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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SARM1 Gene

protein-coding   GIFtS: 58
GCID: GC17P026698

Sterile Alpha And TIR Motif Containing 1

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sterile Alpha And TIR Motif Containing 11 2     SAMD22 3
SARM2 3 5     SAM Domain-Containing Protein 22 3
Sterile Alpha And Armadillo Repeat Protein2 3     KIAA05243 5
Sterile Alpha Motif Domain-Containing Protein 22 3     Sterile Alpha And HEAT/Armadillo Motif Protein, Ortholog Of Drosophila2
Tir-1 Homolog2 3     Sterile Alpha And TIR Motif-Containing Protein 12
MyD88-52 3     

External Ids:    HGNC: 170741   Entrez Gene: 230982   Ensembl: ENSG000000041397   OMIM: 6077325   UniProtKB: Q6SZW13   

Export aliases for SARM1 gene to outside databases

Previous GC identifers: GC17P026550 GC17P026844 GC17P023723 GC17P026685 GC17P022907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SARM1 Gene: 
SARM1 (sterile alpha and TIR motif containing 1) is a protein-coding gene. Diseases associated with SARM1 include retinoschisis, and wallerian degeneration, and among its related super-pathways are Toll-Like Receptors Cascades and Immune System.

UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1
Function: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a
pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an
injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can
activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway.
Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1,
TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SARM1 gene promoter:
         AhR   p300   NRSF form 1   NF-kappaB   NRSF form 2   GATA-2   ARP-1   NF-kappaB1   LyF-1   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SARM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SARM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11

SARM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SARM1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026698:  view genomic region     (about GC identifiers)

Start:
26,691,378 bp from pter      End:
26,728,065 bp from pter
Size:
36,688 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1 (See protein sequence)
Recommended Name: Sterile alpha and TIR motif-containing protein 1 precursor  
Size: 724 amino acids; 79388 Da
Subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. Interacts with MAPK10/JNK3
and SDC2 (via cytoplasmic domain) (By similarity)
Subcellular location: Cytoplasm. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity).
Cell junction, synapse (By similarity). Mitochondrion. Note=Associated with microtubules (By similarity)
Caution: Was initially (PubMed:11386760) reported to contain ARM repeats. Such repeats are however not predicted
by any detection method
Secondary accessions: O60277 Q7LGG3 Q9NXY5
Alternative splicing: 2 isoforms:  Q6SZW1-1   Q6SZW1-2   

Explore the universe of human proteins at neXtProt for SARM1: NX_Q6SZW1

Explore proteomics data for SARM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6SZW1

  • SARM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SARM1 Protein Expression
    REFSEQ proteins: NP_055892.2  
    ENSEMBL proteins: 
     ENSP00000406738   ENSP00000464166   ENSP00000462479   ENSP00000462228  
    Reactome Protein details: Q6SZW1
    Human Recombinant Protein Products for SARM1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule ISS--
    GO:0030054cell junction IEA--

    SARM1 for ontologies           About GeneDecksing



    SARM1 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SAMD: Sterile alpha motif (SAM) domain containing

    5/6 InterPro protein domains (see all 6):
     IPR013761 SAM/pointed
     IPR011989 ARM-like
     IPR001660 SAM
     IPR011510 SAM_2
     IPR000157 TIR_dom

    Graphical View of Domain Structure for InterPro Entry Q6SZW1

    ProtoNet protein and cluster: Q6SZW1

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1
    Similarity: Contains 2 SAM (sterile alpha motif) domains
    Similarity: Contains 1 TIR domain


    SARM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SARM1_HUMAN, Q6SZW1
    Function: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a
    pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an
    injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can
    activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway.
    Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1,
    TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38
    Induction: Up-regulated by lipopolysaccharides (LPS)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    SARM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SARM1:
     Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sarm1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system 

    SARM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SARM1: Sarm1tm1.1Diam Sarm1tm1Aidi

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SARM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SARM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SARM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SARM1 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SARM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    2Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for SARM1 (see all 7)
        MyD88-independent cascade
    Toll Like Receptor 3 (TLR3) Cascade
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    Activated TLR4 signalling



    SARM1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SARM1

    5/21 Interacting proteins for SARM1 (Q6SZW13) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078583I2D: score=4 
    SIAH1Q8IUQ43I2D: score=4 
    TNPO1Q929733I2D: score=4 
    CCDC47Q96A333I2D: score=1 
    CDIPTO147353I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0007165signal transduction ----
    GO:0009749response to glucose stimulus ----
    GO:0034138toll-like receptor 3 signaling pathway TAS--

    SARM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SARM1

    Search CenterWatch for drugs/clinical trials and news about SARM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SARM1 gene: 
    NM_015077.3  

    Unigene Cluster for SARM1:

    Sterile alpha and TIR motif containing 1
    Hs.743510  [show with all ESTs]
    Unigene Representative Sequence: NM_015077
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379061(uc010waj.1) ENST00000457710(uc010crl.1 uc002hbe.1)
    ENST00000003834 ENST00000582323 ENST00000578128 ENST00000577870 ENST00000580711
    ENST00000579593

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SARM1

    Additional mRNA sequence: 

    AB011096.1 AF086363.1 AJ290445.1 AK026397.1 AK093615.1 AK302038.1 AK314609.1 AY444166.1 
    BC040429.1 BC122860.1 

    8 DOTS entries:

    DT.95373041  DT.99968346  DT.100782897  DT.40240655  DT.100025807  DT.120988319  DT.99941606  DT.120988299 

    24/102 AceView cDNA sequences (see all 102):

    BM795235 AA281198 CR616327 BQ068917 AW770507 AA729916 CR623769 AA281090 
    BX106603 BM791687 BX090713 CR626592 BU178839 AI084200 AI497683 AK026397 
    BI063212 AI693737 BM672700 AW572933 AY444166 AI962488 NM_015077 BG820141 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SARM1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a · 12b · 12c
    SP1:                                                        -     -     -     -           -                                   -                     
    SP2:                          -     -                       -     -     -     -                                                                     
    SP3:                                                        -           -     -           -                                                         
    SP4:                                                        -     -     -                 -                                   -                     
    SP5:                                                              -     -     -                                               -                     


    ECgene alternative splicing isoforms for SARM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SARM1 expression in normal human tissues (normalized intensities)      SARM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATGACAA
    SARM1 Expression
    About this image


    SARM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See SARM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SARM1

    SOURCE GeneReport for Unigene cluster: Hs.743510

    UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1
    Tissue specificity: Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta

        SABiosciences Expression via Pathway-Focused PCR Array including SARM1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SARM1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sarm11 , 5 sterile alpha and HEAT/Armadillo motif containing 11, 5 88.18(n)1
    94.04(a)1
      11 (46.74 cM)5
    2378681  NM_001168521.11  NP_001161993.11 
     784723305 
    chicken
    (Gallus gallus)
    Aves SARM11 sterile alpha and TIR motif containing 1 72.45(n)
    72.87(a)
      417568  XM_415814.3  XP_415814.3 
    lizard
    (Anolis carolinensis)
    Reptilia SARM16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343470.1(554217-564472)
    zebrafish
    (Danio rerio)
    Actinopterygii sarm11 sterile alpha and TIR motif containing 1 64.9(n)
    63.85(a)
      403143  NM_001130596.1  NP_001124068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ect41 CG43119-PD 54.92(n)
    49.18(a)
      38895  NM_001104071.2  NP_001097541.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tir-11 Protein TIR-1 47.11(n)
    41.32(a)
      175502  NM_001026080.1  NP_001021251.1 


    ENSEMBL Gene Tree for SARM1 (if available)
    TreeFam Gene Tree for SARM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/434 SNPs in SARM1 are shown (see all 434)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0617024
    ----see VAR_0617022 P R mis40--------
    rs1402484171,2
    C,F--22905397(+) CAGCTC/GTGGTA 1 -- us2k11Minor allele frequency- G:0.00NA 4550
    rs1114906531,2
    C,F--22905418(-) TGTGAC/TGAGCT 1 -- us2k13Minor allele frequency- T:0.00NS WA NA 5226
    rs1458617451,2
    F--22905442(+) TCCACG/ATTGAA 1 -- us2k11Minor allele frequency- A:0.00NA 4552
    rs22277211,2
    C,F,O,A,H--22905860(-) AGCTCG/TCCCAG 1 -- us2k129Minor allele frequency- T:0.16NS MN EA NA CSA WA 3998
    rs1423376391,2
    C--22905861(+) TGGGCA/GAGCTG 1 -- us2k10--------
    rs22277201,2
    C,F,A,H--22905930(-) CCAGAT/CCCACG 1 -- us2k124Minor allele frequency- C:0.16NS MN EA NA CSA WA 3400
    rs22277191,2
    C,F--22905972(-) AGAGAG/CATAAA 1 -- us2k1 tfbs310Minor allele frequency- C:0.04NS WA 1436
    rs169642361,2
    C,H--22906142(-) CCAGGG/AATGTG 1 -- us2k15Minor allele frequency- A:0.01MN EA NS NA 532
    rs22277181,2
    C,F,H--22906513(-) GTTCTG/TTGGAC 1 -- us2k121Minor allele frequency- T:0.16NS EA NA WA 3028

    HapMap Linkage Disequilibrium report for SARM1 (26691378 - 26728065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SARM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715786CNV Deletion23290073
    nsv519388CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607732    OMIM disorders: --

    7 diseases for SARM1:    About MalaCards
    retinoschisis    wallerian degeneration    hypogonadism    chronic lymphocytic leukemia
    retinitis    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SARM1:
    Retinoschisis

    SARM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): SARM1
    Human Genome Epidemiology (HuGE) Navigator: SARM1 (4 documents)

    Export disorders for SARM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SARM1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SARM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    2. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. (PubMed id 15123841)1, 2, 9 Liberati N.T....Ausubel F.M. (2004)
    3. Targeting of pro-apoptotic TLR adaptor SARM to mitocho ndria: definition of the critical region and residues in the signal sequence. (PubMed id 22145856)1, 2 Panneerselvam P....Ding J.L. (2012)
    4. SARM inhibits both TRIF- and MyD88-mediated AP-1 acti vation. (PubMed id 20306472)1, 2 Peng J....Ding J.L. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Studies of SARM1 uncover similarities between immune and neuronal responses to danger. (PubMed id 18089857)1, 2 Dalod M. (2007)
    7. The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PubMed id 16964262)1, 2 Carty M....Bowie A.G. (2006)
    8. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. (PubMed id 11386760)1, 2 Mink M.... Csiszar K. (2001)
    9. SARM1 and TRAF6 bind to and stabilize PINK1 on depolar ized mitochondria. (PubMed id 23885119)1 Murata H....Huh N.H. (2013)
    10. T-cell death following immune activation is mediated b y mitochondria-localized SARM. (PubMed id 23175186)1 Panneerselvam P....Ding J.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23098 HGNC: 17074 AceView: SARM1 Ensembl:ENSG00000004139 euGenes: HUgn23098
    ECgene: SARM1 H-InvDB: SARM1

    (According to HUGE)
    About This Section
    HUGE: KIAA0524

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SARM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SARM1 gene:
    Search GeneIP for patents involving SARM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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