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Aliases for SARM1 Gene

Aliases for SARM1 Gene

  • Sterile Alpha And TIR Motif Containing 1 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 2 3 4
  • Sterile Alpha And Armadillo Repeat Protein 3 4
  • SAM Domain-Containing Protein 2 3 4
  • Tir-1 Homolog 3 4
  • MyD88-5 3 4
  • SAMD2 3 4
  • SARM 3 4
  • Sterile Alpha And HEAT/Armadillo Motif Protein, Ortholog Of Drosophila 3
  • Sterile Alpha And TIR Motif-Containing Protein 1 3
  • KIAA0524 4

External Ids for SARM1 Gene

Previous GeneCards Identifiers for SARM1 Gene

  • GC17P026550
  • GC17P026844
  • GC17P023723
  • GC17P026685
  • GC17P026698
  • GC17P022907

Summaries for SARM1 Gene

GeneCards Summary for SARM1 Gene

SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include Wallerian Degeneration and Gastric Signet Ring Cell Adenocarcinoma. Among its related pathways are Immune System and Activated TLR4 signalling. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for SARM1 Gene

  • Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARM1 Gene

Genomics for SARM1 Gene

Regulatory Elements for SARM1 Gene

Enhancers for SARM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F028393 1.1 Ensembl ENCODE 11.7 +32.5 32511 5.7 BCOR GTF2F1 TBP TFAP4 TAL1 JUN ZFP64 ZMYM3 RARA POLR2A POLDIP2 VTN SARM1 TMEM199 MIR4723 TNFAIP1 IFT20 FOXN1 UNC119 PIGS
GH17F028715 1.2 ENCODE 10.2 +358.6 358568 14.4 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PROCA1 ENSG00000264647 ENSG00000264577 LOC105371715 LOC105371716 NDUFS5P7 ENSG00000264029 ENSG00000266111 SDF2 MIR4723
GH17F028892 1.1 ENCODE 10.8 +531.0 530968 7.4 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 PROCA1 SARM1 ENSG00000264044 TRAF4 FLOT2 ENSG00000264304
GH17F029045 1.1 Ensembl ENCODE 10.8 +681.9 681881 1.1 ELF3 ARID4B RAD21 RARA YY1 CREM MIXL1 EGR2 THAP11 HMG20B TIAF1 MYO18A SARM1 ENSG00000264044 NDUFS5P7
GH17F028841 1.1 ENCODE 10.8 +478.0 478011 2.1 HDGF CREB3L1 ARID4B SIN3A FEZF1 ZNF2 SP3 REST SMARCB1 KAT8 TRAF4 SARM1 ENSG00000264044 GIT1 ENSG00000238516 ENSG00000264138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SARM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SARM1 Gene

Chromosome:
17
Start:
28,364,356 bp from pter
End:
28,404,049 bp from pter
Size:
39,694 bases
Orientation:
Plus strand

Genomic View for SARM1 Gene

Genes around SARM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SARM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARM1 Gene

Proteins for SARM1 Gene

  • Protein details for SARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6SZW1-SARM1_HUMAN
    Recommended name:
    Sterile alpha and TIR motif-containing protein 1
    Protein Accession:
    Q6SZW1
    Secondary Accessions:
    • O60277
    • Q7LGG3
    • Q9NXY5

    Protein attributes for SARM1 Gene

    Size:
    724 amino acids
    Molecular mass:
    79388 Da
    Quaternary structure:
    • Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. Interacts with MAPK10/JNK3 and SDC2 (via cytoplasmic domain) (By similarity).

    Alternative splice isoforms for SARM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SARM1 Gene

Post-translational modifications for SARM1 Gene

  • Ubiquitination at Lys 363
  • Modification sites at PhosphoSitePlus

Other Protein References for SARM1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SARM1 (SARM1)

No data available for DME Specific Peptides for SARM1 Gene

Domains & Families for SARM1 Gene

Suggested Antigen Peptide Sequences for SARM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6SZW1

UniProtKB/Swiss-Prot:

SARM1_HUMAN :
  • Contains 2 SAM (sterile alpha motif) domains.
Domain:
  • Contains 2 SAM (sterile alpha motif) domains.
  • Contains 1 TIR domain.
genes like me logo Genes that share domains with SARM1: view

Function for SARM1 Gene

Molecular function for SARM1 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
UniProtKB/Swiss-Prot Induction:
Up-regulated by lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17258210
genes like me logo Genes that share ontologies with SARM1: view
genes like me logo Genes that share phenotypes with SARM1: view

Animal Models for SARM1 Gene

MGI Knock Outs for SARM1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SARM1 Gene

