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Aliases for SART3 Gene

Aliases for SART3 Gene

  • Squamous Cell Carcinoma Antigen Recognized By T Cells 3 2 3
  • TIP110 3 4 6
  • Tat-Interacting Protein Of 110 KDa 3 4
  • P110 Nuclear RNA-Binding Protein 3 4
  • KIAA0156 4 6
  • SART-3 3 4
  • DSAP1 3 6
  • P100 3 6
  • Squamous Cell Carcinoma Antigen Recognised By T Cells 3 2
  • Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 3
  • RP11-13G14 3
  • P110(Nrb) 3
  • HSART-3 3
  • P110 3

External Ids for SART3 Gene

Previous GeneCards Identifiers for SART3 Gene

  • GC12M108022
  • GC12M108797
  • GC12M107418
  • GC12M108915
  • GC12M105980

Summaries for SART3 Gene

Entrez Gene Summary for SART3 Gene

  • The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for SART3 Gene

SART3 (Squamous Cell Carcinoma Antigen Recognized By T Cells 3) is a Protein Coding gene. Diseases associated with SART3 include porokeratosis 3, disseminated superficial actinic and porokeratosis. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for SART3 Gene

  • U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).

  • Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.

Gene Wiki entry for SART3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SART3 Gene

Genomics for SART3 Gene

Regulatory Elements for SART3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SART3 Gene

Start:
108,522,214 bp from pter
End:
108,561,400 bp from pter
Size:
39,187 bases
Orientation:
Minus strand

Genomic View for SART3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SART3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SART3 Gene

Proteins for SART3 Gene

  • Protein details for SART3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15020-SART3_HUMAN
    Recommended name:
    Squamous cell carcinoma antigen recognized by T-cells 3
    Protein Accession:
    Q15020
    Secondary Accessions:
    • A8K2E4
    • B7ZKM0
    • Q2M2H0
    • Q58F06
    • Q8IUS1
    • Q96J95

    Protein attributes for SART3 Gene

    Size:
    963 amino acids
    Molecular mass:
    109935 Da
    Quaternary structure:
    • Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs (PubMed:17643375). Interacts with AGO1 and AGO2 (PubMed:17932509). Interacts with PRPF3 and USP4; the interaction with PRPF3 is direct and recruits USP4 to its substrate PRPF3 (PubMed:15314151, PubMed:20595234). Interacts with USP15; the interaction is direct (PubMed:24526689). Interacts with HIV-1 Tat (PubMed:11959860).

    Three dimensional structures from OCA and Proteopedia for SART3 Gene

    Alternative splice isoforms for SART3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SART3 Gene

Proteomics data for SART3 Gene at MOPED

Post-translational modifications for SART3 Gene

  • Ubiquitination at Lys568
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SART3 Gene

Domains for SART3 Gene

Gene Families for SART3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for SART3 Gene

Suggested Antigen Peptide Sequences for SART3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15020

UniProtKB/Swiss-Prot:

SART3_HUMAN :
  • Q15020
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Similarity:
  • Contains 8 HAT repeats.
genes like me logo Genes that share domains with SART3: view

Function for SART3 Gene

Molecular function for SART3 Gene

UniProtKB/Swiss-Prot Function: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).
UniProtKB/Swiss-Prot Function: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.

Gene Ontology (GO) - Molecular Function for SART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 11477570
GO:0017070 NOT U6 snRNA binding IDA 15314151
GO:0030621 NOT U4 snRNA binding IDA 15314151
genes like me logo Genes that share ontologies with SART3: view

Phenotypes for SART3 Gene

MGI mutant phenotypes for SART3:
inferred from 1 alleles
GenomeRNAi human phenotypes for SART3:
genes like me logo Genes that share phenotypes with SART3: view

Animal Model Products

CRISPR Products

miRNA for SART3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SART3 Gene

Localization for SART3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SART3 Gene

Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SART3 Gene COMPARTMENTS Subcellular localization image for SART3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 24526689
GO:0005654 nucleoplasm IDA 12578909
GO:0005691 colocalizes_with U6atac snRNP IDA 14749385
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SART3: view

