Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SART3 Gene

protein-coding   GIFtS: 55
GCID: GC12M108915

squamous cell carcinoma antigen recognized by T cells 3

(Previous name: squamous cell carcinoma antigen recognised by T cells 3...)
 Explore 11 diseases affiliated with
SART3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SART3    

Aliases
for SART3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Squamous Cell Carcinoma Antigen Recognized By T Cells 31 2     HSART-31
TIP1101 2 3 5     DSAP12 5
KIAA01561 3 5     P1002 5
RP11-13G141 2     Squamous Cell Carcinoma Antigen Recognised By T Cells 31
P1101     P110(Nrb)1
Tat-Interacting Protein Of 110 KDa2 3     Squamous Cell Carcinoma Antigen Recognized By T-Cells 32
SART-32 3     Tip1103

External Ids:    HGNC: 168601   Entrez Gene: 97332   Ensembl: ENSG000000758567   OMIM: 6116845   UniProtKB: Q150203   

Export aliases for SART3 gene to outside databases

Previous GC identifers: GC12M108022 GC12M108797 GC12M107418 GC12M105980


Summaries
for SART3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SART3:
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen
possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer
patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor
for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the
recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA
splicing. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
Function: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene
expression and viral replication

Gene Wiki entry for SART3


Genomic Views
for SART3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SART3 gene promoter:
         Pax-5   AML1a   NCX/Ncx   XBP-1   CUTL1   E4BP4   Evi-1   C/EBPalpha   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SART3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SART3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SART3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.11

SART3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SART3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M108915:  view genomic region     (about GC identifiers)

Start:
 108,915,991 bp from pter      End:
 108,955,176 bp from pter
Size:
 39,186 bases      Orientation:
 minus strand

Proteins
for SART3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020 (See protein sequence)
Recommended Name: Squamous cell carcinoma antigen recognized by T-cells 3  
Size: 963 amino acids; 109935 Da
Subunit: Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1,
HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with HIV-1 Tat. Interacts with EIF2C1 and EIF2C2
Subcellular location: Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of the
malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell
carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus
of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all
the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and
the fetal liver
1 PDB 3D structure from and Proteopedia for SART3:
2DO4 (3D)    
Secondary accessions: A8K2E4 Q2M2H0 Q58F06 Q8IUS1 Q96J95
Alternative splicing: 3 isoforms:  Q15020-1   Q15020-2   Q15020-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SART3: NX_Q15020

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15020

    • SART3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055521.1  
    ENSEMBL proteins: 
     ENSP00000228284   ENSP00000449743   ENSP00000414453   ENSP00000447875   ENSP00000449386  
     ENSP00000446577   ENSP00000447324   ENSP00000449602   ENSP00000448554  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SART3
    OriGene Protein Over-expression Lysate: SART3
    OriGene Custom Protein Services for SART3 
    GenScript Custom Purified and Recombinant Proteins Services for SART3
    Novus Biologicals SART3 Protein
    Novus Biologicals SART3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SART3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    SART3 for ontologies           About GeneDecksing



    SART3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: SART3
    OriGene Custom Antibody Services for SART3 
    GenScript Custom Superior Antibodies Services for SART3
    Novus Biologicals SART3 Antibodies
    Search for Antibodies for SART3 at Abcam  
    Uscn Antibodies for SART3
    ThermoFisher Antibodies for SART3

    Assay Products for SART3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SART3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SART3

    Protein Domains /
    Families
    for SART3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SART3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008669 LSM_interact
     IPR003107 HAT
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q15020

    ProtoNet protein and cluster: Q15020

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
    Similarity: Contains 8 HAT repeats
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for SART3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
    Function: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene
    expression and viral replication

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SART3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SART3
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SART3 (see all 15):
    hsa-miR-3163 hsa-miR-3910 hsa-miR-16-2* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-1911 hsa-miR-3175 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmid: SART3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SART3 (see all 7)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SART3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SART3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SART3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SART3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SART3 (NM_014706)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SART3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SART3
    Search LifeMap BioReagents cell lines for SART3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI11477570


    SART3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SART3:
     Increased circadian period len 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sart3):
     hematopoietic system 

    SART3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SART3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SART3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/224 Interacting proteins for SART3 (Q150201, 2, 3 ENSP000002282844) via UniProtKB, MINT, STRING, and/or I2D (see all 224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGO1Q9UL182, ENSP000003623004MINT-6167588 MINT-6488590 MINT-6488488 MINT-6488791 STRING: ENSP00000362300
    DDX47Q9H0S42, 3, ENSP000003506984MINT-6488791 I2D: score=2 STRING: ENSP00000350698
    RNPS1Q152871, 3, ENSP000003158594EBI-308619,EBI-395959 I2D: score=4 STRING: ENSP00000315859
    COILP384322, 3, ENSP000002403164MINT-2867369 I2D: score=3 STRING: ENSP00000240316
    EEF1A1P681042MINT-6488590 MINT-6488488 MINT-6488791
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--


