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SAT1 Gene

protein-coding   GIFtS: 67
GCID: GC0XP023815

Spermidine/Spermine N1-Acetyltransferase 1

(Previous name: spermidine/spermine N1-acetyltransferase)
(Previous symbol: SAT)
  See SAT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Spermidine/Spermine N1-Acetyltransferase 11 2     EC 2.3.1.573 8
SAT1 2 3     KFSD2 5
SSAT2 3 5     KFSDX2 5
Diamine N-Acetyltransferase 11 2     Spermidine/Spermine N1-Acetyltransferase1
Polyamine N-Acetyltransferase 12 3     DC212
Putrescine Acetyltransferase2 3     Diamine Acetyltransferase 12
Spermidine/Spermine N(1)-Acetyltransferase 12 3     Spermidine/Spermine N1-Acetyltransferase Alpha2
SSAT-12 3     

External Ids:    HGNC: 105401   Entrez Gene: 63032   Ensembl: ENSG000001300667   OMIM: 3130205   UniProtKB: P216733   
ORGUL members:         

Export aliases for SAT1 gene to outside databases

Previous GC identifers: GC0XP023711 GC0XP021540 GC0XP023802 GC0XP023807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SAT1 Gene:
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the
catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is
involved in the regulation of the intracellular concentration of polyamines and their transport out of cells.
Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced
transcripts have been found for this gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for SAT1 Gene:
SAT1 (spermidine/spermine N1-acetyltransferase 1) is a protein-coding gene. Diseases associated with SAT1 include keratosis, and keratosis follicularis spinulosa decalvans. GO annotations related to this gene include diamine N-acetyltransferase activity and spermidine binding. An important paralog of this gene is SAT2.

UniProtKB/Swiss-Prot: SAT1_HUMAN, P21673
Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine
>> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the
intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells.
Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine),
spermine, N(1)-acetylspermidine and N(8)-acetylspermidine

Gene Wiki entry for SAT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAT1 gene promoter:
         Sp1   HNF-4alpha2   POU3F2   HNF-4alpha1   Max   PPAR-alpha   Nkx6-1   NRF-2   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAT1 promoter sequence
   Search Chromatin IP Primers for SAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.1   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.1

SAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAT1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP023815:  view genomic region     (about GC identifiers)

Start:
23,801,275 bp from pter      End:
23,804,343 bp from pter
Size:
3,069 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SAT1_HUMAN, P21673 (See protein sequence)
Recommended Name: Diamine acetyltransferase 1  
Size: 171 amino acids; 20024 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for SAT1 (see all 10):
2B3U (3D)        2B3V (3D)        2B4B (3D)        2B4D (3D)        2B58 (3D)        2B5G (3D)    

Explore the universe of human proteins at neXtProt for SAT1: NX_P21673

Explore proteomics data for SAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys3, Lys158, Lys161
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SAT1 (P21673) (see all 5)
     LRLIKELAKYE  FYKRRGASDLS  GIGSEILKNLSQVA  EEGWRLFKIDKEYLLKMA 


    See SAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002961.1  
    ENSEMBL proteins: 
     ENSP00000368553   ENSP00000368555   ENSP00000368556   ENSP00000368572  
    Reactome Protein details: P21673

    SAT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SAT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SAT1
    GenScript Custom Purified and Recombinant Proteins Services for SAT1
    Novus Biologicals SAT1 Proteins
    Novus Biologicals SAT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SAT1
    Cloud-Clone Corp. Proteins for SAT1

     
    Search eBioscience for Proteins for SAT1 

    SAT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SAT1
    OriGene Custom Antibody Services for SAT1
    Novus Biologicals SAT1 Antibodies
    Abcam antibodies for SAT1
    Cloud-Clone Corp. Antibodies for SAT1
    ThermoFisher Antibodies for SAT1
    LSBio Antibodies in human, mouse, rat for SAT1

