Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SARS2 Gene

protein-coding   GIFtS: 59
GCID: GC19M039405

seryl-tRNA synthetase 2, mitochondrial

(Previous names: serine-tRNA ligase, mitochondrial, seryl-tRNA synthetase...)
(Previous symbol: SARSM)
 Explore 10 diseases affiliated with
SARS2 via our new
 Human Malady Compendium 
Biological research products
for SARS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Seryl-TRNA Synthetase 2, Mitochondrial1 2     SerRS2 3
SARSM1 2 3     EC 6.1.1.113 8
SerRSmt1 2 3     FLJ204501
SARS1 2     Seryl-TRNA Synthetase 21
SERS1 2     Mitochondrial Seryl-TRNA Synthetase2
SYS1 2     Serine TRNA Ligase 2, Mitochondrial2
MtSerRS1     Serine--TRNA Ligase, Mitochondrial2
Serine-TRNA Ligase, Mitochondrial1 2     Seryl-TRNA Synthetase, Mitochondrial2
Seryl-TRNA(Ser/Sec) Synthetase2 3     Seryl-TRNA Synthetase3

External Ids:    HGNC: 176971   Entrez Gene: 549382   Ensembl: ENSG000001048357   OMIM: 6128045   UniProtKB: Q9NP813   

Export aliases for SARS2 gene to outside databases

Previous GC identifers: GC19M040018 GC19M039797 GC19M044081 GC19M044097


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SARS2:
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family.
The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of
selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic
domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a
bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within
the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple
transcript variants encoding different isoforms have been identified for this gene. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: SYSM_HUMAN, Q9NP81
Function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form
the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)

Gene Wiki entry for SARS2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SARS2 gene promoter:
         AhR   AML1a   ATF-2   p300   Arnt   CRE-BP1   POU2F1   POU2F1a   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSARS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SARS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

SARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SARS2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039405:  view genomic region     (about GC identifiers)

Start:
39,405,904 bp from pter      End:
39,466,380 bp from pter
Size:
60,477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYSM_HUMAN, Q9NP81 (See protein sequence)
Recommended Name: Serine--tRNA ligase, mitochondrial precursor  
Size: 518 amino acids; 58283 Da
Subunit: Homodimer. The tRNA molecule binds across the dimer (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
Sequence caution: Sequence=AAH01020.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NHW7 B4DE10 Q9BVP3
Alternative splicing: 2 isoforms:  Q9NP81-1   Q9NP81-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SARS2: NX_Q9NP81

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NP81

  • 2 DME Specific Peptides for SARS2 (Q9NP81)
     EAWMPGR  SASNCTD 

    SARS2 Protein expression data from MOPED and PaxDb:    About this image 
    SARS2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139373.1  NP_060297.1  

    ENSEMBL proteins: 
     ENSP00000399330   ENSP00000406754   ENSP00000221431   ENSP00000414954   ENSP00000292852  
    Reactome Protein details: Q9NP81
    Human Recombinant Protein Products for SARS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SARS2
    OriGene Protein Over-expression Lysate: SARS2
    OriGene Custom Protein Services for SARS2 
    GenScript Custom Purified and Recombinant Proteins Services for SARS2
    Novus Biologicals SARS2 Protein
    Novus Biologicals SARS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SARS2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ISS10764807
    GO:0005759mitochondrial matrix TAS--
    GO:0019005SCF ubiquitin ligase complex ----

    SARS2 for ontologies           About GeneDecksing



    SARS2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SARS2 
    GenScript Custom Superior Antibodies Services for SARS2
    Novus Biologicals SARS2 Antibodies
    Abcam antibodies for SARS2 
    Uscn Antibodies for SARS2
    ThermoFisher Antibodies for SARS2

