Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SART1 Gene

protein-coding   GIFtS: 63
GCID: GC11P065730

Squamous Cell Carcinoma Antigen Recognized By T Cells

(Previous name: squamous cell carcinoma antigen recognised by T cells)
  See SART1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Squamous Cell Carcinoma Antigen Recognized By T Cells1 2     Ara12
Squamous Cell Carcinoma Antigen Recognised By T Cells1 2     SART12592
Small Nuclear Ribonucleoprotein 110kDa (U4/U6.U5)1 2     SNRNP1102
Squamous Cell Carcinoma Antigen Recognized By T-Cells 12 3     Snu662
SART-12 3     IgE Autoantigen2
hSART-12 3     SART1(259) Protein2
hSnu662 3     SART1(800) Protein2
SNU66 Homolog2 3     Squamous Cell Carcinoma Antigen Recognized By T Cells 12
U4/U6.U5 Tri-SnRNP-Associated 110 KDa Protein2 3     U4/U6.U5 Tri-SnRNP-Associated Protein 12
HOMS12 5     Allergen Hom S 13

External Ids:    HGNC: 105381   Entrez Gene: 90922   Ensembl: ENSG000001754677   OMIM: 6059415   UniProtKB: O432903   

Export aliases for SART1 gene to outside databases

Previous GC identifers: GC11P068263 GC11P067410 GC11P065979 GC11P065504 GC11P065485 GC11P062055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SART1 Gene:
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating
cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is
translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence
is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation.
Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing
HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in
specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment
of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to
the pre-spliceosome in the spliceosome assembly pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for SART1 Gene:
SART1 (squamous cell carcinoma antigen recognized by T cells) is a protein-coding gene. Diseases associated with SART1 include atopy.

UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
Function: Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of
the spliceosome. May also bind to DNA

Gene Wiki entry for SART1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SART1 gene promoter:
         STAT1   STAT1beta   STAT1alpha   YY1   Max   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSART1 promoter sequence
   Search Chromatin IP Primers for SART1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SART1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SART1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SART1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065730:  view genomic region     (about GC identifiers)

Start:
65,729,160 bp from pter      End:
65,747,607 bp from pter
Size:
18,448 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290 (See protein sequence)
Recommended Name: U4/U6.U5 tri-snRNP-associated protein 1  
Size: 800 amino acids; 90255 Da
Subunit: Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4,
U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH,
NHP2L1, EFTUD2, SART1 and USP39
Allergen: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as
an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations
Secondary accessions: A6NDN1 Q53GB5
Alternative splicing: 1 isoform:  O43290-1   

Explore the universe of human proteins at neXtProt for SART1: NX_O43290

Explore proteomics data for SART1 at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO21
  • Ubiquitination2 at Lys129, Lys648
  • Modification sites at PhosphoSitePlus

  • See SART1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005137.1  
    ENSEMBL proteins: 
     ENSP00000310448   ENSP00000436218  

    SART1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SART1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SART1
    GenScript Custom Purified and Recombinant Proteins Services for SART1
    Novus Biologicals SART1 Proteins
    Novus Biologicals SART1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SART1

     
    Search eBioscience for Proteins for SART1 

    SART1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SART1
    OriGene Antibodies for SART1
    OriGene Custom Antibody Services for SART1
    Novus Biologicals SART1 Antibodies
    Abcam antibodies for SART1
    Cloud-Clone Corp. Antibodies for SART1
    ThermoFisher Antibody for SART1
    LSBio Antibodies in human, mouse, rat for SART1

    SART1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SART1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SART1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SART1
    Cloud-Clone Corp. CLIAs for SART1
    Search eBioscience for ELISAs for SART1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR005011 SART_1

    Graphical View of Domain Structure for InterPro Entry O43290

    ProtoNet protein and cluster: O43290

    UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
    Similarity: Belongs to the SNU66/SART1 family


    Find genes that share domains with SART1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNUT1_HUMAN, O43290
    Function: Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of
    the spliceosome. May also bind to DNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI17000644
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SART1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SART1:
     Cell division defect  Decreased cell number  Decreased influenza A virus in  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sart1):
     no phenotypic analysis 

    Find genes that share phenotypes with SART1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SART1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SART1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SART1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SART1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SART1:
    hsa-mir-615-3p (MIRT039840), hsa-mir-16-5p (MIRT051199), hsa-mir-222-3p (MIRT046653)

    Block miRNA regulation of human, mouse, rat SART1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SART1:
    hsa-miR-3173-3p hsa-miR-3148 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidSART1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SART1
    Predesigned siRNA for gene silencing in human, mouse, rat SART1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SART1

    Clone
    Products:
         
