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SAPS3 Gene

protein-coding GIFtS: 51

GC11P067985

SAPS domain family, member 3
(Previous name: chromosome 11 open reading frame 23 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C11orf23)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C11orf23 ^², ³, ⁵
DKFZp781E17107 ^¹, ²
DKFZp781E2374 ^¹, ²
DKFZp781O2362 ^¹, ²
FLJ11058 ^¹, ²
FLJ43065 ^¹, ²
KIAA1558 ^¹, ², ³, ⁵
MGC125711 ^¹, ²
MGC125712 ^¹, ²
PP6R3 ^¹, ², ³, ⁵
SAP190 ^¹, ²
SAPL ^¹, ², ³
SAPLa ^¹, ²

Descriptions
SAPS domain family member 3 ^³
SAPS domain family, member 3 ^²
Sporulation-induced transcript 4-associated protein SAPL ^³
chromosome 11 open reading frame 23 ^¹
protein phosphatase 6 regulatory subunit 3 ^²
sporulation-induced transcript 4-associated protein ^²

External Ids
HGNC: 1173¹
Entrez Gene: 55291²
UniProtKB: Q5H9R7³
Ensembl: ENSG00000110075⁷

Search outside databases for aliases for SAPS3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SAPS3:

Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein

phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and

determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for

the protein phosphatase-6 catalytic subunit (PPP6C; MIM 300141) (Stefansson and Brautigan, 2006

[PubMed 16769727]).[supplied by OMIM]

UniProtKB/Swiss-Prot: SAPS3_HUMAN, Q5H9R7

Function: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6

subunit. May have an important role in maintaining immune self-tolerance

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAPS3 gene

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13

SAPS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P067985: (about GC identifiers)

Start:	67,984,775 bp from pter
End:	68,139,378 bp from pter
Size:	154,604 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SAPS3_HUMAN, Q5H9R7 (See protein sequence)

Recommended Name: Serine/threonine-protein phosphatase 6 regulatory subunit 3

Size: 873 amino acids; 97669 Da

Subunit: Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by

the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain

containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28

Subcellular location: Cytoplasm. Nucleus

Secondary accessions: Q3B7I1 Q3I4Y0 Q3KR35 Q68CR3 Q7L4R8 Q8N3B2 Q96MB2 Q9H2K5 Q9H2K6 Q9HCL4 Q9NUY3

Alternative splicing: 6 isoforms: Q5H9R7-1 Q5H9R7-2 Q5H9R7-3 Q5H9R7-4 Q5H9R7-5 Q5H9R7-6

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_060782.2

ENSEMBL proteins:

ENSP00000377388 ENSP00000265637 ENSP00000377390 ENSP00000265636 ENSP00000377389

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SAPS3)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: SAPS3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for SAPS3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SAPS3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SAPS3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for SAPS3

Assays for SAPS3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5H9R7

ProtoNet protein and cluster: Q5H9R7

1 Blocks protein family: IPB007587 SIT4 phosphatase-associated protein

UniProtKB/Swiss-Prot: SAPS3_HUMAN, Q5H9R7

Similarity: Belongs to the SAPS family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAPS3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018312

Applied Biosystems Silencer® siRNAs for SAPS3

Sigma-Aldrich siRNA and siRNA Panels for SAPS3

Sigma-Aldrich shRNA for SAPS3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018312
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018312
untagged cDNA clone in CMV expression vector: NM_018312

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018312

UniProtKB/Swiss-Prot: SAPS3_HUMAN, Q5H9R7

Function: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6

subunit. May have an important role in maintaining immune self-tolerance

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18186651
GO:0019903	protein phosphatase binding	IPI	16716191

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Interacting proteins for SAPS3 (Q5H9R7¹ ENSP00000265636³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP6C	O00743¹, ENSP00000362648³	EBI-355498, EBI-359751 STRING (score=.978)
ANKRD28	O15084¹, ENSP00000373287³	EBI-355498, EBI-359567 STRING (score=.87)
NFKBIE	ENSP00000275015³	STRING (score=.873)
PPP2CA	ENSP00000231504³	STRING (score=.705)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043666	regulation of phosphoprotein phosphatase activity	IDA	16716191

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAPS3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAPS3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018312

Sigma-Aldrich siRNA and siRNA Panels for SAPS3

Sigma-Aldrich shRNA for SAPS3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018312

REFSEQ mRNAs for SAPS3 gene:

NM_018312.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018312

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018312
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018312
                                 untagged cDNA clone in CMV expression vector: NM_018312

Additional cDNA sequence:

AF264779.1 AF264780.1 AK001920.1 AK023950.1 AK057250.1 AK125055.1 AK298180.1 AK300359.1

AK302611.1 AK303315.1 AK315136.1 AL389982.1 AL834471.1 BC007738.2 BC020953.1 BC070121.1

BC105933.1 BC105934.1 BC107599.1 CR593310.1 CR604147.1 CR749815.1 CR933658.1 CR936718.1

DQ111954.2

24/33 DOTS entries (see all 33 ):

DT.100819128 DT.100819125 DT.80101945 DT.100690486 DT.91839330 DT.95228686 DT.91836528 DT.95190004

DT.92440078 DT.120685456 DT.40268979 DT.40310526 DT.100739749 DT.75148277 DT.91962698 DT.95202556

DT.95228724 DT.97786499 DT.40270828 DT.40288313 DT.97859323 DT.100036037 DT.100663510 DT.120685431

24/308 AceView cDNA sequences (see all 308 ):

AW449948 AK125055 BU184323 AI264636 AI097191 AW440506 AU136636 AA730124

AI375602 BQ424158 CB989885 AU121246 AI423743 BM671204 BM977372 AF264779

AL597561 AL523771 BM554171 BM994672 AI381972 BM710048 BF436246 AW276258

highest scoring ESTs for SAPS3:

AI200641 N63911 AA279064 AA336568 AA397741 AA420972 AA604175 AA632819 AA694446 AA770328

Unigene Cluster for SAPS3:

SAPS domain family, member 3

Hs.503022 [show with all ESTs]

Unigene Representative Sequence: CR936718

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SAPS3 (see all 17 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^
SP1:																			-																						-
SP2:									-		-		-						-																						-								-
SP3:									-		-		-						-																						-								-
SP4:																			-																						-
SP5:

ExUns:	15	^	16	^	17a	·	17b	^	18	^	19a	·	19b	·	19c	^	20	^	21	^	22	^	23	^	24	^	25	^	26a	·	26b	·	26c	^	27a	·	27b	·	27c	·	27d	^	28
SP1:											-																		-						-
SP2:									-		-																		-						-
SP3:									-		-																		-						-		-		-		-
SP4:									-		-																		-						-
SP5:									-		-		-																-						-

About this scheme

ECgene alternative splicing isoforms for SAPS3

5 Ensembl transcripts including schematic representations:

ENST00000393799 ENST00000265637 ENST00000393801 ENST00000265636 ENST00000393800

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAPS3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAPS3

¹ / ² / ³

10 probe-sets matching SAPS3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77863_s_at²^{, 3}	U95-D	1	1.00	1.00	0.85	0.75	AA902830	0.60	1.00	0.82	1
81396_at²^{, 3}	U95-E	1	1.00	1.00	0.46	0.82	AI200641	1.00	1.00	1.00	1
45247_at²^{, 3}	U95-B	1	1.00	1.00	-0.32	1.68	N63911	1.00	1.00	1.00	1
77865_at²^{, 3}	U95-D	1	1.00	1.00	0.69	0.78	AI381972	0.60	1.00	0.82	1
222467_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK023950	0.80	1.00	0.91	1
217928_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018312	0.60	1.00	0.82	1
232312_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AB046778	0.60	1.00	0.82	1
222467_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217928_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232312_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks SAPS3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCAGGGTTT

SOURCE GeneReport for Unigene cluster: Hs.503022
UniProtKB/Swiss-Prot: SAPS3_HUMAN, Q5H9R7
Tissue specificity: Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung,
liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAPS3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAPS3¹	--	SAPS domain family, member 3	92.31(n) 95.21(a)	483688 XM_858717.1 XP_863810.1
chimpanzee (Pan troglodytes)	SAPS3¹	--	SAPS domain family, member 3	98.32(n) 98.11(a)	747492 XM_001173737.1 XP_001173737.1
cow (Bos taurus)	SAPS3¹	--	SAPS domain family, member 3	91.97(n) 95.84(a)	515218 XM_869848.2 XP_874941.1
mouse (Mus musculus)	Saps3^{1, 5}	19 (0.00 cM)⁵	SAPS domain family, member 3^{1, 5}	90.46(n)¹ 96.22(a)¹	52036¹ NM_029456.1¹ NP_083732.1¹ AI449653⁵ AI843849⁵ (see all 19)
chicken (Gallus gallus)	RCJMB04_2j4¹	--	SAPS domain family, member 3	82.91(n) 91.16(a)	423116 NM_001031183.1 NP_001026354.1

About this table Species with no ortholog for SAPS3

ENSEMBL Gene Tree for SAPS3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SAPS3 gene