    Assay Products for SARS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SARS2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SARS2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SARS2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR010978 tRNA-bd_arm
     IPR002314 aa-tRNA-synt_IIb_cons-dom
     IPR015866 Ser-tRNA-synth_1_N
     IPR002317 Ser-tRNA-ligase_type_1
     IPR006195 aa-tRNA-synth_II

    Graphical View of Domain Structure for InterPro Entry Q9NP81

    ProtoNet protein and cluster: Q9NP81

    1 Blocks protein family: IPB002317 Seryl-tRNA SYNTHETASE signature

    UniProtKB/Swiss-Prot: SYSM_HUMAN, Q9NP81
    Domain: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding
    (By similarity)
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYSM_HUMAN, Q9NP81
    Function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form
    the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
    Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)
    Catalytic activity: ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec)

         Enzyme Number (IUBMB): EC 6.1.1.111 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding ----
    GO:0004828serine-tRNA ligase activity TAS--
    GO:0005515protein binding ----
    GO:0005524ATP binding ISS10764807
         
    SARS2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SARS2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): SARS2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SARS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SARS2
    SwitchGear 3'UTR luciferase reporter plasmidSARS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SARS2 (see all 7)
    OriGene shRNA RFP: SARS2
    OriGene siRNA: SARS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SARS2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SARS2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SARS2
    Sirion Biotech Customized adenovirus for overexpression of SARS2 
    Sirion Biotech Customized adenovirus for potent knockdown of SARS2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SARS2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SARS2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SARS2 (NM_017827)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SARS2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SARS2
    Search LifeMap BioReagents cell lines for SARS2
    Sirion Biotech Customized stable knockdown cell line services for SARS2 
    Sirion Biotech Customized inducible knockdown cell line services for SARS2
    Sirion Biotech Customized stable overexpressing cell line services for SARS2
    Sirion Biotech Customized inducible overexpressing cell line services for SARS2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    tRNA Aminoacylation1.00
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.54
    2Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins1.00
    3Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SARS2 
        Selenium Metabolism and Selenoproteins

    3        Reactome Pathways for SARS2
        tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    1         Kegg Pathway  (Kegg details for SARS2):
        Aminoacyl-tRNA biosynthesis

    UniProtKB/Swiss-Prot: SYSM_HUMAN, Q9NP81
    Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and
    tRNA(Sec): step 1/1


    SARS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/353 Interacting proteins for SARS2 (Q9NP812, 3 ENSP000002214314) via UniProtKB, MINT, STRING, and/or I2D (see all 353)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRMT10CQ7L0Y32, 3, ENSP000003123564MINT-8079030 I2D: score=1 STRING: ENSP00000312356
    ADCK3Q8NI602, 3MINT-8079030 I2D: score=1 
    OATP041812, 3MINT-8079030 I2D: score=1 
    PSMD2Q132002, 3MINT-8415512 I2D: score=1 
    VDAC3Q9Y2772, 3MINT-8079030 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006434seryl-tRNA aminoacylation ISS10764807
    GO:0010467gene expression TAS--
    GO:0030163protein catabolic process ----
    GO:0097056selenocysteinyl-tRNA(Sec) biosynthetic process IEA--

    SARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SARS2

    5 HMDB Compounds for SARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Serine(-)-Serine (see all 26)56-45-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about SARS2 / SYSM 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SARS2 gene (2 alternative transcripts): 
    NM_001145901.1  NM_017827.3  

    Unigene Cluster for SARS2:

    Seryl-tRNA synthetase 2, mitochondrial
    Hs.709416  [show with all ESTs]
    Unigene Representative Sequence: NM_001145901
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448145(uc010xuq.1) ENST00000430193(uc010xup.1 uc010xus.1)
    ENST00000221431(uc002ojz.2 uc002oka.2 uc010xur.1) ENST00000455102
    ENST00000292852(uc002okf.1 uc002okg.1)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): SARS2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SARS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SARS2
    SwitchGear 3'UTR luciferase reporter plasmidSARS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SARS2 (see all 7)
    OriGene shRNA RFP: SARS2
    OriGene siRNA: SARS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SARS2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SARS2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SARS2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SARS2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SARS2 (NM_017827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SARS2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SARS2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SARS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SARS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SARS2

