Aliases for SATB1 Gene
Aliases for SATB1 Gene
External Ids for SATB1 Gene
- HGNC: 10541
- Entrez Gene: 6304
- Ensembl: ENSG00000182568
- OMIM: 602075
- UniProtKB: Q01826
Previous GeneCards Identifiers for SATB1 Gene
- GC03U990069
- GC03M018050
- GC03M018264
Summaries for SATB1 Gene
-
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]
GeneCards Summary for SATB1 Gene
SATB1 (SATB Homeobox 1) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is SATB2.
UniProtKB/Swiss-Prot for SATB1 Gene
-
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SATB1 Gene
Genomics for SATB1 Gene
Regulatory Elements for SATB1 Gene
Enhancers for SATB1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03F018422 | 1 | ENCODE | 22.5 | +21.0 | 21022 | 5.2 | PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF263 SP3 JUNB TBX21 | SATB1 SATB1-AS1 TBC1D5 GC03P018426 ENSG00000272477 |
| GH03F018402 | 1.8 | Ensembl | 11.3 | +42.9 | 42888 | 0.6 | ZSCAN5A KLF1 SUZ12 ZNF76 ZNF2 ZNF335 GLIS2 ZNF366 SCRT2 PATZ1 | TBC1D5 SATB1 SATB1-AS1 ENSG00000272477 GC03P018376 |
| GH03F018738 | 1.4 | FANTOM5 Ensembl ENCODE | 12.3 | -296.8 | -296814 | 7.6 | WRNIP1 ASH2L RBBP5 BMI1 EBF1 RFX5 GATA3 CHD2 MTA2 CBFB | SATB1 SATB1-AS1 TBC1D5 LOC105376976 GC03M018291 |
| GH03F018419 | 1.4 | Ensembl | 12.2 | +26.2 | 26188 | 0.4 | ZNF692 SCRT2 | SATB1 SATB1-AS1 TBC1D5 GC03P018426 ENSG00000272477 |
| GH03F018369 | 1.7 | ENCODE | 9.8 | +76.0 | 75965 | 0.2 | ZNF146 KLF17 ZEB2 ZIC2 ZNF843 ZNF2 ZEB1 OSR2 SP7 ZNF18 | SATB1 SATB1-AS1 TBC1D5 GC03P018370 GC03P018348 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SATB1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SATB1 gene promoter:
Regulatory Element Products
Genomic Location for SATB1 Gene
- Chromosome:
- 3
- Start:
- 18,345,387 bp from pter
- End:
- 18,445,588 bp from pter
- Size:
- 100,202 bases
- Orientation:
- Minus strand
Genomic View for SATB1 Gene
Genes around SATB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p24.3 by Ensembl
- 3p24.3 by Entrez Gene
- 3p24.3 by HGNC
SATB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SATB1 Gene
Proteins for SATB1 Gene
-
Protein details for SATB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q01826-SATB1_HUMAN
- Recommended name:
- DNA-binding protein SATB1
- Protein Accession:
- Q01826
- B3KXF1
- C9JTR6
- Q59EQ0
Protein attributes for SATB1 Gene
- Size:
- 763 amino acids
- Molecular mass:
- 85957 Da
- Quaternary structure:
-
- Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300.
- SequenceCaution:
-
- Sequence=BAD92998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SATB1 Gene
Protein Expression for SATB1 Gene
Post-translational modifications for SATB1 Gene
- Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms cannot dimerize and lose transcription regulation function because of impaired DNA and chromatin association.
- Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
- Sumoylated. Sumoylation promotes cleavage by caspases.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SATB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for SATB1
- R&D Systems Antibodies for SATB1 (SATB1)
- Cell Signaling Technology (CST) Antibodies for SATB1 (SATB1)
- Novus Biologicals Antibodies for SATB1
- Invitrogen Antibodies for SATB1
- antibodies-online Antibodies for SATB1: See all 117
- GeneTex SATB1 antibody for SATB1
-
St John's Laboratory Antibodies for SATB1
-
Custom Antibody ServicesProSci Antibodies for SATB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SATB1
Protein Products
-
OriGene Purified Proteins for SATB1
- Search Origene for MassSpec and Protein Over-expression Lysates for SATB1
- Origene Custom Protein Services for SATB1
- antibodies-online Proteins for SATB1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SATB1
Assay Products
- antibodies-online Kits for SATB1: See all 4
No data available for DME Specific Peptides for SATB1 Gene
Domains & Families for SATB1 Gene
Gene Families for SATB1 Gene
Protein Domains for SATB1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SATB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q01826UniProtKB/Swiss-Prot:
SATB1_HUMAN :- Contains 2 CUT DNA-binding domains.
- Belongs to the CUT homeobox family.
- Domain:
-
- Contains 2 CUT DNA-binding domains.
- Contains 1 homeobox DNA-binding domain.
- Family:
-
- Belongs to the CUT homeobox family.
Function for SATB1 Gene
Molecular function for SATB1 Gene
- GENATLAS Biochemistry:
- special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e. MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats
- UniProtKB/Swiss-Prot Function:
- Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 15851481 |
| GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | IDA | 15851481 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | TAS | 1505028 |
Phenotypes for SATB1 Gene
- MGI mutant phenotypes for SATB1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for SATB1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased viability with paclitaxel
Animal Models for SATB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SATB1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SATB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SATB1 gene
- Search ViGene Biosciences for SATB1
CRISPR Products
-
OriGene CRISPR knockouts for SATB1
- GenScript: Design CRISPR guide RNA sequences for SATB1
miRNA for SATB1 Gene
- miRTarBase miRNAs that target SATB1
-
- hsa-mir-448 (MIRT005643)
- hsa-mir-191-5p (MIRT006722)
- hsa-mir-548b-3p (MIRT016235)
- hsa-mir-335-5p (MIRT017626)
- hsa-mir-296-3p (MIRT038509)
- hsa-mir-21-5p (MIRT052948)
- hsa-mir-567 (MIRT306362)
- hsa-mir-297 (MIRT306364)
- hsa-mir-3680-3p (MIRT505780)
- hsa-mir-557 (MIRT505781)
- hsa-mir-507 (MIRT505782)
- hsa-mir-450b-5p (MIRT505783)
- hsa-mir-588 (MIRT505784)
- hsa-mir-4701-5p (MIRT505785)
- hsa-mir-8066 (MIRT505786)
- hsa-mir-8076 (MIRT505787)
- hsa-mir-19a-3p (MIRT505788)
- hsa-mir-19b-3p (MIRT505789)
- hsa-mir-129-5p (MIRT505790)
- hsa-mir-153-3p (MIRT505791)
- hsa-mir-2054 (MIRT554423)
- hsa-mir-759 (MIRT554424)
- hsa-mir-4797-5p (MIRT554425)
- hsa-mir-374c-5p (MIRT554426)
- hsa-mir-655-3p (MIRT554427)
- hsa-mir-574-5p (MIRT607878)
- hsa-mir-302c-5p (MIRT607879)
- hsa-mir-147a (MIRT607880)
- hsa-mir-6818-5p (MIRT607881)
- hsa-mir-3143 (MIRT607882)
- hsa-mir-6867-5p (MIRT607883)
- hsa-mir-644a (MIRT607884)
- hsa-mir-3911 (MIRT607885)
- hsa-mir-223-5p (MIRT607886)
- hsa-mir-636 (MIRT607887)
- hsa-mir-581 (MIRT607888)
- hsa-mir-511-3p (MIRT607889)
- hsa-mir-4322 (MIRT608934)
- hsa-mir-4296 (MIRT608935)
- hsa-mir-4265 (MIRT608936)
- hsa-mir-4417 (MIRT608937)
miRNA Products
- Search ViGene Biosciences for SATB1
Clone Products
-
- MR210533L2
- RC226152
- RR209478L2
- RR209478L1
- RR209478
- RG200421
- RC200421L2
- RC200421L1
- RC200421