Localization for SARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARM1 Gene

Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Note=Associated with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SARM1 gene
Compartment Confidence
mitochondrion 5
cytosol 5
cytoskeleton 4
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IEA,IDA 22145856
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA,ISS --
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with SARM1: view

Pathways & Interactions for SARM1 Gene

genes like me logo Genes that share pathways with SARM1: view

Pathways by source for SARM1 Gene

Gene Ontology (GO) - Biological Process for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development IEA --
GO:0009749 response to glucose IEA --
GO:0030154 cell differentiation IEA --
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SARM1: view

No data available for SIGNOR curated interactions for SARM1 Gene

Transcripts for SARM1 Gene

Unigene Clusters for SARM1 Gene

Sterile alpha and TIR motif containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for SARM1 Gene

GeneLoc Exon Structure for
SARM1
ECgene alternative splicing isoforms for
SARM1

Expression for SARM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SARM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SARM1 Gene

This gene is overexpressed in Testis (14.5), Fetal Brain (12.8), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SARM1 Gene



Protein tissue co-expression partners for SARM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SARM1 Gene:

SARM1

SOURCE GeneReport for Unigene cluster for SARM1 Gene:

Hs.743510

mRNA Expression by UniProt/SwissProt for SARM1 Gene:

Q6SZW1-SARM1_HUMAN
Tissue specificity: Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.
genes like me logo Genes that share expression patterns with SARM1: view

No data available for mRNA differential expression in normal tissues for SARM1 Gene

Orthologs for SARM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SARM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SARM1 34 35
  • 99.95 (n)
dog
(Canis familiaris)
Mammalia SARM1 34 35
  • 92.22 (n)
mouse
(Mus musculus)
Mammalia Sarm1 34 16 35
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia Sarm1 34
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia SARM1 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SARM1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARM1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves SARM1 34 35
  • 72.35 (n)
lizard
(Anolis carolinensis)
Reptilia SARM1 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sarm1 34
  • 63.83 (n)
zebrafish
(Danio rerio)
Actinopterygii sarm1 34 35
  • 64.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005901 34
  • 56.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ect4 34 35
  • 54.99 (n)
worm
(Caenorhabditis elegans)
Secernentea tir-1 34 35
  • 47.1 (n)
Species where no ortholog for SARM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SARM1 Gene

ENSEMBL:
Gene Tree for SARM1 (if available)
TreeFam:
Gene Tree for SARM1 (if available)

Paralogs for SARM1 Gene

No data available for Paralogs for SARM1 Gene

Variants for SARM1 Gene

Sequence variations from dbSNP and Humsavar for SARM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs80338774 Pathogenic 28,400,658(-) GTTCC(C/G)CTTCC intron-variant, reference, missense, utr-variant-3-prime
rs186143284 Likely benign 28,399,670(+) CTGGG(A/G)AAACT reference, synonymous-codon, missense, utr-variant-3-prime
rs1055190 -- 28,398,543(+) ACACA(A/G)GTCTG utr-variant-3-prime
rs1055191 -- 28,398,544(+) CACAG(A/G)TCTGT utr-variant-3-prime
rs10607992 -- 28,374,303(+) AAAAA(-/A)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SARM1 Gene

Variant ID Type Subtype PubMed ID
nsv574653 CNV gain 21841781
nsv519388 CNV loss 19592680
nsv1125214 CNV deletion 24896259
nsv1062056 CNV gain 25217958
nsv1056839 CNV gain 25217958
esv2715789 CNV deletion 23290073
esv2715788 CNV deletion 23290073
esv2715786 CNV deletion 23290073

Variation tolerance for SARM1 Gene

Gene Damage Index Score: 1.99; 36.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SARM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SARM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARM1 Gene

Disorders for SARM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SARM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
gastric signet ring cell adenocarcinoma
  • signet ring cell adenocarcinoma of the stomach
- elite association - COSMIC cancer census association via MalaCards
Search SARM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SARM1

Genetic Association Database (GAD)
SARM1
Human Genome Epidemiology (HuGE) Navigator
SARM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SARM1
genes like me logo Genes that share disorders with SARM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SARM1 Gene

Publications for SARM1 Gene

  1. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. (PMID: 15123841) Liberati N.T. … Ausubel F.M. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence. (PMID: 22145856) Panneerselvam P. … Ding J.L. (Biochem. J. 2012) 3 4 64
  4. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. (PMID: 20306472) Peng J. … Ding J.L. (Eur. J. Immunol. 2010) 3 4 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for SARM1 Gene

Sources for SARM1 Gene

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