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Aliases for SART3 Gene

Aliases for SART3 Gene

  • Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 2 3 5
  • Squamous Cell Carcinoma Antigen Recognized By T Cells 3 2 3
  • Tat-Interacting Protein Of 110 KDa 3 4
  • P110 Nuclear RNA-Binding Protein 3 4
  • SART-3 3 4
  • TIP110 3 4
  • Squamous Cell Carcinoma Antigen Recognised By T Cells 3 2
  • RP11-13G14 3
  • P110(Nrb) 3
  • KIAA0156 4
  • HSART-3 3
  • DSAP1 3
  • P100 3
  • P110 3

External Ids for SART3 Gene

Previous GeneCards Identifiers for SART3 Gene

  • GC12M108022
  • GC12M108797
  • GC12M107418
  • GC12M108915
  • GC12M105980

Summaries for SART3 Gene

Entrez Gene Summary for SART3 Gene

  • The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for SART3 Gene

SART3 (Squamous Cell Carcinoma Antigen Recognized By T-Cells 3) is a Protein Coding gene. Diseases associated with SART3 include Porokeratosis and Hiv-1. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for SART3 Gene

  • U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).

  • Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.

Gene Wiki entry for SART3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SART3 Gene

Genomics for SART3 Gene

Regulatory Elements for SART3 Gene

Enhancers for SART3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SART3 on UCSC Golden Path with GeneCards custom track

Promoters for SART3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SART3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SART3 Gene

Chromosome:
12
Start:
108,522,214 bp from pter
End:
108,561,400 bp from pter
Size:
39,187 bases
Orientation:
Minus strand

Genomic View for SART3 Gene

Genes around SART3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SART3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SART3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SART3 Gene

Proteins for SART3 Gene

  • Protein details for SART3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15020-SART3_HUMAN
    Recommended name:
    Squamous cell carcinoma antigen recognized by T-cells 3
    Protein Accession:
    Q15020
    Secondary Accessions:
    • A8K2E4
    • B7ZKM0
    • Q2M2H0
    • Q58F06
    • Q8IUS1
    • Q96J95

    Protein attributes for SART3 Gene

    Size:
    963 amino acids
    Molecular mass:
    109935 Da
    Quaternary structure:
    • Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3 (PubMed:15314151, PubMed:20595234). Interacts with USP15; the interaction is direct (PubMed:24526689). Interacts with HIV-1 Tat (PubMed:11959860).

    Three dimensional structures from OCA and Proteopedia for SART3 Gene

    Alternative splice isoforms for SART3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SART3 Gene

Proteomics data for SART3 Gene at MOPED

Post-translational modifications for SART3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SART3
  • Santa Cruz Biotechnology (SCBT) Antibodies for SART3

No data available for DME Specific Peptides for SART3 Gene

Domains & Families for SART3 Gene

Gene Families for SART3 Gene

Suggested Antigen Peptide Sequences for SART3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15020

UniProtKB/Swiss-Prot:

SART3_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 8 HAT repeats.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Similarity:
  • Contains 8 HAT repeats.
genes like me logo Genes that share domains with SART3: view

Function for SART3 Gene

Molecular function for SART3 Gene

UniProtKB/Swiss-Prot Function:
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).
UniProtKB/Swiss-Prot Function:
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.

Gene Ontology (GO) - Molecular Function for SART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0030621 NOT U4 snRNA binding IDA 15314151
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SART3: view
genes like me logo Genes that share phenotypes with SART3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SART3 Gene

Localization for SART3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SART3 Gene

Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SART3 Gene COMPARTMENTS Subcellular localization image for SART3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA 12578909
GO:0005737 cytoplasm IEA --
GO:0046540 NOT colocalizes_with U4/U6 x U5 tri-snRNP complex IDA 12032085
genes like me logo Genes that share ontologies with SART3: view

Pathways & Interactions for SART3 Gene

SuperPathways for SART3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000245 spliceosomal complex assembly IBA --
GO:0006396 RNA processing IEA --
GO:0010468 regulation of gene expression IDA 21447833
GO:0048872 homeostasis of number of cells IEA --
genes like me logo Genes that share ontologies with SART3: view