    SART3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SART3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SART3
    Search CenterWatch for drugs/clinical trials and news about SART3 

    Transcripts
    for SART3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SART3 gene: 
    NM_014706.3  

    Unigene Cluster for SART3:

    Squamous cell carcinoma antigen recognized by T cells 3
    Hs.584842  [show with all ESTs]
    Unigene Representative Sequence: CR933631
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228284(uc001tmy.1 uc001tmz.1 uc009zux.1 uc010swx.1 uc010swy.1 uc010swz.1 uc001tna.1)
    ENST00000546728 ENST00000431469 ENST00000547397 ENST00000546815 ENST00000548582
    ENST00000547528 ENST00000547196 ENST00000546808 ENST00000548077 ENST00000548119
    ENST00000550322 ENST00000551416 ENST00000550619 ENST00000552221 ENST00000546611(uc001tnb.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SART3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SART3
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SART3 (see all 15):
    hsa-miR-3163 hsa-miR-3910 hsa-miR-16-2* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-1911 hsa-miR-3175 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmid: SART3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SART3 (see all 7)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SART3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SART3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SART3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SART3 (NM_014706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SART3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SART3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SART3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SART3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SART3

    Additional cDNA sequence: 

    AB020880.1 AB073647.1 AF387506.1 AK225174.1 AK290209.1 AK299250.1 AK302332.1 AK304834.1 
    BC004547.2 BC015627.1 BC024279.1 BC032601.1 BC041638.1 BC093784.1 BC103706.1 BC111983.1 
    BC143253.1 CR933631.1 D63879.1 

    19 DOTS entries:

    DT.95342618  DT.118059  DT.121160638  DT.101984206  DT.95197858  DT.121160514  DT.95342607  DT.100826442 
    DT.100685596  DT.121160594  DT.92438901  DT.95342608  DT.95342615  DT.100826441  DT.91812395  DT.95179052 
    DT.91731475  DT.91750780  DT.95347539 

    24/288 AceView cDNA sequences (see all 288):

    BU787586 AA332427 BQ223392 AI911478 AA489028 CB243522 D63879 N91769 
    AI337586 BM795038 BQ231651 AI765778 BU783860 BM680987 AA743370 BX486106 
    AI250648 AI769307 AW471049 AA973581 BI861041 BU680667 BG057923 R81169 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SART3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                                                  -     -                       -           -           -                                                   
    SP2:                                                  -     -                       -                       -                                                   
    SP3:                                                  -     -                                               -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b
    SP1:                                -               
    SP2:                                -               
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SART3

    Expression
    for SART3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SART3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAAATGCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SART3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SART3

    SOURCE GeneReport for Unigene cluster: Hs.584842

    UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for SART3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SART3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SART3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SART3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SART3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART3

    Orthologs
    for SART3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SART3 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sart31 , 5 squamous cell carcinoma antigen recognized by T cells more1, 5 83.25(n)1
    87.3(a)1    		   5 (55.55 cM)5
    538901  NM_016926.11  NP_058622.11 
     1137424465 
    chicken
    (Gallus gallus)    		 Aves SART31 squamous cell carcinoma antigen recognized by T cells more 72.63(n)
    75.95(a)    		   416890  XM_415181.3  XP_415181.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SART36
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343913.1(90473-120423)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.163442 Transcribed sequence with moderate similarity to protein more 74.36(n)    137694461 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.289822 Transcribed sequence with weak similarity to protein more 75.48(n)    CK029635.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rnp4F1 RNA-binding protein 4F 40.61(n)
    23.74(a)    		   31448  NM_001103414.2  NP_001096884.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0035.121 , 3 polyadenylate-binding protein like3
    Protein B0035.121    		 26(a)3
    43.25(n)1
    30.62(a)1    		   IV(11329938-11333045)3
    1780531  NM_069735.41  NP_502136.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons EMB1401 protein embryo defective 140 44.31(n)
    33.53(a)    		   828529  NM_179220.1  NP_849551.1 
    rice
    (Oryza sativa)    		 Liliopsida Os08g01132001 hypothetical protein 46.37(n)
    33.14(a)    		   4344498  NM_001067373.1  NP_001060838.1 


    ENSEMBL Gene Tree for SART3 (if available)
    TreeFam Gene Tree for SART3 (if available) 

    Paralogs
    for SART3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SART3 gene
    RBM192  NCL2  

