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SARDH Gene

protein-coding GIFtS: 59

GC09M135518

sarcosine dehydrogenase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DMGDHL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BPR-2 ^³
DMGDHL1 ^², ³
EC 1.5.99.1 ^³
FLJ36475 ^²
OTTHUMP00000022503 ^²
OTTHUMP00000064625 ^²
SAR ^², ⁵
SARD ^², ⁵
SDH ^¹, ²
SarDH ^³

Descriptions
dimethylglycine dehydrogenase-like 1 ^²
sarcosine dehydrogenase ^²

External Ids
HGNC: 10536¹
Entrez Gene: 1757²
UniProtKB: Q9UL12³
Ensembl: ENSG00000123453⁷

Search outside databases for aliases for SARDH gene

Previous GC identifers: GC09M127604 GC09P128054 GC09M129954 GC09M131870 GC09M133558

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for SARDH:

This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative

demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme,

dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine.

Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants

have been described. [provided by RefSeq]

Gene Wiki entry for SARDH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SARDH gene

Entrez Gene cytogenetic band: 9q33-q34 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q33-q34

SARDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M135518: (about GC identifiers)

Start:	135,518,503 bp from pter
End:	135,594,863 bp from pter
Size:	76,361 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_035014.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12 (See protein sequence)

Recommended Name: Sarcosine dehydrogenase, mitochondrial precursor

Size: 918 amino acids; 101037 Da

Cofactor: Binds 1 FAD covalently per monomer (By similarity)

Subcellular location: Mitochondrion matrix (By similarity)

Sequence caution: Sequence=AAD33412.1; Type=Frameshift; Positions=867;

Secondary accessions: B2RMR5 Q5SYV0 Q9Y280 Q9Y2Y3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001128179.1 NP_009032.2

ENSEMBL proteins:

ENSP00000360938 ENSP00000360934 ENSP00000376770 ENSP00000360933 ENSP00000298628

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SARDH)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	ISS	--
GO:0005759	mitochondrial matrix	IEA	--

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Antibodies for SARDH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SARDH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SARDH), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for SARDH

Assays for SARDH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UL12

ProtoNet protein and cluster: Q9UL12

1 Blocks protein family: IPB006222 Glycine cleavage T protein (aminomethyl transferase)

UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12

Similarity: Belongs to the gcvT family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SARDH)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007101

Applied Biosystems Silencer® siRNAs for SARDH

Sigma-Aldrich siRNA for SARDH

Sigma-Aldrich shRNA for SARDH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134707
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134707
untagged cDNA clones in CMV expression vector (see all 2): NM_001134707

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001134707

UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12

Catalytic activity: Sarcosine + acceptor + H(2)O = glycine + formaldehyde + reduced acceptor

Enzyme Number (IUBMB): EC 1.5.99.1

Genatlas biochemistry entry for SARDH:

sarcosine dehydrogenase,catalyzing qlycine synthesis,"one-carbone" metabolism,liver motochondrial

flavoenzyme

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004047	aminomethyltransferase activity	IEA	--
GO:0008480	sarcosine dehydrogenase activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for SARDH (Your Favorite Gene powered by Ingenuity)

Urea Cycle and Metabolism of Amino Groups
Glycine, Serine and Threonine Metabolism
One Carbon Pool by Folate
Nitrogen Metabolism

GeneDecks SARDH for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12

Pathway: Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from

sarcosine: step 1/1

5/14 Interacting proteins for SARDH (ENSP00000360938³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIPOX	ENSP00000317721³	STRING (score=.964)
DMGDH	ENSP00000369667³	STRING (score=.929)
AGXT	ENSP00000302620³	STRING (score=.899)
AGXT2	ENSP00000231420³	STRING (score=.899)
ALAS1	ENSP00000309259³	STRING (score=.899)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006546	glycine catabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SARDH
3 Novoseek chemical compound relationships for SARDH gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcosine	94.07	34	10444331 (4), 9528896 (2), 1700744 (1), 1372986 (1) (see all 16)
dimethylglycine	90.71	5	10444331 (1), 9528896 (1), 11122247 (1), 14744856 (1) (see all 5)
flavin	53.30	1	15069080 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SARDH)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007101

Sigma-Aldrich siRNA for SARDH

Sigma-Aldrich shRNA for SARDH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001134707 NM_007101

REFSEQ mRNAs for SARDH gene (2 alternative transcripts):

NM_001134707.1 NM_007101.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001134707 NM_007101

