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SARS Gene

protein-coding   GIFtS: 67
GCID: GC01P109756

Seryl-TRNA Synthetase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Seryl-TRNA Synthetase1 2 3     SERRS2
SERS2 3 5     Serine TRNA Ligase 1, Cytoplasmic2
Seryl-TRNA(Ser/Sec) Synthetase2 3     Serine--TRNA Ligase, Cytoplasmic2
EC 6.1.1.113 8     Seryl-TRNA Ser/Sec Synthetase2
cytoplasmic1     Seryl-TRNA Synthetase, Cytoplasmic2
Serine TRNA Ligase 11     SerRS3

External Ids:    HGNC: 105371   Entrez Gene: 63012   Ensembl: ENSG000000316987   OMIM: 6075295   UniProtKB: P495913   

Export aliases for SARS gene to outside databases

Previous GC identifers: GC01P110235 GC01P108685 GC01P108858 GC01P109055 GC01P109468 GC01P109558 GC01P107649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SARS Gene:
This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to
tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants
have been described but the biological validity of all variants is unknown. (provided by RefSeq, Jul 2010)

GeneCards Summary for SARS Gene:
SARS (seryl-tRNA synthetase) is a protein-coding gene. Diseases associated with SARS include hyperuricemia, pulmonary hypertension, renal failure, and alkalosis, and hyperuricemia. GO annotations related to this gene include serine-tRNA ligase activity and RNA binding. An important paralog of this gene is SARS2.

UniProtKB/Swiss-Prot: SYSC_HUMAN, P49591
Function: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with
serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into
selenocysteinyl-tRNA(Sec)

Gene Wiki entry for SARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SARS gene promoter:
         AML1a   AP-1   ATF-2   c-Jun   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSARS promoter sequence
   Search Chromatin IP Primers for SARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

SARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SARS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P109756:  view genomic region     (about GC identifiers)

Start:
109,756,515 bp from pter      End:
109,780,804 bp from pter
Size:
24,290 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYSC_HUMAN, P49591 (See protein sequence)
Recommended Name: Serine--tRNA ligase, cytoplasmic  
Size: 514 amino acids; 58777 Da
Subunit: Homodimer. The tRNA molecule binds across the dimer (By similarity)
2 PDB 3D structures from and Proteopedia for SARS:
3VBB (3D)        4L87 (3D)    
Secondary accessions: B2R6Y9 Q5T5C8 Q9NSE3

Explore the universe of human proteins at neXtProt for SARS: NX_P49591

Explore proteomics data for SARS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys376
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SARS (P49591) (see all 14)
     DTRGIFR  AILENYQ  YLIATSE  DLEAWFP 


    See SARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006504.2  
    ENSEMBL proteins: 
     ENSP00000234677   ENSP00000358939  
    Reactome Protein details: P49591

    SARS Human Recombinant Protein Products:

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    SARS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SARS
    Cloud-Clone Corp. CLIAs for SARS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    5 InterPro protein domains:
     IPR010978 tRNA-bd_arm
     IPR002314 aa-tRNA-synt_IIb_cons-dom
     IPR006195 aa-tRNA-synth_II
     IPR015866 Ser-tRNA-synth_1_N
     IPR002317 Ser-tRNA-ligase_type_1

    Graphical View of Domain Structure for InterPro Entry P49591

    ProtoNet protein and cluster: P49591

    1 Blocks protein domain: IPB002317 Seryl-tRNA SYNTHETASE signature

    UniProtKB/Swiss-Prot: SYSC_HUMAN, P49591
    Domain: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA
    binding (By similarity)
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily


    SARS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYSC_HUMAN, P49591
    Function: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with
    serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into
    selenocysteinyl-tRNA(Sec)
    Catalytic activity: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)
    Catalytic activity: ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec)

         Genatlas biochemistry entry for SARS:
    seryl-tRNA synthetase,58kDa

         Enzyme Number (IUBMB): EC 6.1.1.111 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003723RNA binding TAS9431993
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004828serine-tRNA ligase activity TAS--
    GO:0005524ATP binding IEA--
         
    SARS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SARS:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SARS
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    miRNA
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    hsa-mir-16-5p (MIRT031410), hsa-mir-30a-5p (MIRT028392), hsa-mir-29a-3p (MIRT049980), hsa-mir-26a-5p (MIRT050183)

    Block miRNA regulation of human, mouse, rat SARS using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SARS:
    hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSARS 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SARS

