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SATB1 Gene(Protein Coding)

SATB Homeobox 1

GCID:
GC03M018364
GIFtS:
62
Genes Participants
UDN Logo

Aliases for SATB1 Gene

Aliases for SATB1 Gene

  • SATB Homeobox 1 2 3 5
  • Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA) 2
  • Special AT-Rich Sequence-Binding Protein 1 4

External Ids for SATB1 Gene

Previous GeneCards Identifiers for SATB1 Gene

  • GC03U990069
  • GC03M018050
  • GC03M018264

Summaries for SATB1 Gene

Entrez Gene Summary for SATB1 Gene

  • This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]

GeneCards Summary for SATB1 Gene

SATB1 (SATB Homeobox 1) is a Protein Coding gene. Diseases associated with SATB1 include Periampullary Adenocarcinoma. Among its related pathways are Apoptotic cleavage of cellular proteins and Apoptosis and survival Caspase cascade. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is SATB2.

UniProtKB/Swiss-Prot for SATB1 Gene

  • Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Gene Wiki entry for SATB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SATB1 Gene

Genomics for SATB1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SATB1 Gene

Enhancers for SATB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SATB1 on UCSC Golden Path with GeneCards custom track

Promoters for SATB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SATB1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SATB1 gene promoter:

Genomic Location for SATB1 Gene

Chromosome:
3
Start:
18,345,387 bp from pter
End:
18,445,588 bp from pter
Size:
100,202 bases
Orientation:
Minus strand

Genomic View for SATB1 Gene

Genes around SATB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SATB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SATB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SATB1 Gene

Proteins for SATB1 Gene

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  • Protein details for SATB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01826-SATB1_HUMAN
    Recommended name:
    DNA-binding protein SATB1
    Protein Accession:
    Q01826
    Secondary Accessions:
    • B3KXF1
    • C9JTR6
    • Q59EQ0

    Protein attributes for SATB1 Gene

    Size:
    763 amino acids
    Molecular mass:
    85957 Da
    Quaternary structure:
    • Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300.
    SequenceCaution:
    • Sequence=BAD92998.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SATB1 Gene

    Alternative splice isoforms for SATB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SATB1 Gene

Proteomics data for SATB1 Gene at MOPED

Protein Expression for SATB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SATB1 Gene

  • Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin association.
  • Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
  • Sumoylated. Sumoylation promotes cleavage by caspases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SATB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SATB1 (SATB1)

No data available for DME Specific Peptides for SATB1 Gene

Domains & Families for SATB1 Gene

Gene Families for SATB1 Gene

HGNC:

Protein Domains for SATB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SATB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01826

UniProtKB/Swiss-Prot:

SATB1_HUMAN :
  • Contains 2 CUT DNA-binding domains.
  • Belongs to the CUT homeobox family.
Domain:
  • Contains 2 CUT DNA-binding domains.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with SATB1: view

Function for SATB1 Gene

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  7. Flow Cytometry

Molecular function for SATB1 Gene

GENATLAS Biochemistry:
special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e. MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats
UniProtKB/Swiss-Prot Function:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Gene Ontology (GO) - Molecular Function for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 15851481
GO:0003690 double-stranded DNA binding TAS 1505028
GO:0005515 protein binding IPI 18408014
genes like me logo Genes that share ontologies with SATB1: view

Phenotypes for SATB1 Gene

MGI mutant phenotypes for SATB1:
inferred from 5 alleles
GenomeRNAi human phenotypes for SATB1:
genes like me logo Genes that share phenotypes with SATB1: view

Animal Models for SATB1 Gene

MGI Knock Outs for SATB1:

Animal Model Products

miRNA for SATB1 Gene

miRTarBase miRNAs that target SATB1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SATB1 Gene

Localization for SATB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SATB1 Gene

Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SATB1 Gene COMPARTMENTS Subcellular localization image for SATB1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IDA 18408014
genes like me logo Genes that share ontologies with SATB1: view

Pathways & Interactions for SATB1 Gene

genes like me logo Genes that share pathways with SATB1: view

Pathways by source for SATB1 Gene

1 Cell Signaling Technology pathway for SATB1 Gene
1 BioSystems pathway for SATB1 Gene

Gene Ontology (GO) - Biological Process for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 15851481
GO:0006325 chromatin organization TAS 1505028
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0012501 programmed cell death TAS --
genes like me logo Genes that share ontologies with SATB1: view

