V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

TSPAN31 Gene

protein-coding   GIFtS: 53

GC12P056426
tetraspanin 31
(Previous name: sarcoma amplified sequence )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SAS)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
SAS 2, 3, 5
Tspan-31 3
Descriptions
Sarcoma-amplified sequence 3
sarcoma amplified sequence 1, 2
tetraspanin 31 2
transmembrane 4 protein 2
External Ids
HGNC: 105391
Entrez Gene: 63022
UniProtKB: Q129993
Ensembl: ENSG000001354527
Search outside databases for aliases for TSPAN31 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TSPAN31:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the
tetraspanin family. Most of these members are cell-surface proteins that are characterized by the
presence of four hydrophobic domains. The proteins mediate signal transduction events that play a
role in the regulation of cell development, activation, growth and motility. This encoded protein
is thought to be involved in growth-related cellular processes. This gene is associated with
tumorigenesis and osteosarcoma. [provided by RefSeq]

Gene Wiki entry for TSPAN31
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TSPAN31 gene  

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13-q14

TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056426:     (about GC identifiers)

Start:
56,425,051 bp from pter
End:
56,428,293 bp from pter
Size:
3,243 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TSN31_HUMAN, Q12999 (See protein sequence)
Recommended Name: Tetraspanin-31  
Size: 210 amino acids; 23053 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O00577

REFSEQ proteins: NP_005972.1  

ENSEMBL proteins: 
ENSP00000257910 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Tetraspanin 13 + Tetraspanin 31)
Human Recombinant Proteins from Abnova (TSPAN31)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005624 membrane fraction TAS8134123
GO:0005887 integral to plasma membrane TAS8134123
GO:0016020 membrane IEA--
About this table

Antibodies for TSPAN31: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (Tetraspanin 13 + Tetraspanin 31), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (TSPAN31)
Novus Biologicals Antibody for TSPAN31

Assays for TSPAN31: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR018499 Tetraspanin
 IPR018503 Tetraspanin_CS
 IPR000301 Tetraspanin_sub


   GeneDecks  TSPAN31 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q12999

ProtoNet protein and cluster: Q12999

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: TSN31_HUMAN, Q12999
Similarity: Belongs to the tetraspanin (TM4SF) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TSPAN31)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005981

              Applied Biosystems Silencer® siRNAs for TSPAN31

              Sigma-Aldrich siRNA for TSPAN31  
                     Sigma-Aldrich shRNA for TSPAN31  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for TSPAN31
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005981
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005981
                                 untagged cDNA clone in CMV expression vector: NM_005981 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005981

1 MGI phenotypic allele for Tspan31 (no phenotypes)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008284 positive regulation of cell proliferation TAS8134123
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TSPAN31

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TSPAN31)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005981

              Sigma-Aldrich siRNA for TSPAN31  
                     Sigma-Aldrich shRNA for TSPAN31  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005981  

REFSEQ mRNAs for TSPAN31 gene: 

NM_005981.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005981  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005981
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005981
                                 untagged cDNA clone in CMV expression vector: NM_005981 

Additional cDNA sequence: 

AB209699.1 AK294128.1 AK315765.1 BC010377.1 BX647402.1 CR407647.1 CR592832.1 CR616737.1 
CR623983.1 U01160.1 

19 DOTS entries:

DT.92408932  DT.40113477  DT.445603  DT.100800137  DT.219465  DT.100851448  DT.121198928  DT.121642996 
DT.121198876  DT.100701711  DT.121198875  DT.95093290  DT.100667381  DT.100701713  DT.100701889  DT.121198723 
DT.95339116  DT.100851460  DT.121198852 

24/198 AceView cDNA sequences (see all 198 ):

BM544408 AU136058 CA394386 BI822098 AI554284 U01160 AI281002 NM_005981 
BQ436397 BQ072508 AA772366 BI044405 AI272248 BM452411 AU103103 CR623983 
BE350825 BI793069 AA301604 CA449236 CD672750 BM462177 AU103105 CR616737 

highest scoring ESTs for TSPAN31:

U01160 AA095922 AA766502 AA772366 AA860771 AI369972 AI382895 AI740878 AI903792 AL571239 

Unigene Cluster for TSPAN31:

Tetraspanin 31
Hs.632708  [show with all ESTs]
Unigene Representative Sequence: AB209699


GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 (see all 8 )

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1:                    -     -                 -     -     -                 -                           
SP2:                    -     -                 -     -     -                 -                           
SP3:                          -                 -     -     -                                             
SP4:                    -     -                 -     -     -                                             
SP5:                    -     -                 -                                                         

About this scheme

ECgene alternative splicing isoforms for TSPAN31

1 Ensembl transcript including schematic representation:
ENST00000257910  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TSPAN31 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TSPAN31

1 / 2 / 3

6 probe-sets matching TSPAN31 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
36083_at2, 3 U95-A 1 0.94 1.00 0.81 0.72 U01160 1.00 1.00 1.00 1

63906_f_at2, 3 U95-C 3341 0.75 0.00 0.47 1.28 R98835 0.20 0.02 0.14 1

203227_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005981 0.60 1.00 0.82 1

203226_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL514076 0.60 1.00 0.82 1

203227_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

203226_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  TSPAN31 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCAGATGTGT

SOURCE GeneReport for Unigene cluster: Hs.632708
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TSPAN31 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TSPAN311   -- tetraspanin 31 94.13(n)
97.14(a)
403676  XM_531651.2  XP_531651.1 
chimpanzee
(Pan troglodytes)
TSPAN311   -- tetraspanin 31 99.84(n)
100(a)
746219  XM_001167545.1  XP_001167545.1 
cow
(Bos taurus)
TSPAN311   -- tetraspanin 31 93.81(n)
96.19(a)
510619  NM_001037595.1  NP_001032684.1 
rat
(Rattus norvegicus)
Tspan311   -- tetraspanin 31 85.87(n)
88.1(a)
362890  NM_001008378.1  NP_001008379.1 
mouse
(Mus musculus)
Tspan311, 5 105
tetraspanin 311, 5 86.51(n)1
88.1(a)1
671251  NM_025982.21  NP_080258.11 
 AI8443215  AK0124575  (see all 20)
About this table        Species with no ortholog for TSPAN31

ENSEMBL Gene Tree for TSPAN31
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for TSPAN31 gene
TSPAN132  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/16 NCBI SNPs in TSPAN31 are shown (see all 16 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 63)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs32116381,2
A,C,F56427687(-) TATCCC/GTGATT 1 -- ut317Minor allele frequency- G:0.05NS 656
rs32116371,2
F,H56427755(-) GCTAAA/TCTTTC 1 -- ut31 ese32Minor allele frequency- T:0.01NS WA 286
rs283647021,2
F56425091(+) AGTATT/CGGGTT 1 -- ut512Minor allele frequency- C:0.02MN EA 1252
rs26406011,2
H56425957(+) TGCTGT/GTCTTT 1 V/F mis14Minor allele frequency- G:0.00EU EA WA 404
rs25186891,2
H56427733(+) TAATAA/GGCAGG 1 -- ut31 ese34Minor allele frequency- G:0.00EU EA WA 404
rs26405991,2
H56424899(+) TGTAGT/CCCCTA 1 -- ng511Minor allele frequency- C:0.00WA 120
--
rs115423231,2
--56425165(+) CCCCCA/CCAAGT 1 -- ut510--------
--
rs733382361,2
--56424367(+) TTTTGC/TAAGCC 1 -- ng510--------
rs28562911,2
--56424783(-) AGACGC/GCGGGA 1 -- ng510--------
--
rs619357441,2
--56424235(+) CGTGAA/GAAGGA 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for TSPAN31 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 181035

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/14 PubMed articles for TSPAN31 gene (see all 14 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6302 HGNC: 10539 AceView: SAS Ensembl:ENSG00000135452 euGenes: HUgn6302
ECgene: TSPAN31 H-InvDB: TSPAN31
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for TSPAN31 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TSPAN31:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TSPAN31-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for TSPAN31 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for TSPAN31 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (TSPAN31)
 Antibodies (TSPAN31)
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(Tetraspanin 13 + Tetraspanin 31)
 Antibodies (Tetraspanin 13 + Tetraspanin 31)
 Search OriGene for TSPAN31
 Search Tocris compounds for TSPAN31




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for TSPAN31

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TSPAN31 Gene at Home site.
Version 2.41.1
server5.xennexinc.com