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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SARDH Gene

protein-coding   GIFtS: 58
GCID: GC09M136528

Sarcosine Dehydrogenase


(Previous symbol: DMGDHL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sarcosine Dehydrogenase1 2     SDH2
DMGDHL11 2 3     Dimethylglycine Dehydrogenase-Like 12
BPR-22 3     Sarcosine Dehydrogenase, Mitochondrial2
SAR2 5     EC 1.5.8.33
SARD2 5     SarDH3

External Ids:    HGNC: 105361   Entrez Gene: 17572   Ensembl: ENSG000001234537   OMIM: 6044555   UniProtKB: Q9UL123   

Export aliases for SARDH gene to outside databases

Previous GC identifers: GC09M127604 GC09P128054 GC09M129954 GC09M131870 GC09M133558 GC09M135518 GC09M106029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SARDH Gene:
This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of
sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which
catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with
sarcosinemia. Alternatively spliced transcript variants have been described. (provided by RefSeq, Oct 2008)

GeneCards Summary for SARDH Gene: 
SARDH (sarcosine dehydrogenase) is a protein-coding gene. Diseases associated with SARDH include sarcosinemia, and dimethylglycine dehydrogenase deficiency, and among its related super-pathways are Metabolism. GO annotations related to this gene include sarcosine dehydrogenase activity and aminomethyltransferase activity. An important paralog of this gene is PDPR.

Gene Wiki entry for SARDH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SARDH gene promoter:
         N-Myc   Zic1   NF-kappaB   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SARDH promoter sequence
   Search SABiosciences Chromatin IP Primers for SARDH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SARDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33-q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q33-q34

SARDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SARDH gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136528:  view genomic region     (about GC identifiers)

Start:
136,528,682 bp from pter      End:
136,605,077 bp from pter
Size:
76,396 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12 (See protein sequence)
Recommended Name: Sarcosine dehydrogenase, mitochondrial precursor  
Size: 918 amino acids; 101037 Da
Cofactor: Binds 1 FAD covalently per monomer (By similarity)
Subcellular location: Mitochondrion matrix (By similarity)
Sequence caution: Sequence=AAD33412.1; Type=Frameshift; Positions=867;
Secondary accessions: B2RMR5 B7ZLT6 Q5SYV0 Q9Y280 Q9Y2Y3

Explore the universe of human proteins at neXtProt for SARDH: NX_Q9UL12

Explore proteomics data for SARDH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL12

  • SARDH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SARDH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001128179.1  NP_009032.2  

    ENSEMBL proteins: 
     ENSP00000360938   ENSP00000360934   ENSP00000394210   ENSP00000360933   ENSP00000403084  
     ENSP00000415537   ENSP00000298628  

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    Cloud-Clone Corp. Proteins for SARDH 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix IEA--

    SARDH for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006076 FAD-dep_OxRdtase
     IPR006222 GCV_T_N
     IPR027266 TrmE/GcvT_dom1
     IPR013977 GCV_T_C

    Graphical View of Domain Structure for InterPro Entry Q9UL12

    ProtoNet protein and cluster: Q9UL12

    1 Blocks protein domain: IPB006222 Glycine cleavage T protein (aminomethyl transferase)

    UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12
    Similarity: Belongs to the GcvT family


    SARDH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SARDH_HUMAN, Q9UL12
    Catalytic activity: Sarcosine + H(2)O + electron-transfer flavoprotein = glycine + formaldehyde + reduced
    electron-transfer flavoprotein

         Genatlas biochemistry entry for SARDH:
    sarcosine dehydrogenase,catalyzing qlycine synthesis,"one-carbone" metabolism,liver motochondrial flavoenzyme

         Enzyme Number (IUBMB): EC 1.5.8.31

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004047aminomethyltransferase activity IEA--
    GO:0008480sarcosine dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
         
    SARDH for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SARDH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2glycine betaine degradation
    glycine betaine degradation
    3Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SARDH
        glycine betaine degradation


    2         Kegg Pathways  (Kegg details for SARDH):
        Glycine, serine and threonine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12
    Pathway: Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1


    SARDH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SARDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for SARDH (ENSP000003609384) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGXTENSP000003026204STRING: ENSP00000302620
    AGXT2ENSP000002314204STRING: ENSP00000231420
    BHMTENSP000002743534STRING: ENSP00000274353
    BHMT2ENSP000002551924STRING: ENSP00000255192
    DAOENSP000002284764STRING: ENSP00000228476
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006546glycine catabolic process IEA--
    GO:0008150biological_process ----
    GO:0055114oxidation-reduction process ----

