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Aliases & Descriptions for SARM1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ36296 2 | | KIAA0524 1, 2, 3 | | SAMD2 1, 2 | | SARM 1, 2, 3 |
| | | Descriptions |
|---|
| Sterile alpha and Armadillo repeat protein 3 | | Tir-1 homolog 3 | sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila 2 | | sterile alpha and TIR motif containing 1 2 |
|
| | Search outside databases for aliases for SARM1 genePrevious GC identifers: GC17P026550 GC17P026844 |
Summaries for SARM1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1Function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation |
Genomic Location for SARM1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SARM1 gene 
Entrez Gene cytogenetic band: 17q11 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11SARM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P023723:
(about GC identifiers)
Start:
|
23,723,114 bp from pter |
End:
|
23,752,192 bp from pter |
Size:
|
29,079 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010799.14
| Proteins for SARM1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1 (See
protein sequence)Recommended Name: Sterile alpha and TIR motif-containing protein 1 Size: 724 amino acids; 79388 Da
Subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function
Subcellular location: Cytoplasm (By similarity)
Caution: Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method
Secondary accessions: O60277 Q7LGG3 Q9NXY5Alternative splicing: 2 isoforms: Q6SZW1-1 Q6SZW1-2 REFSEQ proteins: NP_055892.2
ENSEMBL proteins: ENSP00000003834 ENSP00000368351
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SARM1: Assays for SARM1: | Protein
Domains/ Families for SARM1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6SZW1
ProtoNet protein and cluster: Q6SZW1 2 Blocks protein families: IPB001660 Sterile alpha motif SAM IPB011510 Sterile alpha motif homology 2
UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1Similarity: Contains 2 SAM (sterile alpha motif) domainsSimilarity: Contains 1 TIR domain | Gene Function for SARM1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015077
Applied Biosystems Silencer® siRNAs for SARM1
Sigma-Aldrich siRNA and siRNA Panels for SARM1  Sigma-Aldrich shRNA for SARM1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015077                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015077                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015077 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015077
UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1Function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sarm1):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004888 | transmembrane receptor activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for SARM1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/14 Interacting proteins for SARM1 (ENSP000003683513) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0009749 | response to glucose stimulus |
IEA | -- | | GO:0042981 | regulation of apoptosis |
IEA | -- | | GO:0045087 | innate immune response |
IEA | -- | About this table
|
Drugs & Compounds for SARM1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SARM1
|
Transcripts for SARM1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015077
Sigma-Aldrich siRNA and siRNA Panels for SARM1  Sigma-Aldrich shRNA for SARM1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015077 REFSEQ mRNAs for SARM1 gene: NM_015077.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015077               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015077                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015077                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015077  Additional cDNA sequence: AB011096.1 AF086363.1 AJ290445.1 AK026397.1 AK093615.1 AK302038.1 AK314609.1 AY444166.1 BC040429.1 BC122860.1 CR616327.1 CR626592.1 8 DOTS entries: DT.95373041 DT.99968346 DT.40240655 DT.100782897 DT.100025807 DT.120988319 DT.99941606 DT.120988299 24/102 AceView cDNA sequences (see all 102
):CR626592 BM791687 BQ068917 BM795235 BX090713 AA281198 AW770507 CR623769 BU178839 AA729916 BX106603 CR616327 AA281090 AA568670 CD511988 NM_015077 BG911443 AJ290445 BX483880 AL534755 BF339050 R70607 BU151384 AY444166
highest scoring ESTs for SARM1:AB011096 AA281090 AA350494 AI934275 AW953254 BG820141 BM672700 BM791687 BQ368533 BQ575644 Unigene Cluster for SARM1: Sterile alpha and TIR motif containing 1 Hs.719354 [show with all ESTs]Unigene Representative Sequence: NM_015077
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SARM1 (see all 8
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SARM1
2 Ensembl transcripts including schematic representations: ENST00000003834
ENST00000379061
|
Expression for SARM1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SARM1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SARM1
1 / 2 / 3 5 probe-sets matching SARM1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.719354
Expression variation in blood from EXPOLDB for SARM1 UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1Tissue specificity: Predominantly expressed in kidney and liver. Expressed at lower level in placenta |
Orthologs for SARM1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SARM1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for SARM1
ENSEMBL Gene Tree for SARM1 | Paralogs for SARM1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for SARM1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SARM1 (up to first 250kb)
|
Disorders & Mutations for SARM1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607732
|
Medical News for SARM1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SARM1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for SARM1 gene (see all 12
):- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)2, 3, 4 Nagase T....Ohara O. (1998)
- Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. (PubMed id 15123841)1, 3, 4 Liberati N.T....Ausubel F.M. (2004)
- The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PubMed id 16964262)3, 4 Carty M....Bowie A.G. (2006)
- A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. (PubMed id 11386760)3, 4 Mink M.... Csiszar K. (2001)
- Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex. (PubMed id 17804407)3 Molday L.L....Molday R.S. (2007)
- Studies of SARM1 uncover similarities between immune and neuronal responses to danger. (PubMed id 18089857)3 Dalod M. (2007)
- DisSARMing Toll-like receptor signaling. (PubMed id 16985498)4 O'Neill L.A.J. (2006)
- SARM1: A candidate gene in the onset of hereditary infectious/inflammatory diseases. (PubMed id 15893701)3 Mink M. and Csiszar K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for SARM1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SARM1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SARM1
(According to HUGE)
About This Section
| |
Specialized Databases showing SARM1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SARM1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SARM1:

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Incremental update: 13 Oct 2009
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