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Aliases for SAPCD2 Gene

Aliases for SAPCD2 Gene

  • Suppressor APC Domain Containing 2 2 3 5
  • Tumor Specificity And Mitosis Phase-Dependent Expression Protein 3 4
  • C9orf140 3 4
  • TS/MDEP 3 4
  • P42.3 3 4
  • Suppressor APC Domain-Containing Protein 2 3
  • Chromosome 9 Open Reading Frame 140 2
  • Protein C9orf140 3
  • 2010317E24Rik 3

External Ids for SAPCD2 Gene

Previous HGNC Symbols for SAPCD2 Gene

  • C9orf140

Previous GeneCards Identifiers for SAPCD2 Gene

  • GC09M139957

Summaries for SAPCD2 Gene

GeneCards Summary for SAPCD2 Gene

SAPCD2 (Suppressor APC Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SAPCD2 Gene

  • Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824).

Additional gene information for SAPCD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAPCD2 Gene

Genomics for SAPCD2 Gene

GeneHancer (GH) Regulatory Elements for SAPCD2 Gene

Promoters and enhancers for SAPCD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I137067 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.1 1058 4.4 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF143 FOS SAPCD2 MAN1B1 EHMT1 DPP7 SEC16A ANAPC2 SDCCAG3 SNHG7 NDOR1 DPH7
GH09I136358 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.9 +709.0 708987 5.5 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B DNLZ INPP5E ANAPC2 SNHG7 NPDC1 SDCCAG3 MAN1B1 SNAPC4 CARD9 AJM1
GH09I136900 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.9 +168.4 168414 4 HDGF ELF3 PKNOX1 FOXA2 SIN3A KLF5 RAD21 YY1 ZNF207 IKZF2 TRAF2 TMEM141 PHPT1 MAN1B1 ANAPC2 LCN12 PAXX SAPCD2 MIR4479 PIR43412
GH09I137511 Enhancer 0.9 ENCODE 5.4 -441.2 -441185 1.4 HDGF HDAC1 PKNOX1 ATF1 TAF9B ARNT ZNF766 SIRT6 FOS ATF7 PIR51097 DPH7 ANAPC2 MAN1B1 EHMT1 SNHG7 NDOR1 LOC651337 EXD3 SAPCD2
GH09I137079 Enhancer 0.5 ENCODE 6.6 -8.5 -8546 0 POLR2A ZBTB33 KLF8 EZH2 UAP1L1 SAPCD2 PIR60888
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAPCD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SAPCD2 Gene

Genomic Locations for SAPCD2 Gene
chr9:137,062,124-137,070,588
(GRCh38/hg38)
Size:
8,465 bases
Orientation:
Minus strand
chr9:139,956,579-139,965,040
(GRCh37/hg19)

Genomic View for SAPCD2 Gene

Genes around SAPCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAPCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAPCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAPCD2 Gene

Proteins for SAPCD2 Gene

  • Protein details for SAPCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD0-SAPC2_HUMAN
    Recommended name:
    Suppressor APC domain-containing protein 2
    Protein Accession:
    Q86UD0

    Protein attributes for SAPCD2 Gene

    Size:
    394 amino acids
    Molecular mass:
    42637 Da
    Quaternary structure:
    • Interacts with a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (PubMed:26766442). Interacts with GPSM2 (via TPR motifs); this interaction is required to prevent GPSM2 anchoring at the mitotic apical cortex and is inhibited in presence of NUMA1 in a dose dependent manner (PubMed:26766442). Interacts with PARD3 (PubMed:26766442).
    SequenceCaution:
    • Sequence=AAH48267.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAZ39408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SAPCD2 Gene

Post-translational modifications for SAPCD2 Gene

No Post-translational modifications

Other Protein References for SAPCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAPCD2 Gene

Domains & Families for SAPCD2 Gene

Gene Families for SAPCD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAPCD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAPCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAPCD2: view

No data available for UniProtKB/Swiss-Prot for SAPCD2 Gene

Function for SAPCD2 Gene

Molecular function for SAPCD2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824).

