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Aliases for SARS Gene

Aliases for SARS Gene

  • Seryl-TRNA Synthetase 2 3 4 5
  • Serine TRNA Ligase 1, Cytoplasmic 2 3
  • Seryl-TRNA(Ser/Sec) Synthetase 3 4
  • EC 6.1.1.11 4 56
  • SERRS 3 4
  • SERS 3 4
  • Seryl-TRNA Synthetase, Cytoplasmic 3
  • Serine--TRNA Ligase, Cytoplasmic 3
  • NEDMAS 3

External Ids for SARS Gene

Previous GeneCards Identifiers for SARS Gene

  • GC01P110235
  • GC01P108685
  • GC01P108858
  • GC01P109055
  • GC01P109468
  • GC01P109558
  • GC01P109756
  • GC01P107649

Summaries for SARS Gene

Entrez Gene Summary for SARS Gene

  • This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

GeneCards Summary for SARS Gene

SARS (Seryl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with SARS include Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Viral mRNA Translation and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and aminoacyl-tRNA ligase activity.

UniProtKB/Swiss-Prot for SARS Gene

  • Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at Lys-16 (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).

Gene Wiki entry for SARS Gene

Additional gene information for SARS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARS Gene

Genomics for SARS Gene

GeneHancer (GH) Regulatory Elements for SARS Gene

Promoters and enhancers for SARS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I109213 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.2 1164 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GC01M109214 SARS GNAI3 SORT1 ENSG00000258634 PSRC1 MYBPHL CELSR2 GC01P109222
GH01I109389 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 +180.6 180565 10.7 CLOCK MLX ZFP64 DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SORT1 SYPL2 PRPF38B RBM15 PSRC1 ENSG00000258634 ENSG00000273373 MYBPHL STRIP1 SARS
GH01I109238 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.9 +26.3 26339 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B ENSG00000258634 PRPF38B STRIP1 SORT1 SARS CELSR2 KIAA1324 PIR56087
GH01I109132 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.6 -77.6 -77628 7.4 PKNOX1 ATF1 ARNT ARID4B FEZF1 TCF12 ZNF766 GATA2 NCOA1 PPARG TMEM167B SARS SORT1 C1orf194 KIAA1324 GPSM2 GC01M109207
GH01I109161 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.4 -51.3 -51338 3.1 HDAC1 PKNOX1 NEUROD1 BACH1 CEBPG ZBTB40 ZKSCAN1 IRF9 ZNF664 E2F1 KIAA1324 SARS TMEM167B C1orf194 GC01M109207
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SARS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SARS gene promoter:

Genomic Locations for SARS Gene

Genomic Locations for SARS Gene
chr1:109,213,893-109,238,182
(GRCh38/hg38)
Size:
24,290 bases
Orientation:
Plus strand
chr1:109,756,515-109,780,804
(GRCh37/hg19)

Genomic View for SARS Gene

Genes around SARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARS Gene

Proteins for SARS Gene

  • Protein details for SARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49591-SYSC_HUMAN
    Recommended name:
    Serine--tRNA ligase, cytoplasmic
    Protein Accession:
    P49591
    Secondary Accessions:
    • B2R6Y9
    • Q5T5C8
    • Q9NSE3

    Protein attributes for SARS Gene

    Size:
    514 amino acids
    Molecular mass:
    58777 Da
    Quaternary structure:
    • Homodimer (PubMed:22353712, PubMed:26433229). The tRNA molecule may bind across the dimer (PubMed:26433229). Interacts with SIRT2 (PubMed:24940000).

    Three dimensional structures from OCA and Proteopedia for SARS Gene

neXtProt entry for SARS Gene

Selected DME Specific Peptides for SARS Gene

P49591:
  • LREIGNLLHPSVPIS
  • AILENYQ
  • VPEKLKEFMPPGLQELIPFVK
  • DLEAWFP
  • KKYSHVDLVVMVDGF
  • HGRDTRG
  • FVHMLNATMCATTR
  • GIFRVHQF
  • DTRGIFR
  • YLIATSE
  • LKVSQIKKVRLL
  • DEAILKCDAERIKLEAERFE
  • SNCTDYQ
  • YTPFFMRKEVMQEVAQLSQFD

Post-translational modifications for SARS Gene

Other Protein References for SARS Gene

Domains & Families for SARS Gene

Gene Families for SARS Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49591

UniProtKB/Swiss-Prot:

SYSC_HUMAN :
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Domain:
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
genes like me logo Genes that share domains with SARS: view

Function for SARS Gene

Molecular function for SARS Gene

GENATLAS Biochemistry:
seryl-tRNA synthetase,58kDa
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at Lys-16 (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).

