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SART3 Gene

protein-coding   GIFtS: 58
GCID: GC12M108915

Squamous Cell Carcinoma Antigen Recognized By T Cells 3

(Previous name: squamous cell carcinoma antigen recognised by T cells 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Squamous Cell Carcinoma Antigen Recognized By T Cells 31 2     KIAA01563 5
TIP1102 3 5     Squamous Cell Carcinoma Antigen Recognised By T Cells 31
Tat-Interacting Protein Of 110 KDa2 3     RP11-13G142
SART-32 3     p1102
hSART-32 3     p110(nrb)2
DSAP12 5     Squamous Cell Carcinoma Antigen Recognized By T-Cells 32
P1002 5     Tip1103

External Ids:    HGNC: 168601   Entrez Gene: 97332   Ensembl: ENSG000000758567   OMIM: 6116845   UniProtKB: Q150203   

Export aliases for SART3 gene to outside databases

Previous GC identifers: GC12M108022 GC12M108797 GC12M107418 GC12M105980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SART3 Gene:
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen
possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in
cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important
cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6
snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the
regulation of mRNA splicing. (provided by RefSeq, Jul 2008)

GeneCards Summary for SART3 Gene:
SART3 (squamous cell carcinoma antigen recognized by T cells 3) is a protein-coding gene. Diseases associated with SART3 include porokeratosis, and porokeratosis, disseminated superficial actinic 1. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
Function: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1
gene expression and viral replication

Gene Wiki entry for SART3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SART3 gene promoter:
         Pax-5   AML1a   NCX/Ncx   XBP-1   CUTL1   E4BP4   Evi-1   C/EBPalpha   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSART3 promoter sequence
   Search Chromatin IP Primers for SART3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SART3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.11

SART3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SART3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M108915:  view genomic region     (about GC identifiers)

Start:
108,915,991 bp from pter      End:
108,955,176 bp from pter
Size:
39,186 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020 (See protein sequence)
Recommended Name: Squamous cell carcinoma antigen recognized by T-cells 3  
Size: 963 amino acids; 109935 Da
Subunit: Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1),
HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with HIV-1 Tat. Interacts with AGO1 and
AGO2
1 PDB 3D structure from and Proteopedia for SART3:
2DO4 (3D)    
Secondary accessions: A8K2E4 Q2M2H0 Q58F06 Q8IUS1 Q96J95
Alternative splicing: 3 isoforms:  Q15020-1   Q15020-2   Q15020-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SART3: NX_Q15020

Explore proteomics data for SART3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys568
  • Modification sites at PhosphoSitePlus

  • See SART3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055521.1  
    ENSEMBL proteins: 
     ENSP00000228284   ENSP00000449743   ENSP00000414453   ENSP00000447875   ENSP00000449386  
     ENSP00000446577   ENSP00000447324   ENSP00000449602   ENSP00000448554  

    SART3 Human Recombinant Protein Products:

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    Novus Biologicals SART3 Protein
    Novus Biologicals SART3 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SART3

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    Cloud-Clone Corp. CLIAs for SART3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR008669 LSM_interact
     IPR012677 Nucleotide-bd_a/b_plait
     IPR003107 HAT
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q15020

    ProtoNet protein and cluster: Q15020

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
    Similarity: Contains 8 HAT repeats
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    SART3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SART3_HUMAN, Q15020
    Function: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1
    gene expression and viral replication

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI11477570
    GO:0044822poly(A) RNA binding IDA--
         
    SART3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SART3:
     Increased circadian period len 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sart3):
     hematopoietic system 

    SART3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SART3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SART3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SART3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SART3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SART3:
    hsa-mir-92a-3p (MIRT049146), hsa-let-7g-5p (MIRT046568), hsa-mir-378a-5p (MIRT043962), hsa-let-7f-5p (MIRT051408)

    Block miRNA regulation of human, mouse, rat SART3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SART3 (see all 15):
    hsa-miR-3163 hsa-miR-3910 hsa-miR-16-2* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-1911 hsa-miR-3175 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidSART3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SART3
    Predesigned siRNA for gene silencing in human, mouse, rat SART3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SART3 (see all 7)
    OriGene ORF clones in mouse, rat for SART3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SART3 (NM_014706)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SART3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SART3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SART3_HUMAN, Q15020: Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of
    the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including
    squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is
    undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis.
    Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in
    normal tissues, except for the testis and the fetal liver
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    SART3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SART3
    Interactions:

