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Aliases for SAT2 Gene

Subcategory (RNA class) for SAT2 Gene

lncRNA

Aliases for SAT2 Gene

  • Spermidine/Spermine N1-Acetyltransferase Family Member 2 2 3
  • Spermidine/Spermine N(1)-Acetyltransferase 2 3 4
  • Spermidine/Spermine N1-Acetyltransferase 2 2 3
  • Thialysine N-Epsilon-Acetyltransferase 3 4
  • Polyamine N-Acetyltransferase 2 3 4
  • Diamine N-Acetyltransferase 2 2 3
  • SSAT2 3 4
  • Diamine Acetyltransferase 2 3
  • EC 2.3.1.57 4
  • S 6

External Ids for SAT2 Gene

ORGUL Members for SAT2 Gene

Summaries for SAT2 Gene

GeneCards Summary for SAT2 Gene

SAT2 (Spermidine/Spermine N1-Acetyltransferase Family Member 2) is a Protein Coding gene, and belongs to lncRNA RNA class. Diseases associated with SAT2 include lung cancer. Among its related pathways are Arginine and proline metabolism and Metabolism. GO annotations related to this gene include diamine N-acetyltransferase activity. An important paralog of this gene is SATL1.

UniProtKB/Swiss-Prot for SAT2 Gene

  • Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine

Gene Wiki entry for SAT2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAT2 Gene

Genomics for SAT2 Gene

Genomic Location for SAT2 Gene

Start:
7,626,234 bp from pter
End:
7,627,876 bp from pter
Size:
1,643 bases
Orientation:
Minus strand

Genomic View for SAT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAT2 Gene

Regulatory Elements for SAT2 Gene

Proteins for SAT2 Gene

  • Protein details for SAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F10-SAT2_HUMAN
    Recommended name:
    Diamine acetyltransferase 2
    Protein Accession:
    Q96F10
    Secondary Accessions:

    Protein attributes for SAT2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19155 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2

    Three dimensional structures from OCA and Proteopedia for SAT2 Gene

neXtProt entry for SAT2 Gene

Proteomics data for SAT2 Gene at MOPED

Post-translational modifications for SAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAT2 Gene

No data available for DME Specific Peptides for SAT2 Gene

Domains for SAT2 Gene

Protein Domains for SAT2 Gene

UniProtKB/Swiss-Prot:

SAT2_HUMAN
Domain:
  • Contains 1 N-acetyltransferase domain.:
    • Q96F10
Family:
  • Belongs to the acetyltransferase family.:
    • Q96F10
genes like me logo Genes that share domains with SAT2: view

No data available for Gene Families for SAT2 Gene

Function for SAT2 Gene

Molecular function for SAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
UniProtKB/Swiss-Prot Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine
UniProtKB/Swiss-Prot Induction: Not inducible by polyamine analogs

Enzyme Numbers (IUBMB) for SAT2 Gene

Gene Ontology (GO) - Molecular Function for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004145 diamine N-acetyltransferase activity IDA 12803540
GO:0008080 N-acetyltransferase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with SAT2: view

miRNA for SAT2 Gene

miRTarBase miRNAs that target SAT2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAT2 Gene

Localization for SAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAT2 Gene

Cytoplasm. Note=Intracellular organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAT2 Gene COMPARTMENTS Subcellular localization image for SAT2 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SAT2: view

Pathways for SAT2 Gene

genes like me logo Genes that share pathways with SAT2: view

Pathways by source for SAT2 Gene

UniProtKB/Swiss-Prot Q96F10-SAT2_HUMAN

  • Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1

Gene Ontology (GO) - Biological Process for SAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009447 putrescine catabolic process IEA --
GO:0032918 spermidine acetylation IDA 12803540
GO:0032919 spermine acetylation IDA 12803540
GO:0032920 putrescine acetylation IDA 12803540
genes like me logo Genes that share ontologies with SAT2: view