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001134707
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001134707
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001134707

Additional cDNA sequence:

AB073898.1 AF047004.1 AF047190.1 AF095735.2 AF095736.2 AF095737.2 AF129265.1 AF129266.1

AF162428.1 AJ223317.1 AK093794.1 AK223402.1 AK291211.1 AK298348.1 AK316494.1 BC033217.1

BC041574.1 BC136363.1 BC136364.1 BC144035.1 CR593278.1 CR597974.1 CR602119.1

12 DOTS entries:

DT.40198284 DT.95157356 DT.100777178 DT.100668990 DT.121145085 DT.95157357 DT.91787189 DT.100777179

DT.95157355 DT.101969589 DT.121145033 DT.121145087

24/65 AceView cDNA sequences (see all 65 ):

CB136701 NM_007101 BE294520 CR602119 AL602561 CR593278 AF095736 BU500834

CR597974 BE207913 AF095735 BC041574 AI245607 AI566543 BP346577 AI823391

BP357983 BM789463 BX463066 AF129265 BE293990 BV207896 BX343603 CD675365

highest scoring ESTs for SARDH:

AF095735 AF095737 AI986213 AA300315 AF095736 AF129265 AF162428 AI214896 AI245607 AI399918

Unigene Cluster for SARDH:

Sarcosine dehydrogenase

Hs.198003 [show with all ESTs]

Unigene Representative Sequence: NM_007101

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SARDH

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16
SP1:																							-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SARDH

5 Ensembl transcripts including schematic representations:

ENST00000371872 ENST00000371868 ENST00000393050 ENST00000371867 ENST00000298628

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SARDH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SARDH

¹ / ² / ³

10 probe-sets matching SARDH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
83446_at²^{, 3}	U95-E	1	1.00	1.00	0.99	1.42	AI986213	0.80	1.00	0.91	1
31595_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.59	AJ223317	0.60	1.00	0.82	1
207889_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007101	0.60	1.00	0.82	1
210862_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF047190	0.40	1.00	0.76	1
211322_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF047004	0.40	1.00	0.76	1
210063_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF162428	0.60	1.00	0.82	1
207889_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210862_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211322_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210063_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SARDH for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTTGTAGCC

SOURCE GeneReport for Unigene cluster: Hs.198003
Expression variation in blood from EXPOLDB for SARDH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SARDH gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SARDH¹	--	sarcosine dehydrogenase	88.29(n) 91.14(a)	491277 XM_548398.2 XP_548398.2
chimpanzee (Pan troglodytes)	SARDH¹	--	sarcosine dehydrogenase	99.09(n) 99.02(a)	464828 XM_001170034.1 XP_001170034.1
cow (Bos taurus)	SARDH¹	--	sarcosine dehydrogenase	86.71(n) 87.47(a)	614603 XM_866163.2 XP_871256.2
rat (Rattus norvegicus)	Sardh¹	--	sarcosine dehydrogenase	85.22(n) 88.67(a)	114123 NM_053664.1 NP_446116.1
mouse (Mus musculus)	Sardh^{1, 5}	2⁵	sarcosine dehydrogenase^{1, 5}	85.29(n)¹ 88.67(a)¹	192166¹ NM_138665.1¹ NP_619606.1¹ AI839995⁵ AK087163⁵ (see all 19)

About this table Species with no ortholog for SARDH

ENSEMBL Gene Tree for SARDH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for SARDH gene

PDPR² ENSG00000214331² DMGDH²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/628 NCBI SNPs in SARDH are shown (see all 628 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 292)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs129886^1,2	A,C,F,H,O	135518542(+)	`ACCTTC/TTAGAA`	2	--	ut3¹ ese³		13	MN EA NA EU WA	1240
	rs129888^1,2	A,C,F,H	135518268(+)	`AGGTCG/CAGCAA`	1	--	ng5¹		8	EU EA WA	836
	rs886016^1,2	A,C,F,H	135545450(-)	`TGGCCA/GTGGGC`	2	M/V	mis¹		13	MN EU EA WA NA	1218
	rs2488553^1,2	A,C,F,H	135589136(+)	`TCAGCA/GAAACA`	2	--	ut5¹		4	EU EA WA	408
	rs129928^1,2	A,C,F,H	135518169(+)	`GGAGGG/ACACCA`	1	--	ng5¹		4	EU EA WA	412
	rs2073817^1,2	C,F,H	135549281(-)	`CCACCG/ATGGGG`	2	H/R	mis¹ ese³		9	EU EA WA NA	910
	rs35559818^1,2	C,F	135589053(+)	`CATGCC/ACCGGG`	2	C/G	mis¹		5	NA EU EA WA	488
	rs35218200^1,2	C,F	135572303(+)	`GTCTTC/ATCCAG`	2	D/E	mis¹		5	NA EU EA WA	494
	rs10465165^1,2	F,H	135596051(+)	`TGCAGG/TCCCCC`	1	--	ng3¹		4	EU EA WA	418
	rs3758346^1,2	H	135596545(-)	`ATCACG/AGGGAT`	1	--	ng3¹		1	EU	120

