SAR1B Gene
protein-coding GIFtS : 56
GC05M133971
SAR1 homolog B (S. cerevisiae) (Previous names: SAR1a gene homolog (S. cerevisiae) 2, SAR1a gene homolog 2 (S. cerevisiae) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: SARA2 )
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Aliases & Descriptions for SAR1B
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 2310075M17Rik 2 ANDD 2 , 5 CMRD 2 , 5 GTBPB 2 , 3 SARA2 2 , 3 , 5 SARB 3
Descriptions GTP-binding protein Sara 2 SAR1 gene homolog B 2 SAR1 homolog B (S. cerevisiae) 2 SAR1a gene homolog (S. cerevisiae) 2 1 SAR1a gene homolog 2 2 SAR1a gene homolog 2 (S. cerevisiae) 1
Search outside databases for aliases for SAR1B gene
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UniProtKB/Swiss-Prot: SAR1B_HUMAN, Q9Y6B6 Function : Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated bythe guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo andthe assembly of the COPII coat complex
Gene Wiki entry for SAR1B
Genomic Location for SAR1B
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the SAR1B gene Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1 SAR1B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M133971:
(about GC identifiers )
Start:
133,970,018 bp from pter
End:
133,996,426 bp from pter
Size:
26,409 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000005.8 NT_034772.5 Proteins for SAR1B
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: SAR1B_HUMAN, Q9Y6B6 (See
protein sequence )Recommended Name: GTP-binding protein SAR1b Size : 198 amino acids; 22410 Da
Subunit : Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails oftarget proteins in the endoplasmic reticulum (By similarity)
Subcellular location : Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity).Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity).Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in thejuxta-nuclear Golgi region (By similarity)
Secondary accessions : Q567T4
REFSEQ proteins (2 alternative transcripts):
NP_001028675.1 NP_057187.1 ENSEMBL proteins: ENSP00000378443 ENSP00000385432 ENSP00000282606 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): SAR1B 5 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for SAR1B: Assays for SAR1B:
Protein
Domains/ Families for SAR1B(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9Y6B6 ProtoNet protein and cluster: Q9Y6B6
2 Blocks protein families : IPB001806 Transforming protein P21 RAS signature IPB006687 GTP-binding protein SAR1 UniProtKB/Swiss-Prot: SAR1B_HUMAN, Q9Y6B6 Similarity : Belongs to the small GTPase superfamily. SAR1 family
Gene Function for SAR1B
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
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Millipore ,
OriGene , and/or
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001033503 Applied Biosystems Silencer ® siRNAs for SAR1B Sigma-Aldrich siRNA for SAR1B Sigma-Aldrich shRNA for SAR1B Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033503                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033503                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001033503  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016103 UniProtKB/Swiss-Prot: SAR1B_HUMAN, Q9Y6B6 Function : Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated bythe guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo andthe assembly of the COPII coat complex
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for SAR1B
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/8 Interacting proteins for SAR1B (ENSP00000282606 3 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for SAR1B (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for SAR1B
Transcripts for SAR1B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001033503 Sigma-Aldrich siRNA for SAR1B Sigma-Aldrich shRNA for SAR1B Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001033503 NM_016103
REFSEQ mRNAs for SAR1B gene (2 alternative transcripts): NM_001033503.1 NM_016103.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001033503 NM_016103
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033503                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001033503                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001033503  
Additional cDNA sequence: AF087850.1 AF092130.1 AK056821.1 AK223452.1 AL512710.1 BC002847.2 BC093034.1 CR601141.1 CR618571.1 CR618910.1
16 DOTS entries : DT.445888 DT.101983014 DT.100024367 DT.120835306 DT.311607 DT.91638410 DT.92003751 DT.70105124 DT.211344 DT.100819990 DT.92435553 DT.100684871 DT.120835293 DT.120835327 DT.92435546 DT.100714357
24/233 AceView cDNA sequences (see all 233
):BM977256 NM_016103 AA732597 AI760512 AA424203 CR618571 CB143242 CR618910 AA292730 AA548862 BE856242 AW087646 BQ772359 AI431818 BE894481 BX504340 AI337180 BX413959 AW136359 BQ776142 BG260295 CD671450 CA454000 BI089805
highest scoring ESTs for SAR1B :AA295606 AA357007 AA383106 AF092130 AI346486 AI394440 AL710660 AV658410 AV706450 AV708365
Unigene Cluster for SAR1B: SAR1 homolog B (S. cerevisiae) Hs.432984 [show with all ESTs ] Unigene Representative Sequence: AK056821 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for SAR1B ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b SP1 :                     SP2 :     -                
About this scheme ECgene alternative splicing isoforms for SAR1B 3 Ensembl transcripts including schematic representations : ENST00000394992
ENST00000402673
ENST00000282606
Expression for SAR1B
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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SAR1B expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for SAR1B 1 / 2 / 3
6 probe-sets matching SAR1B gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAATAAAACASOURCE GeneReport for Unigene cluster: Hs.432984 UniProtKB/Swiss-Prot: SAR1B_HUMAN, Q9Y6B6 Tissue specificity : Expressed in many tissues including small intestine, liver, muscle and brain
Orthologs for SAR1B
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for SAR1B gene from 5/19 species (see all 19
)
About this table Species with no ortholog for SAR1B ENSEMBL Gene Tree for SAR1B Paralogs for SAR1B (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for SAR1B gene ARL9 2 SAR1A 2 ARL10 2
SNPs/Variants for SAR1B (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for SAR1B (up to first 250kb)
Disorders & Mutations for SAR1B
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607690 disorders : 246700 UniProtKB/Swiss-Prot: SAR1B_HUMAN, Q9Y6B6
Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; alsoknown as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fatmalabsorption associated with failure to thrive in infancy. The condition is characterized bydeficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence ofchylomicrons from blood. Affected individuals accumulate chylomicron-like particles inmembrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets
Human Gene Mutation Database : SAR1B
Medical News for SAR1B (Possibly Related Articles in
Doctor's Guide )
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--
Publications for SAR1B (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/17 PubMed articles for SAR1B gene (see all 17
):
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OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SAR1B
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing SAR1B
(According to HUGE )
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Specialized Databases showing SAR1B (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for SAR1B (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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