- RG231415
- RC231415L2
- RC231415L1
- RC231415
- RG226152
- RC226152L2
- RC226152L1
- MR210533L1
- MR210533
- MG210533
- MR223202L2
- MR223202L1
- MR223202
- MG223202
- MR223656L2
- MR223656L1
- MR223656
- MG223656
- MR223653L2
- MR223653L1
- MR223653
- MG223653
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SATB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SATB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SATB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SATB1
-
ViGene Biosciences adenoviral particle packaged cDNA for SATB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SATB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SATB1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-13726 VA6-14051) for SATB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SATB1 Gene
Localization for SATB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SATB1 Gene
- Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IEA | -- |
| GO:0005634 | nucleus | IDA | 18408014 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005720 | nuclear heterochromatin | IEA | -- |
| GO:0016363 | nuclear matrix | IEA | -- |
Pathways & Interactions for SATB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.32
|
|
| 2 | Apoptotic cleavage of cellular proteins | ||
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | Apoptosis and survival Caspase cascade | ||
Pathways by source for SATB1 Gene
1 Cell Signaling Technology pathway for SATB1 Gene
1 BioSystems pathway for SATB1 Gene
4 Reactome pathways for SATB1 Gene
Interacting Proteins for SATB1 Gene
Selected Interacting proteins:
Q01826-SATB1_HUMAN
ENSP00000399518
for SATB1 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IMP | 15851481 |
| GO:0006325 | chromatin organization | TAS | 1505028 |
| GO:0006338 | chromatin remodeling | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for SATB1 Gene
Transcripts for SATB1 Gene
mRNA/cDNA for SATB1 Gene
- (12) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (57) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SATB1 Gene
- SATB homeobox 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SATB1
- GenScript: Design CRISPR guide RNA sequences for SATB1
miRNA Products
- Search ViGene Biosciences for SATB1
Clone Products
-
- MR210533L2
- RC226152
- RR209478L2
- RR209478L1
- RR209478
- RG200421
- RC200421L2
- RC200421L1
- RC200421
- RG231415
- RC231415L2
- RC231415L1
- RC231415
- RG226152
- RC226152L2
- RC226152L1
- MR210533L1
- MR210533
- MG210533
- MR223202L2
- MR223202L1
- MR223202
- MG223202
- MR223656L2
- MR223656L1
- MR223656
- MG223656
- MR223653L2
- MR223653L1
- MR223653
- MG223653
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SATB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SATB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SATB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-13726 VA6-14051) for SATB1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - |
| ExUns: | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | |||||||||||||||||
| SP14: | |||||||||||||||||
| SP15: |
Expression for SATB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
- Thalamus
- Medulla Oblongata
- Cerebral Cortex
- Midbrain tegmentum
- Neural Tube (Nervous System)
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Thymus
- Inner Cell Mass (Early Embryonic Tissues)
-
Neurons
- Adult Dopaminergic Neurons Substantia Nigra pars Compacta
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Gut Tube (Gastrointestinal Tract)
-
Prostate (Endocrine System)
This gene is overexpressed in Cervix (30.6), CD8 Tcells (11.8), and Serum (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SATB1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SATB1 Gene:
SATB1SOURCE GeneReport for Unigene cluster for SATB1 Gene:
Hs.517717mRNA Expression by UniProt/SwissProt for SATB1 Gene:
Q01826-SATB1_HUMAN
Tissue specificity:
Expressed predominantly in thymus.
