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Aliases for SAR1A Gene

Aliases for SAR1A Gene

  • Secretion Associated Ras Related GTPase 1A 2 3 5
  • COPII-Associated Small GTPase 3 4
  • SARA1 3 4
  • SAR1 3 4
  • Sara 3 4
  • Secretion Associated, Ras Related GTPase 1A 2
  • SAR1a Gene Homolog (S. Cerevisiae) 1 2
  • SAR1a Gene Homolog 1 (S. Cerevisiae) 2
  • SAR1 Homolog A (S. Cerevisiae) 2
  • GTP-Binding Protein SAR1a 3
  • SAR1a Gene Homolog 1 3
  • SAR1 Gene Homolog A 3
  • SAR1 Homolog A 3
  • EC 3.6.5 58
  • Masra2 3

External Ids for SAR1A Gene

Previous HGNC Symbols for SAR1A Gene

  • SARA1

Previous GeneCards Identifiers for SAR1A Gene

  • GC10M071580
  • GC10M071909
  • GC10M065902

Summaries for SAR1A Gene

GeneCards Summary for SAR1A Gene

SAR1A (Secretion Associated Ras Related GTPase 1A) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is SAR1B.

UniProtKB/Swiss-Prot for SAR1A Gene

  • Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Additional gene information for SAR1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAR1A Gene

Genomics for SAR1A Gene

Regulatory Elements for SAR1A Gene

Enhancers for SAR1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H069325 1.5 Ensembl ENCODE dbSUPER 19.6 +837.1 837128 16 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF2 ETS1 TCF12 GLIS2 GATA2 CCAR1 DDX50 SAR1A HK1 RPL26P27 MIR1254-1 ENSG00000231748 TYSND1 DDX21 STOX1
GH10H070130 1.3 ENCODE dbSUPER 20.6 +38.6 38584 3.4 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS SAR1A PPA1 AIFM2 PIR50368
GH10H070221 1.1 Ensembl ENCODE 24 -51.8 -51797 2.2 HDGF RB1 ARNT ZNF2 RAD21 RFX5 ZNF121 ELK1 SCRT2 ZNF143 PPA1 SAR1A CEP57L1P1 LRRC20 CALM2P2 NPFFR1 TYSND1 GC10M070217
GH10H069179 1.2 ENCODE 19.7 +989.9 989870 3.3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CCAR1 DDX50 TYSND1 DDX21 HNRNPH3 SAR1A VPS26A HKDC1 RPL26P27 SUPV3L1
GH10H070661 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -493.2 -493197 4.8 HDGF PKNOX1 ATF1 ZNF766 FOS REST MEF2D SMARCA4 GLIS1 NR2C1 ADAMTS14 SAR1A GC10M070611
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAR1A on UCSC Golden Path with GeneCards custom track

Promoters for SAR1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029353 229 2201 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B YY1 ZNF766 ZNF207 ZNF143

Genomic Locations for SAR1A Gene

Genomic Locations for SAR1A Gene
chr10:70,147,289-70,170,529
(GRCh38/hg38)
Size:
23,241 bases
Orientation:
Minus strand
chr10:71,907,045-71,930,285
(GRCh37/hg19)

Genomic View for SAR1A Gene

Genes around SAR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAR1A Gene

Proteins for SAR1A Gene

  • Protein details for SAR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR31-SAR1A_HUMAN
    Recommended name:
    GTP-binding protein SAR1a
    Protein Accession:
    Q9NR31
    Secondary Accessions:
    • B4DQ19

    Protein attributes for SAR1A Gene

    Size:
    198 amino acids
    Molecular mass:
    22367 Da
    Quaternary structure:
    • Interacts with B3GAT1.

    Three dimensional structures from OCA and Proteopedia for SAR1A Gene

    Alternative splice isoforms for SAR1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAR1A Gene

Selected DME Specific Peptides for SAR1A Gene

Q9NR31:
  • GIVFLVD
  • ILGNKID
  • TFDLGGH
  • HPTSEEL

Post-translational modifications for SAR1A Gene

  • Ubiquitination at isoforms=27 and isoforms=2166
  • Modification sites at PhosphoSitePlus

Domains & Families for SAR1A Gene

Gene Families for SAR1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q9NR31

UniProtKB/Swiss-Prot:

SAR1A_HUMAN :
  • Belongs to the small GTPase superfamily. SAR1 family.
Family:
  • Belongs to the small GTPase superfamily. SAR1 family.
genes like me logo Genes that share domains with SAR1A: view

Function for SAR1A Gene

Molecular function for SAR1A Gene

UniProtKB/Swiss-Prot Function:
Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Enzyme Numbers (IUBMB) for SAR1A Gene

Phenotypes From GWAS Catalog for SAR1A Gene

Gene Ontology (GO) - Molecular Function for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 19181664
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SAR1A: view
genes like me logo Genes that share phenotypes with SAR1A: view

Animal Model Products

miRNA for SAR1A Gene

miRTarBase miRNAs that target SAR1A

Clone Products

  • Addgene plasmids for SAR1A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAR1A Gene