    SAT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAT1
    Cloud-Clone Corp. CLIAs for SAT1
    Search eBioscience for ELISAs for SAT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry P21673

    ProtoNet protein and cluster: P21673

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: SAT1_HUMAN, P21673
    Similarity: Belongs to the acetyltransferase family
    Similarity: Contains 1 N-acetyltransferase domain


    Find genes that share domains with SAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAT1_HUMAN, P21673
    Function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine
    >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the
    intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells.
    Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine),
    spermine, N(1)-acetylspermidine and N(8)-acetylspermidine
    Catalytic activity: Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
    Biophysicochemical properties: Kinetic parameters: KM=3.8 uM for acetyl-coenzyme A; KM=5.7 uM for spermine; KM=22
    uM for spermidine; pH dependence: Optimum pH is 8.0;

         Enzyme Number (IUBMB): EC 2.3.1.571 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004145diamine N-acetyltransferase activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0008080N-acetyltransferase activity ----
    GO:0019809spermidine binding IEA--
         
    Find genes that share ontologies with SAT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SAT1:
     Synthetic lethal with imatinib 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sat1):
     adipose tissue  cellular  growth/size/body  homeostasis/metabolism  liver/biliary system 
     normal  reproductive system  tumorigenesis 

    Find genes that share phenotypes with SAT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sat1tm1Alh for SAT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SAT1:
    hsa-mir-455-3p (MIRT037883), hsa-mir-335-5p (MIRT019180), hsa-mir-744-5p (MIRT037497), hsa-mir-100-5p (MIRT048548), hsa-mir-652-3p (MIRT039551), hsa-mir-107 (MIRT026968)

    Block miRNA regulation of human, mouse, rat SAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SAT1 (see all 14):
    hsa-miR-320a hsa-miR-3673 hsa-miR-320d hsa-let-7a-2* hsa-miR-551b* hsa-miR-320b hsa-miR-199a-5p hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidSAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SAT1
    Predesigned siRNA for gene silencing in human, mouse, rat SAT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAT1

    Clone
    Products:
         
    OriGene clones in human, mouse for SAT1 (see all 7)
    OriGene ORF clones in mouse, rat for SAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAT1 (NM_002970)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAT1
    Addgene plasmids for SAT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SAT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAT1_HUMAN, P21673: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SAT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SAT1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Interconversion of polyamines0.00
    Metabolism of polyamines0.00
    3spermine and spermidine degradation I
    spermine and spermidine degradation I
    4putrescine degradation III
    putrescine degradation III
    5Nucleotide Metabolism
    Nucleotide Metabolism


    Find genes that share SuperPaths with SAT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for SAT1
        Nucleotide Metabolism
    spermine and spermidine degradation I
    putrescine degradation III

    1 Reactome Pathway for SAT1
        Interconversion of polyamines


    2 Kegg Pathways  (Kegg details for SAT1):
        Arginine and proline metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SAT1_HUMAN, P21673
    Pathway: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SAT1: 

              Amino Acid Metabolism I in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SAT1 (P216731, 2, 3 ENSP000003685724) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-63591 I2D: score=5 
    HOXB6P175092, 3, ENSP000002256484MINT-66153 I2D: score=5 STRING: ENSP00000225648
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67522 I2D: score=5 STRING: ENSP00000263925
    LUC7L2Q9Y3832, 3MINT-63591 I2D: score=5 
    TCF25Q9BQ701, 3, ENSP000002633464EBI-711613,EBI-745182 I2D: score=5 STRING: ENSP00000263346
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP11866539
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process TAS--
    GO:0006598polyamine catabolic process ----
    GO:0009447putrescine catabolic process IEA--

    Find genes that share ontologies with SAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SAT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    YM 750Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor[138046-43-2]
    VULM 1457Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor[228544-65-8]
    N1,N11-Diethylnorspermine tetrahydrochloride Spermine and spermidine acetyltransferase potentiator[121749-39-1]
    (R)-(+)-Etomoxir sodium saltCarnitine palmitoyltransferase I (CPT1) inhibitor[828934-41-4]
    A 922500Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor[959122-11-3]

