SASS6 Gene
protein-coding GIFtS: 44
GCID: GC01M100549
|
|
spindle assembly 6 homolog (C. elegans)
| |
Aliases
for SASS6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spindle Assembly 6 Homolog (C. Elegans)1 2 | | FLJ220971 | | SAS61 2 3 5 | | HsSAS-63 | | SAS-61 2 | | Spindle Assembly Abnormal Protein 6 Homolog2 | | DKFZp761A0781 | | HsSAS-63 |
Export aliases for SASS6 gene to outside databasesPrevious GC identifers: GC01M100263 GC01M098671 |
Summaries
for SASS6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SASS6:
SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure thateach centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007) (PubMed17681132).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: SAS6_HUMAN, Q6UVJ0Function: Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers
Gene Wiki entry for SASS6
|
Genomic Views
for SASS6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SASS6 gene promoter:
NF-AT AREB6 NF-AT4 NF-AT2 POU2F1 POU2F1b POU2F1a NF-AT3 Cart-1 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SASS6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SASS6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p21.2 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p21.3SASS6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M100549: view genomic region
(about GC identifiers)
Start:
|
100,549,100 bp from pter |
End:
|
100,598,511 bp from pter |
Size:
|
49,412 bases |
Orientation:
|
minus strand |
|
Proteins
for SASS6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SAS6_HUMAN, Q6UVJ0 (See
protein sequence)Recommended Name: Spindle assembly abnormal protein 6 homolog Size: 657 amino acids; 74397 Da
Subunit: Part of a ternary complex composed of SASS6, CENPJ and CEP350. Interacts with FBXW5
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, centrosome, centriole.Note=Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis
Secondary accessions: D3DT55 Q8N3K0Explore the universe of human proteins at neXtProt for SASS6: NX_Q6UVJ0
Post-translational modifications:
Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during S phase, leading to its degradation andpreventing centriole reduplication1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UVJ0
SASS6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_919268.1
ENSEMBL proteins: ENSP00000287482 ENSP00000440169
Human Recombinant Protein Products for SASS6:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SASS6 for ontologies About GeneDecksing
SASS6 Antibody Products:
Assay Products for SASS6: |
Protein
Domains /
Families
for SASS6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6UVJ0 UniProtKB/Swiss-Prot: SAS6_HUMAN, Q6UVJ0Similarity: Contains 1 PISA domain |
Function
for SASS6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SAS6_HUMAN, Q6UVJ0Function: Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SASS6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for SASS6:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SASS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SASS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SASS6 |
|
Pathways & Interactions
for SASS6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SASS6
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/9 Interacting proteins for SASS6 (Q6UVJ02, 3 ENSP000002874824) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SASS6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SASS6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SASS6
Search CenterWatch for drugs/clinical trials and news about SASS6 / SAS6
|
Transcripts
for SASS6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SASS6 gene: NM_194292.1 Unigene Cluster for SASS6: Spindle assembly 6 homolog (C. elegans) Hs.591447 [show with all ESTs]Unigene Representative Sequence: BX6411093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287482(uc001dsu.3 uc009wdz.3) ENST00000462159 ENST00000535161
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SASS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SASS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SASS6 (NM_194292) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SASS6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SASS6 |
Additional cDNA sequence: AK025750.1 AK302513.1 AK307824.1 AL834265.1 AY359522.1 BC054889.1 BC101026.3 BX641109.1 BX648406.1 3 DOTS entries: DT.101982248 DT.91657641 DT.101982247 24/32 AceView cDNA sequences (see all 32): AL834265 AK025750 NM_194292 AA639560 AI254732 BP430287 BF366552 CB151711 BC054889 AY359522 CB117516 AA907721 BF434958 AI567863 AW473121 BE733219 AI439960 AI888918 AA504218 BX641109 BM464035 BU603007 BG250613 BM839677
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SASS6 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SASS6
|
Expression
for SASS6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SASS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SASS6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SASS6
SOURCE GeneReport for Unigene cluster: Hs.591447
SABiosciences Custom PCR Arrays for SASS6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SASS6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SASS6 |
Orthologs
for SASS6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SASS6 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Sass61 , 5 |
spindle assembly 6 homolog (C. elegans)1, 5 |
83.87(n)1
85.6(a)1 |
|
3 (50.40 cM)5
727761 NM_028349.21 NP_082625.21
1165950085 |
chicken
(Gallus gallus) |
Aves |
SASS61 |
spindle assembly 6 homolog (C. elegans) |
69.15(n)
68.46(a) |
|
424471 NM_001031273.1 NP_001026444.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SASS66 |
-- |
67(a) |
1 ↔ 1 |
4(87782468-87804592) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.61212 |
Xenopus laevis transcribed sequences |
77.36(n) |
|
BJ037221.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.25162 |
Danio rerio mRNA similar to RIKEN cDNA 2810453L12 gene more |
73.74(n) |
|
BC045420.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sas-61 |
spindle assembly abnormal 6 |
38.34(n)
25.62(a) |
|
43555 NM_143499.2 NP_651756.1 |
ENSEMBL Gene Tree for SASS6 (if available)
TreeFam Gene Tree for SASS6 (if available) |
Paralogs
for SASS6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SASS6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SASS6 (100549100 - 100598511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SASS6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SASS6 |
|
Disorders
/ Diseases
for SASS6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SASS6 for disorders About GeneDecksing
OMIM gene information: 609321
OMIM disorders: --
3  diseases for SASS6: About MalaCardsbullous pemphigoid microcephaly malaria
Export disorders for SASS6 gene to outside databases
|
Publications
for SASS6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SASS6 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with SASS6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. (PubMed id 15665853)1, 2, 3 Leidel S.... Goenczy P. (2005)
- Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2, 3 Andersen J.S....Mann M. (2003)
- The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PubMed id 21725316)1, 2 Puklowski A....Malek N.P. (2011)
- Plk4-induced centriole biogenesis in human cells. (PubMed id 17681131)1, 2 Kleylein-Sohn J.... Nigg E.A. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The Polo kinase Plk4 functions in centriole duplication. (PubMed id 16244668)1, 2 Habedanck R.... Nigg E.A. (2005)
- Centriole assembly requires both centriolar and pericentriolar material proteins. (PubMed id 15572125)1, 2 Dammermann A.... Oegema K. (2004)
- Cell-cycle-regulated expression of STIL controls centr iole number in human cells. (PubMed id 22349698)1 Arquint C....Nigg E.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for SASS6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SASS6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SASS6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SASS6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SASS6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SASS6 gene:
Search GeneIP for patents involving SASS6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SASS6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SASS6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SASS6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SASS6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SASS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SASS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SASS6 |
| |
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| | | | Search Tocris compounds for SASS6 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SASS6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SASS6 |
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|
