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Aliases for SATB1 Gene

Aliases for SATB1 Gene

  • SATB Homeobox 1 2 3
  • Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA) 2
  • Special AT-Rich Sequence-Binding Protein 1 4

External Ids for SATB1 Gene

Summaries for SATB1 Gene

Entrez Gene Summary for SATB1 Gene

  • This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SATB1 Gene

SATB1 (SATB Homeobox 1) is a Protein Coding gene. Among its related pathways are Apoptosis and survival Caspase cascade and Chromatin Regulation / Acetylation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is SATB2.

UniProtKB/Swiss-Prot for SATB1 Gene

  • Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Gene Wiki entry for SATB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SATB1 Gene

Genomics for SATB1 Gene

Genomic Location for SATB1 Gene

Start:
18,345,387 bp from pter
End:
18,445,588 bp from pter
Size:
100,202 bases
Orientation:
Minus strand

Genomic View for SATB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SATB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SATB1 Gene

Regulatory Elements for SATB1 Gene

Proteins for SATB1 Gene

  • Protein details for SATB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01826-SATB1_HUMAN
    Recommended name:
    DNA-binding protein SATB1
    Protein Accession:
    Q01826
    Secondary Accessions:
    • B3KXF1
    • C9JTR6
    • Q59EQ0

    Protein attributes for SATB1 Gene

    Size:
    763 amino acids
    Molecular mass:
    85957 Da
    Quaternary structure:
    • Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300.
    SequenceCaution:
    • Sequence=BAD92998.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SATB1 Gene

    Alternative splice isoforms for SATB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SATB1 Gene

Proteomics data for SATB1 Gene at MOPED

Post-translational modifications for SATB1 Gene

  • Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin association
  • Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
  • Sumoylated. Sumoylation promotes cleavage by caspases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SATB1 Gene

Domains for SATB1 Gene

Gene Families for SATB1 Gene

HGNC:
  • CUT :Homeoboxes / CUT class

Protein Domains for SATB1 Gene

UniProtKB/Swiss-Prot:

SATB1_HUMAN
Domain:
  • Contains 2 CUT DNA-binding domains.:
    • Q01826
  • Contains 1 homeobox DNA-binding domain.:
    • Q01826
Family:
  • Belongs to the CUT homeobox family.:
    • Q01826
genes like me logo Genes that share domains with SATB1: view

Function for SATB1 Gene

Molecular function for SATB1 Gene

GENATLAS Biochemistry: special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e. MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats
UniProtKB/Swiss-Prot Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

Gene Ontology (GO) - Molecular Function for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 15851481
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 15851481
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003690 double-stranded DNA binding TAS 1505028
genes like me logo Genes that share ontologies with SATB1: view
genes like me logo Genes that share phenotypes with SATB1: view

Animal Models for SATB1 Gene

MGI Knock Outs for SATB1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SATB1 Gene

Localization for SATB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SATB1 Gene

Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SATB1 Gene COMPARTMENTS Subcellular localization image for SATB1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin --
GO:0005634 nucleus IDA 18408014
GO:0005654 nucleoplasm TAS --
GO:0005720 nuclear heterochromatin IEA --
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with SATB1: view

Pathways for SATB1 Gene

genes like me logo Genes that share pathways with SATB1: view

Pathways by source for SATB1 Gene

1 Cell Signaling Technology pathway for SATB1 Gene
1 BioSystems pathway for SATB1 Gene

Gene Ontology (GO) - Biological Process for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 15851481
GO:0006325 chromatin organization TAS 1505028
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with SATB1: view

Transcripts for SATB1 Gene

Unigene Clusters for SATB1 Gene

SATB homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SATB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: -
SP13: - - - - - - - - -
SP14:
SP15: - - - - - - -

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SATB1 Gene

GeneLoc Exon Structure for
SATB1
ECgene alternative splicing isoforms for
SATB1

Expression for SATB1 Gene

mRNA expression in normal human tissues for SATB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SATB1 Gene

SOURCE GeneReport for Unigene cluster for SATB1 Gene Hs.517717

mRNA Expression by UniProt/SwissProt for SATB1 Gene

Q01826-SATB1_HUMAN
Tissue specificity: Expressed predominantly in thymus.
genes like me logo Genes that share expressions with SATB1: view

Orthologs for SATB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SATB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SATB1 36
  • 99.78 (n)
  • 100 (a)
SATB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SATB1 36
  • 86.4 (n)
  • 91.05 (a)
SATB1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SATB1 36
  • 94.52 (n)
  • 97.69 (a)
SATB1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Satb1 36
  • 91.26 (n)
  • 98.43 (a)
Satb1 16
Satb1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SATB1 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 89 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Satb1 36
  • 90.52 (n)
  • 98.3 (a)
chicken
(Gallus gallus)
Aves SATB1 36
  • 88.11 (n)
  • 96.42 (a)
SATB1 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SATB1 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia satb1 36
  • 79.54 (n)
  • 88.02 (a)
Str.19640 36
zebrafish
(Danio rerio)
Actinopterygii LOC571757 36
  • 71.32 (n)
  • 77.89 (a)
SATB1 37
  • 70 (a)
OneToOne
Species with no ortholog for SATB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SATB1 Gene

ENSEMBL:
Gene Tree for SATB1 (if available)
TreeFam:
Gene Tree for SATB1 (if available)

Paralogs for SATB1 Gene

Paralogs for SATB1 Gene

Selected SIMAP similar genes for SATB1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SATB1: view

Variants for SATB1 Gene

Sequence variations from dbSNP and Humsavar for SATB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12022 -- 18,424,680(-) GAGCT(C/T)GGCGA intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs913510 -- 18,434,773(+) AGTTC(A/T)CTTGA intron-variant
rs1140344 -- 18,423,666(-) ATCTC(C/T)TTTTT intron-variant, utr-variant-5-prime
rs1140345 -- 18,423,662(-) CCTTT(C/G/T)TTTTT intron-variant, utr-variant-5-prime
rs1140346 -- 18,423,656(-) TTTTT(G/T)TTTTT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SATB1 Gene

Variant ID Type Subtype PubMed ID
nsv460455 CNV Loss 19166990

Relevant External Links for SATB1 Gene

HapMap Linkage Disequilibrium report
SATB1

Disorders for SATB1 Gene

(3) Novoseek inferred disease relationships for SATB1 Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 62.9 1
breast cancer 8.99 12
necrosis 0 2

Relevant External Links for SATB1

Genetic Association Database (GAD)
SATB1
Human Genome Epidemiology (HuGE) Navigator
SATB1
genes like me logo Genes that share disorders with SATB1: view

No data available for UniProtKB/Swiss-Prot for SATB1 Gene

Publications for SATB1 Gene

  1. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PMID: 1505028) Dickinson L.A. … Kohwi-Shigematsu T. (Cell 1992) 2 3 4 23
  2. SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. (PMID: 11463840) Galande S. … Kohwi-Shigematsu T. (Mol. Cell. Biol. 2001) 3 4 23
  3. SATB1 targets chromatin remodelling to regulate genes over long distances. (PMID: 12374985) Yasui D. … Kohwi-Shigematsu T. (Nature 2002) 3 4 23
  4. Tissue-specific nuclear architecture and gene expression regulated by SATB1. (PMID: 12692553) Cai S. … Kohwi-Shigematsu T. (Nat. Genet. 2003) 3 4 23
  5. SATB1 makes a complex with p300 and represses gp91(phox) promoter activity. (PMID: 14605447) Fujii Y. … Nakamura M. (Microbiol. Immunol. 2003) 3 4 23

Products for SATB1 Gene

Sources for SATB1 Gene

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