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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAR1A Gene

protein-coding   GIFtS: 62
GCID: GC10M071909

SAR1 homolog A (S. cerevisiae)

(Previous names: SAR1a gene homolog (S. cerevisiae) 1, SAR1a gene homolog...)
(Previous symbol: SARA1)
 Explore 5 diseases affiliated with
SAR1A via
MalaCards
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 Human Malady Compendium 
Biological research products
for SAR1A    

Aliases
for SAR1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SAR1 Homolog A (S. Cerevisiae)1 2     GTP-Binding Protein SAR1a2
SARA11 2 3 5     Masra21
SAR11 2 3     SAR1 Gene Homolog A2
Sara1 2     SAR1a Gene Homolog 12
COPII-Associated Small GTPase2 3     SARA3
SAR1a Gene Homolog (S. Cerevisiae) 11     EC 3.6.58
SAR1a Gene Homolog 1 (S. Cerevisiae)1     

External Ids:    HGNC: 105341   Entrez Gene: 566812   Ensembl: ENSG000000793327   OMIM: 6076915   UniProtKB: Q9NR313   

Export aliases for SAR1A gene to outside databases

Previous GC identifers: GC10M071580 GC10M065902


Summaries
for SAR1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31
Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to
maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum
exit sites (ERES)




Genomic Views
for SAR1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAR1A gene promoter:
         Elk-1   POU3F1   FOXO3   FOXO3b   RORalpha2   Pax-3   FAC1   FOXO3a   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SAR1A promoter sequence
   Search SABiosciences Chromatin IP Primers for SAR1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SAR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAR1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071909:  view genomic region     (about GC identifiers)

Start:
 71,909,960 bp from pter      End:
 71,930,285 bp from pter
Size:
 20,326 bases      Orientation:
 minus strand

Proteins
for SAR1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31 (See protein sequence)
Recommended Name: GTP-binding protein SAR1a  
Size: 198 amino acids; 22367 Da
Subcellular location: Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity)
1 PDB 3D structure from and Proteopedia for SAR1A:
2GAO (3D)    

Explore the universe of human proteins at neXtProt for SAR1A: NX_Q9NR31

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NR31

    • 4 DME Specific Peptides for SAR1A (Q9NR31)
     HPTSEEL  GIVFLVD  ILGNKID  TFDLGGH 

    SAR1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136120.1  NP_064535.1  

    ENSEMBL proteins: 
     ENSP00000362338   ENSP00000362336   ENSP00000362335   ENSP00000362339   ENSP00000398165  
     ENSP00000362333   ENSP00000399698   ENSP00000437979  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): SAR1A
    OriGene Protein Over-expression Lysate (see all 2): SAR1A
    OriGene Custom Protein Services for SAR1A 
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    Novus Biologicals SAR1A Proteins
    Novus Biologicals SAR1A Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SAR1A
    Uscn Proteins for SAR1A

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0016529sarcoplasmic reticulum IEA--


    SAR1A for ontologies           About GeneDecksing



    SAR1A Antibody Products: 
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    Assay Products for SAR1A: 
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    Uscn ELISAs and CLIAs for SAR1A

    Protein Domains /
    Families
    for SAR1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SAR1A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006687 Small_GTPase_SAR1
     IPR006689 Small_GTPase_ARF/SAR
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NR31

    ProtoNet protein and cluster: Q9NR31

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB006687 GTP-binding protein SAR1


    UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31
    Similarity: Belongs to the small GTPase superfamily. SAR1 family


    Function
    for SAR1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31
    Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to
    maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
    SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum
    exit sites (ERES)

    Enzyme Number (IUBMB): EC 3.6.52

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAR1A
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate SAR1A (see all 63):
    hsa-miR-323-3p hsa-miR-1197 hsa-miR-200a hsa-miR-1258 hsa-miR-128 hsa-miR-486-3p hsa-miR-766 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: SAR1A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SAR1A (see all 7)
    OriGene shRNA RFP: SAR1A
    OriGene siRNA: SAR1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAR1A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SAR1A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAR1A (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SAR1A (NM_020150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAR1A 

    Cell Line
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    Search LifeMap BioReagents cell lines for SAR1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAR1A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS--
    GO:0005525GTP binding IEA--