Localization for SAR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAR1A Gene

Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAR1A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030127 COPII vesicle coat IDA 17499046
genes like me logo Genes that share ontologies with SAR1A: view

Pathways & Interactions for SAR1A Gene

genes like me logo Genes that share pathways with SAR1A: view

Gene Ontology (GO) - Biological Process for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0090110 cargo loading into COPII-coated vesicle IDA 17499046
genes like me logo Genes that share ontologies with SAR1A: view

No data available for SIGNOR curated interactions for SAR1A Gene

Drugs & Compounds for SAR1A Gene

(1) Drugs for SAR1A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SAR1A: view

Transcripts for SAR1A Gene

Unigene Clusters for SAR1A Gene

SAR1 homolog A (S. cerevisiae):
Representative Sequences:

Clone Products

  • Addgene plasmids for SAR1A

Alternative Splicing Database (ASD) splice patterns (SP) for SAR1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for SAR1A Gene

GeneLoc Exon Structure for
SAR1A
ECgene alternative splicing isoforms for
SAR1A

Expression for SAR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAR1A Gene

Protein differential expression in normal tissues from HIPED for SAR1A Gene

This gene is overexpressed in Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAR1A Gene



Protein tissue co-expression partners for SAR1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAR1A Gene:

SAR1A

SOURCE GeneReport for Unigene cluster for SAR1A Gene:

Hs.499960

Evidence on tissue expression from TISSUES for SAR1A Gene

  • Lung(4.5)
  • Skin(4.5)
  • Kidney(4.4)
  • Nervous system(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with SAR1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAR1A Gene

Orthologs for SAR1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SAR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAR1A 33 34
  • 99.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SAR1A 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAR1A 33 34
  • 95.29 (n)
dog
(Canis familiaris)
Mammalia SAR1A 33
  • 94.78 (n)
rat
(Rattus norvegicus)
Mammalia Sar1a 33
  • 93.27 (n)
mouse
(Mus musculus)
Mammalia Sar1a 33 16 34
  • 93.1 (n)
oppossum
(Monodelphis domestica)
Mammalia SAR1A 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAR1A 33 34
  • 85.19 (n)
lizard
(Anolis carolinensis)
Reptilia SAR1A 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sar1a 33
  • 84.18 (n)
sar1a-prov 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25405 33
zebrafish
(Danio rerio)
Actinopterygii sar1ab 33 34
  • 74.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta sar1 34
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sar-1 34
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAR1 33 34
  • 59.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02046g 33
  • 57.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL114W 33
  • 56.58 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SAR1B 33
  • 61.11 (n)
soybean
(Glycine max)
eudicotyledons Gma.6113 33
rice
(Oryza sativa)
Liliopsida Os01g0338000 33
  • 60.73 (n)
Os.10984 33
bread mold
(Neurospora crassa)
Ascomycetes NCU11181 33
  • 62.22 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sar1 33
  • 61.38 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1569 33
Species where no ortholog for SAR1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAR1A Gene

ENSEMBL:
Gene Tree for SAR1A (if available)
TreeFam:
Gene Tree for SAR1A (if available)

Paralogs for SAR1A Gene

Paralogs for SAR1A Gene

Pseudogenes.org Pseudogenes for SAR1A Gene

genes like me logo Genes that share paralogs with SAR1A: view

Variants for SAR1A Gene

Sequence variations from dbSNP and Humsavar for SAR1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000293945 -- 70,158,406(+) CTTAG(A/G)GAGAC intron-variant
rs1000602365 -- 70,160,572(+) GAAGC(A/G)ATACA intron-variant
rs1000647144 -- 70,164,976(+) TCAAG(G/T)AGTAT intron-variant
rs1000658992 -- 70,157,959(+) TGGTC(A/G)GGTTT intron-variant
rs1000678383 -- 70,165,133(+) AGTGG(A/C/T)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAR1A Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv551479 CNV loss 21841781
nsv7054 CNV insertion 18451855

Variation tolerance for SAR1A Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAR1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAR1A Gene

Disorders for SAR1A Gene

Relevant External Links for SAR1A

Genetic Association Database (GAD)
SAR1A
Human Genome Epidemiology (HuGE) Navigator
SAR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAR1A

No disorders were found for SAR1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAR1A Gene

Publications for SAR1A Gene

  1. Distinct transport and intracellular activities of two GlcAT-P isoforms. (PMID: 19181664) Kizuka Y … Oka S (The Journal of biological chemistry 2009) 3 4 22 60
  2. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis. (PMID: 10871277) South ST … Gould SJ (The Journal of cell biology 2000) 2 3 4 60
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 60
  4. Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia. (PMID: 18318767) Kumkhaek C … Rodgers GP (British journal of haematology 2008) 3 45 60
  5. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan AR … Williams J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 45 60

Products for SAR1A Gene

  • Addgene plasmids for SAR1A

Sources for SAR1A Gene

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