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Aliases for SATB1 Gene

Aliases for SATB1 Gene

  • SATB Homeobox 1 2 3 5
  • Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA) 2
  • Special AT-Rich Sequence-Binding Protein 1 4

External Ids for SATB1 Gene

Previous GeneCards Identifiers for SATB1 Gene

  • GC03U990069
  • GC03M018050
  • GC03M018264

Summaries for SATB1 Gene

Entrez Gene Summary for SATB1 Gene

  • This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]

GeneCards Summary for SATB1 Gene

SATB1 (SATB Homeobox 1) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is SATB2.

UniProtKB/Swiss-Prot for SATB1 Gene

  • Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Gene Wiki entry for SATB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SATB1 Gene

Genomics for SATB1 Gene

Regulatory Elements for SATB1 Gene

Enhancers for SATB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F018422 1 ENCODE 22.5 +21.0 21022 5.2 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF263 SP3 JUNB TBX21 SATB1 SATB1-AS1 TBC1D5 GC03P018426 ENSG00000272477
GH03F018402 1.8 Ensembl 11.3 +42.9 42888 0.6 ZSCAN5A KLF1 SUZ12 ZNF76 ZNF2 ZNF335 GLIS2 ZNF366 SCRT2 PATZ1 TBC1D5 SATB1 SATB1-AS1 ENSG00000272477 GC03P018376
GH03F018738 1.4 FANTOM5 Ensembl ENCODE 12.3 -296.8 -296814 7.6 WRNIP1 ASH2L RBBP5 BMI1 EBF1 RFX5 GATA3 CHD2 MTA2 CBFB SATB1 SATB1-AS1 TBC1D5 LOC105376976 GC03M018291
GH03F018419 1.4 Ensembl 12.2 +26.2 26188 0.4 ZNF692 SCRT2 SATB1 SATB1-AS1 TBC1D5 GC03P018426 ENSG00000272477
GH03F018369 1.7 ENCODE 9.8 +76.0 75965 0.2 ZNF146 KLF17 ZEB2 ZIC2 ZNF843 ZNF2 ZEB1 OSR2 SP7 ZNF18 SATB1 SATB1-AS1 TBC1D5 GC03P018370 GC03P018348
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SATB1 on UCSC Golden Path with GeneCards custom track

Promoters for SATB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404848 1088 5000 PKNOX1 ZNF76 ZNF2 RAD21 GLIS2 ZNF366 SCRT2 EGR2 ZNF680 REST

Genomic Location for SATB1 Gene

Chromosome:
3
Start:
18,345,387 bp from pter
End:
18,445,588 bp from pter
Size:
100,202 bases
Orientation:
Minus strand

Genomic View for SATB1 Gene

Genes around SATB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SATB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SATB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SATB1 Gene

Proteins for SATB1 Gene

  • Protein details for SATB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01826-SATB1_HUMAN
    Recommended name:
    DNA-binding protein SATB1
    Protein Accession:
    Q01826
    Secondary Accessions:
    • B3KXF1
    • C9JTR6
    • Q59EQ0

    Protein attributes for SATB1 Gene

    Size:
    763 amino acids
    Molecular mass:
    85957 Da
    Quaternary structure:
    • Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300.
    SequenceCaution:
    • Sequence=BAD92998.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SATB1 Gene

    Alternative splice isoforms for SATB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SATB1 Gene

Post-translational modifications for SATB1 Gene

  • Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms cannot dimerize and lose transcription regulation function because of impaired DNA and chromatin association.
  • Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
  • Sumoylated. Sumoylation promotes cleavage by caspases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SATB1 (SATB1)

No data available for DME Specific Peptides for SATB1 Gene

Domains & Families for SATB1 Gene

Gene Families for SATB1 Gene

Suggested Antigen Peptide Sequences for SATB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01826

UniProtKB/Swiss-Prot:

SATB1_HUMAN :
  • Contains 2 CUT DNA-binding domains.
  • Belongs to the CUT homeobox family.
Domain:
  • Contains 2 CUT DNA-binding domains.
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with SATB1: view

Function for SATB1 Gene

Molecular function for SATB1 Gene

GENATLAS Biochemistry:
special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e. MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats
UniProtKB/Swiss-Prot Function:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Gene Ontology (GO) - Molecular Function for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 15851481
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 15851481
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003690 double-stranded DNA binding TAS 1505028
genes like me logo Genes that share ontologies with SATB1: view
genes like me logo Genes that share phenotypes with SATB1: view

Animal Models for SATB1 Gene

MGI Knock Outs for SATB1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SATB1 Gene

