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SARM1 Gene

protein-coding   GIFtS: 55
GCID: GC17P026698

Sterile Alpha And TIR Motif Containing 1

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sterile Alpha And TIR Motif Containing 11 2     SAMD22 3
SARM2 3 5     SAM Domain-Containing Protein 22 3
Sterile Alpha And Armadillo Repeat Protein2 3     KIAA05243 5
Sterile Alpha Motif Domain-Containing Protein 22 3     Sterile Alpha And HEAT/Armadillo Motif Protein, Ortholog Of Drosophila2
Tir-1 Homolog2 3     Sterile Alpha And TIR Motif-Containing Protein 12
MyD88-52 3     

External Ids:    HGNC: 170741   Entrez Gene: 230982   Ensembl: ENSG000000041397   OMIM: 6077325   UniProtKB: Q6SZW13   

Export aliases for SARM1 gene to outside databases

Previous GC identifers: GC17P026550 GC17P026844 GC17P023723 GC17P026685 GC17P022907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SARM1 Gene:
SARM1 (sterile alpha and TIR motif containing 1) is a protein-coding gene. Diseases associated with SARM1 include wallerian degeneration, and retinoschisis.

UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1
Function: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a
pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an
injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can
activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway.
Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1,
TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SARM1 gene promoter:
         AhR   p300   NRSF form 1   NF-kappaB   NRSF form 2   GATA-2   ARP-1   NF-kappaB1   LyF-1   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SARM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SARM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11

SARM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SARM1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P026698:  view genomic region     (about GC identifiers)

Start:
26,691,378 bp from pter      End:
26,728,065 bp from pter
Size:
36,688 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1 (See protein sequence)
Recommended Name: Sterile alpha and TIR motif-containing protein 1 precursor  
Size: 724 amino acids; 79388 Da
Subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. Interacts with MAPK10/JNK3
and SDC2 (via cytoplasmic domain) (By similarity)
Caution: Was initially (PubMed:11386760) reported to contain ARM repeats. Such repeats are however not predicted
by any detection method
Secondary accessions: O60277 Q7LGG3 Q9NXY5
Alternative splicing: 2 isoforms:  Q6SZW1-1   Q6SZW1-2   

Explore the universe of human proteins at neXtProt for SARM1: NX_Q6SZW1

Explore proteomics data for SARM1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys363
  • Modification sites at PhosphoSitePlus

  • See SARM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055892.2  
    ENSEMBL proteins: 
     ENSP00000406738   ENSP00000464166   ENSP00000462479   ENSP00000462228  
    Reactome Protein details: Q6SZW1

    SARM1 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for SARM1
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    Novus Biologicals SARM1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SARM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SARM1
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    Novus Biologicals SARM1 Antibodies
    Abcam antibodies for SARM1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SARM1
    LSBio Antibodies in human, mouse, rat for SARM1

    SARM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SARM1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 6):
     IPR011989 ARM-like
     IPR000157 TIR_dom
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry Q6SZW1

    ProtoNet protein and cluster: Q6SZW1

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1
    Similarity: Contains 2 SAM (sterile alpha motif) domains
    Similarity: Contains 1 TIR domain


    SARM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SARM1_HUMAN, Q6SZW1
    Function: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a
    pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an
    injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can
    activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway.
    Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1,
    TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38
    Induction: Up-regulated by lipopolysaccharides (LPS)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    SARM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SARM1:
     Synthetic lethal with c-Myc af 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sarm1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system 

    SARM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SARM1: Sarm1tm1.1Diam Sarm1tm1Aidi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SARM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SARM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SARM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SARM1

    miRNA
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    Block miRNA regulation of human, mouse, rat SARM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SARM1 (see all 41):
    hsa-miR-4254 hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-29a hsa-miR-342-3p hsa-miR-654-5p hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SARM1
    Predesigned siRNA for gene silencing in human, mouse, rat SARM1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SARM1

