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Aliases for SARS Gene

Aliases for SARS Gene

  • Seryl-TRNA Synthetase 2 3 4
  • Seryl-TRNA(Ser/Sec) Synthetase 3 4
  • EC 6.1.1.11 4 63
  • SERRS 3 4
  • SERS 3 4
  • Seryl-TRNA Synthetase, Cytoplasmic 3
  • Serine TRNA Ligase 1, Cytoplasmic 3
  • Serine TRNA Ligase 1 2
  • Cytoplasmic 2

External Ids for SARS Gene

Previous GeneCards Identifiers for SARS Gene

  • GC01P110235
  • GC01P108685
  • GC01P108858
  • GC01P109055
  • GC01P109468
  • GC01P109558
  • GC01P109756
  • GC01P107649

Summaries for SARS Gene

Entrez Gene Summary for SARS Gene

  • This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

GeneCards Summary for SARS Gene

SARS (Seryl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with SARS include epidemic typhus. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include RNA binding and aminoacyl-tRNA ligase activity. An important paralog of this gene is ENSG00000269547.

UniProtKB/Swiss-Prot for SARS Gene

  • Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Gene Wiki entry for SARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARS Gene

Genomics for SARS Gene

Regulatory Elements for SARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SARS Gene

Chromosome:
1
Start:
109,213,893 bp from pter
End:
109,238,182 bp from pter
Size:
24,290 bases
Orientation:
Plus strand

Genomic View for SARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARS Gene

Proteins for SARS Gene

  • Protein details for SARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49591-SYSC_HUMAN
    Recommended name:
    Serine--tRNA ligase, cytoplasmic
    Protein Accession:
    P49591
    Secondary Accessions:
    • B2R6Y9
    • Q5T5C8
    • Q9NSE3

    Protein attributes for SARS Gene

    Size:
    514 amino acids
    Molecular mass:
    58777 Da
    Quaternary structure:
    • Homodimer. The tRNA molecule binds across the dimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for SARS Gene

neXtProt entry for SARS Gene

Proteomics data for SARS Gene at MOPED

Post-translational modifications for SARS Gene

  • Ubiquitination at Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for SARS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for SARS Gene

Gene Families for SARS Gene

Suggested Antigen Peptide Sequences for SARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49591

UniProtKB/Swiss-Prot:

SYSC_HUMAN :
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Domain:
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
genes like me logo Genes that share domains with SARS: view

Function for SARS Gene

Molecular function for SARS Gene

GENATLAS Biochemistry:
seryl-tRNA synthetase,58kDa
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec)
UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Enzyme Numbers (IUBMB) for SARS Gene

Gene Ontology (GO) - Molecular Function for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003723 RNA binding TAS 9431993
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004828 serine-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SARS: view
genes like me logo Genes that share phenotypes with SARS: view

Animal Model Products

miRNA for SARS Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SARS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SARS Gene

Localization for SARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SARS Gene COMPARTMENTS Subcellular localization image for SARS gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 2
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SARS: view

Pathways & Interactions for SARS Gene

genes like me logo Genes that share pathways with SARS: view

Pathways by source for SARS Gene

1 KEGG pathway for SARS Gene

UniProtKB/Swiss-Prot P49591-SYSC_HUMAN

  • Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1

Gene Ontology (GO) - Biological Process for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9431993
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006434 seryl-tRNA aminoacylation IBA --
GO:0008033 tRNA processing TAS 9431993
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SARS: view

No data available for SIGNOR curated interactions for SARS Gene

Drugs & Compounds for SARS Gene

(10) Drugs for SARS Gene - From: NovoSeek, HMDB, DrugBank, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist, Target Weak endogenous glycine receptor agonist 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Selenocysteine Experimental Pharma 0

(5) Additional Compounds for SARS Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Aminoacyl-tRNA
tRNA
tRNA(Leu)
tRNA(Ser)
genes like me logo Genes that share compounds with SARS: view

Transcripts for SARS Gene

Unigene Clusters for SARS Gene

Seryl-tRNA synthetase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SARS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SARS Gene

GeneLoc Exon Structure for
SARS
ECgene alternative splicing isoforms for
SARS

Expression for SARS Gene

mRNA expression in normal human tissues for SARS Gene

Protein differential expression in normal tissues from HIPED for SARS Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SARS Gene



SOURCE GeneReport for Unigene cluster for SARS Gene Hs.531176

genes like me logo Genes that share expression patterns with SARS: view

Protein tissue co-expression partners for SARS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SARS Gene

