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SATB1 Gene

protein-coding   GIFtS: 61
GCID: GC03M018364

SATB Homeobox 1

(Previous name: special AT-rich sequence binding protein 1 (binds to nuclear...)
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Aliases
for SATB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SATB Homeobox 11 2
Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear
Matrix/Scaffold-Associating DNA)1 2
Special AT-Rich Sequence-Binding Protein 12 3
DNA-Binding Protein SATB12

External Ids:    HGNC: 105411   Entrez Gene: 63042   Ensembl: ENSG000001825687   OMIM: 6020755   UniProtKB: Q018263   

Export aliases for SATB1 gene to outside databases

Previous GC identifers: GC03U990069 GC03M018050 GC03M018264


Summaries
for SATB1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SATB1 Gene:
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique
nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure
and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2010)

GeneCards Summary for SATB1 Gene:
SATB1 (SATB homeobox 1) is a protein-coding gene. Diseases associated with SATB1 include cutaneous malignant melanoma, and breast disease. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SATB2.

UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that
occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the
consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize
the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral
gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment
regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several
chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or
coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of
the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and
gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and
nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like
motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the
HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA
(interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications
at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor
genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and
metastasis

Gene Wiki entry for SATB1 Gene


Genomic Views
for SATB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SATB1 gene promoter:
         ATF-2   p300   RelA   IRF-1   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SATB1 promoter sequence
   Search Chromatin IP Primers for SATB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SATB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p23   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

SATB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SATB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M018364:  view genomic region     (about GC identifiers)

Start:
 18,386,879 bp from pter      End:
 18,487,080 bp from pter
Size:
 100,202 bases      Orientation:
 minus strand

Proteins
for SATB1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826 (See protein sequence)
Recommended Name: DNA-binding protein SATB1  
Size: 763 amino acids; 85957 Da
Subunit: Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA (By similarity).
Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE)
composed at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and
promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via
the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300
Sequence caution: Sequence=BAD92998.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for SATB1:
1YSE (3D)        2L1P (3D)        2O49 (3D)        2O4A (3D)        3NZL (3D)        3TUO (3D)    
Secondary accessions: B3KXF1 C9JTR6 Q59EQ0
Alternative splicing: 2 isoforms:  Q01826-1   Q01826-2   

Explore the universe of human proteins at neXtProt for SATB1: NX_Q01826

Explore proteomics data for SATB1 at MOPED

Post-translational modifications: 

  • Sumoylated. Sumoylation promotes cleavage by caspases1
  • Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form
    interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In
    opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation1
  • Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The
    cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin
    association1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See SATB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124482.1  NP_001182399.1  NP_002962.1  

    ENSEMBL proteins: 
     ENSP00000341024   ENSP00000399518   ENSP00000399708   ENSP00000402982   ENSP00000406727  
     ENSP00000390529   ENSP00000398072   ENSP00000408871   ENSP00000453908   ENSP00000391344  
     ENSP00000394520  
    Reactome Protein details: Q01826

    SATB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for SATB1
    OriGene Protein Over-expression Lysate for SATB1
    OriGene MassSpec for SATB1
    OriGene Custom Protein Services for SATB1
    GenScript Custom Purified and Recombinant Proteins Services for SATB1
    Novus Biologicals SATB1 Proteins
    Novus Biologicals SATB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SATB1

    SATB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SATB1
    R&D Systems Antibodies for SATB1
    Cell Signaling Technology (CST) Antibodies for SATB1 
    OriGene Antibodies for SATB1
    OriGene Custom Antibody Services for SATB1
    Novus Biologicals SATB1 Antibodies
    Abcam antibodies for SATB1
    Cloud-Clone Corp. Antibodies for SATB1
    ThermoFisher Antibodies for SATB1
    LSBio Antibodies in human, mouse, rat for SATB1

    SATB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SATB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SATB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SATB1
    Cloud-Clone Corp. CLIAs for SATB1

    Domains /
    Families
    for SATB1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    CUT: Homeoboxes / CUT class

    4 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR003350 Hmoeo_CUT
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q01826