    SARDH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SARDH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SARDH

    10/11 HMDB Compounds for SARDH (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    FormaldehydeAldeide formica (see all 16)50-00-0--
    Glycine2-Aminoacetate (see all 15)56-40-6--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Sarcosine(Methylamino)acetate (see all 15)107-97-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    9 Novoseek inferred chemical compound relationships for SARDH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcosine 93.9 35 10444331 (4), 9528896 (2), 1700744 (1), 1372986 (1) (see all 17)
    dimethylglycine 90 5 10444331 (1), 9528896 (1), 11122247 (1), 14744856 (1) (see all 5)
    mannitol 55.2 7 15658461 (1), 8753449 (1), 10503458 (1), 11954740 (1) (see all 7)
    n-ethyl-n-nitrosourea 52.7 1 8812433 (1)
    flavin 51.6 1 15069080 (1)
    succinate 27.5 2 9528896 (1), 10448053 (1)
    folate 14.6 2 10767172 (1)
    creatinine 13.7 2 10448053 (1), 20347908 (1)
    lactate 0 1 8621045 (1)

    Search CenterWatch for drugs/clinical trials and news about SARDH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SARDH gene (2 alternative transcripts): 
    NM_001134707.1  NM_007101.3  

    Unigene Cluster for SARDH:

    Sarcosine dehydrogenase
    Hs.198003  [show with all ESTs]
    Unigene Representative Sequence: NM_007101
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371872(uc004ceo.3 uc011mdo.2 uc011mdn.2) ENST00000371868(uc004cen.3)
    ENST00000469828 ENST00000427237 ENST00000371867 ENST00000439388(uc004cep.4)
    ENST00000422262 ENST00000298628
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB073898.1 AF047004.1 AF047190.1 AF095735.2 AF095736.2 AF095737.2 AF129265.1 AF129266.1 
    AF162428.1 AJ223317.1 AK093794.1 AK223402.1 AK291211.1 AK298348.1 AK316494.1 BC033217.1 
    BC041574.1 BC136363.1 BC136364.1 BC144035.1 

    12 DOTS entries:

    DT.40198284  DT.95157356  DT.100777178  DT.95157357  DT.100668990  DT.91787189  DT.100777179  DT.95157355 
    DT.101969589  DT.121145033  DT.121145085  DT.121145087 

    24/65 AceView cDNA sequences (see all 65):

    AF095736 BE207913 CR593278 AL602561 CR602119 BU500834 CR597974 BE294520 
    CB136701 NM_007101 AF095735 BX463066 BE019111 AW731973 AX748310 BV207896 
    AK093794 AF047190 BP357983 AI566543 AK124777 BX283767 AJ223317 CD675365 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SARDH    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                    -                                       
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SARDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SARDH expression in normal human tissues (normalized intensities)      SARDH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTGTAGCC
    SARDH Expression
    About this image


    SARDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)
             reticulocytes   
     
     Neural Tube (Nervous System)
             Rhombencephalon
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)

    See SARDH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SARDH

    SOURCE GeneReport for Unigene cluster: Hs.198003
        SABiosciences Expression via Pathway-Focused PCR Array including SARDH: 
              Amino Acid Metabolism II in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SARDH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SARDH gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sardh1 , 5 sarcosine dehydrogenase1, 5 85.26(n)1
    88.67(a)1
      2 (19.31 cM)5
    1921661  NM_138665.21  NP_619606.11 
     271883935 
    chicken
    (Gallus gallus)
    Aves SARDH1 sarcosine dehydrogenase 77.36(n)
    81.71(a)
      417146  XM_415428.3  XP_415428.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    80(a)
    74(a)
    1 ↔ many
    1 ↔ many
    GL344411.1(32212-38763)
    GL343736.1(220826-271553)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126822 Xenopus laevis transcribed sequence with weak similarity more 73.67(n)    BJ072373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563632 similar to sarcosine dehydrogenase 76.73(n)   394103  BC051605.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63851 , 3 sarcosine dehydrogenase3
    CG63851
    50(a)
    (best of 2)3
    56.73(n)1
    52.28(a)1
      54E83
    370261  NM_137419.21  NP_611263.11 