    OriGene clones in human, mouse for SART1 (see all 7)
    OriGene ORF clones in mouse, rat for SART1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SART1 (NM_005146)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART1
    Addgene plasmids for SART1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SART1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SART1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SNUT1_HUMAN, O43290: Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells
    (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in
    unstimulated PBMCs, suggesting preferential expression in proliferating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    golgi apparatus4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA16687569
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS9856836
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with SART1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SART1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SART1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SART1):
        Spliceosome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SART1: 
              Telomeres & Telomerase in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SART1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SART1 (O432901, 2, 3 ENSP000003104484) via UniProtKB, MINT, STRING, and/or I2D (see all 912)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNW1Q135731, 2, ENSP000002615314EBI-607761,EBI-632715 MINT-7945693 MINT-8331921 MINT-8336562 MINT-7947479 STRING: ENSP00000261531
    SF3A2Q154282, 3, ENSP000002214944MINT-5205692 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    USP39Q53GS92, 3, ENSP000003129814MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000312981
    SUMO1P631651, 2, 3, ENSP000003760764EBI-607761,EBI-80140 MINT-7947479 I2D: score=2 STRING: ENSP00000376076
    SRSF4Q081702, ENSP000003629004MINT-8336595 MINT-7947479 STRING: ENSP00000362900
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS16687569
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0007050cell cycle arrest NAS16158934
    GO:0045585positive regulation of cytotoxic T cell differentiation IDA10209962
    GO:0097193intrinsic apoptotic signaling pathway NAS16158934

    Find genes that share ontologies with SART1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SART1 (SNUT1)

    1 Novoseek inferred chemical compound relationship for SART1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 31.8 2 9765622 (1)



    Find genes that share compounds with SART1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SART1 gene: 
    NM_005146.4  

    Unigene Cluster for SART1:

    Squamous cell carcinoma antigen recognized by T cells
    Hs.502883  [show with all ESTs]
    Unigene Representative Sequence: NM_005146
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312397(uc001ogl.3) ENST00000532333(uc009yqy.1) ENST00000529532(uc010rot.1)
    ENST00000528573 ENST00000530251 ENST00000533386 ENST00000529580 ENST00000528137

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SART1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate SART1:
    hsa-miR-3173-3p hsa-miR-3148 hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidSART1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SART1
    Predesigned siRNA for gene silencing in human, mouse, rat SART1
    Clone
    Products:
         
    OriGene clones in human, mouse for SART1 (see all 7)
    OriGene ORF clones in mouse, rat for SART1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SART1 (NM_005146)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART1
    Addgene plasmids for SART1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SART1
    OriGene qSTAR qPCR primer pairs in human, mouse for SART1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SART1
      QuantiTect SYBR Green Assays in human, mouse, rat SART1
      QuantiFast Probe-based Assays in human, mouse, rat SART1

    Additional mRNA sequence: 

    AB006198.1 AF353625.1 AK223016.1 AK293200.1 AK297589.1 AK298184.1 AK309104.1 AL162042.1 
    BC001058.2 BC018607.1 BT006637.1 BX648500.1 Y14314.1 

    14 DOTS entries:

    DT.444262  DT.95125833  DT.203630  DT.97775742  DT.95163945  DT.102831545  DT.40282834  DT.100781489 
    DT.100892166  DT.120694154  DT.95163785  DT.97854769  DT.100892145  DT.95253152 

    Selected AceView cDNA sequences (see all 303):

    BQ879021 AI352467 CA455038 BQ687380 AB006198 BQ650677 BM712339 C04465 
    BE253792 AA599522 BE252565 BG035169 CR611735 BC001058 BE295074 AF353625 
    CA422671 BQ015506 BC018607 BU845294 BM562665 BU620155 BF794686 BQ897701 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SART1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:              -           -           -                                                                                                           -         
    SP2:                                                                                            -                                                               
    SP3:              -           -                                                                                                                                 
    SP4:                                                                                      -     -     -                                                         
    SP5:                          -           -                                                                                                                     

    ExUns: 20a · 20b ^ 21
    SP1:        -         
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SART1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SART1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGCGAACA
    SART1 Expression
    About this image


    SART1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SART1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SART1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502883

    UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SART1: 
              Telomeres & Telomerase in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SART1
    OriGene qSTAR qPCR primer pairs in human, mouse for SART1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SART1
    QuantiTect SYBR Green Assays in human, mouse, rat SART1
    QuantiFast Probe-based Assays in human, mouse, rat SART1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SART1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sart11 , 5 squamous cell carcinoma antigen recognized by T cells more1, 5 88.29(n)1
    95.12(a)1
      19 (4.31 cM)5
    202271  NM_016882.31  NP_058578.31 
     53775235 
    lizard
    (Anolis carolinensis)
    Reptilia SART16
    squamous cell carcinoma antigen recognized by T ce...
    56(a)
    1 ↔ 1
    GL344298.1(31304-46092)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC536792 similar to squamous cell carcinoma antigen recognised more 71.7(n)    BC043853.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.10882 Transcribed sequence with weak similarity to protein more 77.22(n)    57064343 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66863   -- 38(a)   33B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F19F10.93   -- 29(a)   V(7574697-7578223)   --


