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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAT2 Gene

protein-coding   GIFtS: 58
GCID: GC17M007529

Spermidine/Spermine N1-Acetyltransferase Family Member 2

(Previous name: spermidine/spermine N1-acetyltransferase 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spermidine/Spermine N1-Acetyltransferase Family Member 21 2     Thialysine N-Epsilon-Acetyltransferase2 3
Spermidine/Spermine N1-Acetyltransferase 21 2     SSAT22 3
Diamine N-Acetyltransferase 21 2     Diamine Acetyltransferase 22
Polyamine N-Acetyltransferase 22 3     EC 2.3.1.573
Spermidine/Spermine N(1)-Acetyltransferase 22 3     S5

External Ids:    HGNC: 231601   Entrez Gene: 1124832   Ensembl: ENSG000001415047   OMIM: 6114635   UniProtKB: Q96F103   

Export aliases for SAT2 gene to outside databases

Previous GC identifers: GC17M007472 GC17M007730 GC17M007470 GC17M007423


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SAT2 Gene: 
SAT2 (spermidine/spermine N1-acetyltransferase family member 2) is a protein-coding gene. Diseases associated with SAT2 include mouth disease, and hypoxia, and among its related super-pathways are Interconversion of polyamines and Metabolism. GO annotations related to this gene include diamine N-acetyltransferase activity. An important paralog of this gene is SATL1.

UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine
= spermine >> N(1)acetylspermine = putrescine

Gene Wiki entry for SAT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAT2 gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

SAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAT2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007529:  view genomic region     (about GC identifiers)

Start:
7,529,552 bp from pter      End:
7,531,194 bp from pter
Size:
1,643 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10 (See protein sequence)
Recommended Name: Diamine acetyltransferase 2  
Size: 170 amino acids; 19155 Da
Subunit: Homodimer
Subcellular location: Cytoplasm. Note=Intracellular organelles
Miscellaneous: Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues
express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland
expressed only SSAT2
2 PDB 3D structures from and Proteopedia for SAT2:
2BEI (3D)        2Q4V (3D)    

Explore the universe of human proteins at neXtProt for SAT2: NX_Q96F10

Explore proteomics data for SAT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96F10

  • SAT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SAT2 Protein Expression
    REFSEQ proteins: NP_597998.1  
    ENSEMBL proteins: 
     ENSP00000269298   ENSP00000459985   ENSP00000458818   ENSP00000458385  

    Human Recombinant Protein Products for SAT2: 
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    OriGene Protein Over-expression Lysate for SAT2
    OriGene MassSpec for SAT2 
    OriGene Custom Protein Services for SAT2
    GenScript Custom Purified and Recombinant Proteins Services for SAT2
    Novus Biologicals SAT2 Proteins
    Novus Biologicals SAT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SAT2
    Cloud-Clone Corp. Proteins for SAT2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SAT2 for ontologies           About GeneDecksing



    SAT2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SAT2 

    Assay Products for SAT2: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAT2 
    Cloud-Clone Corp. CLIAs for SAT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q96F10

    ProtoNet protein and cluster: Q96F10

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
    Similarity: Belongs to the acetyltransferase family
    Similarity: Contains 1 N-acetyltransferase domain


    SAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAT2_HUMAN, Q96F10
    Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine
    = spermine >> N(1)acetylspermine = putrescine
    Catalytic activity: Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
    Induction: Not inducible by polyamine analogs

         Enzyme Number (IUBMB): EC 2.3.1.571

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004145diamine N-acetyltransferase activity IEA--
    GO:0008080N-acetyltransferase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    SAT2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SAT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAT2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAT2
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    SwitchGear 3'UTR luciferase reporter plasmidSAT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for SAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAT2 (NM_133491)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAT2
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                         Customized lentivirus expression plasmids for stable overexpression of SAT2 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SAT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1melatonin degradation II
    spermine and spermidine degradation I0.40
    2Metabolism
    Metabolic pathways0.40
    3Arginine and proline metabolism
    Arginine and proline metabolism0.35
    4phenylalanine utilization
    putrescine degradation III0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SAT2
        spermine and spermidine degradation I
    putrescine degradation III


    2         Kegg Pathways  (Kegg details for SAT2):
        Arginine and proline metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
    Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1


    SAT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for SAT2 (Q96F102, 3 ENSP000002692984) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216732, 3, ENSP000003685724MINT-67346 I2D: score=4 STRING: ENSP00000368572
    HIF1AQ166653, ENSP000003380184I2D: score=1 STRING: ENSP00000338018
    TCEB1Q153693, ENSP000002848114I2D: score=1 STRING: ENSP00000284811
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009447putrescine catabolic process IEA--

    SAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SAT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAT2

    7 HMDB Compounds for SAT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    N-AcetylputrescineAcetylputrescine (see all 3)18233-70-0--
    N1-Acetylspermidine1-N-Acetylspermidine (see all 7)14278-49-0--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for SAT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3enzymesubstrate17011643 15283699 10986239 12803540