    Additional cDNA sequence: 

    AB029948.1 AK000457.1 AK098522.1 AK293414.1 AK296170.1 BC001020.2 BC042912.1 

    12 DOTS entries:

    DT.109655  DT.100778004  DT.97845416  DT.95070365  DT.100778008  DT.95070364  DT.121448218  DT.100641924 
    DT.100807435  DT.100839528  DT.95120726  DT.40238903 

    24/175 AceView cDNA sequences (see all 175):

    BQ070460 BG250432 BQ054152 AL521384 CR599609 BM788801 AL523540 BQ227012 
    BX098767 BC042912 AI392724 CR611000 BE905396 BM791903 AL559404 BF002302 
    BI860987 AA336553 AI590551 BU196970 BM912108 BQ690710 BU617807 CA488180 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SARS2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
    SP1:                          -     -                       -                                   -           -                                                   
    SP2:        -                 -                             -                                   -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                        -                                                                                                   
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for SARS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SARS2 Expression
    About this image
    See SARS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SARS2

    SOURCE GeneReport for Unigene cluster: Hs.709416
        SABiosciences Custom PCR Arrays for SARS2

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SARS2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SARS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SARS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SARS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SARS2 gene from 9/38 species (see all 38)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008582141 seryl-tRNA synthetase, mitochondrial-like 69.45(n)
    63.11(a)
      100858214  XM_003643499.1  XP_003643547.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BQ390056.12   -- 74.23(n)    BQ390056.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055610.12   -- 76.1(n)   394154  BC055610.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-ser1 Seryl-tRNA synthetase 49.79(n)
    38.42(a)
      41862  NM_079641.2  NP_524365.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sars-21 Protein SARS-2 50.37(n)
    42.86(a)
      177200  NM_068148.5  NP_500549.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIA4(YHR011W)4
    DIA41
    Probable mitochondrial seryl-tRNA synthetase, mutant more4
    Dia4p1
    43.94(n)1
    33.97(a)1
      8(127780-129120)4
    8564021, 4  NP_011875.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SRS1 Seryl-tRNA synthetase 47.45(n)
    40.85(a)
      837734  NM_101058.2  NP_172651.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06109001 hypothetical protein 49.87(n)
    43.83(a)
      4350906  NM_001074797.1  NP_001068265.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria serS6
    seryl-tRNA synthetase, also charges selenocysteiny...
    25(a)
    possible ortholog
    Chromosome(938651-939943)


    ENSEMBL Gene Tree for SARS2 (if available)
    TreeFam Gene Tree for SARS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/335 NCBI SNPs in SARS2 are shown (see all 335    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743990891,2
    --35852854(+) AACACA/CGATGT 2 -- ut312Minor allele frequency- C:0.07CSA WA 120
    rs739302291,2
    C,F--35853863(+) AGAGAG/ATTGTG 2 -- int13Minor allele frequency- A:0.31WA CSA 122
    rs797460141,2
    --35854866(+) CTGTTC/TGTGCT 2 -- int12Minor allele frequency- T:0.09CSA WA 120
    rs1125753571,2
    C--35854882(+) TACAGT/CCCTGT 2 -- int12Minor allele frequency- C:0.08CSA WA 120
    rs735415061,2
    C--35856429(+) ATCGTG/CCTACT 2 -- int12Minor allele frequency- C:0.06WA 120
    rs118784721,2
    H--35856474(+) aaaaaA/Gaaaaa 2 -- int1 trp30--------
    rs794104271,2
    F--35856654(+) GTACAG/CATTTG 2 -- int11Minor allele frequency- C:0.03NA 120
    rs743424801,2
    --35857383(+) GCTGTC/GGGGGT 2 -- int10--------
    rs748234741,2
    F--35857648(+) GAAAGG/AGAGGG 2 -- int11Minor allele frequency- A:0.02WA 118
    rs753452211,2
    C--35859109(+) TGGACA/GTTCAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for SARS2 (39405904 - 39466380 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SARS2: --
    Human Gene Mutation Database (HGMD): SARS2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SARS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SARS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SARS2 for disorders           About GeneDecksing