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SARS (NM_006513)
    Sino Biological Human cDNA Clone for SARS
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SARS

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYSC_HUMAN, P49591: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    SARS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SARS About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SARS
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for SARS):
        Aminoacyl-tRNA biosynthesis

    UniProtKB/Swiss-Prot: SYSC_HUMAN, P49591
    Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and
    tRNA(Sec): step 1/1


    SARS for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SARS
    Interactions:

        GeneGlobe Interaction Network for SARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SARS (P495913 ENSP000002346774) via UniProtKB, MINT, STRING, and/or I2D (see all 198)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS9431993
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006434seryl-tRNA aminoacylation IEA--
    GO:0008033tRNA processing TAS9431993
    GO:0010467gene expression TAS--

    SARS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SARS (SYSC)

    5 HMDB Compounds for SARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Serine(-)-Serine (see all 26)56-45-1--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for SARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Serine(-)-Serine (see all 11)56-45-1target--17139284 16517553 17016423 16950556 16081124

    8 Novoseek inferred chemical compound relationships for SARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trna(ser) 96.2 15 9637248 (2), 2263446 (1), 7986071 (1), 17719008 (1) (see all 6)
    aminoacyl-trna 84.7 5 17931630 (1), 7523371 (1), 9431993 (1), 9548745 (1) (see all 5)
    selenocysteine 82.2 4 7986071 (1), 9870610 (1), 17194211 (1), 17916946 (1)
    trna(leu) 80.1 1 8602350 (1)
    trna 80 48 9431993 (5), 1852601 (3), 9637248 (3), 7986071 (2) (see all 12)
    serine 57.3 8 8284203 (1), 16054140 (1), 17719008 (1), 17194211 (1) (see all 5)
    asparagine 34.9 1 12700400 (1)
    atp 28.8 4 17194211 (1), 17916946 (1)



    SARS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SARS gene: 
    NM_006513.3  

    Unigene Cluster for SARS:

    Seryl-tRNA synthetase
    Hs.531176  [show with all ESTs]
    Unigene Representative Sequence: NR_034072
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234677(uc001dwu.2) ENST00000482384(uc021orc.1) ENST00000477544
    ENST00000369923 ENST00000471705 ENST00000468588
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate SARS:
    hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidSARS 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SARS
      QuantiFast Probe-based Assays in human, mouse, rat SARS

    Additional mRNA sequence: 

    AK022339.1 AK222677.1 AK312771.1 BC000716.1 BC009390.2 BC111398.1 D49914.1 NR_034072.1 
    X91257.1 

    Selected DOTS entries (see all 29):

    DT.97760158  DT.448830  DT.100044887  DT.121373900  DT.121373806  DT.100044885  DT.95173341  DT.95358072 
    DT.100880193  DT.100880200  DT.97760153  DT.121373884  DT.91901376  DT.101960368  DT.91771112  DT.121373844 
    DT.97760154  DT.100880178  DT.40303592  DT.121373795  DT.121373815  DT.121373835  DT.95330361  DT.100880179 

    Selected AceView cDNA sequences (see all 912):

    BE278026 BI092310 AU121081 BM850645 CR600786 BQ889859 BQ049132 BU166771 
    BQ424982 CR606223 BM463428 BG314883 CR623378 CR625256 CB148637 BM808096 
    BM695281 BF795111 BQ066731 BM837528 BG746716 CB130039 BE386217 AU133780 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SARS (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a ·
    SP1:                                -     -     -                             -                                         -                             -         
    SP2:                                -     -     -                             -                                         -                                       
    SP3:                                                                                                                                                  -         
    SP4:                                -           -                             -                                                                                 
    SP5:                                -     -     -                             -                       -     -     -     -     -     -                           

    ExUns: 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:  -           -                     
    SP2:                                    
    SP3:  -                                 
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATAAAGCA
    SARS Expression
    About this image


    SARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531176
        Custom PCR Arrays for SARS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SARS gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sars1 , 5 seryl-aminoacyl-tRNA synthetase1, 5 90.49(n)1
    95.9(a)1
      3 (47.08 cM)5
    202261  NM_011319.31  NP_035449.11 
     1084248655 
    chicken
    (Gallus gallus)
    Aves SARS1 seryl-tRNA synthetase 78.4(n)
    85.8(a)
      426697  NM_001031392.1  NP_001026563.1 
    lizard
    (Anolis carolinensis)
    Reptilia SARS6
    seryl-tRNA synthetase
    87(a)
    1 ↔ 1
    4(124900718-124924821)
    African clawed frog
    (Xenopus laevis)
    Amphibia sars-prov2 seryl-aminoacyl-tRNA synthetase 1 75.99(n)    BC043975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.290782 Transcribed sequence with moderate similarity to protein more 77.26(n)    CK024591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172591 , 3 seryl-tRNA aminoacylation serine-tRNA
    ligase3
    CG172591
    79(a)3
    66.67(n)1
    69.96(a)1
      23C53
    335181  NM_134899.31  NP_608743.21 
    worm
    (Caenorhabditis elegans)
    Secernentea srs-23
    sars-11
    seryl-tRNA synthetase3
    sars-11
    65(a)3
    61.52(n)1
    66.05(a)1
      IV(10003929-10005599)3
    1778591  NM_069403.51  NP_501804.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SES1(YDR023W)4
    SES11
    Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA more4
    SES11
    53.17(n)1
    52.35(a)1
      4(489508-490896)4
    8515871, 4  NP_010306.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G274701 AT5G27470 58.3(n)
    53.62(a)
      832806  NM_122629.2  NP_198099.1 
    rice
    (Oryza sativa)
    Liliopsida Os.59522 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.9(n)    AK059522.1 


    ENSEMBL Gene Tree for SARS (if available)
    TreeFam Gene Tree for SARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SARS gene
    SARS22  ENSG000002695472  

    SARS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SARS (see all 556)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898696511,2
    --109754528(+) GACCTA/TGCCCT 2 -- us2k10--------
    rs1152342001,2
    C,F--109754583(+) GATGTT/CTTCCT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs176434261,2
    C,F,H--109754718(+) AGCTCT/GATCAT 2 -- us2k122Minor allele frequency- G:0.03NA NS EA WA 2656
    rs1928293711,2
    --109754806(+) AAAAAA/TACAAA 2 -- us2k10--------
    rs1439118951,2
    C--109754817(+) AAACA-/AAAAAC
            
    AAAAA
    2 -- us2k10--------
    rs1874132401,2
    C--109754822(+) AAAAAA/CAAAAA 2 -- us2k10--------
    rs1509234591,2
    --109754851(+) ACACAA/GCATTT 2 -- us2k10--------
    rs785249161,2
    C,F--109754956(+) CAATTC/TGATTC 2 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1165384181,2
    C,F--109754977(+) ACTAGC/TTACCT 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1124156261,2
    C,F--109754991(+) GGTAGC/TGTCAG 2 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for SARS (109756515 - 109780804 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SARS: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SARS
    DNA2.0 Custom Variant and Variant Library Synthesis for SARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607529    OMIM disorders: --

    14 diseases for SARS:    
    About MalaCards
    hyperuricemia, pulmonary hypertension, renal failure, and alkalosis    hyperuricemia    appendicitis    contact dermatitis
    allergic contact dermatitis    myositis    dermatitis    hypertension
    pneumonia    tonsillitis    thyroiditis    cerebritis
    malaria    prostatitis


    SARS for disorders           About GeneDecksing

    Genetic Association Database (GAD): SARS
    Human Genome Epidemiology (HuGE) Navigator: SARS (31 documents)

    Export disorders for SARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SARS gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with SARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PubMed id 9431993)1, 2, 3, 9 Vincent C.... Haertlein M. (Eur. J. Biochem. 1997)
    2. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Minimal tRNA(Ser) and tRNA(Sec) substrates for human seryl-tRNA synthetase: contribution of tRNA domains to serylation and tertiary structure. (PubMed id 9637248)1, 9 Heckl M....Gross H.J. (FEBS Lett. 1998)
    7. Structure, function and evolution of seryl-tRNA synthetases: implications for the evolution of aminoacyl-tRNA synthetases and the genetic code. (PubMed id 7540217)1, 9 HAortlein M. and Cusack S. (J. Mol. Evol. 1995)
    8. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PubMed id 19423847)1, 9 Herzog W....Stainier D.Y. (Circ. Res. 2009)
    9. Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis. (PubMed id 11331419)1, 9 Casas C....Esquerda J.E. (J. Neurochem. 2001)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6301 HGNC: 10537 AceView: SARS Ensembl:ENSG00000031698 euGenes: HUgn6301
    ECgene: SARS Kegg: 6301 H-InvDB: SARS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SARS gene:
    Search GeneIP for patents involving SARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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