1 35
  • 99.71 (n)
  • 100 (a)
SAV1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sav1 35
  • 89.73 (n)
  • 94.52 (a)
oppossum
(Monodelphis domestica)
Mammalia SAV1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAV1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAV1 35
  • 75.47 (n)
  • 85.23 (a)
SAV1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAV1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sav1 35
  • 75.04 (n)
  • 81.68 (a)
Str.20182 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16360 35
zebrafish
(Danio rerio)
Actinopterygii sav1 35
  • 65.96 (n)
  • 70.13 (a)
sav1 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sav 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sav-1 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for SAV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAV1 Gene

ENSEMBL:
Gene Tree for SAV1 (if available)
TreeFam:
Gene Tree for SAV1 (if available)

Paralogs for SAV1 Gene

Paralogs for SAV1 Gene

Pseudogenes.org Pseudogenes for SAV1 Gene

genes like me logo Genes that share paralogs with SAV1: view

Variants for SAV1 Gene

Sequence variations from dbSNP and Humsavar for SAV1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs871643 -- 50,640,734(-) TTACA(A/G)CACAA intron-variant
rs903279 -- 50,640,005(+) GTcag(A/G)gtctc intron-variant
rs923908 -- 50,656,877(-) TTTTG(A/G)TAATG intron-variant
rs1054275 -- 50,634,811(-) TTTTT(A/T)AAAAA utr-variant-3-prime
rs1057019 -- 50,664,816(-) TTGAC(A/G/T)GAGTC intron-variant

Relevant External Links for SAV1 Gene

HapMap Linkage Disequilibrium report
SAV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAV1 Gene

Disorders for SAV1 Gene

(3) Novoseek inferred disease relationships for SAV1 Gene

Disease -log(P) Hits PubMed IDs
warts 76.2 5
cancer 14.9 3
tumors 0 3
genes like me logo Genes that share disorders with SAV1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for SAV1 Gene

Publications for SAV1 Gene

  1. The human WW45 protein enhances MST1-mediated apoptosis in vivo. (PMID: 19212654) Luo X. … Gong J. (Int. J. Mol. Med. 2009) 3 4 23
  2. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. (PMID: 16930133) Callus B.A. … Vaux D.L. (FEBS J. 2006) 3 4 23
  3. Cloning, expression and mapping of hWW45, a novel WW-domain containing gene. (PMID: 11027580) Valverde P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  4. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. (PMID: 12202036) Tapon N. … Hariharan I.K. (Cell 2002) 2 3 4
  5. Mutational analysis of salvador gene in human carcinomas. (PMID: 12969014) Yoo N.J. … Lee S.H. (APMIS 2003) 3 23

Products for SAV1 Gene

Sources for SAV1 Gene

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