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Aliases for SAT1 Gene

Aliases for SAT1 Gene

  • Spermidine/Spermine N1-Acetyltransferase 1 2 3 5
  • Polyamine N-Acetyltransferase 1 3 4
  • Diamine N-Acetyltransferase 1 2 3
  • Putrescine Acetyltransferase 3 4
  • EC 2.3.1.57 4 63
  • SSAT-1 3 4
  • SSAT 3 4
  • SAT 3 4
  • Spermidine/Spermine N1-Acetyltransferase Alpha 3
  • Spermidine/Spermine N(1)-Acetyltransferase 1 4
  • Spermidine/Spermine N1-Acetyltransferase 2
  • KFSDX 3
  • KFSD 3
  • DC21 3

External Ids for SAT1 Gene

Previous HGNC Symbols for SAT1 Gene

  • SAT

Previous GeneCards Identifiers for SAT1 Gene

  • GC0XP023711
  • GC0XP021540
  • GC0XP023802
  • GC0XP023807
  • GC0XP023815

Summaries for SAT1 Gene

Entrez Gene Summary for SAT1 Gene

  • The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for SAT1 Gene

SAT1 (Spermidine/Spermine N1-Acetyltransferase 1) is a Protein Coding gene. Diseases associated with SAT1 include keratosis follicularis spinulosa decalvans, x-linked and keratosis follicularis spinulosa decalvans. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include N-acetyltransferase activity and spermidine binding. An important paralog of this gene is SATL1.

UniProtKB/Swiss-Prot for SAT1 Gene

  • Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.

Tocris Summary for SAT1 Gene

Gene Wiki entry for SAT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAT1 Gene

Genomics for SAT1 Gene

Regulatory Elements for SAT1 Gene

Promoters for SAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SAT1 Gene

Chromosome:
X
Start:
23,783,158 bp from pter
End:
23,786,226 bp from pter
Size:
3,069 bases
Orientation:
Plus strand

Genomic View for SAT1 Gene

Genes around SAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAT1 Gene

Proteins for SAT1 Gene

  • Protein details for SAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21673-SAT1_HUMAN
    Recommended name:
    Diamine acetyltransferase 1
    Protein Accession:
    P21673

    Protein attributes for SAT1 Gene

    Size:
    171 amino acids
    Molecular mass:
    20024 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SAT1 Gene

neXtProt entry for SAT1 Gene

Proteomics data for SAT1 Gene at MOPED

Post-translational modifications for SAT1 Gene

  • Ubiquitination at Lys 3, Lys 158, and Lys 161
  • Modification sites at PhosphoSitePlus

Other Protein References for SAT1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SAT1 (SAT)

Domains & Families for SAT1 Gene

Gene Families for SAT1 Gene

Protein Domains for SAT1 Gene

Graphical View of Domain Structure for InterPro Entry

P21673

UniProtKB/Swiss-Prot:

SAT1_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the acetyltransferase family.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with SAT1: view

Function for SAT1 Gene

Molecular function for SAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.8 uM for acetyl-coenzyme A {ECO:0000269 PubMed:17516632}; KM=5.7 uM for spermine {ECO:0000269 PubMed:17516632}; KM=22 uM for spermidine {ECO:0000269 PubMed:17516632}; pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:17516632};
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.
UniProtKB/Swiss-Prot Function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.

Enzyme Numbers (IUBMB) for SAT1 Gene

genes like me logo Genes that share phenotypes with SAT1: view

Human Phenotype Ontology for SAT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SAT1 Gene

MGI Knock Outs for SAT1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SAT1 Gene

Localization for SAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAT1 Gene COMPARTMENTS Subcellular localization image for SAT1 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SAT1 Gene

Pathways & Interactions for SAT1 Gene

genes like me logo Genes that share pathways with SAT1: view

UniProtKB/Swiss-Prot P21673-SAT1_HUMAN

  • Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.

Gene Ontology (GO) - Biological Process for SAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0006596 polyamine biosynthetic process TAS --
GO:0009447 putrescine catabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SAT1: view

No data available for SIGNOR curated interactions for SAT1 Gene

Drugs & Compounds for SAT1 Gene

(21) Drugs for SAT1 Gene - From: Novoseek, HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
spermine Approved Nutra Full agonist, Agonist, Enzyme, substrate 0
Vigabatrin Approved Pharma Inhibition, Inhibitor GABA-T inhibitor 19
putrescine Experimental Pharma Antagonist, Pore Blocker 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0
N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine Experimental Pharma Target 0

(24) Additional Compounds for SAT1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
N1-Acetylspermidine
  • 1-N-Acetylspermidine
  • An N-acetylspermidine
  • N(1)-Acetylspermidine
  • N-(3-((4-Aminobutyl)amino)propyl)-Acetamide
  • N-(3-((4-Aminobutyl)amino)propyl)acetamide
14278-49-0
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
25593-72-0
N-Acetylputrescine
  • Acetylputrescine
  • Monoacetylputrescine
  • N-(4-Aminobutyl)acetamide
18233-70-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
56-18-8

