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Aliases for SARS Gene

Aliases for SARS Gene

  • Seryl-TRNA Synthetase 2 3 4 5
  • Serine TRNA Ligase 1, Cytoplasmic 2 3
  • Seryl-TRNA(Ser/Sec) Synthetase 3 4
  • EC 6.1.1.11 4 61
  • SERRS 3 4
  • SERS 3 4
  • Seryl-TRNA Synthetase, Cytoplasmic 3
  • Serine--TRNA Ligase, Cytoplasmic 3

External Ids for SARS Gene

Previous GeneCards Identifiers for SARS Gene

  • GC01P110235
  • GC01P108685
  • GC01P108858
  • GC01P109055
  • GC01P109468
  • GC01P109558
  • GC01P109756
  • GC01P107649

Summaries for SARS Gene

Entrez Gene Summary for SARS Gene

  • This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

GeneCards Summary for SARS Gene

SARS (Seryl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with SARS include Epidemic Typhus. Among its related pathways are tRNA Aminoacylation and Viral mRNA Translation. GO annotations related to this gene include RNA binding and aminoacyl-tRNA ligase activity.

UniProtKB/Swiss-Prot for SARS Gene

  • Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Gene Wiki entry for SARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARS Gene

Genomics for SARS Gene

Regulatory Elements for SARS Gene

Enhancers for SARS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SARS on UCSC Golden Path with GeneCards custom track

Promoters for SARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SARS on UCSC Golden Path with GeneCards custom track

Genomic Location for SARS Gene

Chromosome:
1
Start:
109,213,893 bp from pter
End:
109,238,182 bp from pter
Size:
24,290 bases
Orientation:
Plus strand

Genomic View for SARS Gene

Genes around SARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARS Gene

Proteins for SARS Gene

  • Protein details for SARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49591-SYSC_HUMAN
    Recommended name:
    Serine--tRNA ligase, cytoplasmic
    Protein Accession:
    P49591
    Secondary Accessions:
    • B2R6Y9
    • Q5T5C8
    • Q9NSE3

    Protein attributes for SARS Gene

    Size:
    514 amino acids
    Molecular mass:
    58777 Da
    Quaternary structure:
    • Homodimer. The tRNA molecule binds across the dimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for SARS Gene

neXtProt entry for SARS Gene

Post-translational modifications for SARS Gene

  • Ubiquitination at Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for SARS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SARS Gene

Gene Families for SARS Gene

Suggested Antigen Peptide Sequences for SARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49591

UniProtKB/Swiss-Prot:

SYSC_HUMAN :
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Domain:
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
genes like me logo Genes that share domains with SARS: view

Function for SARS Gene

Molecular function for SARS Gene

GENATLAS Biochemistry:
seryl-tRNA synthetase,58kDa
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Enzyme Numbers (IUBMB) for SARS Gene

Gene Ontology (GO) - Molecular Function for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9431993
GO:0004828 serine-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
GO:0098619 selenocysteine-tRNA ligase activity TAS --
genes like me logo Genes that share ontologies with SARS: view
genes like me logo Genes that share phenotypes with SARS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SARS

CRISPR Products

miRNA for SARS Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SARS Gene

Localization for SARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SARS Gene COMPARTMENTS Subcellular localization image for SARS gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SARS: view

Pathways & Interactions for SARS Gene

genes like me logo Genes that share pathways with SARS: view

Pathways by source for SARS Gene

UniProtKB/Swiss-Prot P49591-SYSC_HUMAN

  • Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Gene Ontology (GO) - Biological Process for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9431993
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006434 seryl-tRNA aminoacylation IBA --
GO:0008033 tRNA processing TAS 9431993
GO:0016259 selenocysteine metabolic process TAS --
genes like me logo Genes that share ontologies with SARS: view

No data available for SIGNOR curated interactions for SARS Gene

Drugs & Compounds for SARS Gene

(8) Drugs for SARS Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist, Target Weak endogenous glycine receptor agonist 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
interferons Pharma 2112

(19) Additional Compounds for SARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with SARS: view

Transcripts for SARS Gene

Unigene Clusters for SARS Gene

Seryl-tRNA synthetase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SARS Gene

GeneLoc Exon Structure for
SARS
ECgene alternative splicing isoforms for
SARS

Expression for SARS Gene

mRNA expression in normal human tissues for SARS Gene

Protein differential expression in normal tissues from HIPED for SARS Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SARS Gene



