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SAR1A Gene

protein-coding   GIFtS: 64
GCID: GC10M071909

Secretion Associated, Ras Related GTPase 1A

(Previous names: SAR1a gene homolog (S. cerevisiae) 1, SAR1a gene homolog...)
(Previous symbol: SARA1)
  See SAR1A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretion Associated, Ras Related GTPase 1A1 2     GTP-Binding Protein SAR1a2
SARA11 2 3 5     masra22
SAR12 3     SAR1 Gene Homolog A2
COPII-Associated Small GTPase2 3     SAR1 Homolog A2
SAR1 Homolog A (S. Cerevisiae)1     SAR1a Gene Homolog 12
SAR1a Gene Homolog (S. Cerevisiae) 11     SARA3
SAR1a Gene Homolog 1 (S. Cerevisiae)1     EC 3.6.58
Sara2     

External Ids:    HGNC: 105341   Entrez Gene: 566812   Ensembl: ENSG000000793327   OMIM: 6076915   UniProtKB: Q9NR313   

Export aliases for SAR1A gene to outside databases

Previous GC identifers: GC10M071580 GC10M065902


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SAR1A Gene:
SAR1A (secretion associated, Ras related GTPase 1A) is a protein-coding gene. Diseases associated with SAR1A include platelet storage pool deficiency. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is SAR1B.

UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31
Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to
maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic
reticulum exit sites (ERES)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAR1A gene promoter:
         Elk-1   POU3F1   FOXO3   FOXO3b   RORalpha2   Pax-3   FAC1   FOXO3a   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAR1A promoter sequence
   Search Chromatin IP Primers for SAR1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SAR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAR1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M071909:  view genomic region     (about GC identifiers)

Start:
71,907,045 bp from pter      End:
71,930,285 bp from pter
Size:
23,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31 (See protein sequence)
Recommended Name: GTP-binding protein SAR1a  
Size: 198 amino acids; 22367 Da
1 PDB 3D structure from and Proteopedia for SAR1A:
2GAO (3D)    

Explore the universe of human proteins at neXtProt for SAR1A: NX_Q9NR31

Explore proteomics data for SAR1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27, Lys166
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for SAR1A (Q9NR31)
     HPTSEEL  GIVFLVD  ILGNKID  TFDLGGH 


    See SAR1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136120.1  NP_064535.1  

    ENSEMBL proteins: 
     ENSP00000362339   ENSP00000362335   ENSP00000362338   ENSP00000398165   ENSP00000362333  
     ENSP00000362336   ENSP00000399698   ENSP00000437979  

    SAR1A Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for SAR1A
    Novus Biologicals SAR1A Proteins
    Novus Biologicals SAR1A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SAR1A
    Cloud-Clone Corp. Proteins for SAR1A

     
    Search eBioscience for Proteins for SAR1A 

     
    antibodies-online proteins for SAR1A (18 products) 

     
    antibodies-online peptides for SAR1A

    SAR1A Antibody Products:

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    Abcam antibodies for SAR1A (Q9Y6B6, Q9NR31)
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    ThermoFisher Antibodies for SAR1A
    antibodies-online antibodies for SAR1A (21 products) 

    SAR1A Assay Products:

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    Cloud-Clone Corp. ELISAs for SAR1A
    Cloud-Clone Corp. CLIAs for SAR1A
    Search eBioscience for ELISAs for SAR1A 
    antibodies-online kits for SAR1A (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR006687 Small_GTPase_SAR1
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR

    Graphical View of Domain Structure for InterPro Entry Q9NR31

    ProtoNet protein and cluster: Q9NR31

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB006687 GTP-binding protein SAR1


    UniProtKB/Swiss-Prot: SAR1A_HUMAN, Q9NR31
    Similarity: Belongs to the small GTPase superfamily. SAR1 family


    Find genes that share domains with SAR1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAR1A_HUMAN, Q9NR31
    Function: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to
    maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
    SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic
    reticulum exit sites (ERES)

         Enzyme Number (IUBMB): EC 3.6.52

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
    GO:0031683G-protein beta/gamma-subunit complex binding ----
         
    Find genes that share ontologies with SAR1A           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SAR1A:
     Decreased viability with pacli  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella-containin 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SAR1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target SAR1A:
    hsa-mir-21-5p (MIRT031053), hsa-mir-615-3p (MIRT039781), hsa-mir-149-5p (MIRT045552)

