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Aliases for SARS Gene

Aliases for SARS Gene

  • Seryl-TRNA Synthetase 2 3 4
  • SERS 3 4 6
  • Seryl-TRNA(Ser/Sec) Synthetase 3 4
  • EC 6.1.1.11 4 64
  • SERRS 3 4
  • Seryl-TRNA Synthetase, Cytoplasmic 3
  • Serine TRNA Ligase 1, Cytoplasmic 3
  • Serine--TRNA Ligase, Cytoplasmic 3
  • Seryl-TRNA Ser/Sec Synthetase 3
  • Serine TRNA Ligase 1 2
  • Cytoplasmic 2

External Ids for SARS Gene

Summaries for SARS Gene

Entrez Gene Summary for SARS Gene

  • This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

GeneCards Summary for SARS Gene

SARS (Seryl-TRNA Synthetase) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include RNA binding and serine-tRNA ligase activity. An important paralog of this gene is ENSG00000269547.

UniProtKB/Swiss-Prot for SARS Gene

  • Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Gene Wiki entry for SARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARS Gene

Genomics for SARS Gene

Genomic Location for SARS Gene

Start:
109,213,893 bp from pter
End:
109,238,182 bp from pter
Size:
24,290 bases
Orientation:
Plus strand

Genomic View for SARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARS Gene

Regulatory Elements for SARS Gene

Proteins for SARS Gene

  • Protein details for SARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49591-SYSC_HUMAN
    Recommended name:
    Serine--tRNA ligase, cytoplasmic
    Protein Accession:
    P49591
    Secondary Accessions:
    • B2R6Y9
    • Q5T5C8
    • Q9NSE3

    Protein attributes for SARS Gene

    Size:
    514 amino acids
    Molecular mass:
    58777 Da
    Quaternary structure:
    • Homodimer. The tRNA molecule binds across the dimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for SARS Gene

neXtProt entry for SARS Gene

Proteomics data for SARS Gene at MOPED

Post-translational modifications for SARS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys376

Other Protein References for SARS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SARS Gene

Gene Families for SARS Gene

HGNC:
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

UniProtKB/Swiss-Prot:

SYSC_HUMAN
Domain:
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.:
    • P49591
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.:
    • P49591
genes like me logo Genes that share domains with SARS: view

Function for SARS Gene

Molecular function for SARS Gene

GENATLAS Biochemistry: seryl-tRNA synthetase,58kDa
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec)
UniProtKB/Swiss-Prot Function: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Enzyme Numbers (IUBMB) for SARS Gene

Gene Ontology (GO) - Molecular Function for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003723 RNA binding TAS 9431993
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004828 serine-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SARS: view

Phenotypes for SARS Gene

GenomeRNAi human phenotypes for SARS:
genes like me logo Genes that share phenotypes with SARS: view

miRNA for SARS Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SARS Gene

Localization for SARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SARS Gene COMPARTMENTS Subcellular localization image for SARS gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SARS: view

Pathways for SARS Gene

genes like me logo Genes that share pathways with SARS: view

Pathways by source for SARS Gene

1 KEGG pathway for SARS Gene

UniProtKB/Swiss-Prot P49591-SYSC_HUMAN

  • Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1

Gene Ontology (GO) - Biological Process for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9431993
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006434 seryl-tRNA aminoacylation IEA --
GO:0008033 tRNA processing TAS 9431993
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SARS: view

Compounds for SARS Gene

(5) HMDB Compounds for SARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Serine
  • (-)-Serine
56-45-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for SARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Serine
  • (-)-Serine
56-45-1 target

(8) Novoseek inferred chemical compound relationships for SARS Gene

Compound -log(P) Hits PubMed IDs
trna(ser) 96.2 7
aminoacyl-trna 84.7 5
selenocysteine 82.2 4
trna(leu) 80.1 1
trna 80 21
genes like me logo Genes that share compounds with SARS: view

Transcripts for SARS Gene

Unigene Clusters for SARS Gene

Seryl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SARS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SARS Gene

GeneLoc Exon Structure for
SARS
ECgene alternative splicing isoforms for
SARS

Expression for SARS Gene

mRNA expression in normal human tissues for SARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SARS Gene

SOURCE GeneReport for Unigene cluster for SARS Gene Hs.531176

genes like me logo Genes that share expressions with SARS: view

Orthologs for SARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SARS 36
  • 99.81 (n)
  • 99.81 (a)
SARS 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SARS 36
  • 91.57 (n)
  • 95.32 (a)
SARS 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SARS 36
  • 92.14 (n)
  • 96.3 (a)
SARS 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sars 36
  • 90.49 (n)
  • 95.9 (a)
Sars 16
Sars 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SARS 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARS 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sars 36
  • 90.3 (n)
  • 95.7 (a)
chicken
(Gallus gallus)
Aves SARS 36
  • 78.4 (n)
  • 85.8 (a)
SARS 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SARS 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sars-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sars 36
  • 73.32 (n)
  • 81.6 (a)
Str.657 36
zebrafish
(Danio rerio)
Actinopterygii Dr.29078 36
sars 36
  • 72.89 (n)
  • 81.52 (a)
sars 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008265 36
  • 66.6 (n)
  • 69.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17259 36
  • 66.67 (n)
  • 69.96 (a)
CG17259 37
  • 68 (a)
OneToOne
CG17259 38
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea sars-1 36
  • 61.52 (n)
  • 66.05 (a)
sars-1 37
  • 66 (a)
OneToOne
srs-2 38
  • 65 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL088C 36
  • 55.15 (n)
  • 51.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SES1 36
  • 53.17 (n)
  • 52.35 (a)
SES1 37
  • 49 (a)
OneToMany
SES1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10593g 36
  • 55.66 (n)
  • 51.36 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.311 36
soybean
(Glycine max)
eudicotyledons Gma.9981 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G27470 36
  • 58.3 (n)
  • 53.62 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6290 36
corn
(Zea mays)
Liliopsida Zm.15927 36
rice
(Oryza sativa)
Liliopsida Os.5952 36
Os01g0559100 36
  • 58.96 (n)
  • 56.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20463 36
bread mold
(Neurospora crassa)
Ascomycetes NCU01443 36
  • 55.11 (n)
  • 51.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29A4.15 36
  • 55.2 (n)
  • 54.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3798 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 70 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
Species with no ortholog for SARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SARS Gene

ENSEMBL:
Gene Tree for SARS (if available)
TreeFam:
Gene Tree for SARS (if available)

Paralogs for SARS Gene

Paralogs for SARS Gene

genes like me logo Genes that share paralogs with SARS: view

Variants for SARS Gene

Sequence variations from dbSNP and Humsavar for SARS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2924 -- 109,217,376(-) TTACA(C/T)GAGAT intron-variant, nc-transcript-variant
rs584116 -- 109,232,735(-) TTAGC(C/G)AGTAA intron-variant
rs600711 -- 109,231,404(-) TTATC(C/T)TGATG intron-variant
rs607087 -- 109,233,910(-) cctgg(A/G)tgaaa intron-variant
rs608511 -- 109,233,548(-) AAGCA(A/G)ATAAT intron-variant

Relevant External Links for SARS Gene

HapMap Linkage Disequilibrium report
SARS

No data available for Structural Variations from Database of Genomic Variants (DGV) for SARS Gene

Disorders for SARS Gene

Relevant External Links for SARS

Genetic Association Database (GAD)
SARS
Human Genome Epidemiology (HuGE) Navigator
SARS
genes like me logo Genes that share disorders with SARS: view

No data available for UniProtKB/Swiss-Prot for SARS Gene

Publications for SARS Gene

  1. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PMID: 9431993) Vincent C. … Haertlein M. (Eur. J. Biochem. 1997) 2 3 4 23
  2. Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure. (PMID: 9637248) Heckl M. … Gross H.J. (FEBS Lett. 1998) 3 23
  3. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PMID: 19423847) Herzog W. … Stainier D.Y. (Circ. Res. 2009) 3 23
  4. Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis. (PMID: 11331419) Casas C. … Esquerda J.E. (J. Neurochem. 2001) 3 23
  5. Structure, function and evolution of seryl-tRNA synthetases: implications for the evolution of aminoacyl-tRNA synthetases and the genetic code. (PMID: 7540217) HAortlein M. … Cusack S. (J. Mol. Evol. 1995) 3 23

Products for SARS Gene

Sources for SARS Gene

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