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Aliases for SASH3 Gene

Aliases for SASH3 Gene

  • SAM And SH3 Domain Containing 3 2 3 5
  • SH3 Protein Expressed In Lymphocytes Homolog 3 4
  • CXorf9 3 4
  • SLY 3 4
  • Chromosome X Open Reading Frame 9 2
  • SH3D6C 3
  • 753P9 3
  • HACS2 3

External Ids for SASH3 Gene

Previous HGNC Symbols for SASH3 Gene

  • CXorf9

Previous GeneCards Identifiers for SASH3 Gene

  • GC0XP128742
  • GC0XP128913
  • GC0XP118315

Summaries for SASH3 Gene

Entrez Gene Summary for SASH3 Gene

  • The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.[provided by RefSeq, Sep 2009]

GeneCards Summary for SASH3 Gene

SASH3 (SAM And SH3 Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is SAMSN1.

UniProtKB/Swiss-Prot for SASH3 Gene

  • May function as a signaling adapter protein in lymphocytes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SASH3 Gene

Genomics for SASH3 Gene

Regulatory Elements for SASH3 Gene

Enhancers for SASH3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SASH3 on UCSC Golden Path with GeneCards custom track

Promoters for SASH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SASH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SASH3 Gene

129,779,916 bp from pter
129,795,201 bp from pter
15,286 bases
Plus strand

Genomic View for SASH3 Gene

Genes around SASH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SASH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SASH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SASH3 Gene

Proteins for SASH3 Gene

  • Protein details for SASH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SAM and SH3 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A6NCH1
    • A8K7K8
    • Q5JZ38

    Protein attributes for SASH3 Gene

    380 amino acids
    Molecular mass:
    41595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SASH3 Gene

Proteomics data for SASH3 Gene at MOPED

Post-translational modifications for SASH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SASH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SASH3 Gene

Domains & Families for SASH3 Gene

Suggested Antigen Peptide Sequences for SASH3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with SASH3: view

Function for SASH3 Gene

Molecular function for SASH3 Gene

UniProtKB/Swiss-Prot Function:
May function as a signaling adapter protein in lymphocytes.
genes like me logo Genes that share phenotypes with SASH3: view

Animal Models for SASH3 Gene

MGI Knock Outs for SASH3:

Animal Model Products

CRISPR Products

miRNA for SASH3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SASH3 Gene

Localization for SASH3 Gene

Subcellular locations from

Jensen Localization Image for SASH3 Gene COMPARTMENTS Subcellular localization image for SASH3 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SASH3 Gene

Pathways & Interactions for SASH3 Gene

SuperPathways for SASH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SASH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002726 positive regulation of T cell cytokine production IEA --
GO:0002821 positive regulation of adaptive immune response IEA --
GO:0030890 positive regulation of B cell proliferation IEA --
GO:0032729 positive regulation of interferon-gamma production IEA --
genes like me logo Genes that share ontologies with SASH3: view

No data available for Pathways by source and SIGNOR curated interactions for SASH3 Gene

Drugs & Compounds for SASH3 Gene

No Compound Related Data Available

Transcripts for SASH3 Gene

mRNA/cDNA for SASH3 Gene

Unigene Clusters for SASH3 Gene

SAM and SH3 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SASH3 Gene

No ASD Table

Relevant External Links for SASH3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SASH3 Gene

mRNA expression in normal human tissues for SASH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SASH3 Gene

This gene is overexpressed in Whole Blood (x23.0) and Spleen (x6.3).

Protein differential expression in normal tissues from HIPED for SASH3 Gene

This gene is overexpressed in Lymph node (19.0), CD8 Tcells (10.3), Blymphocyte (9.6), CD4 Tcells (9.3), NK cells (6.3), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SASH3 Gene

SOURCE GeneReport for Unigene cluster for SASH3 Gene Hs.61469

genes like me logo Genes that share expression patterns with SASH3: view

Protein tissue co-expression partners for SASH3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SASH3 Gene

Orthologs for SASH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SASH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SASH3 35
  • 90.63 (n)
  • 93.59 (a)
SASH3 36
  • 90 (a)
(Canis familiaris)
Mammalia SASH3 35
  • 92.19 (n)
  • 95.26 (a)
SASH3 36
  • 89 (a)
(Mus musculus)
Mammalia Sash3 35
  • 89.39 (n)
  • 95 (a)
Sash3 16
Sash3 36
  • 90 (a)
(Pan troglodytes)
Mammalia SASH3 35
  • 99.62 (n)
  • 99.43 (a)
SASH3 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Sash3 35
  • 89.3 (n)
  • 94.47 (a)
(Monodelphis domestica)
Mammalia SASH3 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SASH3 36
  • 70 (a)
(Gallus gallus)
Aves SASH3 35
  • 71.86 (n)
  • 70.97 (a)
SASH3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia SASH3 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sash3 35
  • 62.86 (n)
  • 62.67 (a)
Str.12240 35
(Danio rerio)
Actinopterygii LOC561954 35
  • 56.82 (n)
  • 53.8 (a)
BX004980.1 36
  • 47 (a)
Species with no ortholog for SASH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SASH3 Gene

Gene Tree for SASH3 (if available)
Gene Tree for SASH3 (if available)

Paralogs for SASH3 Gene

Paralogs for SASH3 Gene

(2) SIMAP similar genes for SASH3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SASH3: view

Variants for SASH3 Gene

Sequence variations from dbSNP and Humsavar for SASH3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747669832 -- 129,792,351(+) CCAGC(C/T)CAGGT reference, missense
rs747716638 -- 129,793,592(+) CCCAA(G/T)GTCCC intron-variant
rs747753522 -- 129,778,503(+) AGACA(A/G)AGTGA upstream-variant-2KB
rs747830018 -- 129,794,675(+) AACAC(A/C)ATGCC utr-variant-3-prime
rs747881410 -- 129,779,616(+) ACCGG(C/G)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SASH3 Gene

Variant ID Type Subtype PubMed ID
dgv2475e1 CNV Complex 17122850
nsv528290 CNV Gain 19592680
nsv526197 CNV Gain 19592680
nsv818036 CNV Loss 17921354

Variation tolerance for SASH3 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SASH3 Gene

Disorders for SASH3 Gene

Relevant External Links for SASH3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SASH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SASH3 Gene

Publications for SASH3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells. (PMID: 11470164) Beer S. … Holzmann B. (Biochim. Biophys. Acta 2001) 2 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3

Products for SASH3 Gene

Sources for SASH3 Gene