Aliases for SARS2 Gene
External Ids for SARS2 Gene
Previous HGNC Symbols for SARS2 Gene
Previous GeneCards Identifiers for SARS2 Gene
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for SARS2 Gene
SARS2 (Seryl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with SARS2 include hyperuricemia, pulmonary hypertension, renal failure, and alkalosis and hyperuricemia. Among its related pathways are Gene Expression and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include serine-tRNA ligase activity. An important paralog of this gene is ENSG00000269547.
UniProtKB/Swiss-Prot for SARS2 Gene
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).