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Aliases for SARS Gene

Aliases for SARS Gene

  • Seryl-TRNA Synthetase 2 3 4 5
  • Serine TRNA Ligase 1, Cytoplasmic 2 3
  • Seryl-TRNA(Ser/Sec) Synthetase 3 4
  • EC 6.1.1.11 4 61
  • SERRS 3 4
  • SERS 3 4
  • Seryl-TRNA Synthetase, Cytoplasmic 3
  • Serine--TRNA Ligase, Cytoplasmic 3

External Ids for SARS Gene

Previous GeneCards Identifiers for SARS Gene

  • GC01P110235
  • GC01P108685
  • GC01P108858
  • GC01P109055
  • GC01P109468
  • GC01P109558
  • GC01P109756
  • GC01P107649

Summaries for SARS Gene

Entrez Gene Summary for SARS Gene

  • This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

GeneCards Summary for SARS Gene

SARS (Seryl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with SARS include Epidemic Typhus. Among its related pathways are Selenium Metabolism and Selenoproteins and Viral mRNA Translation. GO annotations related to this gene include RNA binding and aminoacyl-tRNA ligase activity.

UniProtKB/Swiss-Prot for SARS Gene

  • Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Gene Wiki entry for SARS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARS Gene

Genomics for SARS Gene

Regulatory Elements for SARS Gene

Enhancers for SARS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G109389 2 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +180.6 180566 10.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 SLC30A9 SP3 NFYC TBX21 MEF2D SYPL2 PSRC1 MYBPHL SARS AMIGO1 ATXN7L2 SORT1 TMEM167B GSTM3 GNAI3
GH01G109238 1.5 Ensembl ENCODE dbSUPER 10.9 +26.3 26339 3.7 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A ZNF2 ZBTB7B GLIS2 ZNF143 SORT1 SARS CELSR2 KIAA1324 PIR56087
GH01G109132 1.5 Ensembl ENCODE dbSUPER 10.6 -77.6 -77629 7.4 PKNOX1 ATF1 CREB3L1 ARNT ARID4B E2F7 FEZF1 TCF12 ZNF766 ELK1 TMEM167B SARS SORT1 C1orf194 KIAA1324 GPSM2 GC01M109207
GH01G109161 1.3 Ensembl ENCODE dbSUPER 10.4 -51.3 -51339 3.1 HDAC1 CTCF PKNOX1 BACH1 CEBPG RAD21 ZKSCAN1 IRF9 ZNF664 E2F1 KIAA1324 SARS TMEM167B GC01M109207 C1orf194
GH01G109184 1 Ensembl dbSUPER 10.7 -27.9 -27924 2.5 KLF1 FOXA2 ZIC2 ZNF121 ZFHX2 ZNF316 POLR2A EGR1 ZBTB48 ZSCAN29 KIAA1324 SARS TMEM167B GC01M109207 C1orf194
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SARS on UCSC Golden Path with GeneCards custom track

Promoters for SARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011046 507 1601 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS

Genomic Location for SARS Gene

Chromosome:
1
Start:
109,213,893 bp from pter
End:
109,238,182 bp from pter
Size:
24,290 bases
Orientation:
Plus strand

Genomic View for SARS Gene

Genes around SARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARS Gene

Proteins for SARS Gene

  • Protein details for SARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49591-SYSC_HUMAN
    Recommended name:
    Serine--tRNA ligase, cytoplasmic
    Protein Accession:
    P49591
    Secondary Accessions:
    • B2R6Y9
    • Q5T5C8
    • Q9NSE3

    Protein attributes for SARS Gene

    Size:
    514 amino acids
    Molecular mass:
    58777 Da
    Quaternary structure:
    • Homodimer. The tRNA molecule binds across the dimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for SARS Gene

neXtProt entry for SARS Gene

Selected DME Specific Peptides for SARS Gene

P49591:
  • LREIGNLLHPSVPIS
  • AILENYQ
  • VPEKLKEFMPPGLQELIPFVK
  • DLEAWFP
  • KKYSHVDLVVMVDGF
  • HGRDTRG
  • FVHMLNATMCATTR
  • GIFRVHQF
  • DTRGIFR
  • YLIATSE
  • LKVSQIKKVRLL
  • DEAILKCDAERIKLEAERFE
  • SNCTDYQ
  • YTPFFMRKEVMQEVAQLSQFD

Post-translational modifications for SARS Gene

  • Ubiquitination at isoforms=376
  • Modification sites at PhosphoSitePlus

Other Protein References for SARS Gene

Domains & Families for SARS Gene

Gene Families for SARS Gene

Suggested Antigen Peptide Sequences for SARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49591

UniProtKB/Swiss-Prot:

SYSC_HUMAN :
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Domain:
  • Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
genes like me logo Genes that share domains with SARS: view

Function for SARS Gene

Molecular function for SARS Gene

GENATLAS Biochemistry:
seryl-tRNA synthetase,58kDa
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).

