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Aliases for SAT1 Gene

Aliases for SAT1 Gene

  • Spermidine/Spermine N1-Acetyltransferase 1 2 3
  • SSAT 3 4 6
  • Polyamine N-Acetyltransferase 1 3 4
  • Diamine N-Acetyltransferase 1 2 3
  • Putrescine Acetyltransferase 3 4
  • EC 2.3.1.57 4 63
  • SSAT-1 3 4
  • KFSDX 3 6
  • KFSD 3 6
  • SAT 3 4
  • Spermidine/Spermine N1-Acetyltransferase Alpha 3
  • Spermidine/Spermine N(1)-Acetyltransferase 1 4
  • Spermidine/Spermine N1-Acetyltransferase 2
  • Diamine Acetyltransferase 1 3
  • DC21 3

External Ids for SAT1 Gene

Previous HGNC Symbols for SAT1 Gene

  • SAT

Previous GeneCards Identifiers for SAT1 Gene

  • GC0XP023711
  • GC0XP021540
  • GC0XP023802
  • GC0XP023807
  • GC0XP023815

Summaries for SAT1 Gene

Entrez Gene Summary for SAT1 Gene

  • The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for SAT1 Gene

SAT1 (Spermidine/Spermine N1-Acetyltransferase 1) is a Protein Coding gene. Diseases associated with SAT1 include keratosis follicularis spinulosa decalvans, x-linked and keratosis. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include diamine N-acetyltransferase activity and spermidine binding. An important paralog of this gene is SATL1.

UniProtKB/Swiss-Prot for SAT1 Gene

  • Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine

Tocris Summary for SAT1 Gene

Gene Wiki entry for SAT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAT1 Gene

Genomics for SAT1 Gene

Regulatory Elements for SAT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAT1 Gene

Start:
23,783,158 bp from pter
End:
23,786,226 bp from pter
Size:
3,069 bases
Orientation:
Plus strand

Genomic View for SAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAT1 Gene

Proteins for SAT1 Gene

  • Protein details for SAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21673-SAT1_HUMAN
    Recommended name:
    Diamine acetyltransferase 1
    Protein Accession:
    P21673
    Secondary Accessions:

    Protein attributes for SAT1 Gene

    Size:
    171 amino acids
    Molecular mass:
    20024 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SAT1 Gene

neXtProt entry for SAT1 Gene

Proteomics data for SAT1 Gene at MOPED

Post-translational modifications for SAT1 Gene

  • Ubiquitination at Lys3, Lys158, and Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for SAT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for SAT1 Gene

Protein Domains for SAT1 Gene

Suggested Antigen Peptide Sequences for SAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21673

UniProtKB/Swiss-Prot:

SAT1_HUMAN :
  • P21673
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with SAT1: view

No data available for Gene Families for SAT1 Gene

Function for SAT1 Gene

Molecular function for SAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.8 uM for acetyl-coenzyme A {ECO:0000269 PubMed:17516632}; KM=5.7 uM for spermine {ECO:0000269 PubMed:17516632}; KM=22 uM for spermidine {ECO:0000269 PubMed:17516632}; pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:17516632};
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
UniProtKB/Swiss-Prot Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine

Enzyme Numbers (IUBMB) for SAT1 Gene

Gene Ontology (GO) - Molecular Function for SAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004145 diamine N-acetyltransferase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008080 N-acetyltransferase activity --
GO:0019809 spermidine binding IEA --
genes like me logo Genes that share ontologies with SAT1: view
genes like me logo Genes that share phenotypes with SAT1: view

Animal Models for SAT1 Gene

MGI Knock Outs for SAT1:

Animal Model Products

No data available for Transcription Factor Targeting and HOMER Transcription for SAT1 Gene

Localization for SAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAT1 Gene COMPARTMENTS Subcellular localization image for SAT1 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SAT1: view

Pathways for SAT1 Gene

genes like me logo Genes that share pathways with SAT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P21673-SAT1_HUMAN

  • Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1

Gene Ontology (GO) - Biological Process for SAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0006595 polyamine metabolic process TAS --
GO:0006596 polyamine biosynthetic process TAS --
GO:0006598 polyamine catabolic process --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with SAT1: view

Compounds for SAT1 Gene

(5) Tocris Compounds for SAT1 Gene

Compound Action Cas Number
(R)-(+)-Etomoxir sodium salt Carnitine palmitoyltransferase I (CPT1) inhibitor [828934-41-4]
A 922500 Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor [959122-11-3]
Fumonisin B1 Inhibitor of sphingosine N-acyltransferase [116355-83-0]
N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator [156886-85-0]
Wnt-C59 Highly potent Porcn inhibitor [1243243-89-1]

(9) HMDB Compounds for SAT1 Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
N1-Acetylspermidine
  • 1-N-Acetylspermidine
14278-49-0
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0
N-Acetylputrescine
  • Acetylputrescine
18233-70-0

(2) Drugbank Compounds for SAT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
  • B33
target
Spermine
  • 1, 4-Bis(aminopropyl)butanediamine
71-44-3 enzyme substrate

(36) Novoseek inferred chemical compound relationships for SAT1 Gene

Compound -log(P) Hits PubMed IDs
denspm 96.9 63
n(1),n(12)-bis(ethyl)spermine 96.6 30
spermidine 96.3 133
spermine 95.8 143
apao 92.8 4
genes like me logo Genes that share compounds with SAT1: view

Transcripts for SAT1 Gene

Unigene Clusters for SAT1 Gene

Spermidine/spermine N1-acetyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for SAT1 Gene

GeneLoc Exon Structure for
SAT1
ECgene alternative splicing isoforms for
SAT1

Expression for SAT1 Gene

mRNA expression in normal human tissues for SAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAT1 Gene

This gene is overexpressed in Whole Blood (7.6).