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HapMap Linkage Disequilibrium images for SARDH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 604455 disorders: 268900

UniProtKB/Swiss-Prot: SARDH_HUMAN, Q9UL12

Defects in SARDH are a ause of sarcosinemia [MIM:268900]. Sarcosinemia is a metabolic

disorder characterized by an increased concentration of sarcosine in plasma and urine due to

sarcosine dehydrogenase deficiency. Prevalence has been estimated at 1:28'000 to 1:350'000 in

newborn screening programs. Sarcosinemia is most probably a benign condition without significant

clinical problems. It is transmitted in an autosomal recessive manner

3 Novoseek disease relationships for SARDH gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcosinemia	96.54	5	10444331 (3), 8812433 (1), 10876657 (1)
myocarditis	44.95	1	9528896 (1)
dilated cardiomyopathy	27.05	1	9528896 (1)

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Genatlas disease: SARDH

sarcosinemia

Human Genome Epidemiology Navigator: SARDH (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/49 PubMed articles for SARDH gene (see all 49 ):

Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia. (PubMed id 10444331)^{1, 2, 3, 4} Eschenbrenner M. and Jorns M.S. (1999)
Physical and cDNA mapping in the DBH region of human chromosome 9q34. (PubMed id 10686491)^{3, 4} Gilbert J.R.... Pericak-Vance M.A. (2000)
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)³ Franke B....Blom H.J. (2009)
Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)⁴ Tang L.Y....Zeng R. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Molecular cloning and tissue distribution of rat sarcosine dehydrogenase. (PubMed id 9839943)³ Bergeron F....Bataille D. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1757	HGNC: 10536	AceView: SARDH	Ensembl:ENSG00000123453	euGenes: HUgn1757
ECgene: SARDH	H-InvDB: SARDH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for SARDH
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SARDH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SARDH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SARDH		Antibodies for SARDH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SARDH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for SARDH

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SARDH Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for SARDH

Summaries
for SARDH

Genomic Location
for SARDH

Proteins
for SARDH

Protein Domains/
Families
for SARDH

Gene Function
for SARDH

Pathways & Interactions
for SARDH

Drugs & Compounds
for SARDH

Transcripts
for SARDH

Expression
for SARDH

Orthologs
for SARDH

Paralogs
for SARDH

SNPs/Variants
for SARDH

Disorders & Mutations
for SARDH

Medical News
for SARDH

Publications
for SARDH

Search for SARDH

Genome Databases showing SARDH

Other Databases showing SARDH

Specialized Databases showing SARDH

Licensable Technologies
for SARDH

Services
for SARDH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SARDH Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor SARDH

Summariesfor SARDH

Genomic Locationfor SARDH

Proteinsfor SARDH

Protein Domains/Familiesfor SARDH

Gene Functionfor SARDH

Pathways & Interactionsfor SARDH

Drugs & Compoundsfor SARDH

Transcriptsfor SARDH

Expression for SARDH

Orthologsfor SARDH

Paralogsfor SARDH

SNPs/Variantsfor SARDH

Disorders & Mutationsfor SARDH

Medical Newsfor SARDH

Publicationsfor SARDH

Search for SARDH

Genome Databases showing SARDH

Other Databases showing SARDH

Specialized Databases showing SARDH

Licensable Technologiesfor SARDH

Servicesfor SARDH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SARDH

Summaries
for SARDH

Genomic Location
for SARDH

Proteins
for SARDH

Protein Domains/
Families
for SARDH

Gene Function
for SARDH

Pathways & Interactions
for SARDH

Drugs & Compounds
for SARDH

Transcripts
for SARDH

Expression
for SARDH

Orthologs
for SARDH

Paralogs
for SARDH

SNPs/Variants
for SARDH

Disorders & Mutations
for SARDH

Medical News
for SARDH

Publications
for SARDH

Licensable Technologies
for SARDH

Services
for SARDH