Enzyme Numbers (IUBMB) for SARS Gene

Gene Ontology (GO) - Molecular Function for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9431993
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004828 serine-tRNA ligase activity TAS,IEA --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with SARS: view
genes like me logo Genes that share phenotypes with SARS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SARS

miRNA for SARS Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SARS Gene

Localization for SARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SARS gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 28236339
GO:0005829 cytosol IDA,TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SARS: view

Pathways & Interactions for SARS Gene

genes like me logo Genes that share pathways with SARS: view

Pathways by source for SARS Gene

UniProtKB/Swiss-Prot P49591-SYSC_HUMAN

  • Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Gene Ontology (GO) - Biological Process for SARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 9431993
GO:0006418 tRNA aminoacylation for protein translation IEA,TAS --
GO:0006434 seryl-tRNA aminoacylation IEA,IMP 28236339
GO:0008033 tRNA processing TAS 9431993
GO:0016259 selenocysteine metabolic process TAS --
genes like me logo Genes that share ontologies with SARS: view

No data available for SIGNOR curated interactions for SARS Gene

Drugs & Compounds for SARS Gene

(23) Drugs for SARS Gene - From: DrugBank, ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Serine Approved Nutra Full agonist, Agonist, Target Weak endogenous glycine receptor agonist 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Antibodies Pharma 6394

(6) Additional Compounds for SARS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with SARS: view

Transcripts for SARS Gene

Unigene Clusters for SARS Gene

Seryl-tRNA synthetase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - -
SP9: - - -
SP10: - - - - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SARS Gene

GeneLoc Exon Structure for
SARS
ECgene alternative splicing isoforms for
SARS

Expression for SARS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SARS Gene

Protein differential expression in normal tissues from HIPED for SARS Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SARS Gene



Protein tissue co-expression partners for SARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SARS Gene:

SARS

SOURCE GeneReport for Unigene cluster for SARS Gene:

Hs.531176

Evidence on tissue expression from TISSUES for SARS Gene

  • Nervous system(5)
  • Liver(4.6)
  • Lung(4)
  • Skin(3.7)
  • Intestine(3.4)
  • Blood(3)
  • Eye(2.8)
  • Muscle(2.8)
  • Kidney(2.4)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SARS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SARS Gene

Orthologs for SARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SARS 34 35
  • 99.81 (n)
oppossum
(Monodelphis domestica)
Mammalia SARS 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARS 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SARS 34 35
  • 92.14 (n)
cow
(Bos Taurus)
Mammalia SARS 34 35
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Sars 34 16 35
  • 90.49 (n)
rat
(Rattus norvegicus)
Mammalia Sars 34
  • 90.3 (n)
chicken
(Gallus gallus)
Aves SARS 34 35
  • 78.4 (n)
lizard
(Anolis carolinensis)
Reptilia SARS 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sars 34
  • 73.32 (n)
Str.657 34
African clawed frog
(Xenopus laevis)
Amphibia sars-prov 34
zebrafish
(Danio rerio)
Actinopterygii sars 34 35
  • 72.89 (n)
Dr.29078 34
fruit fly
(Drosophila melanogaster)
Insecta CG17259 36 34 35
  • 66.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008265 34
  • 66.6 (n)
worm
(Caenorhabditis elegans)
Secernentea srs-2 36
  • 65 (a)
sars-1 34 35
  • 61.52 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A10593g 34
  • 55.66 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL088C 34
  • 55.15 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SES1 34 35 37
  • 53.17 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G27470 34
  • 58.3 (n)
soybean
(Glycine max)
eudicotyledons Gma.9981 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.311 34
rice
(Oryza sativa)
Liliopsida Os01g0559100 34
  • 58.96 (n)
Os.5952 34
barley
(Hordeum vulgare)
Liliopsida Hv.6290 34
wheat
(Triticum aestivum)
Liliopsida Ta.20463 34
corn
(Zea mays)
Liliopsida Zm.15927 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 78 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC29A4.15 34
  • 55.2 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01443 34
  • 55.11 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3798 34
Species where no ortholog for SARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SARS Gene

ENSEMBL:
Gene Tree for SARS (if available)
TreeFam:
Gene Tree for SARS (if available)

Paralogs for SARS Gene

No data available for Paralogs for SARS Gene

Variants for SARS Gene

Sequence variations from dbSNP and Humsavar for SARS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000021436 -- 109,235,717(+) GCCTG(C/T)CTCAC intron-variant
rs1000263706 -- 109,214,305(+) CATCC(A/C)ACTTT intron-variant
rs1000367586 -- 109,214,974(+) CTGTC(A/G)AGTAC intron-variant, nc-transcript-variant
rs1000453357 -- 109,222,404(+) GTGCA(A/G)TCTTA intron-variant
rs1000606118 -- 109,222,087(+) TCGAA(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SARS Gene

Variant ID Type Subtype PubMed ID
nsv1008458 CNV gain 25217958
nsv1012267 CNV gain 25217958

Variation tolerance for SARS Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SARS Gene

Human Gene Mutation Database (HGMD)
SARS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARS Gene

Disorders for SARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for SARS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
epidemic typhus
  • sylvatic typhus
- elite association - COSMIC cancer census association via MalaCards
Search SARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for SARS

Genetic Association Database (GAD)
SARS
Human Genome Epidemiology (HuGE) Navigator
SARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SARS
genes like me logo Genes that share disorders with SARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SARS Gene

Publications for SARS Gene

  1. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PMID: 9431993) Vincent C. … Haertlein M. (Eur. J. Biochem. 1997) 2 3 4 22 64
  2. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PMID: 19423847) Herzog W. … Stainier D.Y. (Circ. Res. 2009) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SARS Gene

Sources for SARS Gene

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