Phenotypes From GWAS Catalog for SAPCD2 Gene

Gene Ontology (GO) - Molecular Function for SAPCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26766442
genes like me logo Genes that share ontologies with SAPCD2: view
genes like me logo Genes that share phenotypes with SAPCD2: view

Animal Models for SAPCD2 Gene

MGI Knock Outs for SAPCD2:

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SAPCD2 Gene

Localization for SAPCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAPCD2 Gene

Cytoplasm. Nucleus. Cytoplasm, cell cortex. Apical cell membrane. Cell junction, tight junction. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis. {ECO:0000250 UniProtKB:Q9D818}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAPCD2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAPCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SAPCD2: view

Pathways & Interactions for SAPCD2 Gene

SuperPathways for SAPCD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAPCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation ISS --
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP 23576022
GO:0051301 cell division IEA --
GO:0090175 regulation of establishment of planar polarity IEA,ISS --
genes like me logo Genes that share ontologies with SAPCD2: view

No data available for Pathways by source and SIGNOR curated interactions for SAPCD2 Gene

Drugs & Compounds for SAPCD2 Gene

No Compound Related Data Available

Transcripts for SAPCD2 Gene

mRNA/cDNA for SAPCD2 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(168) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAPCD2 Gene

Suppressor APC domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAPCD2 Gene

No ASD Table

Relevant External Links for SAPCD2 Gene

GeneLoc Exon Structure for
SAPCD2
ECgene alternative splicing isoforms for
SAPCD2

Expression for SAPCD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAPCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAPCD2 Gene

This gene is overexpressed in Nasal epithelium (49.3), Lung (8.6), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAPCD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SAPCD2 Gene:

SAPCD2

SOURCE GeneReport for Unigene cluster for SAPCD2 Gene:

Hs.19322

mRNA Expression by UniProt/SwissProt for SAPCD2 Gene:

Q86UD0-SAPC2_HUMAN
Tissue specificity: Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824).

Evidence on tissue expression from TISSUES for SAPCD2 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with SAPCD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAPCD2 Gene

Orthologs for SAPCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAPCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAPCD2 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAPCD2 33 34
  • 85.38 (n)
dog
(Canis familiaris)
Mammalia SAPCD2 33
  • 84.94 (n)
C9ORF140 34
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sapcd2 33
  • 82.08 (n)
mouse
(Mus musculus)
Mammalia Sapcd2 33 16 34
  • 81.93 (n)
oppossum
(Monodelphis domestica)
Mammalia SAPCD2 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAPCD2 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAPCD2 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487796 33
  • 44.58 (n)
Str.7058 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24300 33
fruit fly
(Drosophila melanogaster)
Insecta CG3880 34
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1097 34
  • 17 (a)
OneToOne
Species where no ortholog for SAPCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAPCD2 Gene

ENSEMBL:
Gene Tree for SAPCD2 (if available)
TreeFam:
Gene Tree for SAPCD2 (if available)

Paralogs for SAPCD2 Gene

Pseudogenes.org Pseudogenes for SAPCD2 Gene

genes like me logo Genes that share paralogs with SAPCD2: view

No data available for Paralogs for SAPCD2 Gene

Variants for SAPCD2 Gene

Sequence variations from dbSNP and Humsavar for SAPCD2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000077145 -- 137,067,706(-) G/A intron_variant
rs1000805957 -- 137,064,559(-) G/T 3_prime_UTR_variant
rs1001047509 -- 137,064,383(-) A/T 3_prime_UTR_variant
rs1001155899 -- 137,069,226(-) A/G intron_variant
rs1001828812 -- 137,066,894(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAPCD2 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2739405 CNV deletion 23290073
esv2739407 CNV deletion 23290073
esv2761561 CNV gain 21179565
nsv1124489 CNV deletion 24896259
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616005 CNV loss 21841781
nsv616006 CNV loss 21841781
nsv831761 CNV loss 17160897
nsv951206 CNV deletion 24416366
nsv982354 CNV duplication 23825009

Variation tolerance for SAPCD2 Gene

Gene Damage Index Score: 12.87; 94.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAPCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAPCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAPCD2 Gene

Disorders for SAPCD2 Gene

Additional Disease Information for SAPCD2

No disorders were found for SAPCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAPCD2 Gene

Publications for SAPCD2 Gene

  1. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. (PMID: 26766442) Chiu CWN … Angers S (Developmental cell 2016) 3 4 58
  2. p42.3: a promising biomarker for the progression and prognosis of human colorectal cancer. (PMID: 23576022) Yuan XS … Hao CY (Journal of cancer research and clinical oncology 2013) 3 4 58
  3. Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinoma. (PMID: 23704824) Sun W … Lu YY (World journal of gastroenterology 2013) 3 4 58
  4. Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer. (PMID: 17525738) Xu X … Lu Y (Oncogene 2007) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for SAPCD2 Gene

Sources for SAPCD2 Gene

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