Primer Products
-
OriGene qPCR primer pairs for SATB1
-
OriGene qPCR primer pairs and template standards for SATB1
No data available for mRNA differential expression in normal tissues for SATB1 Gene
Orthologs for SATB1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SATB1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SATB1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SATB1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Satb1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Satb1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SATB1 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | SATB1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SATB1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | satb1 34 |
|
||
| Str.19640 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | LOC571757 34 |
|
||
| SATB1 35 |
|
OneToOne |
- Species where no ortholog for SATB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SATB1 Gene
(1) SIMAP similar genes for SATB1 Gene using alignment to 8 proteins:
Variants for SATB1 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10460975 | -- | 18,376,522(+) | GATAT(C/T)CTCAT | intron-variant | |
| rs10460976 | -- | 18,378,367(+) | TGGCT(A/G)AATTG | intron-variant | |
| rs10539857 | -- | 18,357,563(+) | TTTTT(-/T)AAATA | intron-variant, downstream-variant-500B | |
| rs10545234 | -- | 18,393,347(+) | TTGTT(-/G)TTTTT | intron-variant | |
| rs10575786 | -- | 18,383,676(+) | TATCC(-/TTTAT)TTTAA | intron-variant |
Residual Variation Intolerance Score:
4.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.09;
61.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SATB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SATB1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SATB1 Gene
Disorders for SATB1 Gene
Relevant External Links for SATB1
No disorders were found for SATB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SATB1 Gene
Publications for SATB1 Gene
- A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PMID: 1505028) Dickinson L.A. … Kohwi-Shigematsu T. (Cell 1992) 2 3 4 22 64
- Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PMID: 19103759) Purbey P.K. … Galande S. (Mol. Cell. Biol. 2009) 3 4 22 64
- SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. (PMID: 19332023) Gong H. … Liang C.-C. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
- SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. (PMID: 18337816) Han H.-J. … Kohwi-Shigematsu T. (Nature 2008) 3 4 22 64
- Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. (PMID: 17173041) Kumar P.P. … Galande S. (Nat. Cell Biol. 2007) 3 4 22 64
Products for SATB1 Gene
- R&D Systems Antibodies for SATB1 (SATB1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for SATB1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SATB1
- Search Origene for MassSpec and Protein Over-expression Lysates for SATB1
- Origene Custom Protein Services for SATB1
- Origene siRNA, mouse_rna, rat_shrna, shRNA, and RNAi products in human, mouse, rat for SATB1
- Browse OriGene Inhibitory RNA Products For SATB1
- OriGene qPCR primer pairs and template standards for SATB1
- OriGene qPCR primer pairs for SATB1
- OriGene CRISPR knockouts for SATB1
- MG223653
- MR223653
- MR223653L1
- MR223653L2
- MG223656
- MR223656
- MR223656L1
- MR223656L2
- MG223202
- MR223202
- MR223202L1
- MR223202L2
- MG210533
- MR210533
- MR210533L1
- MR210533L2
- RC226152
- RC226152L1
- RC226152L2
- RG226152
- RC231415
- RC231415L1
- RC231415L2
- RG231415
- RC200421
- RC200421L1
- RC200421L2
- RG200421
- RR209478
- RR209478L1
- RR209478L2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SATB1
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for SATB1
- GenScript Custom Assay Services for SATB1
- GenScript Custom overexpressing Cell Line Services for SATB1
- GenScript: Design CRISPR guide RNA sequences for SATB1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SATB1
- Cell Signaling Technology (CST) Antibodies for SATB1 (SATB1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for SATB1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for SATB1
- Novus Biologicals proteins and lysates for SATB1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for SATB1: See all 117
- antibodies-online Kits for SATB1: See all 4
- antibodies-online Proteins for SATB1: See all 5
- Search antibodies-online for peptides
- GeneTex SATB1 antibody for SATB1
- Search GeneTex for Proteins for SATB1
- ViGene Biosciences adenoviral particle packaged cDNA for SATB1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SATB1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SATB1 gene
- Search ViGene Biosciences for SATB1
- Santa Cruz Biotechnology (SCBT) Antibodies for SATB1
- Search Santa Cruz Biotechnology (SCBT) for SATB1 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for SATB1 CRISPR
- Custom Antibody ServicesProSci Antibodies for SATB1
- Horizon Cell Lines for SATB1
- Cyagen custom Knockout/knockin (KOKI) mouse models for SATB1
- VectorBuilder custom plasmid, inducible vectors for SATB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SATB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SATB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab