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SARNP Gene

protein-coding   GIFtS: 50
GCID: GC12M056146

SAP Domain Containing Ribonucleoprotein

  See SARNP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SAP Domain Containing Ribonucleoprotein1 2     Proliferation-Associated Cytokine-Inducible Protein CIP292 3
HCC12 3 5     CIP292 5
Cytokine Induced Protein 29 KDa1 2     HSPC3162 5
Hepatocellular Carcinoma 11 2     THO12
Cytokine-Induced Protein Of 29 KDa2 3     Proliferation Associated Cytokine-Inducible Protein CIP292
Nuclear Protein Hcc-12 3     SAP Domain-Containing Ribonucleoprotein2

External Ids:    HGNC: 244321   Entrez Gene: 843242   Ensembl: ENSG000002053237   OMIM: 6100495   UniProtKB: P829793   

Export aliases for SARNP gene to outside databases

Previous GC identifers: GC12M054442 GC12M053185


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SARNP Gene:
This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a
role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene,
resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia.
Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described.
(provided by RefSeq, Feb 2009)

GeneCards Summary for SARNP Gene:
SARNP (SAP domain containing ribonucleoprotein) is a protein-coding gene. Diseases associated with SARNP include hepatocellular carcinoma. GO annotations related to this gene include RNA binding and nucleic acid binding.

UniProtKB/Swiss-Prot: SARNP_HUMAN, P82979
Function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form.
Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA
unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell
growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA
transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with
unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA
upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region
near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX
complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and
infectious virus production

Gene Wiki entry for SARNP (CIP29) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SARNP gene promoter:
         STAT1   NF-1   CUTL1   STAT1alpha   CREB   deltaCREB   FOXJ2 (long isoform)   ZID   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSARNP promoter sequence
   Search Chromatin IP Primers for SARNP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SARNP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

SARNP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SARNP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056146:  view genomic region     (about GC identifiers)

Start:
56,146,247 bp from pter      End:
56,211,540 bp from pter
Size:
65,294 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SARNP_HUMAN, P82979 (See protein sequence)
Recommended Name: SAP domain-containing ribonucleoprotein  
Size: 210 amino acids; 23671 Da
Subunit: Interacts with DDX39A. Interacts with FUS. Component of the transcription/export (TREX) complex at least
composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure
involving ATP-dependent remodeling; in the complex interacts directly with DDX39B in a ATP-dependent manner which
bridges it to ALYREF/THOC4
Sequence caution: Sequence=AAF28994.1; Type=Frameshift; Positions=134, 149;
1 PDB 3D structure from and Proteopedia for SARNP:
2DO1 (3D)    
Secondary accessions: A8K393 Q9P066

Explore the universe of human proteins at neXtProt for SARNP: NX_P82979

Explore proteomics data for SARNP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys92, Lys135
  • Modification sites at PhosphoSitePlus

  • See SARNP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149073.1  
    ENSEMBL proteins: 
     ENSP00000449409   ENSP00000448455   ENSP00000337632   ENSP00000447690   ENSP00000392892  

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    antibodies-online proteins for SARNP (5 products) 

     
    antibodies-online peptides for SARNP

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003034 SAP_dom

    Graphical View of Domain Structure for InterPro Entry P82979

    ProtoNet protein and cluster: P82979

    1 Blocks protein domain: IPB003034 DNA-binding SAP

    UniProtKB/Swiss-Prot: SARNP_HUMAN, P82979
    Similarity: Contains 1 SAP domain


    Find genes that share domains with SARNP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SARNP_HUMAN, P82979
    Function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form.
    Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA
    unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell
    growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA
    transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with
    unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA
    upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region
    near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX
    complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and
    infectious virus production
    Induction: By EPO/erythropoietin

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SARNP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SARNP:
     High actin ratio cells 

         1 MGI phenotypic allele for Sarnp (no phenotypes)

    Find genes that share phenotypes with SARNP           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SARNP

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SARNP:
    hsa-miR-3688-3p hsa-miR-943
    SwitchGear 3'UTR luciferase reporter plasmidSARNP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SARNP_HUMAN, P82979: Nucleus. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA--
    GO:0005634nucleus NAS11356193
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SARNP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SARNP
    Interactions:

        GeneGlobe Interaction Network for SARNP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for SARNP (P829792, 3 ENSP000003376324) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253165 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253165 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253165 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253165 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253165 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006406mRNA export from nucleus IDA--
    GO:0006417regulation of translation IEA--

    Find genes that share ontologies with SARNP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SARNP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SARNP gene: 
    NM_033082.3  

    Unigene Cluster for SARNP:

    SAP domain containing ribonucleoprotein
    Hs.505676  [show with all ESTs]
    Unigene Representative Sequence: BG394042
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546604(uc009zoa.2 uc001shs.3) ENST00000552884 ENST00000552946
    ENST00000336133(uc001sht.3) ENST00000552080 ENST00000552207(uc001shv.4)
    ENST00000444631
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SARNP:
    hsa-miR-3688-3p hsa-miR-943
    SwitchGear 3'UTR luciferase reporter plasmidSARNP 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SARNP

