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Aliases for SAPCD2 Gene

Aliases for SAPCD2 Gene

  • Suppressor APC Domain Containing 2 2 3 5
  • Tumor Specificity And Mitosis Phase-Dependent Expression Protein 3 4
  • C9orf140 3 4
  • TS/MDEP 3 4
  • P42.3 3 4
  • Chromosome 9 Open Reading Frame 140 2
  • Protein C9orf140 3
  • 2010317E24Rik 3

External Ids for SAPCD2 Gene

Previous HGNC Symbols for SAPCD2 Gene

  • C9orf140

Previous GeneCards Identifiers for SAPCD2 Gene

  • GC09M139957

Summaries for SAPCD2 Gene

GeneCards Summary for SAPCD2 Gene

SAPCD2 (Suppressor APC Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAPCD2 Gene

Genomics for SAPCD2 Gene

Regulatory Elements for SAPCD2 Gene

Enhancers for SAPCD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SAPCD2 on UCSC Golden Path with GeneCards custom track

Promoters for SAPCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAPCD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SAPCD2 Gene

Chromosome:
9
Start:
137,062,124 bp from pter
End:
137,070,588 bp from pter
Size:
8,465 bases
Orientation:
Minus strand

Genomic View for SAPCD2 Gene

Genes around SAPCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAPCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAPCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAPCD2 Gene

Proteins for SAPCD2 Gene

  • Protein details for SAPCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD0-SAPC2_HUMAN
    Recommended name:
    Suppressor APC domain-containing protein 2
    Protein Accession:
    Q86UD0

    Protein attributes for SAPCD2 Gene

    Size:
    394 amino acids
    Molecular mass:
    42637 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH48267.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAZ39408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SAPCD2 Gene

Proteomics data for SAPCD2 Gene at MOPED

Post-translational modifications for SAPCD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAPCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAPCD2 Gene

Domains & Families for SAPCD2 Gene

Protein Domains for SAPCD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAPCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAPCD2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SAPCD2 Gene

Function for SAPCD2 Gene

Phenotypes for SAPCD2 Gene

genes like me logo Genes that share phenotypes with SAPCD2: view

Animal Models for SAPCD2 Gene

MGI Knock Outs for SAPCD2:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SAPCD2 Gene

Localization for SAPCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAPCD2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAPCD2 Gene COMPARTMENTS Subcellular localization image for SAPCD2 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SAPCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SAPCD2: view

Pathways & Interactions for SAPCD2 Gene

SuperPathways for SAPCD2 Gene

No Data Available

Interacting Proteins for SAPCD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386348%0d%0a9606.ENSP00000354884%0d%0a
Selected Interacting proteins: ENSP00000386348 Q86UD0-SAPC2_HUMAN for SAPCD2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SAPCD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAPCD2 Gene

Drugs & Compounds for SAPCD2 Gene

No Compound Related Data Available

Transcripts for SAPCD2 Gene

mRNA/cDNA for SAPCD2 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(168) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAPCD2 Gene

Suppressor APC domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAPCD2 Gene

No ASD Table

Relevant External Links for SAPCD2 Gene

GeneLoc Exon Structure for
SAPCD2
ECgene alternative splicing isoforms for
SAPCD2

Expression for SAPCD2 Gene

mRNA expression in normal human tissues for SAPCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAPCD2 Gene

This gene is overexpressed in Nasal epithelium (49.3), Lung (8.6), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAPCD2 Gene



SOURCE GeneReport for Unigene cluster for SAPCD2 Gene Hs.19322

mRNA Expression by UniProt/SwissProt for SAPCD2 Gene

Q86UD0-SAPC2_HUMAN
Tissue specificity: Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney. Undetectable in non-cancerous adult tissues. Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa. Expressed preferentially in M and G1 phases, compared to S and G2 phases.
genes like me logo Genes that share expression patterns with SAPCD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SAPCD2 Gene

Orthologs for SAPCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAPCD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAPCD2 35
  • 85.38 (n)
  • 80.93 (a)
SAPCD2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAPCD2 35
  • 84.94 (n)
  • 83.76 (a)
C9ORF140 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sapcd2 35
  • 81.93 (n)
  • 81.07 (a)
Sapcd2 16
Sapcd2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sapcd2 35
  • 82.08 (n)
  • 79.84 (a)
oppossum
(Monodelphis domestica)
Mammalia SAPCD2 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAPCD2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAPCD2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAPCD2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487796 35
  • 44.58 (n)
  • 37.4 (a)
Str.7058 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24300 35
fruit fly
(Drosophila melanogaster)
Insecta CG3880 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1097 36
  • 17 (a)
OneToOne
Species with no ortholog for SAPCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAPCD2 Gene

ENSEMBL:
Gene Tree for SAPCD2 (if available)
TreeFam:
Gene Tree for SAPCD2 (if available)

Paralogs for SAPCD2 Gene

genes like me logo Genes that share paralogs with SAPCD2: view

No data available for Paralogs for SAPCD2 Gene

Variants for SAPCD2 Gene

Sequence variations from dbSNP and Humsavar for SAPCD2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs867475 -- 137,064,125(+) GGCAG(C/G)CACCC utr-variant-3-prime
rs867476 -- 137,064,131(+) CACCC(C/G)CCGCT utr-variant-3-prime
rs113090012 -- 137,066,365(+) TGCAC(A/G)CCACT reference, missense
rs113372403 -- 137,064,354(+) GCTAA(C/T)TCATG utr-variant-3-prime
rs113590362 -- 137,062,826(+) TTGCA(C/T)GGAAC utr-variant-3-prime

Variation tolerance for SAPCD2 Gene

Gene Damage Index Score: 12.87; 94.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAPCD2 Gene

HapMap Linkage Disequilibrium report
SAPCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAPCD2 Gene

Disorders for SAPCD2 Gene

Relevant External Links for SAPCD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAPCD2

No disorders were found for SAPCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAPCD2 Gene

Publications for SAPCD2 Gene

  1. Identification and characterization of a novel p42.3 gene as tumor- specific and mitosis phase-dependent expression in gastric cancer. (PMID: 17525738) Xu X. … Lu Y. (Oncogene 2007) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Optimization and Corroboration of the Regulatory Pathway of p42.3 Protein in the Pathogenesis of Gastric Carcinoma. (PMID: 26106439) Hao Y. … Nan K. (Comput Math Methods Med 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SAPCD2 Gene

Sources for SAPCD2 Gene

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