Aliases for SARM1 Gene
External Ids for SARM1 Gene
Previous GeneCards Identifiers for SARM1 Gene
GeneCards Summary for SARM1 Gene
SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include retinoschisis and wallerian degeneration. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll Like Receptor 7/8 (TLR7/8) Cascade.
UniProtKB/Swiss-Prot for SARM1 Gene
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.