    ProtoNet protein and cluster: Q01826

    1 Blocks protein domain: IPB003350 Homeodomain protein CUT

    UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
    Similarity: Belongs to the CUT homeobox family
    Similarity: Contains 2 CUT DNA-binding domains
    Similarity: Contains 1 homeobox DNA-binding domain


    SATB1 for domains           About GeneDecksing


    Function
    for SATB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SATB1_HUMAN, Q01826
    Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that
    occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the
    consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize
    the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral
    gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment
    regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several
    chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or
    coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of
    the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and
    gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and
    nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like
    motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the
    HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA
    (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications
    at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor
    genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and
    metastasis

         Genatlas biochemistry entry for SATB1:
    special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e.
    MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003690double-stranded DNA binding TAS1505028
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18408014
         
    SATB1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Satb1):
     behavior/neurological  growth/size/body  hematopoietic system  immune system  mortality/aging 
     nervous system  vision/eye 

    SATB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Satb1tm1Kos for SATB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SATB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SATB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SATB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SATB1

    miRNA
    Products:            		miRTarBase miRNAs that target SATB1:
    hsa-mir-191-5p (MIRT006722), hsa-mir-335-5p (MIRT017626), hsa-mir-448 (MIRT005643), hsa-mir-548b-3p (MIRT016235), hsa-mir-296-3p (MIRT038509)

    Block miRNA regulation of human, mouse, rat SATB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SATB1 (see all 106):
    hsa-miR-411* hsa-miR-100* hsa-miR-376b hsa-miR-300 hsa-miR-219-5p hsa-miR-30d hsa-miR-374a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: SATB1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for SATB1
    Predesigned siRNA for gene silencing in human, mouse, rat SATB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SATB1

    Clone
    Products:             		 OriGene clones in human, mouse for SATB1 (see all 17)
    OriGene ORF clones in mouse, rat for SATB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SATB1 (NM_002971)
    Sino Biological Human cDNA Clone for SATB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SATB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SATB1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SATB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SATB1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SATB1


    Localization
    for SATB1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    SATB1_HUMAN, Q01826: Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops
    of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia
    nuclear bodies (PML NBs)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0005634nucleus IDA18408014
    GO:0005654nucleoplasm TAS--
    GO:0005720nuclear heterochromatin IEA--
    GO:0016363nuclear matrix IEA--

    SATB1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for SATB1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SATB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    		Apoptotic cleavage of cellular proteins0.74
    		Apoptotic execution phase0.74
    2Apoptosis and survival Caspase cascade
    		Caspase cascade in apoptosis0.42
    3CDK-mediated phosphorylation and removal of Cdc6
    		Apoptosis0.38
    4Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SATB1
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for SATB1
        Caspase cascade in apoptosis


    1 Reactome Pathway for SATB1
        Apoptotic cleavage of cellular proteins



    SATB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SATB1: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SATB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SATB1 (Q018261, 2, 3 ENSP000003410244) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP6P552121, 3, ENSP000002651644EBI-743747,EBI-718729 I2D: score=1 STRING: ENSP00000265164
    SUMO1P631651, 3, ENSP000003760764EBI-743747,EBI-80140 I2D: score=1 STRING: ENSP00000376076
    UBE2IP632793, ENSP000003248974I2D: score=4 STRING: ENSP00000324897
    CHD3Q128733, ENSP000003697164I2D: score=2 STRING: ENSP00000369716
    MTA2O947763, ENSP000002788234I2D: score=2 STRING: ENSP00000278823
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP15851481
    GO:0006325chromatin organization TAS1505028
    GO:0006338chromatin remodeling IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    SATB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SATB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SATB1



    Transcripts
    for SATB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SATB1 gene (3 alternative transcripts): 
    NM_001131010.2  NM_001195470.1  NM_002971.4  

    Unigene Cluster for SATB1:

