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Aliases for SAR1A Gene

Aliases for SAR1A Gene

  • Secretion Associated, Ras Related GTPase 1A 2 3
  • COPII-Associated Small GTPase 3 4
  • SARA1 3 4
  • SAR1 3 4
  • Sara 3 4
  • SAR1a Gene Homolog (S. Cerevisiae) 1 2
  • SAR1a Gene Homolog 1 (S. Cerevisiae) 2
  • SAR1 Homolog A (S. Cerevisiae) 2
  • GTP-Binding Protein SAR1a 3
  • SAR1a Gene Homolog 1 3
  • SAR1 Gene Homolog A 3
  • SAR1 Homolog A 3
  • EC 3.6.5 63
  • Masra2 3
  • SARA1, 6

External Ids for SAR1A Gene

Previous HGNC Symbols for SAR1A Gene

  • SARA1

Previous GeneCards Identifiers for SAR1A Gene

  • GC10M071580
  • GC10M071909
  • GC10M065902

Summaries for SAR1A Gene

GeneCards Summary for SAR1A Gene

SAR1A (Secretion Associated, Ras Related GTPase 1A) is a Protein Coding gene. Diseases associated with SAR1A include platelet storage pool deficiency. Among its related pathways are TGF-Beta Pathway and Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is SAR1B.

UniProtKB/Swiss-Prot for SAR1A Gene

  • Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAR1A Gene

Genomics for SAR1A Gene

Regulatory Elements for SAR1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAR1A Gene

Start:
70,147,289 bp from pter
End:
70,170,529 bp from pter
Size:
23,241 bases
Orientation:
Minus strand

Genomic View for SAR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAR1A Gene

Proteins for SAR1A Gene

  • Protein details for SAR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR31-SAR1A_HUMAN
    Recommended name:
    GTP-binding protein SAR1a
    Protein Accession:
    Q9NR31
    Secondary Accessions:
    • B4DQ19

    Protein attributes for SAR1A Gene

    Size:
    198 amino acids
    Molecular mass:
    22367 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SAR1A Gene

    Alternative splice isoforms for SAR1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAR1A Gene

Proteomics data for SAR1A Gene at MOPED

Selected DME Specific Peptides for SAR1A Gene

Post-translational modifications for SAR1A Gene

  • Ubiquitination at Lys27 and Lys166
  • Modification sites at PhosphoSitePlus

Domains for SAR1A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR31

UniProtKB/Swiss-Prot:

SAR1A_HUMAN :
  • Q9NR31
Family:
  • Belongs to the small GTPase superfamily. SAR1 family.
genes like me logo Genes that share domains with SAR1A: view

No data available for Gene Families for SAR1A Gene

Function for SAR1A Gene

Molecular function for SAR1A Gene

UniProtKB/Swiss-Prot Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Enzyme Numbers (IUBMB) for SAR1A Gene

Gene Ontology (GO) - Molecular Function for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0004871 signal transducer activity --
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
GO:0031683 G-protein beta/gamma-subunit complex binding --
genes like me logo Genes that share ontologies with SAR1A: view
genes like me logo Genes that share phenotypes with SAR1A: view

Animal Model Products

CRISPR Products

miRNA for SAR1A Gene

miRTarBase miRNAs that target SAR1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAR1A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SAR1A Gene

Localization for SAR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAR1A Gene

Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAR1A Gene COMPARTMENTS Subcellular localization image for SAR1A gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
cytoskeleton 2
endosome 2
golgi apparatus 2
nucleus 2
plasma membrane 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with SAR1A: view

Pathways for SAR1A Gene

genes like me logo Genes that share pathways with SAR1A: view

Pathways by source for SAR1A Gene

Gene Ontology (GO) - Biological Process for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction --
GO:0016192 vesicle-mediated transport IEA --
GO:1901301 regulation of cargo loading into COPII-coated vesicle --
genes like me logo Genes that share ontologies with SAR1A: view

Compounds for SAR1A Gene

(1) HMDB Compounds for SAR1A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with SAR1A: view