    Block miRNA regulation of human, mouse, rat SAR1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SAR1A (see all 63):
    hsa-miR-323-3p hsa-miR-1197 hsa-miR-200a hsa-miR-1258 hsa-miR-128 hsa-miR-486-3p hsa-miR-766 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidSAR1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SAR1A
    Predesigned siRNA for gene silencing in human, mouse, rat SAR1A

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SAR1A (NM_020150)
    Sino Biological Human cDNA Clone for SAR1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAR1A
    Addgene plasmids for SAR1A 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAR1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAR1A_HUMAN, Q9NR31: Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    cytosol3
    cytoskeleton2
    endosome2
    golgi apparatus2
    nucleus2
    plasma membrane2
    extracellular1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum ----
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with SAR1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SAR1A About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    5Legionellosis
    Legionellosis


    Find genes that share SuperPaths with SAR1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SAR1A
        TGF-Beta Pathway
    SREBP Proteolysis

    4 GeneGo (Thomson Reuters) Pathways for SAR1A
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 BioSystems Pathway for SAR1A
        SREBP signalling



    2 Kegg Pathways  (Kegg details for SAR1A):
        Protein processing in endoplasmic reticulum
    Legionellosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAR1A
    Interactions:

        Search GeneGlobe Interaction Network for SAR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SAR1A (Q9NR313 ENSP000003623354) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542533, ENSP000002447694I2D: score=1 STRING: ENSP00000244769
    DCTN1Q142033I2D: score=1 
    SEC13ENSP000003121224STRING: ENSP00000312122
    UBCENSP000003448184STRING: ENSP00000344818
    STX5ENSP000002941794STRING: ENSP00000294179
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport IEA--
    GO:0006888ER to Golgi vesicle-mediated transport ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction ----

    Find genes that share ontologies with SAR1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAR1A

    1 HMDB Compound for SAR1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SAR1A gene (2 alternative transcripts): 
    NM_001142648.1  NM_020150.4  

    Unigene Cluster for SAR1A:

    SAR1 homolog A (S. cerevisiae)
    Hs.499960  [show with all ESTs]
    Unigene Representative Sequence: NM_001142648
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373242(uc010qjh.2) ENST00000373238 ENST00000373241(uc010qji.2 uc010qjj.2)
    ENST00000452767 ENST00000373236 ENST00000477464 ENST00000373239 ENST00000431664
    ENST00000458634
    miRNA
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    Block miRNA regulation of human, mouse, rat SAR1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SAR1A (see all 63):
    hsa-miR-323-3p hsa-miR-1197 hsa-miR-200a hsa-miR-1258 hsa-miR-128 hsa-miR-486-3p hsa-miR-766 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidSAR1A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SAR1A
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SAR1A (NM_020150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAR1A
    Addgene plasmids for SAR1A 
    Primer
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    OriGene qPCR primer pairs and template standards for SAR1A
    OriGene qSTAR qPCR primer pairs in human, mouse for SAR1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAR1A
      QuantiTect SYBR Green Assays in human, mouse, rat SAR1A
      QuantiFast Probe-based Assays in human, mouse, rat SAR1A

    Additional mRNA sequence: 

    AF086166.1 AF087897.1 AF217959.1 AF261717.1 AF274026.1 AF318066.1 AK025857.1 AK074257.1 
    AK298591.1 AK312469.1 AL136724.1 AY008268.1 BC003658.2 CR533492.1 

    16 DOTS entries:

    DT.95259145  DT.97862695  DT.87016923  DT.121261144  DT.92433004  DT.95188941  DT.100042097  DT.430391 
    DT.121261116  DT.100792928  DT.121261035  DT.91733074  DT.95100927  DT.95112223  DT.101958209  DT.91716170 

    Selected AceView cDNA sequences (see all 356):

    AA938282 BQ954254 BM556837 AA972543 CA447918 BM453963 AA301377 AF086166 
    AI868032 AA938505 BM714357 BM670758 CR600689 BM670777 AA905973 CB270682 
    BP372457 BQ941426 BU072468 BQ003860 CB530037 BM835777 AI470275 AI086814 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SAR1A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                                                            


    ECgene alternative splicing isoforms for SAR1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SAR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTATGACT
    SAR1A Expression
    About this image