Protein tissue co-expression partners for SARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SARS Gene:

SARS

SOURCE GeneReport for Unigene cluster for SARS Gene:

Hs.531176
genes like me logo Genes that share expression patterns with SARS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SARS Gene

Orthologs for SARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SARS 34
  • 91.57 (n)
  • 95.32 (a)
SARS 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SARS 34
  • 92.14 (n)
  • 96.3 (a)
SARS 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sars 34
  • 90.49 (n)
  • 95.9 (a)
Sars 16
Sars 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SARS 34
  • 99.81 (n)
  • 99.81 (a)
SARS 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sars 34
  • 90.3 (n)
  • 95.7 (a)
oppossum
(Monodelphis domestica)
Mammalia SARS 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARS 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves SARS 34
  • 78.4 (n)
  • 85.8 (a)
SARS 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SARS 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sars 34
  • 73.32 (n)
  • 81.6 (a)
Str.657 34
African clawed frog
(Xenopus laevis)
Amphibia sars-prov 34
zebrafish
(Danio rerio)
Actinopterygii Dr.29078 34
sars 34
  • 72.89 (n)
  • 81.52 (a)
sars 35
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17259 36
  • 79 (a)
CG17259 34
  • 66.67 (n)
  • 69.96 (a)
CG17259 35
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008265 34
  • 66.6 (n)
  • 69.7 (a)
worm
(Caenorhabditis elegans)
Secernentea srs-2 36
  • 65 (a)
sars-1 34
  • 61.52 (n)
  • 66.05 (a)
sars-1 35
  • 66 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL088C 34
  • 55.15 (n)
  • 51.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10593g 34
  • 55.66 (n)
  • 51.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SES1 34
  • 53.17 (n)
  • 52.35 (a)
SES1 35
  • 49 (a)
OneToMany
SES1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G27470 34
  • 58.3 (n)
  • 53.62 (a)
soybean
(Glycine max)
eudicotyledons Gma.9981 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.311 34
barley
(Hordeum vulgare)
Liliopsida Hv.6290 34
rice
(Oryza sativa)
Liliopsida Os.5952 34
Os01g0559100 34
  • 58.96 (n)
  • 56.93 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20463 34
corn
(Zea mays)
Liliopsida Zm.15927 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3798 34
bread mold
(Neurospora crassa)
Ascomycetes NCU01443 34
  • 55.11 (n)
  • 51.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29A4.15 34
  • 55.2 (n)
  • 54.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
Species where no ortholog for SARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SARS Gene

ENSEMBL:
Gene Tree for SARS (if available)
TreeFam:
Gene Tree for SARS (if available)

Paralogs for SARS Gene

No data available for Paralogs for SARS Gene

Variants for SARS Gene

Sequence variations from dbSNP and Humsavar for SARS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2924 -- 109,217,376(-) TTACA(C/T)GAGAT intron-variant, nc-transcript-variant
rs600711 -- 109,231,404(-) TTATC(C/T)TGATG intron-variant
rs654040 -- 109,230,335(-) TGGGA(A/G)TGATG intron-variant
rs607087 -- 109,233,910(-) cctgg(A/G)tgaaa intron-variant
rs654469 -- 109,222,002(-) aaaaa(A/T)atata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SARS Gene

Variant ID Type Subtype PubMed ID
nsv1008458 CNV gain 25217958
nsv1012267 CNV gain 25217958

Variation tolerance for SARS Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SARS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARS Gene

Disorders for SARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SARS Gene - From: DISEASES

Disorder Aliases PubMed IDs
epidemic typhus
  • sylvatic typhus
- elite association - COSMIC cancer census association via MalaCards
Search SARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for SARS

Genetic Association Database (GAD)
SARS
Human Genome Epidemiology (HuGE) Navigator
SARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SARS
genes like me logo Genes that share disorders with SARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SARS Gene

Publications for SARS Gene

  1. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PMID: 9431993) Vincent C. … Haertlein M. (Eur. J. Biochem. 1997) 2 3 4 22 65
  2. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 65
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  4. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PMID: 19423847) Herzog W. … Stainier D.Y. (Circ. Res. 2009) 3 22 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for SARS Gene

Sources for SARS Gene

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