Transcripts for SAR1A Gene

Unigene Clusters for SAR1A Gene

SAR1 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAR1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAR1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for SAR1A Gene

GeneLoc Exon Structure for
SAR1A
ECgene alternative splicing isoforms for
SAR1A

Expression for SAR1A Gene

mRNA expression in normal human tissues for SAR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAR1A Gene

SOURCE GeneReport for Unigene cluster for SAR1A Gene Hs.499960

genes like me logo Genes that share expressions with SAR1A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SAR1A Gene

Orthologs for SAR1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SAR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAR1A 35
  • 99.83 (n)
  • 100 (a)
SAR1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAR1A 35
  • 95.29 (n)
  • 98.99 (a)
SAR1A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAR1A 35
  • 94.78 (n)
  • 98.99 (a)
mouse
(Mus musculus)
Mammalia Sar1a 35
  • 93.1 (n)
  • 99.49 (a)
Sar1a 16
Sar1a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAR1A 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAR1A 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sar1a 35
  • 93.27 (n)
  • 99.49 (a)
chicken
(Gallus gallus)
Aves SAR1A 35
  • 85.19 (n)
  • 97.47 (a)
SAR1A 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAR1A 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25405 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sar1a 35
  • 84.18 (n)
  • 96.46 (a)
sar1a-prov 35
zebrafish
(Danio rerio)
Actinopterygii sar1ab 35
  • 74.07 (n)
  • 87.88 (a)
sar1ab 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sar1 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sar-1 36
  • 63 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL114W 35
  • 56.58 (n)
  • 59.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAR1 35
  • 59.46 (n)
  • 61.62 (a)
SAR1 36
  • 61 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02046g 35
  • 57.12 (n)
  • 58.38 (a)
soybean
(Glycine max)
eudicotyledons Gma.6113 35
thale cress
(Arabidopsis thaliana)
eudicotyledons SAR1B 35
  • 61.11 (n)
  • 60.42 (a)
rice
(Oryza sativa)
Liliopsida Os.10984 35
Os01g0338000 35
  • 60.73 (n)
  • 60.73 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11181 35
  • 62.22 (n)
  • 64.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sar1 35
  • 61.38 (n)
  • 64.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1569 35
Species with no ortholog for SAR1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAR1A Gene

ENSEMBL:
Gene Tree for SAR1A (if available)
TreeFam:
Gene Tree for SAR1A (if available)

Paralogs for SAR1A Gene

Paralogs for SAR1A Gene

Pseudogenes.org Pseudogenes for SAR1A Gene

genes like me logo Genes that share paralogs with SAR1A: view

Variants for SAR1A Gene

Sequence variations from dbSNP and Humsavar for SAR1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7653 -- 70,150,560(-) TTTTT(C/T)CCCCT utr-variant-3-prime
rs10586 -- 70,150,276(+) CTTTT(C/G)CTGAA utr-variant-3-prime
rs15801 -- 70,150,907(-) GGTGA(A/G)GGAGG utr-variant-3-prime
rs870801 -- 70,169,990(-) AGCGA(G/T)TGTGA intron-variant
rs1046747 -- 70,150,874(-) TCATT(C/T)TTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SAR1A Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv7054 CNV Insertion 18451855

Relevant External Links for SAR1A Gene

HapMap Linkage Disequilibrium report
SAR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAR1A Gene

Disorders for SAR1A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SAR1A Gene including...

Search for SAR1A Gene in MalaCards »

(1) University of Copenhagen DISEASES for SAR1A Gene

Relevant External Links for SAR1A

Genetic Association Database (GAD)
SAR1A
Human Genome Epidemiology (HuGE) Navigator
SAR1A
genes like me logo Genes that share disorders with SAR1A: view

No data available for UniProtKB/Swiss-Prot for SAR1A Gene

Publications for SAR1A Gene

  1. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis. (PMID: 10871277) South S.T. … Gould S.J. (J. Cell Biol. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan A.R. … Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 48

Products for SAR1A Gene

  • Addgene plasmids for SAR1A

Sources for SAR1A Gene

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