    SAR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    SAR1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAR1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499960
        Custom PCR Arrays for SAR1A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SAR1A
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    QuantiFast Probe-based Assays in human, mouse, rat SAR1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAR1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SAR1A gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sar1a1 , 5 SAR1 gene homolog A (S. cerevisiae)1, 5 93.1(n)1
    99.49(a)1
      10 (32.26 cM)5
    202241  NM_009120.21  NP_033146.11 
     616803215 
    chicken
    (Gallus gallus)
    Aves SAR1A1 SAR1 homolog A (S. cerevisiae) 85.19(n)
    97.47(a)
      423711  XM_421589.4  XP_421589.2 
    lizard
    (Anolis carolinensis)
    Reptilia SAR1A6
    SAR1 homolog A (S. cerevisiae)
    94(a)
    1 ↔ 1
    3(51292499-51296439)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.254052 Xenopus laevis transcribed sequence with strong similarity more 83.17(n)    CF549146.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sar1ab1 SAR1 gene homolog Ab (S. cerevisiae) 74.07(n)
    87.88(a)
      550581  NM_001017882.1  NP_001017882.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sar16
    sar1
    70(a)
    1 → many
    3R(18182407-18186433)
    worm
    (Caenorhabditis elegans)
    Secernentea sar-16
    Protein SAR-1 (sar-1) mRNA, complete cds
    63(a)
    1 → many
    IV(4511893-4513321) WBGene00022678
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAR11 SAR1 59.46(n)
    61.62(a)
      855883   NP_015106.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SAR1B1 SAR1B 61.11(n)
    60.42(a)
      842086  NM_104512.2  NP_176029.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109842 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.44(n)    AK103351.1 


    ENSEMBL Gene Tree for SAR1A (if available)
    TreeFam Gene Tree for SAR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAR1A gene
    SAR1B2  
    Selected SIMAP similar genes for SAR1A using alignment to 5 protein entries:     SAR1A_HUMAN (see all proteins) (see all similar genes):
    SARA1    SAR1B    DKFZp434B2017    ARL8B    ARL7    ARL8A
    ARL2    ARL4C    ARL6    ARL4A    ARF6    ARF3
    ARL11    ARF1    ARL13B    ARF5    ARL14    TRIM23

    Find genes that share paralogs with SAR1A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SAR1A
    PGOHUM00000250794 PGOHUM00000260971


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SAR1A (see all 499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392422381,2
    C--65906741(+) TTTTT-/TCTTTTT 2 -- int10--------
    rs1911984991,2
    --71909590(+) ACAGCA/GTGAGC 2 -- int10--------
    rs1480647831,2
    --71909620(+) TAATTC/TTGTGT 2 -- int10--------
    rs1417659041,2
    C--71909750(+) AGCATA/GTTCCA 2 -- int10--------
    rs741392781,2
    C,F--71909898(+) ATAAAC/TGGCAT 2 -- int18Minor allele frequency- T:0.28WA NA CSA EA 368
    rs125730971,2
    C,F,H--71909903(+) CGGCAT/CTGTTC 2 -- int122Minor allele frequency- C:0.38NA NS EA WA CSA 1676
    rs781608281,2
    C,F--71909934(+) ACCAAT/AGAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs2001546931,2
    C--71909936(+) CAATG-/AAAAAA 2 -- int10--------
    rs752944981,2
    C,F--71909957(+) ATAGCG/ATATTT 2 -- int12Minor allele frequency- A:0.12WA EA 238
    rs1833590251,2
    --71910011(+) CTTTCA/GTAAAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SAR1A (71907045 - 71930285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SAR1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7054CNV Insertion18451855
    esv32737CNV Gain+Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SAR1A
    DNA2.0 Custom Variant and Variant Library Synthesis for SAR1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607691    OMIM disorders: --

    1 disease for SAR1A:    
    About MalaCards
    platelet storage pool deficiency

    1 disease from the University of Copenhagen DISEASES database for SAR1A:
    Platelet storage pool deficiency

    Find genes that share disorders with SAR1A           About GenesLikeMe

    Genetic Association Database (GAD): SAR1A
    Human Genome Epidemiology (HuGE) Navigator: SAR1A (4 documents)

    Export disorders for SAR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAR1A gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with SAR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis. (PubMed id 10871277)1, 2, 3 South S.T.... Gould S.J. (J. Cell Biol. 2000)
    2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    3. Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia. (PubMed id 18318767)1, 4 Kumkhaek C....Rodgers G.P. (Br. J. Haematol. 2008)
    4. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Altering membrane topology with Sar1 does not impair spindle assembly in Xenopus egg extracts. (PubMed id 22605651)1 Riggs B....Heald R. (Cytoskeleton (Hoboken) 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56681 HGNC: 10534 AceView: SARA1 Ensembl:ENSG00000079332 euGenes: HUgn56681
    ECgene: SAR1A Kegg: 56681 H-InvDB: SAR1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SAR1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SAR1A gene:
    Search GeneIP for patents involving SAR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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