    2 Novoseek inferred chemical compound relationships for SAT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spermidine 82.9 9 17011643 (2), 15283699 (2), 17558023 (1), 15239838 (1) (see all 5)
    spermine 79.7 7 17011643 (2), 15252142 (1), 15239838 (1), 20212040 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SAT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SAT2 gene: 
    NM_133491.3  

    Unigene Cluster for SAT2:

    Spermidine/spermine N1-acetyltransferase family member 2
    Hs.10846  [show with all ESTs]
    Unigene Representative Sequence: BC065922
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576846 ENST00000269298 ENST00000570914 ENST00000380466(uc002gib.1 uc002gic.2)
    ENST00000576579 ENST00000571074 ENST00000575826 ENST00000571195 ENST00000573566
    ENST00000570850 ENST00000576686 ENST00000572224 ENST00000575114 ENST00000573930

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAT2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SAT2
    SwitchGear 3'UTR luciferase reporter plasmidSAT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAT2
    Clone
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    OriGene clones in human, mouse for SAT2 (see all 7)
    OriGene ORF clones in mouse, rat for SAT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAT2 (NM_133491)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAT2
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                         Customized lentivirus expression plasmids for stable overexpression of SAT2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SAT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAT2

    Additional mRNA sequence: 

    AF348524.1 BC011751.2 BC065922.1 BC095466.1 

    10 DOTS entries:

    DT.95297411  DT.448525  DT.95297405  DT.120928684  DT.100031291  DT.97845694  DT.40190533  DT.100821855 
    DT.100821845  DT.120928687 

    24/204 AceView cDNA sequences (see all 204):

    AI083558 BM970704 AW827218 AA757796 CR610611 BM981808 AA128283 W86405 
    CF126728 BC065922 CA425620 BI084862 BM998757 CR604966 AI972420 CB160322 
    BQ045009 AA953547 BQ446994 CB265419 BM924016 CF126883 NM_133491 BQ926514 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SAT2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                                                    -                       -                                             
    SP2:                                                  -                 -                       -                                             
    SP3:                                                                    -                       -                                             
    SP4:                                                                    -     -     -           -                                             
    SP5:                                                  -                 -     -     -           -                                             


    ECgene alternative splicing isoforms for SAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAT2 expression in normal human tissues (normalized intensities)      SAT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAAAAAA
    SAT2 Expression
    About this image


    SAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle

    See SAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAT2

    SOURCE GeneReport for Unigene cluster: Hs.10846

    UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for SAT2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SAT2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sat21 , 5 spermidine/spermine N1-acetyl transferase 21, 5 82.75(n)1
    80(a)1
      11 (42.86 cM)5
    692151  NM_026991.21  NP_081267.11 
     696220245 
    lizard
    (Anolis carolinensis)
    Reptilia SAT26
    Uncharacterized protein
    39(a)
    1 ↔ 1
    GL343660.1(1254-7380)
    zebrafish
    (Danio rerio)
    Actinopterygii sat2b1 spermidine/spermine N1-acetyltransferase family member more 57.67(n)
    54.6(a)
      436827  NM_001002554.1  NP_001002554.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42101 CG4210 47.56(n)
    40.13(a)
      41832  NM_142173.2  NP_650430.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_D2023.41 Protein D2023.4 48.12(n)
    40.85(a)
      183946  NM_073577.3  NP_505978.1 


    ENSEMBL Gene Tree for SAT2 (if available)
    TreeFam Gene Tree for SAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAT2 gene
    SATL12  SAT12  
    4 SIMAP similar genes for SAT2 using alignment to 4 protein entries:     SAT2_HUMAN (see all proteins):
    AILE3    SAT    SAT1    SATL1

    SAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in SAT2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0204654
    ----see VAR_0204652 R C mis40--------

    HapMap Linkage Disequilibrium report for SAT2 (7529552 - 7531194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SAT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611463    OMIM disorders: --

    6 diseases for SAT2:    About MalaCards
    mouth disease    hypoxia    tuberculosis    colon cancer
    colorectal cancer    lung cancer


    SAT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SAT2
    Human Genome Epidemiology (HuGE) Navigator: SAT2 (5 documents)

    Export disorders for SAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAT2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. (PubMed id 15283699)1, 3, 7, 9 Coleman C.S....Pegg A.E. (2004)
    2. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. (PubMed id 12803540)1, 2, 7, 9 Chen Y.... Porter C.W. (2003)
    3. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. (PubMed id 17558023)1, 3, 9 Baek J.H....Semenza G.L. (2007)
    4. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    5. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    8. Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A. (PubMed id 16596569)1, 2 Han B.W....Phillips G.N. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance NF-kappaB-dependent transcription. (PubMed id 17011643)7, 9 Vogel N.L....Ashburner B.P. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112483 HGNC: 23160 AceView: SAT2 Ensembl:ENSG00000141504 euGenes: HUgn112483
    ECgene: SAT2 Kegg: 112483 H-InvDB: SAT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SAT2 gene:
    Search GeneIP for patents involving SAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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