        GeneGlobe Interaction Network for SART3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SART3 (Q150201, 2, 3 ENSP000002282844) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=2 STRING: ENSP00000414634
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=2 STRING: ENSP00000414006
    ENSG00000172850Q9Y3333I2D: score=2 
    ENSG00000225998Q9Y3333I2D: score=2 
    ENSG00000231502Q9Y3333I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--
    GO:0010468regulation of gene expression IDA--

    SART3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SART3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SART3 gene: 
    NM_014706.3  

    Unigene Cluster for SART3:

    Squamous cell carcinoma antigen recognized by T cells 3
    Hs.584842  [show with all ESTs]
    Unigene Representative Sequence: CR933631
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228284(uc001tmy.1 uc001tmz.1 uc009zux.1 uc010swx.1 uc010swy.1 uc010swz.1 uc001tna.1)
    ENST00000546728 ENST00000431469 ENST00000547397 ENST00000546815 ENST00000548582
    ENST00000547528 ENST00000547196 ENST00000546808 ENST00000548077 ENST00000548119
    ENST00000550322 ENST00000551416 ENST00000550619 ENST00000552221 ENST00000546611(uc001tnb.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat SART3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SART3 (see all 15):
    hsa-miR-3163 hsa-miR-3910 hsa-miR-16-2* hsa-miR-4328 hsa-miR-520d-5p hsa-miR-1911 hsa-miR-3175 hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidSART3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SART3
    Predesigned siRNA for gene silencing in human, mouse, rat SART3
    Clone
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    OriGene clones in human, mouse for SART3 (see all 7)
    OriGene ORF clones in mouse, rat for SART3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SART3 (NM_014706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SART3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART3
    Primer
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    OriGene qPCR primer pairs and template standards for SART3
    OriGene qSTAR qPCR primer pairs in human, mouse for SART3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SART3
      QuantiTect SYBR Green Assays in human, mouse, rat SART3
      QuantiFast Probe-based Assays in human, mouse, rat SART3

    Additional mRNA sequence: 

    AB020880.1 AB073647.1 AF387506.1 AK225174.1 AK290209.1 AK299250.1 AK302332.1 AK304834.1 
    BC004547.2 BC015627.1 BC024279.1 BC032601.1 BC041638.1 BC093784.1 BC103706.1 BC111983.1 
    BC143253.1 CR933631.1 D63879.1 

    19 DOTS entries:

    DT.95342618  DT.118059  DT.121160638  DT.101984206  DT.95197858  DT.121160514  DT.95342607  DT.100826442 
    DT.100685596  DT.121160594  DT.92438901  DT.95342608  DT.95342615  DT.100826441  DT.91812395  DT.95179052 
    DT.91731475  DT.91750780  DT.95347539 

    Selected AceView cDNA sequences (see all 288):

    AI911478 AI769307 BX486106 AI337586 AA973581 BG057923 AA743370 AA332427 
    CB243522 D63879 BM795038 BU787586 N91769 BM725979 BU680667 BU078039 
    BF968380 AA489028 BE739868 AA091693 BQ215978 T84835 CB529576 AU131500 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SART3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                                                  -     -                       -           -           -                                                   
    SP2:                                                  -     -                       -                       -                                                   
    SP3:                                                  -     -                                               -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b
    SP1:                                -               
    SP2:                                -               
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SART3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SART3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAATGCAA
    SART3 Expression
    About this image

    SART3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SART3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584842

    UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for SART3
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    QuantiTect SYBR Green Assays in human, mouse, rat SART3
    QuantiFast Probe-based Assays in human, mouse, rat SART3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SART3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sart31 , 5 squamous cell carcinoma antigen recognized by T cells more1, 5 83.25(n)1
    87.3(a)1
      5 (55.55 cM)5
    538901  NM_016926.11  NP_058622.11 
     1137424465 
    chicken
    (Gallus gallus)
    Aves SART31 squamous cell carcinoma antigen recognized by T cells more 72.45(n)
    75.73(a)
      416890  XM_004945611.1  XP_004945668.1 
    lizard
    (Anolis carolinensis)
    Reptilia SART36
    squamous cell carcinoma antigen recognized by T ce...
    64(a)
    1 ↔ 1
    GL343913.1(90259-121649)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.163442 Transcribed sequence with moderate similarity to protein more 74.36(n)    137694461 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.289822 Transcribed sequence with weak similarity to protein more 75.48(n)    CK029635.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rnp4F6
    RNA-binding protein 4F
    17(a)
    1 ↔ 1
    X(5212961-5216759)
    worm
    (Caenorhabditis elegans)
    Secernentea B0035.121 , 3 polyadenylate-binding protein like3
    B0035.121
    26(a)3
    43.21(n)1
    30.63(a)1
      IV(11329938-11333045)3
    1780531  NM_069735.51  NP_502136.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB1401 EMB140 45.47(n)
    35.16(a)
      828529  NM_118560.3  NP_194158.3 
    rice
    (Oryza sativa)
    Liliopsida Os08g01132001 Os08g0113200 46.43(n)
    34.59(a)
      4344498  NM_001067373.1  NP_001060838.1 