    OMIM gene information: 612804    OMIM disorders: --

    UniProtKB/Swiss-Prot: SYSM_HUMAN, Q9NP81
  • Defects in SARS2 are the cause of hyperuricemia pulmonary hypertension renal failure and alkalosis (HUPRA)
  • [MIM:613845]. HUPRA is a multisystem disorder characterized by onset in infancy of progressive renal failure leading
    to electrolyte imbalances, metabolic alkalosis, pulmonary hypertension, hypotonia, and delayed development. Affected
    individuals are born prematurely

    10 diseases for SARS2:    About MalaCards
    hyperuricemia, pulmonary hypertension, renal failure, and alkalosis    hyperuricemia    pulmonary hypertension    hypotonia
    hypertension    myopathy    pneumonia    tuberculosis
    malaria    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: SARS2 (1 document)

    Export disorders for SARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SARS2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase. (PubMed id 10764807)1, 2, 3, 9 Yokogawa T.... Watanabe K. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Novel coding-region polymorphisms in mitochondrial seryl-tRNA synthetase (SARSM) and mitoribosomal protein S12 (RPMS12) genes in DFNA4 autosomal dominant deafness families. (PubMed id 11317363)1, 9 Shah Z.H....Jacobs H.T. (2001)
    5. NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells. (PubMed id 19439209)1, 9 Zanotto E....Jacobs H.T. (2009)
    6. Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress. (PubMed id 18755224)1, 9 Zanotto E....Jacobs H.T. (2008)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54938 HGNC: 17697 AceView: SARS2 Ensembl:ENSG00000104835 euGenes: HUgn54938
    ECgene: SARS2 Kegg: 54938 H-InvDB: SARS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SARS2 gene:
    Search GeneIP for patents involving SARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SARS2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SARS2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SARS2  
     OriGene Protein Over-expression Lysate for SARS2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SARS2   OriGene 3'-UTR Clone for SARS2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SARS2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SARS2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SARS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SARS2   OriGene Custom Protein Services for SARS2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SARS2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SARS2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SARS2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SARS2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SARS2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SARS2
     GenScript Custom Purified and Recombinant Proteins Services for SARS2 GenScript cDNA clones with any tag delivered in your preferred vector for SARS2
     GenScript Custom Assay Services for SARS2 GenScript Custom Superior Antibodies Services for SARS2
     GenScript Custom overexpressing Cell Line Services for SARS2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SARS2 promoter
     Search Chromatin IP Primers for SARS2
     RT2 qPCR Primer Assay in human, mouse, rat SARS2
     Search GNC Networks for SARS2
     SABiosciences Custom PCR Arrays for SARS2
     Search Tocris compounds for SARS2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SARS2 antibodies
     SARS2 proteins
     SARS2 lysates
     Antibodies for SARS2
     See all of Abcam's Antibodies, Kits and Proteins for SARS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SARS2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SARS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARS2
     SwitchGear 3'UTR luciferase reporter plasmids for SARS2
     SwitchGear Promoter luciferase reporter plasmids for SARS2
     ThermoFisher Antibodies for SARS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SARS2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SARS2
    Sirion Biotech Customized:
     stable knockdown cell line services for SARS2
     inducible knockdown cell line services for SARS2
     design and validation of potent shRNA sequences against SARS2
     adenovirus for potent knockdown of SARS2
     adenovirus for overexpression of SARS2
     stable overexpressing cell line services for SARS2
     inducible overexpressing cell line services for SARS2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SARS2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4