    9 HMDB Compounds for SAT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    N-AcetylputrescineAcetylputrescine (see all 3)18233-70-0--
    N1-Acetylspermidine1-N-Acetylspermidine (see all 7)14278-49-0--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    2 DrugBank Compounds for SAT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Spermine1, 4-Bis(aminopropyl)butanediamine (see all 5)71-44-3enzymesubstrate11166157 11709547 10978316 10986239 11114236 11171097
    N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamineB33 (see all 2)--target--16455797 10592235

    Selected Novoseek inferred chemical compound relationships for SAT1 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    denspm 96.9 98 15138709 (5), 8916930 (4), 12902979 (4), 17987291 (4) (see all 25)
    n(1),n(12)-bis(ethyl)spermine 96.6 47 14592538 (6), 11166157 (4), 8360194 (4), 15905201 (4) (see all 15)
    spermidine 96.3 209 18089555 (4), 7873553 (3), 15799689 (3), 7982492 (3) (see all 99)
    spermine 95.8 229 18089555 (4), 18690703 (3), 8477847 (3), 7982492 (3) (see all 99)
    apao 92.8 5 12653639 (3), 19589128 (1)
    cpenspm 91.9 2 9326648 (1), 8818232 (1)
    thialysine 88.1 6 16194533 (4), 16455797 (1), 18349109 (1)
    n1-acetylspermine 86.8 2 1989509 (1), 15096507 (1)
    putrescine 84.5 27 12215835 (3), 15213272 (2), 12803540 (2), 18571584 (2) (see all 18)
    n1-acetylspermidine 84 6 7873553 (1), 16452302 (1), 15096507 (1), 20212040 (1)



    Find genes that share compounds with SAT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SAT1 gene: 
    NM_002970.2  

    Unigene Cluster for SAT1:

    Spermidine/spermine N1-acetyltransferase 1
    Hs.28491  [show with all ESTs]
    Unigene Representative Sequence: BF680536
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379251 ENST00000379253(uc010nfv.3) ENST00000379254 ENST00000379270(uc004dau.3)
    ENST00000489394(uc004dav.3) ENST00000463236 ENST00000487713 ENST00000474223
    ENST00000462639
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SAT1 (see all 14):
    hsa-miR-320a hsa-miR-3673 hsa-miR-320d hsa-let-7a-2* hsa-miR-551b* hsa-miR-320b hsa-miR-199a-5p hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidSAT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SAT1
    Predesigned siRNA for gene silencing in human, mouse, rat SAT1
    Clone
    Products:
         
    OriGene clones in human, mouse for SAT1 (see all 7)
    OriGene ORF clones in mouse, rat for SAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAT1 (NM_002970)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAT1
    Addgene plasmids for SAT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for SAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAT1
      QuantiTect SYBR Green Assays in human, mouse, rat SAT1
      QuantiFast Probe-based Assays in human, mouse, rat SAT1

    Additional mRNA sequence: 

    AF251292.1 AK310078.1 AK310094.1 AK312162.1 AK315888.1 BC002503.2 BC008424.1 BT006825.1 
    CR450294.1 M55580.1 M77693.1 NR_027783.1 

    Selected DOTS entries (see all 49):

    DT.100698362  DT.454407  DT.100698353  DT.91779649  DT.91779637  DT.420346  DT.121291999  DT.100698361 
    DT.100773712  DT.95236826  DT.95302628  DT.91779624  DT.100698364  DT.91779721  DT.95302650  DT.91779724 
    DT.95302547  DT.91779631  DT.121291961  DT.100698355  DT.86840209  DT.95302661  DT.91860457  DT.121291907 

    Selected AceView cDNA sequences (see all 1274):