SAPS1² SAPS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/774 NCBI SNPs in SAPS3 are shown (see all 774 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 200)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3740628^1,2	A,C,F,H	68137991(-)	`CCAAAT/CGAAAC`	1	--	ut3¹		9	EA NA EU WA	2192
	rs1996^1,2	A,C,F,H	68139167(-)	`GCTACG/AAAAGA`	1	--	ut3¹ ese³		9	MN NA EU EA WA	918
	rs4988291^1,2	C,F,H	68138183(+)	`TAAAAG/ATAGAA`	1	--	ut3¹ ese³		4	EU EA WA	394
	rs584003^1,2	C,F,H	67984156(-)	`TTGCGG/ATCTCT`	1	--	ng5¹		6	NA EU EA WA	522
	rs11605824^1,2	F,H	67984428(+)	`AAGCAT/CTGGCC`	1	--	ng5¹		4	EU EA WA	416
--	rs1201557^1,2	A,C	67982870(+)	`aggagG/Tcagag`	1	--	ng5¹		1	EA	172
	rs2298702^1,2	C,F	68124519(+)	`TTTCAG/CAGTTC`	1	Q/E	mis¹ ese³		8	EA NA EU WA	1314
	rs34009811^1,2	C,F	68134022(+)	`AGAGGC/TGAAGT`	1	A/V	mis¹		5	NA EU EA WA	498
--	rs12941^1,2	C,F	68138769(-)	`CTGAGG/AAGGCG`	1	--	ut3¹ ese³		5	MN NA	514
	rs3740630^1,2	H	68100011(-)	`CTTCGT/ACGGGA`	1	V/D	mis¹ ese³		4	EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for SAPS3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610879

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/18 PubMed articles for SAPS3 gene (see all 18 ):

The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. (PubMed id 11401438)^{2, 3, 4} Twells R.C....Hess J.F. (2001)
Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (PubMed id 18186651)^{3, 4} Stefansson B.... Brautigan D.L. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (PubMed id 16769727)^{3, 4} Stefansson B. and Brautigan D.L. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{3, 4} Nagase T....Ohara O. (2000)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55291	HGNC: 1173	AceView: C11orf23	Ensembl:ENSG00000110075	euGenes: HUgn55291
ECgene: SAPS3	H-InvDB: SAPS3

(According to HUGE)
About This Section

HUGE: KIAA1558

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for SAPS3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SAPS3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAPS3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAPS3		Antibodies for SAPS3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAPS3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for SAPS3

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SAPS3 Gene at Home site.
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SAPS3 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for SAPS3

Summaries
for SAPS3

Genomic Location
for SAPS3

Proteins
for SAPS3

Protein Domains/
Families
for SAPS3

Gene Function
for SAPS3

Pathways & Interactions
for SAPS3

Drugs & Compounds
for SAPS3

Transcripts
for SAPS3

Expression
for SAPS3

Orthologs
for SAPS3

Paralogs
for SAPS3

SNPs/Variants
for SAPS3

Disorders & Mutations
for SAPS3

Medical News
for SAPS3

Publications
for SAPS3

Search for SAPS3

Genome Databases showing SAPS3

Other Databases showing SAPS3

Specialized Databases showing SAPS3

Licensable Technologies
for SAPS3

Services
for SAPS3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAPS3 (Gene Symbol)
C11orf23
DKFZp781E17107
DKFZp781E2374
DKFZp781O2362
FLJ11058
FLJ43065
KIAA1558
MGC125711
MGC125712
PP6R3
SAP190
SAPL
SAPLa
SAPS domain family member 3
SAPS domain family, member 3
Sporulation-induced transcript 4-associated protein SAPL
chromosome 11 open reading frame 23
protein phosphatase 6 regulatory subunit 3
sporulation-induced transcript 4-associated protein

SAPS3 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor SAPS3

Summariesfor SAPS3

Genomic Locationfor SAPS3

Proteinsfor SAPS3

Protein Domains/Familiesfor SAPS3

Gene Functionfor SAPS3

Pathways & Interactionsfor SAPS3

Drugs & Compoundsfor SAPS3

Transcriptsfor SAPS3

Expression for SAPS3

Orthologsfor SAPS3

Paralogsfor SAPS3

SNPs/Variantsfor SAPS3

Disorders & Mutationsfor SAPS3

Medical Newsfor SAPS3

Publicationsfor SAPS3

Search for SAPS3

Genome Databases showing SAPS3

Other Databases showing SAPS3

Specialized Databases showing SAPS3

Licensable Technologiesfor SAPS3

Servicesfor SAPS3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAPS3

Summaries
for SAPS3

Genomic Location
for SAPS3

Proteins
for SAPS3

Protein Domains/
Families
for SAPS3

Gene Function
for SAPS3

Pathways & Interactions
for SAPS3

Drugs & Compounds
for SAPS3

Transcripts
for SAPS3

Expression
for SAPS3

Orthologs
for SAPS3

Paralogs
for SAPS3

SNPs/Variants
for SAPS3

Disorders & Mutations
for SAPS3

Medical News
for SAPS3

Publications
for SAPS3

Licensable Technologies
for SAPS3

Services
for SAPS3