Enzyme Numbers (IUBMB) for SARS Gene

Gene Ontology (GO) - Molecular Function for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001046 core promoter sequence-specific DNA binding IDA 24940000
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding TAS 9431993
GO:0004812 aminoacyl-tRNA ligase activity IEA --
genes like me logo Genes that share ontologies with SARS: view
genes like me logo Genes that share phenotypes with SARS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SARS Gene

Localization for SARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARS Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000269 PubMed:22353712}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SARS gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 28236339
GO:0005829 cytosol TAS,IDA --
GO:0070062 extracellular exosome IDA,HDA 20458337
genes like me logo Genes that share ontologies with SARS: view

Pathways & Interactions for SARS Gene

genes like me logo Genes that share pathways with SARS: view

Pathways by source for SARS Gene

UniProtKB/Swiss-Prot P49591-SYSC_HUMAN

  • Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Gene Ontology (GO) - Biological Process for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 24940000
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006412 translation TAS 9431993
GO:0006418 tRNA aminoacylation for protein translation TAS,IEA --
genes like me logo Genes that share ontologies with SARS: view

No data available for SIGNOR curated interactions for SARS Gene

Drugs & Compounds for SARS Gene

(22) Drugs for SARS Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0
Antibodies Pharma 7224
Anti-Infective Agents Pharma 23607

(6) Additional Compounds for SARS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with SARS: view

Transcripts for SARS Gene

Unigene Clusters for SARS Gene

Seryl-tRNA synthetase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SARS Gene

GeneLoc Exon Structure for
SARS
ECgene alternative splicing isoforms for
SARS

Expression for SARS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SARS Gene

Protein differential expression in normal tissues from HIPED for SARS Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SARS Gene



Protein tissue co-expression partners for SARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SARS Gene:

SARS

SOURCE GeneReport for Unigene cluster for SARS Gene:

Hs.531176

mRNA Expression by UniProt/SwissProt for SARS Gene:

P49591-SYSC_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for SARS Gene

  • Nervous system(5)
  • Liver(4.6)
  • Lung(4)
  • Skin(3.7)
  • Intestine(3.4)
  • Blood(3)
  • Eye(2.8)
  • Muscle(2.8)
  • Kidney(2.4)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SARS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SARS Gene

Orthologs for SARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SARS 33 34
  • 99.81 (n)
oppossum
(Monodelphis domestica)
Mammalia SARS 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARS 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SARS 33 34
  • 92.14 (n)
cow
(Bos Taurus)
Mammalia SARS 33 34
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Sars 33 16 34
  • 90.49 (n)
rat
(Rattus norvegicus)
Mammalia Sars 33
  • 90.3 (n)
chicken
(Gallus gallus)
Aves SARS 33 34
  • 78.4 (n)
lizard
(Anolis carolinensis)
Reptilia SARS 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sars 33
  • 73.32 (n)
Str.657 33
African clawed frog
(Xenopus laevis)
Amphibia sars-prov 33
zebrafish
(Danio rerio)
Actinopterygii sars 33 34
  • 72.89 (n)
Dr.29078 33
fruit fly
(Drosophila melanogaster)
Insecta CG17259 35 33 34
  • 66.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008265 33
  • 66.6 (n)
worm
(Caenorhabditis elegans)
Secernentea srs-2 35
  • 65 (a)
sars-1 34 33
  • 61.52 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10593g 33
  • 55.66 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL088C 33
  • 55.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SES1 33 34 36
  • 53.17 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G27470 33
  • 58.3 (n)
soybean
(Glycine max)
eudicotyledons Gma.9981 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.311 33
rice
(Oryza sativa)
Liliopsida Os01g0559100 33
  • 58.96 (n)
Os.5952 33
barley
(Hordeum vulgare)
Liliopsida Hv.6290 33
wheat
(Triticum aestivum)
Liliopsida Ta.20463 33
corn
(Zea mays)
Liliopsida Zm.15927 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 78 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29A4.15 33
  • 55.2 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01443 33
  • 55.11 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3798 33
Species where no ortholog for SARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SARS Gene

ENSEMBL:
Gene Tree for SARS (if available)
TreeFam:
Gene Tree for SARS (if available)

Paralogs for SARS Gene

No data available for Paralogs for SARS Gene

Variants for SARS Gene

Sequence variations from dbSNP and Humsavar for SARS Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000021436 -- 109,235,717(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000263706 -- 109,214,305(+) C/A intron_variant
rs1000367586 -- 109,214,974(+) A/G intron_variant, non_coding_transcript_variant
rs1000453357 -- 109,222,404(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000606118 -- 109,222,087(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SARS Gene

Variant ID Type Subtype PubMed ID
nsv1008458 CNV gain 25217958
nsv1012267 CNV gain 25217958

Variation tolerance for SARS Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SARS Gene

Human Gene Mutation Database (HGMD)
SARS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARS Gene

Disorders for SARS Gene

MalaCards: The human disease database

(3) MalaCards diseases for SARS Gene - From: HGMD, OMIM, ClinVar, Orphanet, and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search SARS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SARS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SARS Gene

Publications for SARS Gene

  1. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PMID: 9431993) Vincent C … Härtlein M (European journal of biochemistry 1997) 2 3 4 22 58
  2. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PMID: 19423847) Herzog W … Stainier DY (Circulation research 2009) 3 4 22 58
  3. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. (PMID: 28236339) Musante L … Kuss AW (Human mutation 2017) 3 4 58
  4. SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. (PMID: 26433229) Wang C … Xie W (Nucleic acids research 2015) 3 4 58
  5. tRNA synthetase counteracts c-Myc to develop functional vasculature. (PMID: 24940000) Shi Y … Yang XL (eLife 2014) 3 4 58

Products for SARS Gene

Sources for SARS Gene

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