    BM551585 CB111001 AU185122 AI582227 BX417221 CB161789 BM708138 AI888026 
    BQ688268 CD516700 AI561213 CA426772 CD520939 AA486439 BG545664 AA371005 
    AW103465 NM_002970 CR597630 AA298286 AU185145 T28371 AA377151 AW084292 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SAT1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                      -     -           -     -     -                                       
    SP2:                                      -     -     -     -     -     -                                       
    SP3:                                      -     -     -     -     -     -                                       
    SP4:                                            -     -     -     -     -                                       
    SP5:                                      -     -                                                               


    ECgene alternative splicing isoforms for SAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAAATGA
    SAT1 Expression
    About this image


    SAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Thymus (Hematopoietic System)
             Thymus
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    SAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.28491
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SAT1: 
              Amino Acid Metabolism I in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SAT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sat11 , 5 spermidine/spermine N1-acetyl transferase 11, 5 91.42(n)1
    96.49(a)1
      X (72.38 cM)5
    202291  NM_009121.31  NP_033147.11 
     1552131325 
    chicken
    (Gallus gallus)
    Aves SAT11 spermidine/spermine N1-acetyltransferase 1 77.97(n)
    87.13(a)
      374006  NM_204186.1  NP_989517.1 
    lizard
    (Anolis carolinensis)
    Reptilia SAT16
    spermidine/spermine N1-acetyltransferase 1
    79(a)
    1 ↔ 1
    3(125678340-125685320)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48802 Xenopus laevis transcribed sequence with moderate similarity more 78.37(n)    CA986298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufr42a112 wufr42a11 77.47(n)   386952  BM140846.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42106
    --
    30(a)
    1 → many
    3R(11039696-11040567)
    worm
    (Caenorhabditis elegans)
    Secernentea D2023.46
    Protein D2023.4 (D2023.4) mRNA, complete cds
    28(a)
    1 → many
    V(11825030-11825762) WBGene00008408


    ENSEMBL Gene Tree for SAT1 (if available)
    TreeFam Gene Tree for SAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAT1 gene
    SAT22  SATL12  
    4 SIMAP similar genes for SAT1 using alignment to 4 protein entries:     SAT1_HUMAN (see all proteins):
    AILE3    SAT    SAT2    SATL1

    Find genes that share paralogs with SAT1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SAT1
    PGOHUM00000246068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SAT1 (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899499201,2
    --23713805(+) TTTTTA/TAAATT 2 -- us2k10--------
    rs128326601,2
    C--23713829(+) acggcA/Gtttta 2 -- us2k10--------
    rs59259341,2
    C,F,A,H--23713952(+) TCTGCT/CTTTGC 2 -- us2k118Minor allele frequency- C:0.38NS EA NA WA CSA 1973
    rs128388691,2
    C--23714023(+) CTAGGA/GGGATT 2 -- us2k1 tfbs31Minor allele frequency- G:0.00NA 2
    rs65263421,2
    C,F,A,H--23714218(+) AGGAGA/CGCTTG 2 -- us2k125Minor allele frequency- N:0.00NS EA NA WA CSA 2397
    rs1828991681,2
    --23714254(+) TTAGAC/TCGCTA 2 -- us2k10--------
    rs1858596501,2
    --23714308(+) AGCCAA/TCTTCT 2 -- us2k10--------
    rs19602641,2
    C,F,H--23714355(+) TTGGCT/CGGGCA 2 -- us2k16Minor allele frequency- C:0.15NA CSA 13
    rs1910548761,2
    --23714406(+) AGGTGA/GGAGGA 2 -- us2k10--------
    rs9289311,2
    C,F,H--23714413(+) AGGAGT/CACTTG 2 -- us2k1 tfbs35Minor allele frequency- C:0.18NA CSA 11

    HapMap Linkage Disequilibrium report for SAT1 (23801275 - 23804343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470346CNV Gain18288195