    ENSEMBL Gene Tree for SARDH (if available)
    TreeFam Gene Tree for SARDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SARDH gene
    PDPR2  DMGDH2  
    4 SIMAP similar genes for SARDH using alignment to 8 protein entries:     SARDH_HUMAN (see all proteins):
    C3orf64    DSERG1    PDPR    DMGDH

    SARDH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2187 SNPs in SARDH are shown (see all 2187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692724
    Sarcosinemia (SARCOS)4--see VAR_0692722 V F mis40--------
    rs1494811471,2,4
    C,FSarcosinemia (SARCOS)4 --136610854(+) CCAGCG/AGGACC 4 /P /L mis12Minor allele frequency- A:0.00NA EU 5811
    rs1907597061,2
    --136533553(+) TCACCC/TTCCCT 2 -- int10--------
    rs1175962351,2
    F--136533565(+) TCCCTT/CACCCT 2 -- int11Minor allele frequency- C:0.21EA 120
    rs1462431461,2
    --136533569(+) TTACCC/TTCCCT 2 -- int10--------
    rs3741007031,2
    C--136533576(+) CCTCT-/CCCCTC 2 -- int10--------
    rs1926007971,2
    --136533599(+) CCCTCA/GCCCTC 2 -- int10--------
    rs1115895901,2
    C--136533623(+) CCTCAC/TCCTCC 2 -- int10--------
    rs1840948071,2
    C--136544286(+) AGACAA/CAGGTC 2 -- int10--------
    rs1885899681,2
    --136544291(+) AAGGTC/TACCTA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SARDH (136528682 - 136605077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for SARDH (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739174CNV Deletion23290073
    esv2739177CNV Deletion23290073
    esv2739171CNV Deletion23290073
    esv2659744CNV Deletion23128226
    esv4163CNV Deletion18987735
    esv2739172CNV Deletion23290073
    esv998446CNV Deletion20482838
    esv2739176CNV Deletion23290073
    esv2739178CNV Deletion23290073
    esv2739175CNV Deletion23290073


    Human Gene Mutation Database (HGMD): SARDH
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SARDH
    DNA2.0 Custom Variant and Variant Library Synthesis for SARDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604455   
    OMIM disorders: 268900  
    UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12
  • Sarcosinemia (SARCOS) [MIM:268900]: A metabolic disorder characterized by an increased concentration of
    sarcosine in plasma and an increased excretion of sarcosine in urine. Sarcosinemia is most probably a benign
    condition without significant clinical problems. Some reports have associated sarcosinemia with mental
    retardation and neurologic problems. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 13 diseases for SARDH:    About MalaCards
    sarcosinemia    dimethylglycine dehydrogenase deficiency    pharyngitis    dilated cardiomyopathy
    spina bifida    myocarditis    prostate cancer, progression of    primary biliary cirrhosis
    metabolic disorders    laryngitis    prostate cancer    prostatitis
    hepatocellular carcinoma


    SARDH for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SARDH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcosinemia 96.4 5 10444331 (3), 8812433 (1), 10876657 (1)
    myocarditis 42.9 1 9528896 (1)
    dilated cardiomyopathy 24.9 1 9528896 (1)

    Genatlas disease: SARDH
    sarcosinemia

    Genetic Association Database (GAD): SARDH
    Human Genome Epidemiology (HuGE) Navigator: SARDH (2 documents)

    Export disorders for SARDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SARDH gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with SARDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia. (PubMed id 10444331)1, 2, 3, 9 Eschenbrenner M. and Jorns M.S. (1999)
    2. Mutations in the sarcosine dehydrogenase gene in patie nts with sarcosinemia. (PubMed id 22825317)1, 2 Bar-joseph I....Anikster Y. (2012)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (2009)
    5. Physical and cDNA mapping in the DBH region of human chromosome 9q34. (PubMed id 10686491)1, 2 Gilbert J.R.... Pericak-Vance M.A. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)4 Lunetta K.L....Murabito J.M. (2007)
    8. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1757 HGNC: 10536 AceView: SARDH Ensembl:ENSG00000123453 euGenes: HUgn1757
    ECgene: SARDH Kegg: 1757 H-InvDB: SARDH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SARDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SARDH gene:
    Search GeneIP for patents involving SARDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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