    ENSEMBL Gene Tree for SART1 (if available)
    TreeFam Gene Tree for SART1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SART1 (see all 653)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561596371,2
    C--65662980(+) TTTTT-/C/TCGAGA 1 -- int10--------
    rs1900613101,2
    C--65728062(+) TTAGTA/GGAGAC 1 -- us2k10--------
    rs1929463461,2
    --65728099(+) GTCTCA/GATCTC 1 -- us2k10--------
    rs1847489361,2
    --65728199(+) TCCCAA/GTAGTT 1 -- us2k10--------
    rs1412992621,2
    C--65728324(+) CAATCC/TTAACA 1 -- us2k10--------
    rs1897281961,2
    --65728546(+) ACTCTA/CGTAGT 1 -- us2k10--------
    rs1454448541,2
    --65728615(+) CAGTGC/TGCTGT 1 -- us2k10--------
    rs802941461,2
    C,F--65728639(+) CACTCC/AAGCCT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1143221311,2
    F--65728641(+) CTCCAG/CCCTGA 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs765762601,2
    C--65728674(+) AAGGG-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SART1 (65729160 - 65747607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SART1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1062790CNV Insertion17803354
    dgv1186n71CNV Loss21882294
    nsv832191CNV Loss17160897
    dgv1185n71CNV Loss21882294
    esv25439CNV Loss19812545

    Human Gene Mutation Database (HGMD): SART1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SART1
    DNA2.0 Custom Variant and Variant Library Synthesis for SART1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605941    OMIM disorders: --

    1 disease for SART1:    
    About MalaCards
    atopy


    Find genes that share disorders with SART1           About GenesLikeMe

    3 Novoseek inferred disease relationships for SART1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 20.2 8 11092984 (1), 10853014 (1), 9765622 (1), 10597192 (1) (see all 7)
    cancer 17.5 4 11092984 (1), 9765622 (1), 11182058 (1)
    carcinoma squamous cell 17.4 1 10929426 (1)

    Genetic Association Database (GAD): SART1
    Human Genome Epidemiology (HuGE) Navigator: SART1 (2 documents)

    Export disorders for SART1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SART1 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with SART1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding antigenic peptides of human squamous cell carcinoma recognized cytotoxic T lymphocytes. (PubMed id 9449708)1, 2, 3 Shichijo S.... Itoh K. (J. Exp. Med. 1998)
    2. Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis. (PubMed id 11410364)1, 2, 9 Bolland D.J. and Hewitt J.E. (Gene 2001)
    3. Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer. (PubMed id 18374504)1, 4 Suga T....Imai T. (Int. J. Radiat. Oncol. Biol. Phys. 2008)
    4. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (RNA 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    8. The 65 and 110 kDa SR-related proteins of the U4/U6*U5 tri-snRNP are essential for the assembly of mature spliceosomes. (PubMed id 11350945)1, 2 Makarova O.V.... Luehrmann R. (EMBO J. 2001)
    9. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. (PubMed id 9856836)1, 2 Valenta R....Stingl G. (J. Invest. Dermatol. 1998)
    10. Expression of the SART1 tumor rejection antigen in renal cell carcinoma. (PubMed id 10929426)1, 9 Shintaku I....Itoh K. (Urol. Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9092 HGNC: 10538 AceView: SART1 Ensembl:ENSG00000175467 euGenes: HUgn9092
    ECgene: SART1 Kegg: 9092 H-InvDB: SART1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SART1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SART1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SART1 gene:
    Search GeneIP for patents involving SART1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SART1 (SART1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SART1   OriGene RNAi products in human, mouse, rat for SART1  
     OriGene qPCR primer pairs and template standards for SART1   OriGene Protein Over-expression Lysate for SART1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SART1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SART1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SART1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SART1   OriGene Custom Protein Services for SART1  

     
     
     Block miRNA regulation of human, mouse, rat SART1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SART1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SART1 Predesigned siRNA for gene silencing in human, mouse, rat SART1
     QuantiFast Probe-based Assays in human, mouse, rat SART1 QuantiTect SYBR Green Assays in human, mouse, rat SART1
     PCR Arrays including human, mouse, rat SART1 Search Chromatin IP Primers for SART1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SART1  GeneGlobe Interaction Network for SART1
     Regulatory tfbs in SART1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SART1 GenScript cDNA clones with any tag delivered in your preferred vector for SART1
     GenScript Custom Assay Services for SART1 GenScript Custom overexpressing Cell Line Services for SART1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SART1 (SNUT1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SART1 antibodies
     SART1 proteins
     SART1 lysates
     Antibodies for SART1
     See all of Abcam's Antibodies, Kits and Proteins for SART1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SART1
     Antibodies for SART1
     ELISAs for SART1
     CLIAs for SART1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SART1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SART1
     SwitchGear 3'UTR luciferase reporter plasmids for SART1
     SwitchGear Promoter luciferase reporter plasmids for SART1
     ThermoFisher Antibody for SART1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SART1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SART1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SART1
     LSBio Antibodies in human, mouse, rat for SART1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for SART1
      Search eBioscience for proteins for SART1
      Search eBioscience for elisas for SART1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SART1 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4