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SAT2 Gene

protein-coding   GIFtS: 59
GCID: GC17M007529

Spermidine/Spermine N1-Acetyltransferase Family Member 2

(Previous name: spermidine/spermine N1-acetyltransferase 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Spermidine/Spermine N1-Acetyltransferase Family Member 21 2     Thialysine N-Epsilon-Acetyltransferase2 3
Spermidine/Spermine N1-Acetyltransferase 21 2     SSAT22 3
Diamine N-Acetyltransferase 21 2     Diamine Acetyltransferase 22
Polyamine N-Acetyltransferase 22 3     EC 2.3.1.573
Spermidine/Spermine N(1)-Acetyltransferase 22 3     S5

External Ids:    HGNC: 231601   Entrez Gene: 1124832   Ensembl: ENSG000001415047   OMIM: 6114635   UniProtKB: Q96F103   
ORGUL members:         

Export aliases for SAT2 gene to outside databases

Previous GC identifers: GC17M007472 GC17M007730 GC17M007470 GC17M007423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SAT2 Gene:
SAT2 (spermidine/spermine N1-acetyltransferase family member 2) is a protein-coding gene. Diseases associated with SAT2 include mouth disease, and lung cancer susceptibility. GO annotations related to this gene include diamine N-acetyltransferase activity. An important paralog of this gene is SATL1.

UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine
= spermine >> N(1)acetylspermine = putrescine

Gene Wiki entry for SAT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAT2 gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAT2 promoter sequence
   Search Chromatin IP Primers for SAT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.2

SAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAT2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007529:  view genomic region     (about GC identifiers)

Start:
7,529,552 bp from pter      End:
7,531,194 bp from pter
Size:
1,643 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10 (See protein sequence)
Recommended Name: Diamine acetyltransferase 2  
Size: 170 amino acids; 19155 Da
Subunit: Homodimer
Miscellaneous: Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues
express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland
expressed only SSAT2
2 PDB 3D structures from and Proteopedia for SAT2:
2BEI (3D)        2Q4V (3D)    

Explore the universe of human proteins at neXtProt for SAT2: NX_Q96F10

Explore proteomics data for SAT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_597998.1  
    ENSEMBL proteins: 
     ENSP00000269298   ENSP00000459985   ENSP00000458818   ENSP00000458385  

    SAT2 Human Recombinant Protein Products:

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    Novus Biologicals SAT2 Proteins
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    ProSpec Recombinant Protein for SAT2
    Cloud-Clone Corp. Proteins for SAT2

    SAT2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SAT2

    SAT2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SAT2
    Cloud-Clone Corp. CLIAs for SAT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q96F10

    ProtoNet protein and cluster: Q96F10

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
    Similarity: Belongs to the acetyltransferase family
    Similarity: Contains 1 N-acetyltransferase domain


    SAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAT2_HUMAN, Q96F10
    Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine
    = spermine >> N(1)acetylspermine = putrescine
    Catalytic activity: Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
    Induction: Not inducible by polyamine analogs

         Enzyme Number (IUBMB): EC 2.3.1.571

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004145diamine N-acetyltransferase activity IDA12803540
    GO:0008080N-acetyltransferase activity ----
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    SAT2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAT2

    miRNA
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    miRTarBase miRNAs that target SAT2:
    hsa-mir-186-5p (MIRT045126)

    Block miRNA regulation of human, mouse, rat SAT2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SAT2
    SwitchGear 3'UTR luciferase reporter plasmidSAT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SAT2

    Gene Editing
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    OriGene ORF clones in mouse, rat for SAT2
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    GenScript: all cDNA clones in your preferred vector: SAT2 (NM_133491)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAT2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SAT2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAT2_HUMAN, Q96F10: Cytoplasm. Note=Intracellular organelles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    extracellular1
    lysosome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    SAT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SAT2 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2spermine and spermidine degradation I
    spermine and spermidine degradation I
    3putrescine degradation III
    putrescine degradation III
    4Arginine and proline metabolism
    Arginine and proline metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SAT2
        spermine and spermidine degradation I
    putrescine degradation III


    2 Kegg Pathways  (Kegg details for SAT2):
        Arginine and proline metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
    Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1


    SAT2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAT2
    Interactions:

        GeneGlobe Interaction Network for SAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for SAT2 (Q96F102, 3 ENSP000002692984) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216732, 3, ENSP000003685724MINT-67346 I2D: score=4 STRING: ENSP00000368572
    HIF1AQ166653, ENSP000003380184I2D: score=1 STRING: ENSP00000338018
    TCEB1Q153693, ENSP000002848114I2D: score=1 STRING: ENSP00000284811
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    KAT2BQ928313, ENSP000002637544I2D: score=2 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009447putrescine catabolic process IEA--
    GO:0032918spermidine acetylation IDA12803540
    GO:0032919spermine acetylation IDA12803540
    GO:0032920putrescine acetylation IDA12803540
    GO:0046204nor-spermidine metabolic process IDA12803540

    SAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAT2

    7 HMDB Compounds for SAT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    N-AcetylputrescineAcetylputrescine (see all 3)18233-70-0--
    N1-Acetylspermidine1-N-Acetylspermidine (see all 7)14278-49-0--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for SAT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3enzymesubstrate17011643 15283699 10986239 12803540