    SART3 for paralogs           About GeneDecksing



    Genomic Variants
    for SART3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/750 NCBI SNPs in SART3 are shown (see all 750)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs111139731,2
    		C,F,A,H,--105980200(+) CCGCCG/ACTTGA 1 -- ds50016Minor allele frequency- A:0.03NS EA NA WA 542
    rs111139741,2
    		C,F,A,H,--105980201(+) CGCCGC/ATTGAA 1 -- ds50012Minor allele frequency- A:0.10NA WA 122
    rs801808061,2
    		F,--105980236(+) AAAAAG/ATTGGT 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs789882991,2
    		F,--105981097(+) AAAACC/TAAAGG 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs734027411,2
    		C,--105981337(+) ACCCCC/TACAAG 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs799335591,2
    		F,--105981348(+) AGGCCA/TTTCTG 1 -- ut311Minor allele frequency- T:0.05EA 120
    rs1156609091,2
    		C,F,--105981509(+) CGTTTC/TGCTTC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1140348341,2
    		C,F,--105981581(+) AGAGTG/TGTCAC 1 -- ut311Minor allele frequency- T:0.05WA 118
    rs1134036621,2
    		C--105981970(+) CCCTCG/CTAAAA 1 -- spa11Minor allele frequency- C:0.00CSA 1
    rs757197181,2
    		--105982959(+) CAAACG/AACCCA 1 -- int11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for SART3 (108915991 - 108955176 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SART3: --
    Human Gene Mutation Database (HGMD): SART3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SART3
    DNA2.0 Custom Variant and Variant Library Synthesis for SART3

    Disorders / Diseases
    for SART3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SART3 for disorders           About GeneDecksing

    OMIM gene information: 611684   
    OMIM disorders: 175900  
    UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
  • Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900].
    • DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a
    slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin

    11 diseases for SART3:    About MalaCards
    porokeratosis, disseminated superficial actinic 1    squamous cell carcinoma    porokeratosis    carcinoma
    renal cell carcinoma    keratosis    bladder carcinoma    prostate cancer
    ataxia    prostatitis    immunodeficiency

    1 disease from the University of Copenhagen DISEASES database for SART3:
    Keratosis

    2 Novoseek disease relationships for SART3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 30.3 3 11092984 (1), 15010873 (1), 10761712 (1)
    tumors 8.65 10 15010873 (4), 11061933 (3), 11398844 (2), 11092984 (1)


    Export disorders for SART3 gene to outside databases

    Publications
    for SART3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SART3 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with SART3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis. (PubMed id 15840095)1, 2, 3, 9 Zhang Z.H.... Huang W. (2005)
    2. Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. (PubMed id 10463607)1, 2, 9 Yang D.... Itoh K. (1999)
    3. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (PubMed id 20595234)1, 3 Song E.J....Rape M. (2010)
    4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. (PubMed id 12032085)1, 3 Bell M....Bindereif A. (2002)
    8. HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. (PubMed id 11959860)1, 2 Liu Y.... He J.J. (2002)
    9. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
    10. Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. (PubMed id 10761712)1, 9 Harada K....Itoh K. (2000)

    External Searches for SART3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SART3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9733 HGNC: 16860 AceView: SART3 Ensembl:ENSG00000075856 euGenes: HUgn9733
    ECgene: SART3 H-InvDB: SART3

    Other Databases showing SART3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0156

    Specialized Databases showing SART3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SART3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SART3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SART3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SART3 gene:
    Search GeneIP for patents involving SART3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SART3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SART3   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SART3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SART3  
     OriGene Protein Over-expression Lysate for SART3   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for SART3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SART3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SART3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SART3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SART3   OriGene Custom Protein Services for SART3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SART3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SART3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SART3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SART3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SART3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SART3
     GenScript Custom Purified and Recombinant Proteins Services for SART3 GenScript cDNA clones with any tag delivered in your preferred vector for SART3
     GenScript Custom Assay Services for SART3 GenScript Custom Superior Antibodies Services for SART3
     GenScript Custom overexpressing Cell Line Services for SART3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SART3 promoter
     Search Chromatin IP Primers for SART3
     RT2 qPCR Primer Assay in human, mouse, rat SART3
     GNC Network for SART3
     SABiosciences Custom PCR Arrays for SART3
     Search Tocris compounds for SART3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SART3 antibodies
     SART3 proteins
     SART3 lysates
     Search for Antibodies for SART3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SART3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SART3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SART3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART3
     SwitchGear 3'UTR luciferase reporter plasmids for SART3
     SwitchGear Promoter luciferase reporter plasmids for SART3
     ThermoFisher Antibodies for SART3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SART3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4