Localization for SATB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SATB1 Gene

Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SATB1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 18408014
GO:0005654 nucleoplasm TAS --
GO:0005720 nuclear heterochromatin IEA --
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with SATB1: view

Pathways & Interactions for SATB1 Gene

genes like me logo Genes that share pathways with SATB1: view

Pathways by source for SATB1 Gene

1 Cell Signaling Technology pathway for SATB1 Gene
1 BioSystems pathway for SATB1 Gene

Gene Ontology (GO) - Biological Process for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 15851481
GO:0006325 chromatin organization TAS 1505028
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SATB1: view

No data available for SIGNOR curated interactions for SATB1 Gene

Transcripts for SATB1 Gene

Unigene Clusters for SATB1 Gene

SATB homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SATB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: -
SP13: - - - - - - - - -
SP14:
SP15: - - - - - - -

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SATB1 Gene

GeneLoc Exon Structure for
SATB1
ECgene alternative splicing isoforms for
SATB1

Expression for SATB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SATB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SATB1 Gene

This gene is overexpressed in Cervix (30.6), CD8 Tcells (11.8), and Serum (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SATB1 Gene



Protein tissue co-expression partners for SATB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SATB1 Gene:

SATB1

SOURCE GeneReport for Unigene cluster for SATB1 Gene:

Hs.517717

mRNA Expression by UniProt/SwissProt for SATB1 Gene:

Q01826-SATB1_HUMAN
Tissue specificity: Expressed predominantly in thymus.
genes like me logo Genes that share expression patterns with SATB1: view

No data available for mRNA differential expression in normal tissues for SATB1 Gene

Orthologs for SATB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SATB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SATB1 34 35
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia SATB1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SATB1 34 35
  • 94.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Satb1 34 16 35
  • 91.26 (n)
rat
(Rattus norvegicus)
Mammalia Satb1 34
  • 90.52 (n)
cow
(Bos Taurus)
Mammalia SATB1 34 35
  • 86.4 (n)
chicken
(Gallus gallus)
Aves SATB1 34 35
  • 88.11 (n)
lizard
(Anolis carolinensis)
Reptilia SATB1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia satb1 34
  • 79.54 (n)
Str.19640 34
zebrafish
(Danio rerio)
Actinopterygii LOC571757 34
  • 71.32 (n)
SATB1 35
  • 70 (a)
OneToOne
Species where no ortholog for SATB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SATB1 Gene

ENSEMBL:
Gene Tree for SATB1 (if available)
TreeFam:
Gene Tree for SATB1 (if available)

Paralogs for SATB1 Gene

Paralogs for SATB1 Gene

(1) SIMAP similar genes for SATB1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SATB1: view

Variants for SATB1 Gene

Sequence variations from dbSNP and Humsavar for SATB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10460975 -- 18,376,522(+) GATAT(C/T)CTCAT intron-variant
rs10460976 -- 18,378,367(+) TGGCT(A/G)AATTG intron-variant
rs10539857 -- 18,357,563(+) TTTTT(-/T)AAATA intron-variant, downstream-variant-500B
rs10545234 -- 18,393,347(+) TTGTT(-/G)TTTTT intron-variant
rs10575786 -- 18,383,676(+) TATCC(-/TTTAT)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SATB1 Gene

Variant ID Type Subtype PubMed ID
esv3330100 CNV insertion 20981092
nsv460455 CNV loss 19166990
nsv589853 CNV loss 21841781
nsv589854 CNV loss 21841781

Variation tolerance for SATB1 Gene

Residual Variation Intolerance Score: 4.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SATB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SATB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SATB1 Gene

Disorders for SATB1 Gene

Relevant External Links for SATB1

Genetic Association Database (GAD)
SATB1
Human Genome Epidemiology (HuGE) Navigator
SATB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SATB1

No disorders were found for SATB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SATB1 Gene

Publications for SATB1 Gene

  1. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PMID: 1505028) Dickinson L.A. … Kohwi-Shigematsu T. (Cell 1992) 2 3 4 22 64
  2. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PMID: 19103759) Purbey P.K. … Galande S. (Mol. Cell. Biol. 2009) 3 4 22 64
  3. SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. (PMID: 19332023) Gong H. … Liang C.-C. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  4. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. (PMID: 18337816) Han H.-J. … Kohwi-Shigematsu T. (Nature 2008) 3 4 22 64
  5. Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. (PMID: 17173041) Kumar P.P. … Galande S. (Nat. Cell Biol. 2007) 3 4 22 64

Products for SATB1 Gene

Sources for SATB1 Gene

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