Orthologs for SARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SARS 35
  • 91.57 (n)
  • 95.32 (a)
SARS 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SARS 35
  • 92.14 (n)
  • 96.3 (a)
SARS 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sars 35
  • 90.49 (n)
  • 95.9 (a)
Sars 16
Sars 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SARS 35
  • 99.81 (n)
  • 99.81 (a)
SARS 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sars 35
  • 90.3 (n)
  • 95.7 (a)
oppossum
(Monodelphis domestica)
Mammalia SARS 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARS 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves SARS 35
  • 78.4 (n)
  • 85.8 (a)
SARS 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SARS 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sars 35
  • 73.32 (n)
  • 81.6 (a)
Str.657 35
African clawed frog
(Xenopus laevis)
Amphibia sars-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29078 35
sars 35
  • 72.89 (n)
  • 81.52 (a)
sars 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17259 37
  • 79 (a)
CG17259 35
  • 66.67 (n)
  • 69.96 (a)
CG17259 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008265 35
  • 66.6 (n)
  • 69.7 (a)
worm
(Caenorhabditis elegans)
Secernentea srs-2 37
  • 65 (a)
sars-1 35
  • 61.52 (n)
  • 66.05 (a)
sars-1 36
  • 66 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL088C 35
  • 55.15 (n)
  • 51.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10593g 35
  • 55.66 (n)
  • 51.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SES1 35
  • 53.17 (n)
  • 52.35 (a)
SES1 36
  • 49 (a)
OneToMany
SES1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G27470 35
  • 58.3 (n)
  • 53.62 (a)
soybean
(Glycine max)
eudicotyledons Gma.9981 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.311 35
barley
(Hordeum vulgare)
Liliopsida Hv.6290 35
rice
(Oryza sativa)
Liliopsida Os.5952 35
Os01g0559100 35
  • 58.96 (n)
  • 56.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20463 35
corn
(Zea mays)
Liliopsida Zm.15927 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3798 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01443 35
  • 55.11 (n)
  • 51.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29A4.15 35
  • 55.2 (n)
  • 54.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
Species with no ortholog for SARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SARS Gene

ENSEMBL:
Gene Tree for SARS (if available)
TreeFam:
Gene Tree for SARS (if available)

Paralogs for SARS Gene

Paralogs for SARS Gene

genes like me logo Genes that share paralogs with SARS: view

Variants for SARS Gene

Sequence variations from dbSNP and Humsavar for SARS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2924 -- 109,217,376(-) TTACA(C/T)GAGAT intron-variant, nc-transcript-variant
rs584116 -- 109,232,735(-) TTAGC(A/C/G)AGTAA intron-variant
rs600711 -- 109,231,404(-) TTATC(C/T)TGATG intron-variant
rs607087 -- 109,233,910(-) cctgg(A/G)tgaaa intron-variant
rs608511 -- 109,233,548(-) AAGCA(A/G)ATAAT intron-variant

Variation tolerance for SARS Gene

Residual Variation Intolerance Score: 29.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SARS Gene

HapMap Linkage Disequilibrium report
SARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SARS Gene

Disorders for SARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SARS Gene - From: DISEASES

Disorder Aliases PubMed IDs
epidemic typhus
  • sylvatic typhus
- elite association
Search SARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for SARS

Genetic Association Database (GAD)
SARS
Human Genome Epidemiology (HuGE) Navigator
SARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SARS
genes like me logo Genes that share disorders with SARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SARS Gene

Publications for SARS Gene

  1. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PMID: 9431993) Vincent C. … Haertlein M. (Eur. J. Biochem. 1997) 2 23 67
  2. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PMID: 19423847) Herzog W. … Stainier D.Y. (Circ. Res. 2009) 23 67
  3. Amino acid modifications on tRNA. (PMID: 18604446) Yuan J. … SAPll D. (Acta Biochim. Biophys. Sin. (Shanghai) 2008) 23 67
  4. Probing the recognition properties of the antiparallel coiled coil motif from PKN by protein grafting. (PMID: 19049388) Li Y. … Oakley M.G. (Biochemistry 2008) 23 67
  5. Biosynthesis of selenocysteine on its tRNA in eukaryotes. (PMID: 17194211) Xu X.M. … Hatfield D.L. (PLoS Biol. 2007) 23 67

Products for SARS Gene

Sources for SARS Gene

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