    SAR1A for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for SAR1A:
     Decreased viability with pacli  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella-containin 


    Pathways & Interactions
    for SAR1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin-dependent protein traffic
    		Clathrin-dependent protein traffic1.00
    		wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    		Transport_Clathrin-coated vesicle cycle0.66
    2COPII (Coat Protein 2) Mediated Vesicle Transport
    		Normal wtCFTR traffic / ER-to-Golgi 0.36
    		Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    3Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00
    4Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    		SREBP signalling0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SAR1A
        Clathrin-dependent protein traffic


    4 GeneGo (Thomson Reuters) Pathways for SAR1A
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SAR1A 
        SREBP signalling


    1         Kegg Pathway  (Kegg details for SAR1A):
        Protein processing in endoplasmic reticulum


    SAR1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for SAR1A (Q9NR313 ENSP000003623354) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542533, ENSP000002447694I2D: score=1 STRING: ENSP00000244769
    DCTN1Q142033I2D: score=1 
    PREBENSP000002606434STRING: ENSP00000260643
    SEC13ENSP000003121224STRING: ENSP00000312122
    SEC31AENSP000003473294STRING: ENSP00000347329
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS--
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport NAS--
    GO:0016192vesicle-mediated transport ----


    SAR1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for SAR1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAR1A

    1 HMDB Compound for SAR1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about SAR1A 

    Transcripts
    for SAR1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SAR1A gene (2 alternative transcripts): 
    NM_001142648.1  NM_020150.4  

    Unigene Cluster for SAR1A:

    SAR1 homolog A (S. cerevisiae)
    Hs.499960  [show with all ESTs]
    Unigene Representative Sequence: NM_001142648
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373241(uc010qji.2 uc010qjj.2) ENST00000373239 ENST00000373238
    ENST00000373242(uc010qjh.2) ENST00000452767 ENST00000373236 ENST00000477464
    ENST00000431664 ENST00000458634

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAR1A
    8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate SAR1A (see all 63):
    hsa-miR-323-3p hsa-miR-1197 hsa-miR-200a hsa-miR-1258 hsa-miR-128 hsa-miR-486-3p hsa-miR-766 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: SAR1A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SAR1A (see all 7)
    OriGene shRNA RFP: SAR1A
    OriGene siRNA: SAR1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAR1A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SAR1A (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SAR1A (NM_020150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAR1A 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAR1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAR1A

    Additional cDNA sequence: 

    AF086166.1 AF087897.1 AF217959.1 AF261717.1 AF274026.1 AF318066.1 AK025857.1 AK074257.1 
    AK298591.1 AK312469.1 AL136724.1 AY008268.1 BC003658.2 CR533492.1 

    16 DOTS entries:

    DT.95259145  DT.97862695  DT.87016923  DT.121261144  DT.92433004  DT.95188941  DT.100042097  DT.430391 
    DT.121261116  DT.100792928  DT.121261035  DT.91733074  DT.95100927  DT.95112223  DT.101958209  DT.91716170 

    24/356 AceView cDNA sequences (see all 356):

    BQ003860 CR600689 AA972543 BM670777 AI474545 CA392755 BX374612 CK822944 
    AA938505 AA886239 CA425843 CF552696 N75852 AI580727 AA558961 CD676038 
    AW152119 AA354348 AI201809 N79652 AV712082 AI123798 W60913 AI086814 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SAR1A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                                                            


    ECgene alternative splicing isoforms for SAR1A

    Expression
    for SAR1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTATGACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SAR1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAR1A

    SOURCE GeneReport for Unigene cluster: Hs.499960
        SABiosciences Custom PCR Arrays for SAR1A
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAR1A