    ENSEMBL Gene Tree for SART3 (if available)
    TreeFam Gene Tree for SART3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SART3 (see all 936)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0386834
    Disseminated superficial actinic porokeratosis 1 (DSAP1)4--see VAR_0386832 V M mis40--------
    rs1182039541,2
    Cunknown1108765568(-) CCCTTA/GTGCAG 2 M V mis10--------
    rs349829441,2
    C--105982078(+) AAAAA-/AGGATA 1 -- int10--------
    rs32173091,2
    C--105982995(-) GACAG-/AGGATGC 1 -- int10--------
    rs15490971,2
    C--105989974(+) CTTTGC/AAAGCC 1 -- int12Minor allele frequency- A:0.25NA 4
    rs15490981,2
    C--105989975(+) TTTGCA/TAGCCA 1 -- int12Minor allele frequency- T:0.25NA 4
    rs15490991,2
    C--105989976(+) TTGCAT/AGCCAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs353471361,2
    C--105998492(+) ATCTT-/AAAAAG 1 -- int10--------
    rs360654811,2
    C--105998979(+) AAAAA-/AGCCAA 1 -- int10--------
    rs354563441,2
    C--106010804(+) AAAAA-/ACTCCA 1 -- int11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for SART3 (108915991 - 108955176 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SART3: --
    Human Gene Mutation Database (HGMD): SART3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SART3
    DNA2.0 Custom Variant and Variant Library Synthesis for SART3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611684   
    OMIM disorders: 175900  
    UniProtKB/Swiss-Prot: SART3_HUMAN, Q15020
  • Disseminated superficial actinic porokeratosis 1 (DSAP1) [MIM:175900]: Autosomal dominant disorder,
    characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border,
    developing during the third or fourth decade of life on sun-exposed areas of skin. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 17 diseases for SART3:    
    About MalaCards
    porokeratosis    porokeratosis, disseminated superficial actinic 1    squamous cell carcinoma    hiv-1
    keratosis    bladder carcinoma    brain cancer    renal cell carcinoma
    ataxia    multiple myeloma    melanoma    myeloma
    prostate cancer    adenocarcinoma    prostatitis    leukemia
    malaria

    1 disease from the University of Copenhagen DISEASES database for SART3:
    Keratosis

    SART3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SART3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 30.3 3 11092984 (1), 15010873 (1), 10761712 (1)
    tumors 8.65 10 15010873 (4), 11061933 (3), 11398844 (2), 11092984 (1)


    Export disorders for SART3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SART3 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with SART3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis. (PubMed id 15840095)1, 2, 3, 9 Zhang Z.H.... Huang W. (Br. J. Dermatol. 2005)
    2. Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. (PubMed id 10463607)1, 2, 9 Yang D.... Itoh K. (Cancer Res. 1999)
    3. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. (PubMed id 20595234)1, 3 Song E.J....Rape M. (amp 2010)
    4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1, 2 Jeronimo C.... Coulombe B. (Mol. Cell 2007)
    5. Proteomic and functional analysis of Argonaute-containing mRNA- protein complexes in human cells. (PubMed id 17932509)1, 2 Hoeck J.... Meister G. (EMBO Rep. 2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. (PubMed id 11959860)1, 2 Liu Y.... He J.J. (J. Biol. Chem. 2002)
    9. p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. (PubMed id 12032085)1, 3 Bell M....Bindereif A. (EMBO J. 2002)
    10. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9733 HGNC: 16860 AceView: SART3 Ensembl:ENSG00000075856 euGenes: HUgn9733
    ECgene: SART3 H-InvDB: SART3

    (According to HUGE)
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    HUGE: KIAA0156

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SART3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SART3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SART3 gene:
    Search GeneIP for patents involving SART3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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