    Clone
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    OriGene clones in human, mouse for SARM1 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SARM1 (NM_015077)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SARM1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SARM1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SARM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SARM1_HUMAN, Q6SZW1: Cytoplasm. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity).
    Cell junction, synapse (By similarity). Mitochondrion. Note=Associated with microtubules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytoskeleton4
    cytosol4
    golgi apparatus2
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--
    GO:0005874microtubule ISS--
    GO:0030054cell junction IEA--

    SARM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SARM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for SARM1
        IKK complex recruitment mediated by RIP1
    MyD88-independent cascade
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
    TRAF6 mediated induction of TAK1 complex



    SARM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SARM1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SARM1

    Selected Interacting proteins for SARM1 (Q6SZW13) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078583I2D: score=4 
    SIAH1Q8IUQ43I2D: score=4 
    TNPO1Q929733I2D: score=4 
    CCDC47Q96A333I2D: score=1 
    CDIPTO147353I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0007165signal transduction ----
    GO:0009749response to glucose ----
    GO:0034138toll-like receptor 3 signaling pathway TAS--

    SARM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SARM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SARM1 gene: 
    NM_015077.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379061(uc010waj.1) ENST00000457710(uc010crl.1 uc002hbe.1)
    ENST00000003834 ENST00000582323 ENST00000578128 ENST00000577870 ENST00000580711
    ENST00000579593

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SARM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SARM1 (see all 41):
    hsa-miR-4254 hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-29a hsa-miR-342-3p hsa-miR-654-5p hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SARM1
    Predesigned siRNA for gene silencing in human, mouse, rat SARM1
    Clone
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    OriGene clones in human, mouse for SARM1 (see all 7)
    OriGene ORF clones in mouse, rat for SARM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SARM1 (NM_015077)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SARM1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SARM1
    Primer
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    OriGene qPCR primer pairs and template standards for SARM1
    OriGene qSTAR qPCR primer pairs in human, mouse for SARM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SARM1
      QuantiTect SYBR Green Assays in human, mouse, rat SARM1
      QuantiFast Probe-based Assays in human, mouse, rat SARM1

    Selected AceView cDNA sequences (see all 102):

    BX106603 BM795235 CR616327 AW770507 AA729916 AA281198 BQ068917 CR623769 
    BM791687 BU178839 CR626592 BX090713 AA281090 AL565643 BE793178 BQ899207 
    BQ894414 NM_015077 AI937297 AW572933 W72040 BF339050 AA974997 BE260736 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SARM1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a · 12b · 12c
    SP1:                                                        -     -     -     -           -                                   -                     
    SP2:                          -     -                       -     -     -     -                                                                     
    SP3:                                                        -           -     -           -                                                         
    SP4:                                                        -     -     -                 -                                   -                     
    SP5:                                                              -     -     -                                               -                     


    ECgene alternative splicing isoforms for SARM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SARM1 expression in normal human tissues (normalized intensities)      SARM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATGACAA
    SARM1 Expression
    About this image


    SARM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SARM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SARM1 Protein Expression

    UniProtKB/Swiss-Prot: SARM1_HUMAN, Q6SZW1
    Tissue specificity: Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including SARM1: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SARM1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SARM1
    QuantiTect SYBR Green Assays in human, mouse, rat SARM1
    QuantiFast Probe-based Assays in human, mouse, rat SARM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SARM1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sarm11 , 5 sterile alpha and HEAT/Armadillo motif containing 11, 5 88.18(n)1
    94.04(a)1
      11 (46.74 cM)5
    2378681  NM_001168521.11  NP_001161993.11 
     784723305 
    chicken
    (Gallus gallus)
    Aves SARM11 sterile alpha and TIR motif containing 1 72.35(n)
    72.87(a)
      417568  XM_415814.4  XP_415814.4 
    lizard
    (Anolis carolinensis)
    Reptilia SARM16
    sterile alpha and TIR motif containing 1
    66(a)
    1 ↔ 1
    GL343470.1(554217-564472)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sarm11 sterile alpha and TIR motif containing 1 63.83(n)
    68.34(a)
      779619  XM_002937143.2  XP_002937189.2 
    zebrafish
    (Danio rerio)
    Actinopterygii sarm11 sterile alpha and TIR motif containing 1 64.53(n)
    63.34(a)
      403143  NM_001130596.1  NP_001124068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ect41 Ectoderm-expressed 4 54.99(n)
    49.26(a)
      38895  NM_001259734.1  NP_001246663.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tir-11 tir-1 47.1(n)
    41.29(a)
      175502  NM_065383.1  NP_497784.1 