    SATB homeobox 1
    Hs.517717  [show with all ESTs]
    Unigene Representative Sequence: NM_001195470
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338745(uc003cbi.3 uc003cbh.3 uc003cbj.3) ENST00000417717
    ENST00000454909 ENST00000606296 ENST00000476178 ENST00000467628 ENST00000475083
    ENST00000440737 ENST00000491519 ENST00000482788 ENST00000452260 ENST00000415069
    ENST00000457005 ENST00000414509 ENST00000493952 ENST00000487699 ENST00000444341
    ENST00000450898
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat SATB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SATB1 (see all 106):
    hsa-miR-411* hsa-miR-100* hsa-miR-376b hsa-miR-300 hsa-miR-219-5p hsa-miR-30d hsa-miR-374a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: SATB1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for SATB1
    Predesigned siRNA for gene silencing in human, mouse, rat SATB1
    Clone
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    OriGene ORF clones in mouse, rat for SATB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SATB1 (NM_002971)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SATB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SATB1
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for SATB1
    OriGene qSTAR qPCR primer pairs in human, mouse for SATB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SATB1
      QuantiTect SYBR Green Assays in human, mouse, rat SATB1
      QuantiFast Probe-based Assays in human, mouse, rat SATB1

    Additional mRNA sequence: 

    AB209761.1 AK127242.1 BC001744.1 BX648762.1 M97287.1 U92993.1 

    17 DOTS entries:

    DT.99977308  DT.95241924  DT.120849565  DT.317164  DT.100817927  DT.100817924  DT.40115556  DT.100817922 
    DT.120849544  DT.91752834  DT.100817925  DT.120849542  DT.120849547  DT.120849622  DT.95200698  DT.91760706 
    DT.95241927 

    Selected AceView cDNA sequences (see all 57):

    AW086483 BE222083 CK905940 BQ272258 BE218845 AI393942 BE696486 BE773817 
    AA403100 AI801288 BE242509 BE773822 AA403099 BE773759 BE773765 AA193295 
    N71153 BE242198 BF511877 AI381176 BE773693 CD616047 AI291575 BE773799 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SATB1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a ·
    SP1:                                                              -     -                 -     -     -     -                                                   
    SP2:                                                              -     -                 -     -     -     -                                                   
    SP3:                    -     -     -     -     -     -     -     -     -                 -     -     -     -                                                   
    SP4:                                                                                                        -                                                   
    SP5:                                      -     -     -     -     -     -                 -     -     -     -                                                   

    ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:                                -                     
    SP2:                                -     -               
    SP3:                                -     -               
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SATB1

    Expression
    for SATB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SATB1 expression in normal human tissues (normalized intensities)      SATB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATAAGCT
    SATB1 Expression
    About this image


    SATB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Dopaminergic Neurons Substantia Nigra pars Compacta
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SATB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    SATB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517717

    UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
    Tissue specificity: Expressed predominantly in thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SATB1: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for SATB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SATB1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Satb11 , 5 special AT-rich sequence binding protein 11, 5 91.26(n)1
    98.43(a)1    		   17 (26.81 cM)5
    202301  NM_009122.21  NP_033148.21 
     517361875 
    chicken
    (Gallus gallus)    		 Aves SATB11 SATB homeobox 1 88.11(n)
    96.42(a)    		   420647  NM_001199644.1  NP_001186573.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SATB16
    		 SATB homeobox 1
    		 91(a)
    		 1 ↔ 1
    		 6(33665512-33751418)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.196402 Transcribed sequence with moderate similarity to protein more 77(n)    BX781808.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5717571 DNA-binding protein SATB1-like 71.32(n)
    77.89(a)    		   571757  XM_005158432.1  XP_005158489.1 


    ENSEMBL Gene Tree for SATB1 (if available)
    TreeFam Gene Tree for SATB1 (if available)

    Paralogs
    for SATB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SATB1 gene
    SATB22  
    1 SIMAP similar gene for SATB1 using alignment to 8 protein entries:     SATB1_HUMAN (see all proteins):
    SATB2

