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Aliases for SART1 Gene

Aliases for SART1 Gene

  • Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 2 3 4 5
  • Squamous Cell Carcinoma Antigen Recognised By T Cells 2 3
  • Small Nuclear Ribonucleoprotein 110kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Tri-SnRNP-Associated 110 KDa Protein 3 4
  • SNU66 Homolog 3 4
  • HSART-1 3 4
  • SART-1 3 4
  • HSnu66 3 4
  • Squamous Cell Carcinoma Antigen Recognized By T Cells 1 2
  • U4/U6.U5 Tri-SnRNP-Associated Protein 1 3
  • SART1(259) Protein 3
  • SART1(800) Protein 3
  • Allergen Hom S 1 4
  • IgE Autoantigen 3
  • SART1259 3
  • SNRNP110 3
  • HOMS1 3
  • Snu66 3
  • Ara1 3

External Ids for SART1 Gene

Previous GeneCards Identifiers for SART1 Gene

  • GC11P068263
  • GC11P067410
  • GC11P065504
  • GC11P065485
  • GC11P065730
  • GC11P062055

Summaries for SART1 Gene

Entrez Gene Summary for SART1 Gene

  • This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SART1 Gene

SART1 (Squamous Cell Carcinoma Antigen Recognized By T-Cells 1) is a Protein Coding gene. Diseases associated with SART1 include Atopy and Esophagus Squamous Cell Carcinoma. Among its related pathways are mRNA Splicing - Major Pathway and HIF Repressor Pathways. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SART1 Gene

  • Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Gene Wiki entry for SART1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SART1 Gene

Genomics for SART1 Gene

Regulatory Elements for SART1 Gene

Enhancers for SART1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065940 0.5 Ensembl ENCODE 12.7 -20.1 -20113 2.4 HDAC1 ATF1 PKNOX1 CBX3 ARNT TBL1XR1 NFXL1 BMI1 RARA ELK1 CTSW SART1 C11orf68 DRAP1 FOSL1 CCDC85B FIBP EFEMP2 CFL1 BANF1
GH11F065927 1.4 FANTOM5 Ensembl ENCODE 12.1 -33.5 -33463 2.5 HDGF NFRKB THAP11 CBFB SP1 NFIL3 ZNF589 SMARCA4 RCOR2 IKZF1 EIF1AD CST6 FIBP CCDC85B CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11F065886 0.8 FANTOM5 ENCODE 12 -66.2 -66231 18.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNX32 CTSW MRPL11 EIF1AD NEAT1 MUS81 ENSG00000258297 KAT5 FAU POLA2
GH11F065932 1.2 Ensembl ENCODE 11.9 -29.3 -29275 0.8 CTCF USF1 L3MBTL2 MAX USF2 REST SREBF1 RAD51 GLIS1 ZBTB33 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 PACS1 ENSG00000255320
GH11F065931 0.9 Ensembl 11.9 -30.0 -29989 0.2 SREBF1 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 EIF1AD PACS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SART1 on UCSC Golden Path with GeneCards custom track

Promoters for SART1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000319743 11 1801 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3

Genomic Location for SART1 Gene

Chromosome:
11
Start:
65,961,689 bp from pter
End:
65,980,136 bp from pter
Size:
18,448 bases
Orientation:
Plus strand

Genomic View for SART1 Gene

Genes around SART1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SART1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SART1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SART1 Gene

Proteins for SART1 Gene

  • Protein details for SART1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43290-SNUT1_HUMAN
    Recommended name:
    U4/U6.U5 tri-snRNP-associated protein 1
    Protein Accession:
    O43290
    Secondary Accessions:
    • A6NDN1
    • Q53GB5

    Protein attributes for SART1 Gene

    Size:
    800 amino acids
    Molecular mass:
    90255 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.

    Three dimensional structures from OCA and Proteopedia for SART1 Gene

    Alternative splice isoforms for SART1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SART1 Gene

Post-translational modifications for SART1 Gene

Other Protein References for SART1 Gene

No data available for DME Specific Peptides for SART1 Gene

Domains & Families for SART1 Gene

Protein Domains for SART1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SART1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43290

UniProtKB/Swiss-Prot:

SNUT1_HUMAN :
  • Belongs to the SNU66/SART1 family.
Family:
  • Belongs to the SNU66/SART1 family.
genes like me logo Genes that share domains with SART1: view

No data available for Gene Families for SART1 Gene

Function for SART1 Gene

Molecular function for SART1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Gene Ontology (GO) - Molecular Function for SART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15620657
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SART1: view
genes like me logo Genes that share phenotypes with SART1: view

Animal Model Products

miRNA for SART1 Gene

miRTarBase miRNAs that target SART1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SART1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SART1 Gene

