 |
 | Services
| |
 |
Aliases & Descriptions for TSPAN31
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| SAS 2, 3, 5 | | Tspan-31 3 |
| | | Descriptions |
|---|
| Sarcoma-amplified sequence 3 | | sarcoma amplified sequence 1, 2 | | tetraspanin 31 2 | | transmembrane 4 protein 2 |
|
| | Search outside databases for aliases for TSPAN31 gene |
Summaries for TSPAN31(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TSPAN31: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq] Gene Wiki entry for TSPAN31 |
Genomic Location for TSPAN31
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TSPAN31 gene 
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13-q14TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P056426:
(about GC identifiers)
Start:
|
56,425,051 bp from pter |
End:
|
56,428,293 bp from pter |
Size:
|
3,243 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for TSPAN31
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TSN31_HUMAN, Q12999 (See
protein sequence)Recommended Name: Tetraspanin-31 Size: 210 amino acids; 23053 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O00577REFSEQ proteins: NP_005972.1
ENSEMBL proteins: ENSP00000257910
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TSPAN31: Assays for TSPAN31: | Protein
Domains/ Families for TSPAN31(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q12999
ProtoNet protein and cluster: Q12999 1 Blocks protein family: IPB000301 Transmembrane four family signature
UniProtKB/Swiss-Prot: TSN31_HUMAN, Q12999Similarity: Belongs to the tetraspanin (TM4SF) family | Gene Function for TSPAN31
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005981
Applied Biosystems Silencer® siRNAs for TSPAN31
Sigma-Aldrich siRNA for TSPAN31  Sigma-Aldrich shRNA for TSPAN31  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005981                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005981                                  untagged cDNA clone in CMV expression vector: NM_005981 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005981
1 MGI phenotypic allele for Tspan31 (no phenotypes)
| Pathways & Interactions for TSPAN31
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008284 | positive regulation of cell proliferation |
TAS | 8134123 | About this table
|
Drugs & Compounds for TSPAN31(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TSPAN31
|
Transcripts for TSPAN31(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005981
Sigma-Aldrich siRNA for TSPAN31  Sigma-Aldrich shRNA for TSPAN31  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005981 REFSEQ mRNAs for TSPAN31 gene: NM_005981.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005981               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005981                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005981                                  untagged cDNA clone in CMV expression vector: NM_005981  Additional cDNA sequence: AB209699.1 AK294128.1 AK315765.1 BC010377.1 BX647402.1 CR407647.1 CR592832.1 CR616737.1 CR623983.1 U01160.1 19 DOTS entries: DT.92408932 DT.40113477 DT.445603 DT.100800137 DT.219465 DT.100851448 DT.121198928 DT.121642996 DT.121198876 DT.100701711 DT.121198875 DT.95093290 DT.100667381 DT.100701713 DT.100701889 DT.121198723 DT.95339116 DT.100851460 DT.121198852 24/198 AceView cDNA sequences (see all 198
):BM544408 AU136058 CA394386 BI822098 AI554284 U01160 AI281002 NM_005981 BQ436397 BQ072508 AA772366 BI044405 AI272248 BM452411 AU103103 CR623983 BE350825 BI793069 AA301604 CA449236 CD672750 BM462177 AU103105 CR616737
highest scoring ESTs for TSPAN31:U01160 AA095922 AA766502 AA772366 AA860771 AI369972 AI382895 AI740878 AI903792 AL571239 Unigene Cluster for TSPAN31: Tetraspanin 31 Hs.632708 [show with all ESTs]Unigene Representative Sequence: AB209699
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TSPAN31
1 Ensembl transcript including schematic representation: ENST00000257910
|
Expression for TSPAN31
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TSPAN31 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TSPAN31
1 / 2 / 3 6 probe-sets matching TSPAN31 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCAGATGTGT
SOURCE GeneReport for Unigene cluster: Hs.632708
|
Orthologs for TSPAN31
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TSPAN31 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for TSPAN31
ENSEMBL Gene Tree for TSPAN31 | Paralogs for TSPAN31(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TSPAN31 gene
- TSPAN132
|
SNPs/Variants for TSPAN31(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TSPAN31 (up to first 250kb)
|
Disorders & Mutations for TSPAN31
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 181035
|
Medical News for TSPAN31(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TSPAN31 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for TSPAN31 gene (see all 14
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. (PubMed id 9192850)3, 4 Elkahloun A.G....Meltzer P.S. (1997)
- SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. (PubMed id 8134123)3, 4 Jankowski S.A.... Meltzer P.S. (1994)
- Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (PubMed id 15024701)1, 3 Ragazzini P....Benassi M.S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Identification and characterization of the potential promoter regions of 1031 kinds of human genes. (PubMed id 11337467)3 Suzuki Y....Sugano S. (2001)
- Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. (PubMed id 10101594)3 Ragazzini P....Picci P. (1999)
- Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. (PubMed id 9989829)3 Wunder J.S....Gogkoz N. (1999)
- Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas. (PubMed id 7789984)3 Jankowski S.A....Meltzer P.S. (1995)
|
Search for TSPAN31
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TSPAN31
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TSPAN31
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPAN31(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TSPAN31(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TSPAN31:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for TSPAN31 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|