    SATB1 for paralogs           About GeneDecksing



    Genomic Variants
    for SATB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SATB1 (see all 1765)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1864933871,2
    		--18325013(+) AGAAGA/GTGGTA 3 -- ds50010--------
    rs1414185661,2
    		--18325107(+) AGCAAA/GTAAAA 3 -- ds50010--------
    rs1140996511,2
    		C--18325110(+) AAATAA/GAAGAA 3 -- ds50010--------
    rs775193571,2
    		C,F--18325119(+) AAAAAT/CCACCC 3 -- ds50011Minor allele frequency- C:0.07EA 120
    rs1433551561,2
    		C--18325357(+) TATAC-/AGAAGGTC 3 -- ds50010--------
    rs39356181,2
    		C,F,H--18325555(-) GCTTAA/GTAAGT 3 -- ut3127Minor allele frequency- G:0.22NS EA NA WA 2980
    rs1131586261,2
    		C,F--18325641(+) AAATTC/TACAGT 3 -- ut311Minor allele frequency- T:0.50NA 2
    rs1831912141,2
    		--18325897(+) ATAGCC/TGTTTT 3 -- ut310--------
    rs730383491,2
    		C--18326044(+) TAAGGC/TGATCT 3 -- ut311Minor allele frequency- T:0.50CSA 2
    rs730383501,2
    		C--18326067(+) TACCTA/GAGCTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SATB1 (18386879 - 18487080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SATB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv460455CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SATB1
    DNA2.0 Custom Variant and Variant Library Synthesis for SATB1

    Disorders / Diseases
    for SATB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 602075    OMIM disorders: --

    Selected diseases for SATB1 (see all 29):    About MalaCards
    cutaneous malignant melanoma    breast disease    cleft palate    cutaneous t cell lymphoma
    laryngeal squamous cell carcinoma    atopic dermatitis    labyrinthitis    dermatitis
    laryngitis    astrocytoma    psoriasis    crohn's disease
    asthma    melanoma    inflammatory bowel disease    breast cancer
    hepatitis b    hiv-1    lung cancer    hepatitis


    SATB1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SATB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 62.9 2 17343824 (1)
    breast cancer 8.99 14 19072498 (5), 19642980 (3), 19860849 (2), 9548713 (1) (see all 5)
    necrosis 0 3 11455567 (1), 10800076 (1)

    Genetic Association Database (GAD): SATB1
    Human Genome Epidemiology (HuGE) Navigator: SATB1 (1 document)

    Export disorders for SATB1 gene to outside databases

    Publications
    for SATB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SATB1 gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with SATB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PubMed id 1505028)1, 2, 3, 9 Dickinson L.A.... Kohwi-Shigematsu T. (Cell 1992)
    2. SATB1 targets chromatin remodelling to regulate genes over long distances. (PubMed id 12374985)1, 2, 9 Yasui D.... Kohwi-Shigematsu T. (Nature 2002)
    3. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. (PubMed id 16630892)1, 2, 9 Kumar P.P.... Galande S. (Mol. Cell 2006)
    4. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PubMed id 19103759)1, 2, 9 Purbey P.K.... Galande S. (Mol. Cell. Biol. 2009)
    5. SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. (PubMed id 11463840)1, 2, 9 Galande S....Kohwi-Shigematsu T. (Mol. Cell. Biol. 2001)
    6. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. (PubMed id 18337816)1, 2, 9 Han H.-J.... Kohwi-Shigematsu T. (Nature 2008)
    7. SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. (PubMed id 19332023)1, 2, 9 Gong H....Liang C.-C. (Biochem. Biophys. Res. Commun. 2009)
    8. The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation. (PubMed id 16377216)1, 2, 9 Sun Y.... Han X. (Cell Biol. Int. 2006)
    9. Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. (PubMed id 15713622)1, 2, 9 Kumar P.P.... Galande S. (Mol. Cell. Biol. 2005)
    10. A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage. (PubMed id 15970696)1, 2, 9 Nakayama Y.... Ogawa T. (Cell Cycle 2005)

    External Searches for SATB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SATB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6304 HGNC: 10541 AceView: SATB1.1 Ensembl:ENSG00000182568 euGenes: HUgn6304
    ECgene: SATB1 H-InvDB: SATB1

    Other Databases showing SATB1 gene

    (According to HUGE)
    About This Section

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    Specialized Databases showing SATB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SATB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SATB1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SATB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for SATB1 gene:
    Search GeneIP for patents involving SATB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SATB1 gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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