(5) Tocris Compounds for SAT1 Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase 476-66-4
Fumonisin B1 Inhibitor of sphingosine N-acyltransferase 116355-83-0
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases 210110-90-0
SKF 91488 dihydrochloride Histamine N-methyltransferase inhibitor 68941-21-9
Vigabatrin GABA-T inhibitor 60643-86-9
genes like me logo Genes that share compounds with SAT1: view

Transcripts for SAT1 Gene

Unigene Clusters for SAT1 Gene

Spermidine/spermine N1-acetyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for SAT1 Gene

GeneLoc Exon Structure for
SAT1
ECgene alternative splicing isoforms for
SAT1

Expression for SAT1 Gene

mRNA expression in normal human tissues for SAT1 Gene

mRNA differential expression in normal tissues according to GTEx for SAT1 Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for SAT1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAT1 Gene



SOURCE GeneReport for Unigene cluster for SAT1 Gene Hs.28491

genes like me logo Genes that share expression patterns with SAT1: view

Protein tissue co-expression partners for SAT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SAT1 Gene

Orthologs for SAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAT1 35
  • 92.2 (n)
  • 97.08 (a)
SAT1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sat1 35
  • 91.42 (n)
  • 96.49 (a)
Sat1 16
Sat1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAT1 35
  • 100 (n)
  • 100 (a)
SAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sat1 35
  • 92.01 (n)
  • 96.49 (a)
dog
(Canis familiaris)
Mammalia SAT1 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAT1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAT1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAT1 35
  • 77.97 (n)
  • 87.13 (a)
SAT1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAT1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sat1 35
  • 76.22 (n)
  • 83.04 (a)
Str.6277 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4880 35
zebrafish
(Danio rerio)
Actinopterygii sat1a.1 35
  • 70.18 (n)
  • 78.36 (a)
wufr42a11 35
sat1a.1 36
  • 78 (a)
OneToMany
sat1b 36
  • 74 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9315 35
fruit fly
(Drosophila melanogaster)
Insecta CG4210 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2023.4 36
  • 28 (a)
OneToMany
Species with no ortholog for SAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAT1 Gene

ENSEMBL:
Gene Tree for SAT1 (if available)
TreeFam:
Gene Tree for SAT1 (if available)

Paralogs for SAT1 Gene

Paralogs for SAT1 Gene

(4) SIMAP similar genes for SAT1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SAT1 Gene

genes like me logo Genes that share paralogs with SAT1: view

Variants for SAT1 Gene

Sequence variations from dbSNP and Humsavar for SAT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11404 -- 23,785,701(+) GGTGT(A/C)GCTGC nc-transcript-variant, reference, missense
rs928933 -- 23,784,943(+) AAGTC(A/G)ACATA intron-variant
rs1804459 -- 23,785,957(+) AGCAC(C/T)CATTC nc-transcript-variant, utr-variant-3-prime
rs1804460 -- 23,785,392(+) TTATT(C/G)TATCT nc-transcript-variant, reference, missense
rs2071030 -- 23,786,101(+) TTAAT(A/G)TATTT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SAT1 Gene

Variant ID Type Subtype PubMed ID
nsv470346 CNV Gain 18288195

Variation tolerance for SAT1 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAT1 Gene

HapMap Linkage Disequilibrium report
SAT1
Human Gene Mutation Database (HGMD)
SAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAT1 Gene

Disorders for SAT1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for SAT1 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
keratosis follicularis spinulosa decalvans, x-linked
  • keratosis follicularis spinulosa decalvans cum ophiasi
keratosis follicularis spinulosa decalvans
  • keratosis follicularis spinulosa decalvans, x-linked
keratosis
  • actinic keratosis
corneal degeneration
tinea barbae
  • dermatophytosis of beard
- elite association - COSMIC cancer census association via MalaCards
Search SAT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SAT1_HUMAN
  • Keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:308800]: A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. {ECO:0000269 PubMed:12215835, ECO:0000269 PubMed:9341865}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for SAT1

Genetic Association Database (GAD)
SAT1
Human Genome Epidemiology (HuGE) Navigator
SAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAT1
genes like me logo Genes that share disorders with SAT1: view

No data available for Genatlas for SAT1 Gene

Publications for SAT1 Gene

  1. Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1). (PMID: 1417826) Xiao L. … Casero R.A. Jr. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). (PMID: 11709547) Min S.H. … Simmen F.A. (J. Biol. Chem. 2002) 23 25 26
  3. Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation. (PMID: 11166157) Marverti G. … Moruzzi M.S. (Eur. J. Cancer 2001) 23 25 26
  4. Manipulation of the expression of regulatory genes of polyamine metabolism results in specific alterations of the cell-cycle progression. (PMID: 11171097) Scorcioni F. … Bettuzzi S. (Biochem. J. 2001) 23 25 26
  5. Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. (PMID: 10978316) Vujcic S. … Porter C.W. (J. Biol. Chem. 2000) 23 25 26

Products for SAT1 Gene

Sources for SAT1 Gene

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