    2 Novoseek inferred chemical compound relationships for SAT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spermidine 82.9 9 17011643 (2), 15283699 (2), 17558023 (1), 15239838 (1) (see all 5)
    spermine 79.7 7 17011643 (2), 15252142 (1), 15239838 (1), 20212040 (1) (see all 5)



    SAT2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SAT2 gene: 
    NM_133491.3  

    Unigene Cluster for SAT2:

    Spermidine/spermine N1-acetyltransferase family member 2
    Hs.10846  [show with all ESTs]
    Unigene Representative Sequence: BC065922
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576846 ENST00000269298 ENST00000570914 ENST00000380466(uc002gib.1 uc002gic.2)
    ENST00000576579 ENST00000571074 ENST00000575826 ENST00000571195 ENST00000573566
    ENST00000570850 ENST00000576686 ENST00000572224 ENST00000575114 ENST00000573930

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate SAT2
    SwitchGear 3'UTR luciferase reporter plasmidSAT2 3' UTR sequence
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    OriGene RNAi products in human, mouse, rat for SAT2
    Predesigned siRNA for gene silencing in human, mouse, rat SAT2
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    GenScript: all cDNA clones in your preferred vector: SAT2 (NM_133491)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAT2
      QuantiTect SYBR Green Assays in human, mouse, rat SAT2
      QuantiFast Probe-based Assays in human, mouse, rat SAT2

    Additional mRNA sequence: 

    AF348524.1 BC011751.2 BC065922.1 BC095466.1 

    10 DOTS entries:

    DT.95297411  DT.448525  DT.95297405  DT.120928684  DT.100031291  DT.97845694  DT.40190533  DT.100821855 
    DT.100821845  DT.120928687 

    Selected AceView cDNA sequences (see all 204):

    BQ045009 AA953547 AI972420 CB528541 BU553453 CA419059 AI248718 CD722434 
    BE670242 BX101905 AI083558 BQ446994 BM924016 AW953940 CF126728 CR610611 
    AI243886 BI084862 NM_133491 BM998757 D12238 BM554050 AI674504 BQ723565 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SAT2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                                                    -                       -                                             
    SP2:                                                  -                 -                       -                                             
    SP3:                                                                    -                       -                                             
    SP4:                                                                    -     -     -           -                                             
    SP5:                                                  -                 -     -     -           -                                             


    ECgene alternative splicing isoforms for SAT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SAT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAAAAAA
    SAT2 Expression
    About this image


    SAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Kidney (Urinary System)
    SAT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10846

    UniProtKB/Swiss-Prot: SAT2_HUMAN, Q96F10
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SAT2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SAT2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sat21 , 5 spermidine/spermine N1-acetyl transferase 21, 5 82.75(n)1
    80(a)1
      11 (42.86 cM)5
    692151  NM_026991.21  NP_081267.11 
     696220245 
    lizard
    (Anolis carolinensis)
    Reptilia SAT26
    spermidine/spermine N1-acetyltransferase family me...
    41(a)
    1 ↔ 1
    GL343660.1(1254-7380)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004871851 diamine acetyltransferase 2-like 58.82(n)
    52.21(a)
      100487185  XM_002944322.2  XP_002944368.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sat2b1 spermidine/spermine N1-acetyltransferase family member more 57.67(n)
    54.6(a)
      436827  NM_001002554.1  NP_001002554.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42101 CG4210 47.59(n)
    39.62(a)
      41832  NM_142173.2  NP_650430.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_D2023.41 CELE_D2023.4 46.41(n)
    37.97(a)
      183946  NM_073577.4  NP_505978.1 


    ENSEMBL Gene Tree for SAT2 (if available)
    TreeFam Gene Tree for SAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAT2 gene
    SATL12  SAT12  
    4 SIMAP similar genes for SAT2 using alignment to 4 protein entries:     SAT2_HUMAN (see all proteins):
    AILE3    SAT    SAT1    SATL1

    SAT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for SAT2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs138941,2,4
    ----see VAR_0204652 mis40--------

    HapMap Linkage Disequilibrium report for SAT2 (7529552 - 7531194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SAT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611463    OMIM disorders: --

    7 diseases for SAT2:    
    About MalaCards
    mouth disease    lung cancer susceptibility    hypoxia    tuberculosis
    lung cancer    malaria    colorectal cancer


    SAT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SAT2
    Human Genome Epidemiology (HuGE) Navigator: SAT2 (5 documents)

    Export disorders for SAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAT2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with SAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. (PubMed id 15283699)1, 3, 7, 9 Coleman C.S....Pegg A.E. (Biochem. J. 2004)
    2. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. (PubMed id 12803540)1, 2, 7, 9 Chen Y.... Porter C.W. (Biochem. J. 2003)
    3. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. (PubMed id 17558023)1, 3, 9 Baek J.H....Semenza G.L. (J. Biol. Chem. 2007)
    4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    7. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    8. Crystal structure of Homo sapiens thialysine Nepsilon- acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A. (PubMed id 16596569)1, 2 Han B.W.... Phillips G.N. Jr. (Proteins 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance NF-kappaB-dependent transcription. (PubMed id 17011643)7, 9 Vogel N.L....Ashburner B.P. (Biochim. Biophys. Acta 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112483 HGNC: 23160 AceView: SAT2 Ensembl:ENSG00000141504 euGenes: HUgn112483
    ECgene: SAT2 Kegg: 112483 H-InvDB: SAT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SAT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SAT2 gene:
    Search GeneIP for patents involving SAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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