SAR1A Gene
protein-coding GIFtS : 59
GC10M071580
SAR1 homolog A (S. cerevisiae) (Previous names: SAR1a gene homolog (S. cerevisiae) 1, SAR1a gene homolog 1 (S. cerevisiae) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: SARA1 )
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Aliases & Descriptions for SAR1A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000019743 2 OTTHUMP00000019744 2 OTTHUMP00000019745 2 OTTHUMP00000019748 2 OTTHUMP00000060603 2 SAR1 1 , 2 , 3 SARA 3 SARA1 2 , 3 , 5 Sara 1 , 2 masra2 2
Descriptions COPII-associated small GTPase 3 SAR1 gene homolog A 2 SAR1 homolog A (S. cerevisiae) 2 SAR1a gene homolog (S. cerevisiae) 1 1 SAR1a gene homolog 1 2 SAR1a gene homolog 1 (S. cerevisiae) 1
Search outside databases for aliases for SAR1A gene
Summaries for SAR1A (According to Entrez Gene ,
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UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31 Function : Involved in transport from the endoplasmic reticulum to the Golgi apparatus (Bysimilarity). Required to maintain SEC16A localization at discrete locations on the ER membraneperhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membraneforms an organized scaffold defining endoplasmic reticulum exit sites (ERES)
Genomic Location for SAR1A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the SAR1A gene Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.1 SAR1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M071580:
(about GC identifiers )
Start:
71,579,966 bp from pter
End:
71,600,285 bp from pter
Size:
20,320 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000010.9 NT_008583.16 Proteins for SAR1A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31 (See
protein sequence )Recommended Name: GTP-binding protein SAR1a Size : 198 amino acids; 22367 Da
Subcellular location : Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity)
PDB structures from and Proteopedia : 2GAO (3D)
 
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001136120.1 NP_064535.1 ENSEMBL proteins: ENSP00000362339 ENSP00000378471 ENSP00000362333 ENSP00000362335 ENSP00000362338 ENSP00000362336 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: SAR1A 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for SAR1A: Assays for SAR1A:
Protein
Domains/ Families for SAR1A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9NR31 ProtoNet protein and cluster: Q9NR31
2 Blocks protein families : IPB001806 Transforming protein P21 RAS signature IPB006687 GTP-binding protein SAR1 UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31 Similarity : Belongs to the small GTPase superfamily. SAR1 family
Gene Function for SAR1A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020150 Applied Biosystems Silencer ® siRNAs for SAR1A Sigma-Aldrich siRNA for SAR1A Sigma-Aldrich shRNA for SAR1A Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142648                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142648                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001142648  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020150 UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31 Function : Involved in transport from the endoplasmic reticulum to the Golgi apparatus (Bysimilarity). Required to maintain SEC16A localization at discrete locations on the ER membraneperhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membraneforms an organized scaffold defining endoplasmic reticulum exit sites (ERES)
3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for SAR1A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/10 Interacting proteins for SAR1A (ENSP00000362336 3 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006886 intracellular protein transport
IEA -- GO:0006888 ER to Golgi vesicle-mediated transport
NAS -- GO:0016192 vesicle-mediated transport
IEA --
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Drugs & Compounds for SAR1A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for SAR1A
Transcripts for SAR1A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020150 Sigma-Aldrich siRNA for SAR1A Sigma-Aldrich shRNA for SAR1A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001142648 NM_020150
REFSEQ mRNAs for SAR1A gene (2 alternative transcripts): NM_001142648.1 NM_020150.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001142648 NM_020150
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142648                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001142648                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001142648  
Additional cDNA sequence: AF086166.1 AF087897.1 AF217959.1 AF261717.1 AF274026.1 AF318066.1 AK025857.1 AK074257.1 AK298591.1 AK312469.1 AL136724.1 AY008268.1 BC003658.2 CR533492.1
12 DOTS entries : DT.95259145 DT.97862695 DT.87016923 DT.121261144 DT.92433004 DT.100042097 DT.121261116 DT.100792928 DT.91733074 DT.95100927 DT.95112223 DT.101958209
24/356 AceView cDNA sequences (see all 356
):BQ941426 BM974100 AI200872 AA290688 BQ954254 AV712082 CA392755 AI086814 CD676038 AI470172 AI201809 CA425843 W60913 BE855644 BQ086264 AA938282 BM974996 AA938505 BX281349 BM556837 AF086166 BM453963 BQ008447 AA769518
highest scoring ESTs for SAR1A :AA046557 AA287759 AA334525 AA354348 AF087897 AF217959 AF261717 AF274026 AI143121 AW406969
Unigene Cluster for SAR1A: SAR1 homolog A (S. cerevisiae) Hs.499960 [show with all ESTs ] Unigene Representative Sequence: NM_001142648 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for SAR1A ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 SP1 :         -             SP2 :         -             SP3 :                    
About this scheme ECgene alternative splicing isoforms for SAR1A 6 Ensembl transcripts including schematic representations : ENST00000373242
ENST00000395026
ENST00000373236
ENST00000373238
ENST00000373241
ENST00000373239
Expression for SAR1A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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SAR1A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for SAR1A 1 / 2 / 3
9 probe-sets matching SAR1A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AATTATGACTSOURCE GeneReport for Unigene cluster: Hs.499960 Expression variation in blood from EXPOLDB for SAR1A
Orthologs for SAR1A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for SAR1A gene from 5/18 species (see all 18
)
About this table Species with no ortholog for SAR1A ENSEMBL Gene Tree for SAR1A Paralogs for SAR1A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for SAR1A gene SAR1B 2 ARL9 2 ARL10 2 Pseudogenes 3 related pseudogenes
SNPs/Variants for SAR1A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for SAR1A (up to first 250kb)
Disorders & Mutations for SAR1A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607691 Human Genome Epidemiology Navigator: SAR1A (2 documents)
Medical News for SAR1A (Possibly Related Articles in
Doctor's Guide )
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--
Publications for SAR1A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/18 PubMed articles for SAR1A gene (see all 18
):
Search for SAR1A
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SAR1A
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing SAR1A
(According to HUGE )
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--
Specialized Databases showing SAR1A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for SAR1A (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for SAR1A:
Recombinant Proteins (SAR1 ) Antibodies (SAR1 )
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