Localization for SART1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SART1 Gene

Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SART1 Gene COMPARTMENTS Subcellular localization image for SART1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm TAS 9856836
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with SART1: view

Pathways & Interactions for SART1 Gene

genes like me logo Genes that share pathways with SART1: view

Pathways by source for SART1 Gene

1 R&D Systems pathway for SART1 Gene

Gene Ontology (GO) - Biological Process for SART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS 16687569
GO:0000398 mRNA splicing, via spliceosome IEA,TAS --
GO:0000481 maturation of 5S rRNA IBA --
GO:0006397 mRNA processing IEA --
GO:0007050 cell cycle arrest NAS 16158934
genes like me logo Genes that share ontologies with SART1: view

No data available for SIGNOR curated interactions for SART1 Gene

Drugs & Compounds for SART1 Gene

(1) Drugs for SART1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SART1: view

Transcripts for SART1 Gene

Unigene Clusters for SART1 Gene

Squamous cell carcinoma antigen recognized by T cells:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SART1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SART1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - -
SP2: -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8:

ExUns: 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SART1 Gene

GeneLoc Exon Structure for
SART1
ECgene alternative splicing isoforms for
SART1

Expression for SART1 Gene

mRNA expression in normal human tissues for SART1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SART1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.8), CD8 Tcells (11.3), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SART1 Gene



Protein tissue co-expression partners for SART1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SART1 Gene:

SART1

SOURCE GeneReport for Unigene cluster for SART1 Gene:

Hs.502883

mRNA Expression by UniProt/SwissProt for SART1 Gene:

O43290-SNUT1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SART1: view

Primer Products

No data available for mRNA differential expression in normal tissues for SART1 Gene

Orthologs for SART1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SART1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SART1 34 35
  • 99.5 (n)
cow
(Bos Taurus)
Mammalia SART1 34 35
  • 90.62 (n)
dog
(Canis familiaris)
Mammalia SART1 34 35
  • 89.83 (n)
mouse
(Mus musculus)
Mammalia Sart1 34 16 35
  • 88.29 (n)
rat
(Rattus norvegicus)
Mammalia Sart1 34
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia SART1 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SART1 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sart1 34
  • 66.32 (n)
Str.8940 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53679 34
zebrafish
(Danio rerio)
Actinopterygii sart1 34 35
  • 66.84 (n)
Dr.1088 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12399 34
fruit fly
(Drosophila melanogaster)
Insecta CG6686 36 35
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea F19F10.9 36 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9207 35
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4237 34
Species where no ortholog for SART1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SART1 Gene

ENSEMBL:
Gene Tree for SART1 (if available)
TreeFam:
Gene Tree for SART1 (if available)

Paralogs for SART1 Gene

No data available for Paralogs for SART1 Gene

Variants for SART1 Gene

Sequence variations from dbSNP and Humsavar for SART1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10791834 -- 65,973,131(+) ATCGC(A/G)CCACT intron-variant
rs10896069 -- 65,970,667(+) AGAGA(C/T)GGGAG intron-variant
rs10896070 -- 65,972,997(+) AACCC(C/T)GTCTC intron-variant
rs10896071 -- 65,974,955(+) GAATG(C/G)TGTGA intron-variant
rs111291053 -- 65,971,963(+) TTGTC(A/C)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SART1 Gene

Variant ID Type Subtype PubMed ID
esv1062790 CNV insertion 17803354
esv25439 CNV loss 19812545
nsv832191 CNV loss 17160897

Variation tolerance for SART1 Gene

Residual Variation Intolerance Score: 9.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SART1 Gene

Human Gene Mutation Database (HGMD)
SART1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SART1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SART1 Gene

Disorders for SART1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SART1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
atopy
  • atopic hypersensitivity
esophagus squamous cell carcinoma
  • esophageal squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SART1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SART1

Genetic Association Database (GAD)
SART1
Human Genome Epidemiology (HuGE) Navigator
SART1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SART1
genes like me logo Genes that share disorders with SART1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SART1 Gene

Publications for SART1 Gene

  1. Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis. (PMID: 11410364) Bolland D.J. … Hewitt J.E. (Gene 2001) 3 4 22 64
  2. A gene encoding antigenic peptides of human squamous cell carcinoma recognized cytotoxic T lymphocytes. (PMID: 9449708) Shichijo S. … Itoh K. (J. Exp. Med. 1998) 2 3 4 64
  3. Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer. (PMID: 18374504) Suga T. … Imai T. (Int. J. Radiat. Oncol. Biol. Phys. 2008) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PMID: 16723661) Liu S. … Luehrmann R. (RNA 2006) 3 4 64

Products for SART1 Gene

Sources for SART1 Gene

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