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Aliases & Descriptions for SAPS1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA1115 1, 2, 3, 5 | | MGC138185 2 | | MGC142003 2 | | PP6R1 2, 3, 5 | | SAP190 1, 2 |
| | | Descriptions |
|---|
| SAPS domain family member 1 3 | | SAPS domain family, member 1 2 |
|
| | Search outside databases for aliases for SAPS1 gene |
Summaries for SAPS1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SAPS1: Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 300141) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM] UniProtKB/Swiss-Prot: SAPS1_HUMAN, Q9UPN7Function: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha |
Genomic Location for SAPS1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAPS1 gene 
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42SAPS1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M060433:
(about GC identifiers)
Start:
|
60,432,959 bp from pter |
End:
|
60,462,175 bp from pter |
Size:
|
29,217 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for SAPS1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAPS1_HUMAN, Q9UPN7 (See
protein sequence)Recommended Name: Serine/threonine-protein phosphatase 6 regulatory subunit 1 Size: 943 amino acids; 103139 Da
Subunit: Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52
Subcellular location: Cytoplasm
Secondary accessions: Q2M2H3 Q504V2 Q6NVJ6 Q9BU97Alternative splicing: 2 isoforms: Q9UPN7-1 Q9UPN7-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055746.3
ENSEMBL proteins: ENSP00000321013
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for SAPS1: Assays for SAPS1: | Protein
Domains/ Families for SAPS1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UPN7
ProtoNet protein and cluster: Q9UPN7 1 Blocks protein family: IPB007587 SIT4 phosphatase-associated protein
UniProtKB/Swiss-Prot: SAPS1_HUMAN, Q9UPN7Similarity: Belongs to the SAPS family | Gene Function for SAPS1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014931
Applied Biosystems Silencer® siRNAs for SAPS1
Sigma-Aldrich siRNA for SAPS1  Sigma-Aldrich shRNA for SAPS1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014931                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014931                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014931 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014931
UniProtKB/Swiss-Prot: SAPS1_HUMAN, Q9UPN7Function: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for SAPS1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/8 Interacting proteins for SAPS1 (Q9UPN71, 2 ENSP000003210133) via UniProtKB, MINT, and/or STRING (see all 8
)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PPP6C | O007431, ENSP000003626483 | EBI-359745, EBI-359751 STRING (score=.978) | | ANKRD28 | O150841, ENSP000003732873 | EBI-359745, EBI-359567 STRING (score=.975) | | ANKRD44 | Q8N8A21, ENSP000003315163 | EBI-359745, EBI-1245329 STRING (score=.879) | | NFKBIE | O002211, 2, ENSP000002750153 | EBI-359745, EBI-355098 MINT-47946 EBI-359745, EBI-355098 MINT-47946 STRING (score=.978) | | ANKRD52 | Q8NB461 | EBI-359745, EBI-1996119 | About this table
|
Drugs & Compounds for SAPS1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAPS1
|
Transcripts for SAPS1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014931
Sigma-Aldrich siRNA for SAPS1  Sigma-Aldrich shRNA for SAPS1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014931 REFSEQ mRNAs for SAPS1 gene: NM_014931.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014931               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014931                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014931                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014931  Additional cDNA sequence: AB029038.2 AK297152.1 BC002799.2 BC007629.1 BC068014.1 BC094753.1 10 DOTS entries: DT.446411 DT.100676429 DT.100043341 DT.121489835 DT.92448959 DT.92448931 DT.95341394 DT.95344034 DT.100649295 DT.95343948 24/362 AceView cDNA sequences (see all 362
):BQ226010 CF125931 BM684816 CO246210 AW024315 BM786186 BQ888296 BQ920736 CN479984 BQ937776 BU149162 BC068014 CF126033 AW519178 AK127755 BF981649 CF122114 BM929765 BC007629 BU541947 BE513401 BQ053475 BQ063473 BM702170
highest scoring ESTs for SAPS1:AB029038 BG772019 CB960580 CN371237 CN371238 CN371239 CN371240 CN371241 CN371242 CN371243 Unigene Cluster for SAPS1: SAPS domain family, member 1 Hs.515610 [show with all ESTs]Unigene Representative Sequence: AB029038
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000327021
|
Expression for SAPS1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAPS1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAPS1
1 / 2 / 3 3 probe-sets matching SAPS1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGGACGGCC
SOURCE GeneReport for Unigene cluster: Hs.515610
Expression variation in blood from EXPOLDB for SAPS1 UniProtKB/Swiss-Prot: SAPS1_HUMAN, Q9UPN7Tissue specificity: Ubiquitous with higher expression in testis |
Orthologs for SAPS1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAPS1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for SAPS1
ENSEMBL Gene Tree for SAPS1 | Paralogs for SAPS1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SAPS1 gene
- SAPS32 SAPS22
|
SNPs/Variants for SAPS1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAPS1 (up to first 250kb)
|
Disorders & Mutations for SAPS1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610875
|
Medical News for SAPS1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAPS1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for SAPS1 gene: |
Search for SAPS1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAPS1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAPS1
(According to HUGE)
About This Section
| |
Specialized Databases showing SAPS1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAPS1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SAPS1:

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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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