Pathways for SART3 Gene

SuperPathways for SART3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly IDA 12032085
GO:0000387 NOT spliceosomal snRNP assembly IDA 15314151
GO:0000398 mRNA splicing, via spliceosome IDA 15314151
GO:0000902 cell morphogenesis IEA --
GO:0006334 nucleosome assembly IDA 24526689
genes like me logo Genes that share ontologies with SART3: view

No data available for Pathways by source for SART3 Gene

Transcripts for SART3 Gene

Unigene Clusters for SART3 Gene

Squamous cell carcinoma antigen recognized by T cells 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SART3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SART3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7:
SP8:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SART3 Gene

GeneLoc Exon Structure for
SART3
ECgene alternative splicing isoforms for
SART3

Expression for SART3 Gene

mRNA expression in normal human tissues for SART3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SART3 Gene

SOURCE GeneReport for Unigene cluster for SART3 Gene Hs.584842

mRNA Expression by UniProt/SwissProt for SART3 Gene

Q15020-SART3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SART3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SART3 Gene

Orthologs for SART3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SART3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SART3 35
  • 99.58 (n)
  • 99.79 (a)
SART3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SART3 35
  • 85.73 (n)
  • 89.78 (a)
SART3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SART3 35
  • 88.85 (n)
  • 91.59 (a)
SART3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sart3 35
  • 83.25 (n)
  • 87.3 (a)
Sart3 16
Sart3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SART3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sart3 35
  • 83.21 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves SART3 35
  • 72.45 (n)
  • 75.73 (a)
SART3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SART3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16344 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2898 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28982 35
sart3 35
  • 64.72 (n)
  • 63.11 (a)
sart3 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002959 35
  • 44.09 (n)
  • 31.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rnp4F 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0035.12 35
  • 43.21 (n)
  • 30.63 (a)
B0035.12 36
  • 28 (a)
OneToOne
B0035.12 37
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB140 35
  • 45.47 (n)
  • 35.16 (a)
rice
(Oryza sativa)
Liliopsida Os08g0113200 35
  • 46.43 (n)
  • 34.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
CSA.6126 36
  • 40 (a)
OneToMany
Species with no ortholog for SART3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SART3 Gene

ENSEMBL:
Gene Tree for SART3 (if available)
TreeFam:
Gene Tree for SART3 (if available)

Paralogs for SART3 Gene

No data available for Paralogs for SART3 Gene

Variants for SART3 Gene

Sequence variations from dbSNP and Humsavar for SART3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703691 -- 108,522,900(+) AACAA(G/T)GGCTG utr-variant-3-prime
rs715447 -- 108,552,942(-) ttgta(C/G)gtttt intron-variant
rs888555 -- 108,542,708(+) tcata(A/G)cttgt intron-variant
rs888556 -- 108,542,740(+) GGAAT(G/T)ATCAT intron-variant
rs888557 -- 108,542,743(+) ATTAT(C/T)ATCAC intron-variant

Relevant External Links for SART3 Gene

HapMap Linkage Disequilibrium report
SART3
Human Gene Mutation Database (HGMD)
SART3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SART3 Gene

Disorders for SART3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SART3 Gene including...

Search for SART3 Gene in MalaCards »

(1) OMIM Diseases for SART3 Gene (611684)

UniProtKB/Swiss-Prot

SART3_HUMAN
  • Disseminated superficial actinic porokeratosis 1 (DSAP1) [MIM:175900]: Autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin. {ECO:0000269 PubMed:15840095}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SART3 Gene

(2) Novoseek inferred disease relationships for SART3 Gene

Disease -log(P) Hits PubMed IDs
cancer 30.3 3
tumors 8.65 10
genes like me logo Genes that share disorders with SART3: view

Publications for SART3 Gene

  1. A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis. (PMID: 15840095) Zhang Z.H. … Huang W. (Br. J. Dermatol. 2005) 2 3 4 23
  2. Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. (PMID: 15314151) Medenbach J. … Bindereif A. (Mol. Cell. Biol. 2004) 3 4 23
  3. Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. (PMID: 10463607) Yang D. … Itoh K. (Cancer Res. 1999) 3 4 23
  4. p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. (PMID: 12032085) Bell M. … Bindereif A. (EMBO J. 2002) 2 3 4
  5. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (PMID: 20595234) Song E.J. … Rape M. (Genes Dev. 2010) 2 3 4

Products for SART3 Gene

Sources for SART3 Gene

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