No data available for Pathways by source and SIGNOR curated interactions for SART3 Gene

Drugs & Compounds for SART3 Gene

No Compound Related Data Available

Transcripts for SART3 Gene

Unigene Clusters for SART3 Gene

Squamous cell carcinoma antigen recognized by T cells 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SART3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7:
SP8:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SART3 Gene

GeneLoc Exon Structure for
SART3
ECgene alternative splicing isoforms for
SART3

Expression for SART3 Gene

mRNA expression in normal human tissues for SART3 Gene

Protein differential expression in normal tissues from HIPED for SART3 Gene

This gene is overexpressed in Lymph node (12.3) and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SART3 Gene



SOURCE GeneReport for Unigene cluster for SART3 Gene Hs.584842

mRNA Expression by UniProt/SwissProt for SART3 Gene

Q15020-SART3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SART3: view

Protein tissue co-expression partners for SART3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SART3 Gene

Orthologs for SART3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SART3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SART3 35
  • 85.73 (n)
  • 89.78 (a)
SART3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SART3 35
  • 88.85 (n)
  • 91.59 (a)
SART3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sart3 35
  • 83.25 (n)
  • 87.3 (a)
Sart3 16
Sart3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SART3 35
  • 99.58 (n)
  • 99.79 (a)
SART3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sart3 35
  • 83.21 (n)
  • 86.62 (a)
oppossum
(Monodelphis domestica)
Mammalia SART3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves SART3 35
  • 72.45 (n)
  • 75.73 (a)
SART3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SART3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16344 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28982 35
sart3 35
  • 64.72 (n)
  • 63.11 (a)
sart3 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2898 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002959 35
  • 44.09 (n)
  • 31.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rnp4F 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0035.12 37
  • 26 (a)
B0035.12 35
  • 43.21 (n)
  • 30.63 (a)
B0035.12 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB140 35
  • 45.47 (n)
  • 35.16 (a)
rice
(Oryza sativa)
Liliopsida Os08g0113200 35
  • 46.43 (n)
  • 34.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
CSA.6126 36
  • 40 (a)
OneToMany
Species with no ortholog for SART3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SART3 Gene

ENSEMBL:
Gene Tree for SART3 (if available)
TreeFam:
Gene Tree for SART3 (if available)

Paralogs for SART3 Gene

No data available for Paralogs for SART3 Gene

Variants for SART3 Gene

Sequence variations from dbSNP and Humsavar for SART3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_038683 -
rs2287546 - 108,530,194(+) CGCTT(A/C)TCTGG reference, missense
VAR_038802 -
rs2032764 -- 108,536,333(+) AATAT(A/G)TGTCA intron-variant
rs2052423 -- 108,549,252(+) ACACC(A/G)TCATC intron-variant, upstream-variant-2KB

Variation tolerance for SART3 Gene

Residual Variation Intolerance Score: 3.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.17; 84.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SART3 Gene

Human Gene Mutation Database (HGMD)
SART3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SART3 Gene

Disorders for SART3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SART3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
porokeratosis
  • disseminated superficial actinic porokeratosis
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search SART3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SART3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SART3
genes like me logo Genes that share disorders with SART3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SART3 Gene

Publications for SART3 Gene

  1. A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis. (PMID: 15840095) Zhang Z.H. … Huang W. (Br. J. Dermatol. 2005) 2 3 4 23 67
  2. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (PMID: 20595234) Song E.J. … Rape M. (Genes Dev. 2010) 2 3
  3. Capability of SART3(109-118) peptide to induce cytotoxic T lymphocytes from prostate cancer patients with HLA class I-A11, -A31 and -A33 alleles. (PMID: 19148489) Mohamed E.R. … Noguchi M. (Int. J. Oncol. 2009) 3 23
  4. Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. (PMID: 15314151) Medenbach J. … Bindereif A. (Mol. Cell. Biol. 2004) 3 23
  5. Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. (PMID: 15452143) StanA9k D. … Neugebauer K.M. (J. Cell Biol. 2004) 3 23

Products for SART3 Gene

Sources for SART3 Gene

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