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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SATB1 Gene

protein-coding GIFtS: 60
GCID: GC03M018364

SATB homeobox 1

(Previous name: special AT-rich sequence binding protein 1 (binds to nuclear...)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SATB Homeobox 1¹ ²
Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA)¹ ²
Special AT-Rich Sequence-Binding Protein 1² ³
DNA-Binding Protein SATB1²

External Ids:	HGNC: 10541¹	Entrez Gene: 6304²	Ensembl: ENSG00000182568⁷	OMIM: 602075⁵	UniProtKB: Q01826³

Export aliases for SATB1 gene to outside databases

Previous GC identifers: GC03U990069 GC03M018050 GC03M018264

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SATB1:

This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear

architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene

expression. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826

Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs

during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus

SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the

sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene

expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs)

of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes

(e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters

and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.

Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid

differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the

unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin

context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome

SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1.

Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes

while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of

breast tumors to promote growth and metastasis

Gene Wiki entry for SATB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SATB1 gene promoter:
ATF-2 p300 RelA IRF-1 CUTL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SATB1 promoter sequence

Search SABiosciences Chromatin IP Primers for SATB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SATB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p23 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24.3

SATB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SATB1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M018364: view genomic region (about GC identifiers)

Start:	18,386,864 bp from pter	End:	18,487,080 bp from pter
Size:	100,217 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826 (See protein sequence)

Recommended Name: DNA-binding protein SATB1

Size: 763 amino acids; 85957 Da

Subunit: Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA (By similarity).

Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed

at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes

transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ-like

dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300

Subcellular location: Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of

heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear

bodies (PML NBs)

Sequence caution: Sequence=BAD92998.1; Type=Erroneous initiation;

6 PDB 3D structures from and Proteopedia for SATB1:

1YSE (3D)

2L1P (3D)

2O49 (3D)

2O4A (3D)

3NZL (3D)

3TUO (3D)

Secondary accessions: B3KXF1 C9JTR6 Q59EQ0

Alternative splicing: 2 isoforms: Q01826-1 Q01826-2

Explore the universe of human proteins at neXtProt for SATB1: NX_Q01826

Post-translational modifications:

Sumoylated. Sumoylation promotes cleavage by caspases¹

Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form

interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In

opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation¹

Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The

cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin

association¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01826

SATB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001124482.1 NP_001182399.1 NP_002962.1

ENSEMBL proteins:

ENSP00000341024 ENSP00000399708 ENSP00000399518 ENSP00000453055 ENSP00000453360

ENSP00000453931 ENSP00000402982 ENSP00000453090 ENSP00000406727 ENSP00000390529

ENSP00000398072 ENSP00000408871 ENSP00000453908 ENSP00000391344 ENSP00000394520

Reactome Protein details: Q01826
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): SATB1 OriGene Protein Over-expression Lysate (see all 2): SATB1 OriGene Custom Protein Services for SATB1
	GenScript Custom Purified and Recombinant Proteins Services for SATB1
	Novus Biologicals SATB1 Proteins Novus Biologicals SATB1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SATB1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	--	--
GO:0005634	nucleus	IDA	18408014
GO:0005654	nucleoplasm	TAS	--
GO:0005720	nuclear heterochromatin	IEA	--
GO:0016363	nuclear matrix	IEA	--

SATB1 for ontologies About GeneDecksing

SATB1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SATB1
	OriGene Antibodies (see all 11): SATB1 OriGene Custom Antibody Services for SATB1
	GenScript Custom Superior Antibodies Services for SATB1
	Novus Biologicals SATB1 Antibodies
	Abcam antibodies for SATB1
	Uscn Antibodies for SATB1
	ThermoFisher Antibodies for SATB1

Assay Products for SATB1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SATB1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SATB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SATB1 for domains About GeneDecksing

4 InterPro domains/families:

IPR003350 Hmoeo_CUT

IPR001356 Homeodomain

IPR010982 Lambda_DNA-bd_dom

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q01826

ProtoNet protein and cluster: Q01826

1 Blocks protein family: IPB003350 Homeodomain protein CUT

UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826

Similarity: Belongs to the CUT homeobox family

Similarity: Contains 2 CUT DNA-binding domains

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: