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Aliases for SAPCD2 Gene

Aliases for SAPCD2 Gene

  • Suppressor APC Domain Containing 2 2 3
  • C9orf140 3 4 6
  • P42.3 3 4 6
  • Tumor Specificity And Mitosis Phase-Dependent Expression Protein 3 4
  • TS/MDEP 3 4
  • Suppressor APC Domain-Containing Protein 2 3
  • Chromosome 9 Open Reading Frame 140 2
  • Protein C9orf140 3
  • 2010317E24Rik 3

External Ids for SAPCD2 Gene

Previous HGNC Symbols for SAPCD2 Gene

  • C9orf140

Previous GeneCards Identifiers for SAPCD2 Gene

  • GC09M139957

Summaries for SAPCD2 Gene

GeneCards Summary for SAPCD2 Gene

SAPCD2 (Suppressor APC Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAPCD2 Gene

Genomics for SAPCD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAPCD2 Gene

Start:
137,062,124 bp from pter
End:
137,070,588 bp from pter
Size:
8,465 bases
Orientation:
Minus strand

Genomic View for SAPCD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAPCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAPCD2 Gene

No data available for Regulatory Elements for SAPCD2 Gene

Proteins for SAPCD2 Gene

  • Protein details for SAPCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD0-SAPC2_HUMAN
    Recommended name:
    Suppressor APC domain-containing protein 2
    Protein Accession:
    Q86UD0
    Secondary Accessions:

    Protein attributes for SAPCD2 Gene

    Size:
    394 amino acids
    Molecular mass:
    42637 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH48267.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAZ39408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SAPCD2 Gene

Proteomics data for SAPCD2 Gene at MOPED

Post-translational modifications for SAPCD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAPCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAPCD2 Gene

Domains for SAPCD2 Gene

Protein Domains for SAPCD2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAPCD2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SAPCD2 Gene

Function for SAPCD2 Gene

Phenotypes for SAPCD2 Gene

genes like me logo Genes that share phenotypes with SAPCD2: view

Animal Models for SAPCD2 Gene

MGI Knock Outs for SAPCD2:

Animal Model Products

CRISPR Products

miRNA for SAPCD2 Gene

miRTarBase miRNAs that target SAPCD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAPCD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for SAPCD2 Gene

Localization for SAPCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAPCD2 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for SAPCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SAPCD2: view

No data available for Subcellular locations from COMPARTMENTS for SAPCD2 Gene

Pathways for SAPCD2 Gene

SuperPathways for SAPCD2 Gene

No Data Available

Interacting Proteins for SAPCD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386348%0d%0a9606.ENSP00000354884%0d%0a
Selected Interacting proteins: ENSP00000386348 Q86UD0-SAPC2_HUMAN for SAPCD2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SAPCD2 Gene

None

No data available for Pathways by source for SAPCD2 Gene

Transcripts for SAPCD2 Gene

mRNA/cDNA for SAPCD2 Gene

Unigene Clusters for SAPCD2 Gene

Suppressor APC domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAPCD2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAPCD2 Gene

No ASD Table

Relevant External Links for SAPCD2 Gene

GeneLoc Exon Structure for
SAPCD2
ECgene alternative splicing isoforms for
SAPCD2

Expression for SAPCD2 Gene

mRNA expression in normal human tissues for SAPCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAPCD2 Gene

SOURCE GeneReport for Unigene cluster for SAPCD2 Gene Hs.19322

mRNA Expression by UniProt/SwissProt for SAPCD2 Gene

Q86UD0-SAPC2_HUMAN
Tissue specificity: Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney. Undetectable in non-cancerous adult tissues. Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa. Expressed preferentially in M and G1 phases, compared to S and G2 phases.
genes like me logo Genes that share expressions with SAPCD2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SAPCD2 Gene

Orthologs for SAPCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAPCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAPCD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAPCD2 35
  • 85.38 (n)
  • 80.93 (a)
SAPCD2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9ORF140 36
  • 82 (a)
OneToOne
SAPCD2 35
  • 84.94 (n)
  • 83.76 (a)
mouse
(Mus musculus)
Mammalia Sapcd2 35
  • 81.93 (n)
  • 81.07 (a)
Sapcd2 16
Sapcd2 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAPCD2 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sapcd2 35
  • 82.08 (n)
  • 79.84 (a)
chicken
(Gallus gallus)
Aves SAPCD2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAPCD2 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24300 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487796 35
  • 44.58 (n)
  • 37.4 (a)
Str.7058 35
fruit fly
(Drosophila melanogaster)
Insecta CG3880 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1097 36
  • 17 (a)
OneToOne
Species with no ortholog for SAPCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAPCD2 Gene

ENSEMBL:
Gene Tree for SAPCD2 (if available)
TreeFam:
Gene Tree for SAPCD2 (if available)

Paralogs for SAPCD2 Gene

genes like me logo Genes that share paralogs with SAPCD2: view

No data available for Paralogs for SAPCD2 Gene

Variants for SAPCD2 Gene

Sequence variations from dbSNP and Humsavar for SAPCD2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs867475 -- 137,064,125(+) GGCAG(C/G)CACCC utr-variant-3-prime
rs867476 -- 137,064,131(+) CACCC(C/G)CCGCT utr-variant-3-prime
rs2176674 -- 137,065,726(-) GCATG(C/T)GTGGA intron-variant
rs3750517 -- 137,063,844(-) TTCCA(A/G)GGCCT utr-variant-3-prime
rs4880086 -- 137,065,725(+) GTCCA(C/T)ACATG intron-variant

Relevant External Links for SAPCD2 Gene

HapMap Linkage Disequilibrium report
SAPCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAPCD2 Gene

Disorders for SAPCD2 Gene

No disorders were found for SAPCD2 Gene.

No data available for UniProtKB/Swiss-Prot for SAPCD2 Gene

Publications for SAPCD2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Identification and characterization of a novel p42.3 gene as tumor- specific and mitosis phase-dependent expression in gastric cancer. (PMID: 17525738) Xu X. … Lu Y. (Oncogene 2007) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. MiR-29a inhibits cell proliferation and induces cell cycle arrest through the downregulation of p42.3 in human gastric cancer. (PMID: 21998710) Cui Y. … Fang J.Y. (PLoS ONE 2011) 3

Products for SAPCD2 Gene

Sources for SAPCD2 Gene

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