Protein differential expression in normal tissues for SAT1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SAT1 Gene

SOURCE GeneReport for Unigene cluster for SAT1 Gene Hs.28491

genes like me logo Genes that share expressions with SAT1: view

Expression partners for SAT1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SAT1 Gene

Orthologs for SAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAT1 35
  • 92.2 (n)
  • 97.08 (a)
SAT1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sat1 35
  • 91.42 (n)
  • 96.49 (a)
Sat1 16
Sat1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAT1 35
  • 100 (n)
  • 100 (a)
SAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sat1 35
  • 92.01 (n)
  • 96.49 (a)
dog
(Canis familiaris)
Mammalia SAT1 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAT1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAT1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAT1 35
  • 77.97 (n)
  • 87.13 (a)
SAT1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAT1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sat1 35
  • 76.22 (n)
  • 83.04 (a)
Str.6277 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4880 35
zebrafish
(Danio rerio)
Actinopterygii sat1a.1 35
  • 70.18 (n)
  • 78.36 (a)
wufr42a11 35
sat1a.1 36
  • 78 (a)
OneToMany
sat1b 36
  • 74 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9315 35
fruit fly
(Drosophila melanogaster)
Insecta CG4210 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2023.4 36
  • 28 (a)
OneToMany
Species with no ortholog for SAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAT1 Gene

ENSEMBL:
Gene Tree for SAT1 (if available)
TreeFam:
Gene Tree for SAT1 (if available)

Paralogs for SAT1 Gene

Paralogs for SAT1 Gene

Selected SIMAP similar genes for SAT1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SAT1 Gene

genes like me logo Genes that share paralogs with SAT1: view

Variants for SAT1 Gene

Sequence variations from dbSNP and Humsavar for SAT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs7929 -- 23,783,966(-) GCCTG(C/T)GTAGT intron-variant
rs11404 -- 23,785,701(+) GGTGT(A/C)GCTGC missense, reference, nc-transcript-variant
rs928931 -- 23,781,816(+) AGGAG(C/T)ACTTG upstream-variant-2KB
rs928932 -- 23,781,922(+) ATCAA(A/G)GAATC upstream-variant-2KB
rs928933 -- 23,784,943(+) AAGTC(A/G)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAT1 Gene

Variant ID Type Subtype PubMed ID
nsv470346 CNV Gain 18288195

Relevant External Links for SAT1 Gene

HapMap Linkage Disequilibrium report
SAT1
Human Gene Mutation Database (HGMD)
SAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAT1 Gene

Disorders for SAT1 Gene

(1) OMIM Diseases for SAT1 Gene (313020)

UniProtKB/Swiss-Prot

SAT1_HUMAN
  • Keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:308800]: A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. {ECO:0000269 PubMed:12215835, ECO:0000269 PubMed:9341865}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SAT1 Gene

(18) Novoseek inferred disease relationships for SAT1 Gene

Disease -log(P) Hits PubMed IDs
ehrlich ascites tumor 54.1 3
carcinoma non-small cell lung 49.4 3
lung carcinoma 48.2 10
melanoma 36.5 12
colon cancer 34.2 5

Relevant External Links for SAT1

Genetic Association Database (GAD)
SAT1
Human Genome Epidemiology (HuGE) Navigator
SAT1
genes like me logo Genes that share disorders with SAT1: view

No data available for Genatlas for SAT1 Gene

Publications for SAT1 Gene

  1. Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1). (PMID: 1417826) Xiao L. … Casero R.A. Jr. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. (PMID: 2241897) Casero R.A. Jr. … Pegg A.E. (Biochem. J. 1990) 3 4 23
  3. Differential transcription of the human spermidine/spermine N1- acetyltransferase (SSAT) gene in human lung carcinoma cells. (PMID: 8573111) Xiao L. … Casero R.A. Jr. (Biochem. J. 1996) 3 4 23
  4. Gene dosage of the spermidine/spermine N(1)-acetyltransferase (SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD). (PMID: 12215835) Gimelli G. … Seri M. (Hum. Genet. 2002) 3 4 23
  5. Implication of SSAT by gene expression and genetic variation in suicide and major depression. (PMID: 16389195) Sequeira A. … Turecki G. (Arch. Gen. Psychiatry 2006) 3 23 48

Products for SAT1 Gene

  • Addgene plasmids for SAT1

Sources for SAT1 Gene

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