SASH3 Gene
protein-coding GIFtS : 46
GCID: GC0X P128913
SAM and SH3 domain containing 3 (Previous name: chromosome X open reading frame 9 ) (Previous symbol: CXorf9 )
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Aliasesfor SASH3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases SAM And SH3 Domain Containing 3 1 2 SH3D6C1 2 CXorf91 2 3 SH3 Protein Expressed In Lymphocytes Homolog2 3 SLY1 2 3 Chromosome X Open Reading Frame 91 753P91 2 SAM And SH3 Domain-Containing Protein 32 HACS21 2
Export aliases for SASH3 gene to outside databases Previous GC identifers: GC0XP128742 GC0XP118315
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Summariesfor SASH3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SASH3 : The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.(provided by RefSeq, Sep 2009) UniProtKB/Swiss-Prot: SASH3_HUMAN, O75995 Function : May function as a signaling adapter protein in lymphocytes (By similarity)
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Genomic Viewsfor SASH3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SASH3 gene promoter: ER-alpha AREB6 NRSF form 1 Olf-1 Nkx2-5 Pax-4a NRSF form 2 Other transcription factors Search SABiosciences Chromatin IP Primers for SASH3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SASH3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq26 Ensembl cytogenetic band: Xq26.1 HGNC cytogenetic band: Xq26 SASH3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP128913: view genomic region
(about GC identifiers )
Start:
128,913,892 bp from pter
End:
128,929,177 bp from pter
Size:
15,286 bases
Orientation:
plus strand
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Proteinsfor SASH3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SASH3_HUMAN, O75995 (See
protein sequence )Recommended Name: SAM and SH3 domain-containing protein 3 Size : 380 amino acids; 41595 Da
Secondary accessions : A6NCH1 A8K7K8 Q5JZ38Explore the universe of human proteins at neXtProt for SASH3: NX_O75995 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75995 SASH3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_061863.1 ENSEMBL proteins: ENSP00000349359 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
SASH3 for ontologies About GeneDecksing SASH3 Antibody Products: Assay Products for SASH3:
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Protein
Domains / Familiesfor SASH3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SASH3 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O75995 ProtoNet protein and cluster: O75995
4 Blocks protein families : IPB001452 SH3 domain signature IPB001660 Sterile alpha motif SAM IPB011510 Sterile alpha motif homology 2 IPB011511 Variant SH3 UniProtKB/Swiss-Prot: SASH3_HUMAN, O75995 Similarity : Contains 1 SAM (sterile alpha motif) domainSimilarity : Contains 1 SH3 domain
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Functionfor SASH3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SASH3_HUMAN, O75995 Function : May function as a signaling adapter protein in lymphocytes (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SASH3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SASH3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SASH3 (NM_018990 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SASH3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SASH3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SASH3
Animal Models: Mouse knock-out Sash3 tm1Hlz for SASH3 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sash3) :
SASH3 for phenotypes About GeneDecksing
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Pathways & Interactionsfor SASH3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SASH3 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/6 Interacting proteins for SASH3 (O75995 3 ENSP00000349359 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002639 positive regulation of immunoglobulin production
IEA -- GO:0002726 positive regulation of T cell cytokine production
IEA -- GO:0002821 positive regulation of adaptive immune response
-- -- GO:0030890 positive regulation of B cell proliferation
IEA -- GO:0032729 positive regulation of interferon-gamma production
IEA --
SASH3 for ontologies About GeneDecksing
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Drugs & Compoundsfor SASH3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SASH3 Search CenterWatch for drugs/clinical trials and news about SASH3
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Transcriptsfor SASH3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SASH3 gene: NM_018990.3 Unigene Cluster for SASH3:
SAM and SH3 domain containing 3 Hs.61469 [show with all ESTs ] Unigene Representative Sequence: NM_018990 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000476532 ENST00000356892 (uc011muo.1 uc004euu.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SASH3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SASH3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SASH3 (NM_018990 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SASH3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SASH3
Additional cDNA sequence: AK292023.1 AK314869.1 AL049683.1 BC051881.1
3 DOTS entries : DT.311972 DT.100784866
DT.121311247 24/116 AceView cDNA sequences (see all 116 ):
AI707839 BM457287 BQ436387 AI826730 BM709097 AW575039 AA628915 BX345780 AI884992 BU180846 BM663865 BQ721729 BM986908 AL049683 BM705056 BM454613 AW268716 BQ423508 BX106789 BM919905 CF593327 BG059825 CA438495 AW402583 GeneLoc Exon Structure
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Expression for SASH3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SASH3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGTAGAACTA
About this image SASH3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SASH3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SASH3 SOURCE GeneReport for Unigene cluster: Hs.61469 SABiosciences Custom PCR Arrays for SASH3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SASH3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SASH3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SASH3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SASH3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SASH3
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Orthologsfor SASH3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for SASH3 gene from 6/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for SASH3 (if available)TreeFam Gene Tree for SASH3 (if available)
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Paralogsfor SASH3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SASH3 gene SASH1 2 SAMSN1 2 2 SIMAP similar genes for SASH3 using alignment to 1 protein entry: SASH3_HUMAN :SAMSN1 SASH1
SASH3 for paralogs About GeneDecksing
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Genomic Variantsfor SASH3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SASH3 (128913892 - 128929177 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SASH3 2 CNVs : 9862 4172 Locus Specific Mutation Databases (LSDB): SASH3
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SASH3
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Disorders
/ Diseasesfor SASH3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SASH3 for disorders About MalaCards
SASH3 for disorders About GeneDecksing
OMIM gene information: 300441
OMIM disorders : --Export disorders for SASH3 gene to outside databases
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Publicationsfor SASH3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SASH3 gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with SASH3) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Approaches to define antigen receptor-induced serine kinase signal transduction pathways. (PubMed id 12515807) 1 , 2 Astoul E....Cantrell D.A. (2003) Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells. (PubMed id 11470164) 1 , 3 Beer S....Holzmann B. (2001) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The DNA sequence of the human X chromosome. (PubMed id 15772651) 2 Ross M.T.... Bentley D.R. (2005) High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153) 1 Barrios-Rodiles M....Wrana J.L. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for SASH3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SASH3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SASH3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SASH3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SASH3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SASH3 gene: Search GeneIP for patents involving SASH3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SASH3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SASH3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SASH3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SASH3 OriGene Protein Over-expression Lysate for SASH3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SASH3 OriGene 3'-UTR Clone for SASH3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SASH3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SASH3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SASH3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SASH3 OriGene Custom Protein Services for SASH3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SASH3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SASH3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SASH3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SASH3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SASH3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SASH3
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SASH3
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SASH3
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