Compounds for SAT2 Gene

(7) HMDB Compounds for SAT2 Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
N1-Acetylspermidine
  • 1-N-Acetylspermidine
14278-49-0
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0
N-Acetylputrescine
  • Acetylputrescine
18233-70-0

(1) Drugbank Compounds for SAT2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Spermine
  • 1, 4-Bis(aminopropyl)butanediamine
71-44-3 enzyme substrate

(2) Novoseek inferred chemical compound relationships for SAT2 Gene

Compound -log(P) Hits PubMed IDs
spermidine 82.9 7
spermine 79.7 6
genes like me logo Genes that share compounds with SAT2: view

Transcripts for SAT2 Gene

Unigene Clusters for SAT2 Gene

Spermidine/spermine N1-acetyltransferase family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11: -

Relevant External Links for SAT2 Gene

GeneLoc Exon Structure for
SAT2
ECgene alternative splicing isoforms for
SAT2

Expression for SAT2 Gene

mRNA expression in normal human tissues for SAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAT2 Gene

SOURCE GeneReport for Unigene cluster for SAT2 Gene Hs.10846

mRNA Expression by UniProt/SwissProt for SAT2 Gene

Q96F10-SAT2_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with SAT2: view

Orthologs for SAT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAT2 36
  • 99.8 (n)
  • 99.41 (a)
SAT2 37
  • 62 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAT2 36
  • 88.63 (n)
  • 87.65 (a)
SAT2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAT2 36
  • 86.27 (n)
  • 85.88 (a)
SAT2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sat2 36
  • 82.75 (n)
  • 80 (a)
Sat2 16
Sat2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAT2 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sat2 36
  • 84.42 (n)
  • 81.07 (a)
lizard
(Anolis carolinensis)
Reptilia SAT2 37
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487185 36
  • 58.82 (n)
  • 52.21 (a)
zebrafish
(Danio rerio)
Actinopterygii sat2b 36
  • 57.67 (n)
  • 54.6 (a)
sat2b 37
  • 51 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002239 36
  • 51.72 (n)
  • 40.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4210 36
  • 47.59 (n)
  • 39.62 (a)
CG4210 37
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_D2023.4 36
  • 46.41 (n)
  • 37.97 (a)
D2023.4 37
  • 37 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07589 36
  • 51.57 (n)
  • 40.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ats1 36
  • 47.38 (n)
  • 42.77 (a)
Species with no ortholog for SAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAT2 Gene

ENSEMBL:
Gene Tree for SAT2 (if available)
TreeFam:
Gene Tree for SAT2 (if available)

Paralogs for SAT2 Gene

Paralogs for SAT2 Gene

Selected SIMAP similar genes for SAT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SAT2: view

Variants for SAT2 Gene

Sequence variations from dbSNP and Humsavar for SAT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_020465 -

Structural Variations from Database of Genomic Variants (DGV) for SAT2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Relevant External Links for SAT2 Gene

HapMap Linkage Disequilibrium report
SAT2

Disorders for SAT2 Gene

(1) MalaCards Diseases for SAT2 Gene

Search for SAT2 Gene in MalaCards »

Relevant External Links for SAT2

Genetic Association Database (GAD)
SAT2
Human Genome Epidemiology (HuGE) Navigator
SAT2
genes like me logo Genes that share disorders with SAT2: view

No data available for UniProtKB/Swiss-Prot for SAT2 Gene

Publications for SAT2 Gene

  1. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. (PMID: 12803540) Chen Y. … Porter C.W. (Biochem. J. 2003) 3 4 23 25
  2. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. (PMID: 15283699) Coleman C.S. … Pegg A.E. (Biochem. J. 2004) 2 3 23 25
  3. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. (PMID: 17558023) Baek J.H. … Semenza G.L. (J. Biol. Chem. 2007) 2 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 49

Products for SAT2 Gene

Sources for SAT2 Gene

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