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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SATL1 Gene

protein-coding   GIFtS: 40
GCID: GC0XM084347

Spermidine/Spermine N1-Acetyl Transferase-Like 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spermidine/Spermine N1-Acetyl Transferase-Like 11 2
Spermidine/Spermine N(1)-Acetyltransferase-Like Protein 12
EC 2.3.1.-3

External Ids:    HGNC: 279921   Entrez Gene: 3405622   Ensembl: ENSG000001847887   UniProtKB: Q86VE33   

Export aliases for SATL1 gene to outside databases

Previous GC identifers: GC0XM083120 GC0XM084153 GC0XM077920


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SATL1 Gene: 
SATL1 (spermidine/spermine N1-acetyl transferase-like 1) is a protein-coding gene. Diseases associated with SATL1 include tuberculosis. GO annotations related to this gene include N-acetyltransferase activity. An important paralog of this gene is SAT2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SATL1 gene promoter:
         Bach1   TBP   AML1a   C/EBPalpha   POU2F1   POU2F1b   POU2F1a   TFIID   Cart-1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSATL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SATL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SATL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21

SATL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SATL1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM084347:  view genomic region     (about GC identifiers)

Start:
84,347,292 bp from pter      End:
84,364,054 bp from pter
Size:
16,763 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SATL1_HUMAN, Q86VE3 (See protein sequence)
Recommended Name: Spermidine/spermine N(1)-acetyltransferase-like protein 1  
Size: 508 amino acids; 55833 Da
Secondary accessions: A0AVK7 Q5H8V9
Alternative splicing: 2 isoforms:  Q86VE3-1   Q86VE3-2   

Explore the universe of human proteins at neXtProt for SATL1: NX_Q86VE3

Explore proteomics data for SATL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VE3

  • SATL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SATL1 Protein Expression
    REFSEQ proteins: NP_001012998.2  
    ENSEMBL proteins: 
     ENSP00000425421   ENSP00000378804   ENSP00000329115  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q86VE3

    ProtoNet protein and cluster: Q86VE3

    UniProtKB/Swiss-Prot: SATL1_HUMAN, Q86VE3
    Similarity: Belongs to the acetyltransferase family
    Similarity: Contains 1 N-acetyltransferase domain


    SATL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008080N-acetyltransferase activity IEA--
         
    SATL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SATL1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SATL1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SATL1

    Search CenterWatch for drugs/clinical trials and news about SATL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SATL1 gene (2 alternative transcripts): 
    NM_001163541.1  NM_001012980.2  

    Unigene Cluster for SATL1:

    Spermidine/spermine N1-acetyl transferase-like 1
    Hs.640783  [show with all ESTs]
    Unigene Representative Sequence: NM_001012980
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509231 ENST00000395409 ENST00000332921(uc004een.3)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SATL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SATL1

    Additional mRNA sequence: 

    BC043215.1 BC126401.1 

    4 DOTS entries:

    DT.95295428  DT.443086  DT.40263763  DT.100752187 

    2 AceView cDNA sequences:

    BI559363 BC043215 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SATL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGAATGA
    SATL1 Expression
    About this image


    See SATL1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.640783
        SABiosciences Custom PCR Arrays for SATL1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SATL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SATL1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Satl11 , 5 spermidine/spermine N1-acetyl transferase-like 11, 5 57.98(n)1
    39.76(a)1
      X (48.76 cM)5
    738091  NM_028655.11  NP_082931.11 
     1123843035 
    lizard
    (Anolis carolinensis)
    Reptilia SATL16
    Uncharacterized protein
    34(a)
    1 ↔ 1
    GL343202.1(1088534-1098219)
    zebrafish
    (Danio rerio)
    Actinopterygii CR318653.16
    sat2b6
    (see all 3)
    Uncharacterized protein
    spermidine/spermine N1-acetyltransferase family me...
    (see all 3)
    22(a)
    22(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    7(21787406-21791755)
    5(63582313-63622810)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42106
    --
    16(a)
    1 → many
    3R(11039696-11040567)
    worm
    (Caenorhabditis elegans)
    Secernentea D2023.46
    Protein D2023.4
    14(a)
    1 → many
    V(11825030-11825764)


    ENSEMBL Gene Tree for SATL1 (if available)
    TreeFam Gene Tree for SATL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SATL1 gene
    SAT22  SAT12  
    4 SIMAP similar genes for SATL1 using alignment to 2 protein entries:     SATL1_HUMAN (see all proteins):
    AILE3    SAT    SAT1    SAT2

    SATL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/274 SNPs in SATL1 are shown (see all 274)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395688081,2
    --77922596(+) ACACCG/TTATGT 1 -- int10--------
    rs1149254001,2
    C,F--77922663(+) GTAATA/GTCATA 1 -- int10--------
    rs2016986681,2
    C--77922756(+) AAGTAC/GTACAT 2 Y * stg10--------
    rs1817619991,2
    C--77922865(+) TTTGGC/TGTTTG 1 -- int10--------
    rs1842107431,2
    C--77922866(+) TTGGCA/GTTTGT 1 -- int10--------
    rs1886220591,2
    --77922893(+) TAAATC/GCTCAC 1 -- int10--------
    rs59684441,2
    C,F,A,H--77922995(+) GTGGTA/GTACGA 1 -- int119Minor allele frequency- G:0.38NS EA NA 2109
    rs1810369031,2
    --77923018(+) TTTTAC/GCTGGG 1 -- int10--------
    rs1510345531,2
    C--77923038(+) TCATGA/GCTGTA 1 -- int10--------
    rs1851131811,2
    --77923296(+) TGTCTC/TTTAAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SATL1 (84347292 - 84364054 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SATL1: --

    Human Gene Mutation Database (HGMD): SATL1

    Locus Specific Mutation Databases (LSDB): SATL1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SATL1:    About MalaCards
    tuberculosis    


    SATL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SATL1

    Export disorders for SATL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SATL1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SATL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17362836)4 Schymick J.C....Traynor B.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340562 HGNC: 27992 AceView: SATL1 Ensembl:ENSG00000184788 euGenes: HUgn340562
    ECgene: SATL1 H-InvDB: SATL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SATL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SATL1 gene:
    Search GeneIP for patents involving SATL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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