    Additional mRNA sequence: 

    AF161434.1 AF486281.1 AK290508.1 BC007099.1 BC093051.1 NR_026722.1 NR_026723.1 

    21 DOTS entries:

    DT.92459604  DT.444275  DT.100659421  DT.100659419  DT.121072335  DT.121194718  DT.95123309  DT.92459608 
    DT.92459626  DT.100031474  DT.121194789  DT.121194657  DT.92459605  DT.97795309  DT.92037465  DT.95121685 
    DT.121072417  DT.121194782  DT.86859077  DT.100020515  DT.86845890 

    Selected AceView cDNA sequences (see all 543):

    BX279991 BE294482 BU956454 CB143179 BC016941 BQ962276 CA428644 R82402 
    BU174287 BM452174 CR593273 BQ058270 AI915446 CD651999 AI311652 BU607407 
    BI870282 AI924300 AI139718 BM559381 T30718 BM722636 BG289677 BM916484 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SARNP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGCGGCA
    SARNP Expression
    About this image

    SARNP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SARNP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505676

    UniProtKB/Swiss-Prot: SARNP_HUMAN, P82979
    Tissue specificity: Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels
    are seen in hepatocellular carcinoma and pancreatic adenocarcinoma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SARNP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sarnp1 , 5 SAP domain containing ribonucleoprotein1, 5 89.52(n)1
    95.71(a)1
      10 (77.16 cM)5
    661181  NM_025364.21  NP_079640.11 
     1288217715 
    chicken
    (Gallus gallus)
    Aves SARNP1 SAP domain containing ribonucleoprotein 78.15(n)
    85.17(a)
      425058  NM_001031324.1  NP_001026495.1 
    lizard
    (Anolis carolinensis)
    Reptilia SARNP6
    SAP domain containing ribonucleoprotein
    78(a)
    1 ↔ 1
    GL343198.1(2942947-3012723)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sarnp1 SAP domain containing ribonucleoprotein 70.26(n)
    75.49(a)
      549238  NM_001016484.3  NP_001016484.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sarnp1 SAP domain containing ribonucleoprotein 61.5(n)
    61.5(a)
      554106  NM_001024407.2  NP_001019578.1 


    ENSEMBL Gene Tree for SARNP (if available)
    TreeFam Gene Tree for SARNP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SARNP gene
    2 SIMAP similar genes for SARNP using alignment to 3 protein entries:     SARNP_HUMAN (see all proteins):
    CIP29    LOC402290

    Find genes that share paralogs with SARNP           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SARNP
    PGOHUM00000232932 PGOHUM00000260418 PGOHUM00000261517


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SARNP (see all 1180)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs742406691,2
    C,F--56147246(+) TGACTC/TACATT 2 -- int11Minor allele frequency- T:0.07EA 120
    rs1884167401,2
    --56147280(+) TGGGCA/GCAGTG 2 -- int10--------
    rs72975231,2
    C,A--56147315(+) TTGGGA/GGGCCG 2 -- int10--------
    rs7722531,2
    F--56147324(-) cgcccG/Acctcg 2 -- int12Minor allele frequency- A:0.00NA 4
    rs1930991741,2
    C--56147427(+) CGTGCA/GCCTGT 2 -- int10--------
    rs1832155911,2
    --56147608(+) CTCCTA/GTAGTT 2 -- int10--------
    rs1495181671,2
    --56147709(+) TGTACG/TCCAAG 2 -- int10--------
    rs1146969781,2
    F--56147795(+) AACCTG/CATCCA 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1166453481,2
    F--56147915(+) GGAAGT/CGGTTG 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1870862221,2
    --56148154(+) TGCCTA/GTATTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for SARNP (56146247 - 56211540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SARNP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672374CNV Deletion23128226
    nsv507644CNV Insertion20534489
    nsv469410CNV Loss19166990
    esv22731CNV Loss19812545
    nsv832423CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610049    OMIM disorders: --

    1 disease for SARNP:    
    About MalaCards
    hepatocellular carcinoma


    Find genes that share disorders with SARNP           About GenesLikeMe


    Export disorders for SARNP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SARNP gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SARNP)
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    world of online information

    1. Cloning and characterization of a proliferation-associated cytokine- inducible protein, CIP29. (PubMed id 11922608)1, 2, 3, 9 Fukuda S.... Pelus L.M. (Biochem. Biophys. Res. Commun. 2002)
    2. An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors. (PubMed id 11356193)1, 2, 3 Choong M.L.... Chung M.C.M. (FEBS Lett. 2001)
    3. Intracellular characterization of DDX39, a novel growth-associated RNA helicase. (PubMed id 17196963)1, 2 Sugiura T.... Nagano Y. (Exp. Cell Res. 2007)
    4. Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function. (PubMed id 15338056)1, 2 Leaw C.L.... Choong M.L. (Cell. Mol. Life Sci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84324 HGNC: 24432 AceView: DNAJC14andCIP29 Ensembl:ENSG00000205323 euGenes: HUgn84324
    ECgene: SARNP H-InvDB: SARNP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SARNP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SARNP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SARNP gene:
    Search GeneIP for patents involving SARNP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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