    ENSEMBL Gene Tree for SARM1 (if available)
    TreeFam Gene Tree for SARM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SARM1 (see all 434)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402484171,2
    C,F--22905397(+) CAGCTC/GTGGTA 1 -- us2k11Minor allele frequency- G:0.00NA 4550
    rs1114906531,2
    C,F--22905418(-) TGTGAC/TGAGCT 1 -- us2k13Minor allele frequency- T:0.00NS WA NA 5226
    rs1458617451,2
    F--22905442(+) TCCACG/ATTGAA 1 -- us2k11Minor allele frequency- A:0.00NA 4552
    rs22277211,2
    C,F,O,A,H--22905860(-) AGCTCG/TCCCAG 1 -- us2k129Minor allele frequency- T:0.16NS MN EA NA CSA WA 3998
    rs1423376391,2
    C--22905861(+) TGGGCA/GAGCTG 1 -- us2k10--------
    rs22277201,2
    C,F,A,H--22905930(-) CCAGAT/CCCACG 1 -- us2k124Minor allele frequency- C:0.16NS MN EA NA CSA WA 3400
    rs22277191,2
    C,F--22905972(-) AGAGAG/CATAAA 1 -- us2k1 tfbs310Minor allele frequency- C:0.04NS WA 1436
    rs169642361,2
    C,H--22906142(-) CCAGGG/AATGTG 1 -- us2k15Minor allele frequency- A:0.01MN EA NS NA 532
    rs22277181,2
    C,F,H--22906513(-) GTTCTG/TTGGAC 1 -- us2k121Minor allele frequency- T:0.16NS EA NA WA 3028
    rs1894682451,2
    --22906664(+) CAATTC/GCCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SARM1 (26691378 - 26728065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SARM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715786CNV Deletion23290073
    nsv519388CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SARM1
    DNA2.0 Custom Variant and Variant Library Synthesis for SARM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607732    OMIM disorders: --

    9 diseases for SARM1:    About MalaCards
    wallerian degeneration    retinoschisis    hypogonadism    chronic lymphocytic leukemia
    retinitis    malaria    cervicitis    neuronitis
    leukemia

    1 disease from the University of Copenhagen DISEASES database for SARM1:
    Retinoschisis

    SARM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): SARM1
    Human Genome Epidemiology (HuGE) Navigator: SARM1 (4 documents)

    Export disorders for SARM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SARM1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with SARM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. (PubMed id 15123841)1, 2, 9 Liberati N.T....Ausubel F.M. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence. (PubMed id 22145856)1, 2 Panneerselvam P.... Ding J.L. (Biochem. J. 2012)
    4. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. (PubMed id 20306472)1, 2 Peng J.... Ding J.L. (Eur. J. Immunol. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Studies of SARM1 uncover similarities between immune and neuronal responses to danger. (PubMed id 18089857)1, 2 Dalod M. (Sci. STKE 2007)
    7. The human adaptor SARM negatively regulates adaptor protein TRIF- dependent Toll-like receptor signaling. (PubMed id 16964262)1, 2 Carty M....Bowie A.G. (Nat. Immunol. 2006)
    8. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. (PubMed id 11386760)1, 2 Mink M.... Csiszar K. (Genomics 2001)
    9. SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. (PubMed id 23885119)1 Murata H....Huh N.H. (Mol. Biol. Cell 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23098 HGNC: 17074 AceView: SARM1 Ensembl:ENSG00000004139 euGenes: HUgn23098
    ECgene: SARM1 H-InvDB: SARM1

    (According to HUGE)
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    HUGE: KIAA0524

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SARM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SARM1 gene:
    Search GeneIP for patents involving SARM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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