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Aliases for SARM1 Gene

Aliases for SARM1 Gene

  • Sterile Alpha And TIR Motif Containing 1 2 3
  • SARM 3 4 6
  • Sterile Alpha Motif Domain-Containing Protein 2 3 4
  • Sterile Alpha And Armadillo Repeat Protein 3 4
  • SAM Domain-Containing Protein 2 3 4
  • Tir-1 Homolog 3 4
  • KIAA0524 4 6
  • MyD88-5 3 4
  • SAMD2 3 4
  • Sterile Alpha And HEAT/Armadillo Motif Protein, Ortholog Of Drosophila 3
  • Sterile Alpha And TIR Motif-Containing Protein 1 3

External Ids for SARM1 Gene

Previous GeneCards Identifiers for SARM1 Gene

  • GC17P026550
  • GC17P026844
  • GC17P023723
  • GC17P026685
  • GC17P026698
  • GC17P022907

Summaries for SARM1 Gene

GeneCards Summary for SARM1 Gene

SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include retinoschisis and wallerian degeneration. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll Like Receptor 7/8 (TLR7/8) Cascade.

UniProtKB/Swiss-Prot for SARM1 Gene

  • Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SARM1 Gene

Genomics for SARM1 Gene

Regulatory Elements for SARM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SARM1 Gene

Start:
28,364,356 bp from pter
End:
28,404,049 bp from pter
Size:
39,694 bases
Orientation:
Plus strand

Genomic View for SARM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARM1 Gene

Proteins for SARM1 Gene

  • Protein details for SARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6SZW1-SARM1_HUMAN
    Recommended name:
    Sterile alpha and TIR motif-containing protein 1
    Protein Accession:
    Q6SZW1
    Secondary Accessions:
    • O60277
    • Q7LGG3
    • Q9NXY5

    Protein attributes for SARM1 Gene

    Size:
    724 amino acids
    Molecular mass:
    79388 Da
    Quaternary structure:
    • Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. Interacts with MAPK10/JNK3 and SDC2 (via cytoplasmic domain) (By similarity).

    Alternative splice isoforms for SARM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SARM1 Gene

Proteomics data for SARM1 Gene at MOPED

Post-translational modifications for SARM1 Gene

  • Ubiquitination at Lys363
  • Modification sites at PhosphoSitePlus

Other Protein References for SARM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SARM1 Gene

Domains for SARM1 Gene

Gene Families for SARM1 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Suggested Antigen Peptide Sequences for SARM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6SZW1

UniProtKB/Swiss-Prot:

SARM1_HUMAN :
  • Q6SZW1
Domain:
  • Contains 2 SAM (sterile alpha motif) domains.
  • Contains 1 TIR domain.
genes like me logo Genes that share domains with SARM1: view

Function for SARM1 Gene

Molecular function for SARM1 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
UniProtKB/Swiss-Prot Induction: Up-regulated by lipopolysaccharides (LPS).

Gene Ontology (GO) - Molecular Function for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SARM1: view
genes like me logo Genes that share phenotypes with SARM1: view

Animal Models for SARM1 Gene

MGI Knock Outs for SARM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SARM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SARM1 Gene

Localization for SARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARM1 Gene

Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Note=Associated with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SARM1 Gene COMPARTMENTS Subcellular localization image for SARM1 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 4
cytosol 4
golgi apparatus 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IDA 22145856
GO:0005829 cytosol TAS --
GO:0005874 microtubule ISS --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with SARM1: view

Pathways for SARM1 Gene

genes like me logo Genes that share pathways with SARM1: view

Pathways by source for SARM1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat

Interacting Proteins for SARM1 Gene

Selected Interacting proteins: Q6SZW1-SARM1_HUMAN for SARM1 Gene via I2D

Gene Ontology (GO) - Biological Process for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0007165 signal transduction --
GO:0009749 response to glucose IEA --
GO:0034138 toll-like receptor 3 signaling pathway TAS --
genes like me logo Genes that share ontologies with SARM1: view

Transcripts for SARM1 Gene

Unigene Clusters for SARM1 Gene

Sterile alpha and TIR motif containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SARM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for SARM1 Gene

GeneLoc Exon Structure for
SARM1
ECgene alternative splicing isoforms for
SARM1

Expression for SARM1 Gene

mRNA expression in normal human tissues for SARM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SARM1 Gene

SOURCE GeneReport for Unigene cluster for SARM1 Gene Hs.743510

mRNA Expression by UniProt/SwissProt for SARM1 Gene

Q6SZW1-SARM1_HUMAN
Tissue specificity: Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.
genes like me logo Genes that share expressions with SARM1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SARM1 Gene

Orthologs for SARM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SARM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SARM1 35
  • 99.95 (n)
  • 100 (a)
SARM1 36
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SARM1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SARM1 35
  • 92.22 (n)
  • 95.72 (a)
SARM1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sarm1 35
  • 88.18 (n)
  • 94.04 (a)
Sarm1 16
Sarm1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SARM1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARM1 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sarm1 35
  • 88.13 (n)
  • 93.49 (a)
chicken
(Gallus gallus)
Aves SARM1 35
  • 72.35 (n)
  • 72.87 (a)
SARM1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SARM1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sarm1 35
  • 63.83 (n)
  • 68.34 (a)
zebrafish
(Danio rerio)
Actinopterygii sarm1 35
  • 64.53 (n)
  • 63.34 (a)
sarm1 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005901 35
  • 56.8 (n)
  • 47.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ect4 35
  • 54.99 (n)
  • 49.26 (a)
Ect4 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tir-1 35
  • 47.1 (n)
  • 41.29 (a)
tir-1 36
  • 24 (a)
OneToOne
Species with no ortholog for SARM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SARM1 Gene

ENSEMBL:
Gene Tree for SARM1 (if available)
TreeFam:
Gene Tree for SARM1 (if available)

Paralogs for SARM1 Gene

No data available for Paralogs for SARM1 Gene

Variants for SARM1 Gene

Sequence variations from dbSNP and Humsavar for SARM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs739437 -- 28,383,599(-) GACAG(A/G)CTGGT intron-variant
rs967645 -- 28,386,951(-) gaaca(A/G)cctgg intron-variant
rs967646 -- 28,386,891(-) tgtgg(G/T)gttgc intron-variant
rs2006232 -- 28,383,292(-) GGTTC(A/C)TGTGA intron-variant
rs2027993 -- 28,379,927(-) gaaat(A/C)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SARM1 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
esv2715786 CNV Deletion 23290073

Relevant External Links for SARM1 Gene

HapMap Linkage Disequilibrium report
SARM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARM1 Gene

Disorders for SARM1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SARM1 Gene including...

Search for SARM1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SARM1 Gene

Relevant External Links for SARM1

Genetic Association Database (GAD)
SARM1
Human Genome Epidemiology (HuGE) Navigator
SARM1
genes like me logo Genes that share disorders with SARM1: view

No data available for UniProtKB/Swiss-Prot for SARM1 Gene

Publications for SARM1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. (PMID: 15123841) Liberati N.T. … Ausubel F.M. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PMID: 16964262) Carty M. … Bowie A.G. (Nat. Immunol. 2006) 3 4
  4. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. (PMID: 11386760) Mink M. … Csiszar K. (Genomics 2001) 3 4
  5. Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence. (PMID: 22145856) Panneerselvam P. … Ding J.L. (Biochem. J. 2012) 3 4

Products for SARM1 Gene

Sources for SARM1 Gene

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