No data available for SIGNOR curated interactions for SATB1 Gene

Drugs & Compounds for SATB1 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for SATB1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SATB1 Gene

(13) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SATB1 Gene

SATB homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SATB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: -
SP13: - - - - - - - - -
SP14:
SP15: - - - - - - -

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SATB1 Gene

GeneLoc Exon Structure for
SATB1
ECgene alternative splicing isoforms for
SATB1

Expression for SATB1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SATB1 Gene

mRNA expression in normal human tissues for SATB1 Gene
mRNA expression by BioGPS for SATB1 GenemRNA expression by GTEx for SATB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SATB1 Gene

This gene is overexpressed in Cervix (30.6), CD8 Tcells (11.8), and Serum (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SATB1 Gene



SOURCE GeneReport for Unigene cluster for SATB1 Gene Hs.517717

mRNA Expression by UniProt/SwissProt for SATB1 Gene

Q01826-SATB1_HUMAN
Tissue specificity: Expressed predominantly in thymus.
genes like me logo Genes that share expression patterns with SATB1: view

Protein tissue co-expression partners for SATB1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for SATB1 Gene

Orthologs for SATB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SATB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SATB1 35
  • 86.4 (n)
  • 91.05 (a)
SATB1 36
  • 91 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SATB1 35
  • 94.52 (n)
  • 97.69 (a)
SATB1 36
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Satb1 35
  • 91.26 (n)
  • 98.43 (a)
Satb1 16
Satb1 36
  • 98 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SATB1 35
  • 99.78 (n)
  • 100 (a)
SATB1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Satb1 35
  • 90.52 (n)
  • 98.3 (a)
oppossum
(Monodelphis domestica)
 Mammalia SATB1 36
  • 96 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 89 (a)
 OneToMany
-- 36
  • 93 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves SATB1 35
  • 88.11 (n)
  • 96.42 (a)
SATB1 36
  • 96 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SATB1 36
  • 91 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia satb1 35
  • 79.54 (n)
  • 88.02 (a)
Str.19640 35
zebrafish
(Danio rerio)
 Actinopterygii LOC571757 35
  • 71.32 (n)
  • 77.89 (a)
SATB1 36
  • 70 (a)
 OneToOne
Species with no ortholog for SATB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SATB1 Gene

ENSEMBL:
Gene Tree for SATB1 (if available)
TreeFam:
Gene Tree for SATB1 (if available)

Paralogs for SATB1 Gene

Paralogs for SATB1 Gene

(1) SIMAP similar genes for SATB1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SATB1: view

Variants for SATB1 Gene

Sequence variations from dbSNP and Humsavar for SATB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12022 -- 18,424,680(-) GAGCT(C/T)GGCGA intron-variant, utr-variant-5-prime
rs1140344 -- 18,423,666(-) ATCTC(C/T)TTTTT intron-variant, utr-variant-5-prime
rs1140345 -- 18,423,662(-) CCTTT(C/G/T)TTTTT intron-variant, utr-variant-5-prime
rs1140346 -- 18,423,656(-) TTTTT(G/T)TTTTT intron-variant, utr-variant-5-prime
rs1328540 -- 18,409,705(+) TTAAT(G/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SATB1 Gene

Variant ID Type Subtype PubMed ID
nsv460455 CNV Loss 19166990

Variation tolerance for SATB1 Gene

Residual Variation Intolerance Score: 4.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SATB1 Gene

Disorders for SATB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SATB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
periampullary adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SATB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SATB1

Genetic Association Database (GAD)
SATB1
Human Genome Epidemiology (HuGE) Navigator
SATB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SATB1
genes like me logo Genes that share disorders with SATB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SATB1 Gene

Publications for SATB1 Gene

  1. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PMID: 1505028) Dickinson L.A. … Kohwi-Shigematsu T. (Cell 1992) 2 3 4 23 67
  2. Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cells. (PMID: 19860849) Li Q.Q. … Xu Z.D. (Cancer Sci. 2010) 3 23
  3. Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner. (PMID: 20126258) Notani D. … Galande S. (PLoS Biol. 2010) 3 23
  4. Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1. (PMID: 20351170) Tan J.A. … Durrin L.K. (Mol. Cell. Biol. 2010) 3 23
  5. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PMID: 19103759) Purbey P.K. … Galande S. (Mol. Cell. Biol. 2009) 3 23

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