    Orthologs
    for SAR1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SAR1A gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SAR1A1 SAR1 homolog A (S. cerevisiae) 85.19(n)
    97.47(a)    		   423711  XM_421589.3  XP_421589.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SAR1A6
    		 --
    		 94(a)
    		 1 ↔ 1
    		 3(51292516-51296439)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.254052 Xenopus laevis transcribed sequence with strong similarity more 83.17(n)    CF549146.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sar1b1 SAR1 homolog B (S. cerevisiae) 76.43(n)
    91.92(a)    		   554177  NM_001024377.1  NP_001019548.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sar11 CG7073-PA 64.58(n)
    71.35(a)    		   42615  NM_170001.2  NP_732718.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea sar-11 Protein SAR-1 62.35(n)
    64.25(a)    		   177217  NM_068181.2  NP_500582.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SAR11 Sar1p 59.46(n)
    61.62(a)    		   855883   NP_015106.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SAR1B1 GTP-binding protein SAR1B 61.11(n)
    60.42(a)    		   842086  NM_104512.2  NP_176029.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.109842 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.44(n)    AK103351.1 


    ENSEMBL Gene Tree for SAR1A (if available)
    TreeFam Gene Tree for SAR1A (if available) 

    Paralogs
    for SAR1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAR1A gene
    SAR1B2  
    18/24 SIMAP similar genes for SAR1A using alignment to 5 protein entries:     SAR1A_HUMAN (see all proteins) (see all similar genes):
    SARA1    SAR1B    DKFZp434B2017    ARL8B    ARL7    ARL8A
    ARL2    ARL4C    ARL6    ARF3    ARL4A    ARF6
    ARL11    ARF1    ARL13B    ARF5    ARL14    TRIM23

    SAR1A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SAR1A
    PGOHUM00000250794 PGOHUM00000260971


    Genomic Variants
    for SAR1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in SAR1A are shown (see all 347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1911984991,2
    		--71909590(+) ACAGCA/GTGAGC 2 -- int10--------
    rs1480647831,2
    		--71909620(+) TAATTC/TTGTGT 2 -- int10--------
    rs1417659041,2
    		--71909750(+) AGCATA/GTTCCA 2 -- int10--------
    rs741392781,2
    		C,F,--71909898(+) ATAAAC/TGGCAT 2 -- int18Minor allele frequency- T:0.28WA NA CSA EA 368
    rs125730971,2
    		C,F,H,--71909903(+) CGGCAT/CTGTTC 2 -- int122Minor allele frequency- C:0.38NA NS EA WA CSA 1676
    rs781608281,2
    		--71909934(+) ACCAAT/AGAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs752944981,2
    		C,F,--71909957(+) ATAGCG/ATATTT 2 -- int12Minor allele frequency- A:0.12WA EA 238
    rs1833590251,2
    		--71910011(+) CTTTCA/GTAAAT 2 -- ut310--------
    rs1466242101,2
    		--71910022(+) GACTG-/TTTTACT 2 -- ut310--------
    rs105861,2
    		C,F,A,H,,--71910032(+) CTTTTC/GCTGAA 2 -- ut31 ese310Minor allele frequency- G:0.04NA NS EA 804

    HapMap Linkage Disequilibrium report for SAR1A (71909960 - 71930285 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SAR1A
         1 CNV: 6879

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    Disorders / Diseases
    for SAR1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SAR1A for disorders           About GeneDecksing

    OMIM gene information: 607691    OMIM disorders: --

    5 diseases for SAR1A:    About MalaCards
    platelet storage pool deficiency    hyperinsulinism    alzheimer's disease    ataxia
    malaria

    1 disease from the University of Copenhagen DISEASES database for SAR1A:
    Platelet storage pool deficiency
    Human Genome Epidemiology (HuGE) Navigator: SAR1A (4 documents)

    Export disorders for SAR1A gene to outside databases

    Publications
    for SAR1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAR1A gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with SAR1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis. (PubMed id 10871277)1, 2, 3 South S.T.... Gould S.J. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Modulation of membrane rigidity by the human vesicle t rafficking proteins Sar1A and Sar1B. (PubMed id 22974979)1 Loftus A.F....Parthasarathy R. (2012)
    6. Sedlin controls the ER export of procollagen by regula ting the Sar1 cycle. (PubMed id 23019651)1 Venditti R....De Matteis M.A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for SAR1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SAR1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56681 HGNC: 10534 AceView: SARA1 Ensembl:ENSG00000079332 euGenes: HUgn56681
    ECgene: SAR1A Kegg: 56681 H-InvDB: SAR1A

    Other Databases showing SAR1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SAR1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAR1A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SAR1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SAR1A gene:
    Search GeneIP for patents involving SAR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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