    Human Gene Mutation Database (HGMD): SAT1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 313020   
    OMIM disorders: 308800  
    UniProtKB/Swiss-Prot: SAT1_HUMAN, P21673
  • Keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:308800]: A rare disorder affecting the
    skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the
    palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion,
    and corneal degeneration. Note=The disease may be caused by mutations affecting the gene represented in this
    entry

  • 5 diseases for SAT1:    
    About MalaCards
    keratosis    keratosis follicularis spinulosa decalvans    keratosis follicularis    keratosis follicularis spinulosa decalvans, x-linked
    venezuelan equine encephalitis

    1 disease from the University of Copenhagen DISEASES database for SAT1:
    Keratosis follicularis

    Find genes that share disorders with SAT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SAT1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ehrlich ascites tumor 54.1 4 1311643 (2), 1581359 (1)
    carcinoma non-small cell lung 49.4 4 8573111 (1), 12697027 (1), 10430062 (1)
    lung carcinoma 48.2 12 8573111 (3), 2241897 (2), 12697027 (2), 1989509 (1) (see all 6)
    melanoma 36.5 14 1503400 (3), 1989509 (2), 8425191 (2), 9224814 (1) (see all 8)
    colon cancer 34.2 5 14506281 (2), 16262603 (1), 16637064 (1), 16849586 (1)
    prostate carcinoma 32.2 1 15096507 (1)
    ovarian carcinoma 31.5 4 14592538 (1), 20031193 (1), 15905201 (1)
    cancer lung 31.1 7 9717831 (1), 12827295 (1), 8411017 (1), 7559809 (1) (see all 6)
    solid tumor 24.8 4 8033120 (1), 15138709 (1), 1417826 (1), 10430062 (1)
    acute pancreatitis 21.4 1 16452302 (1)

    Genetic Association Database (GAD): SAT1
    Human Genome Epidemiology (HuGE) Navigator: SAT1 (10 documents)

    Export disorders for SAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAT1 gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with SAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1). (PubMed id 1417826)1, 2, 3, 9 Xiao L.... Casero R.A. Jr. (Biochem. Biophys. Res. Commun. 1992)
    2. Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase. (PubMed id 1985966)1, 2, 3 Casero R.A. Jr....Pegg A.E. (J. Biol. Chem. 1991)
    3. Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. (PubMed id 19051286)1, 4, 9 Guipponi M....Malafosse A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. Differential transcription of the human spermidine/spermine N1- acetyltransferase (SSAT) gene in human lung carcinoma cells. (PubMed id 8573111)1, 2, 9 Xiao L. and Casero R.A. Jr. (Biochem. J. 1996)
    5. Implication of SSAT by gene expression and genetic variation in suicide and major depression. (PubMed id 16389195)1, 4, 9 Sequeira A....Turecki G. (Arch. Gen. Psychiatry 2006)
    6. Structures of wild-type and mutant human spermidine/spermine N1- acetyltransferase, a potential therapeutic drug target. (PubMed id 16455797)2, 7, 9 Bewley M.C.... Flanagan J.M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    7. Mechanistic and structural analysis of human spermidine/spermine N1- acetyltransferase. (PubMed id 17516632)1, 2, 9 Hegde S.S.... Blanchard J.S. (Biochemistry 2007)
    8. Gene dosage of the spermidine/spermine N(1)-acetyltransferase (SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD). (PubMed id 12215835)1, 2, 9 Gimelli G.... Seri M. (Hum. Genet. 2002)
    9. High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. (PubMed id 2241897)1, 2, 9 Casero R.A. Jr.... Pegg A.E. (Biochem. J. 1990)
    10. Positive association between SAT-1 -1415T/C polymorphism and anxiety. (PubMed id 18759322)1, 4, 9 Vaquero-Lorenzo C....Baca-Garcia E. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6303 HGNC: 10540 AceView: SAT Ensembl:ENSG00000130066 euGenes: HUgn6303
    ECgene: SAT1 Kegg: 6303 H-InvDB: SAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SAT1 gene:
    Search GeneIP for patents involving SAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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