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SAPCD1 Gene

protein-coding   GIFtS: 31
GCID: GC06P031765

Suppressor APC Domain Containing 1

(Previous name: chromosome 6 open reading frame 26)
(Previous symbol: C6orf26)
  Search for SAPCD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Suppressor APC Domain Containing 11 2     Chromosome 6 Open Reading Frame 261
C6orf261 2 3     Suppressor APC Domain-Containing Protein 12
Protein G7d2 3     G7D3
NG232 3     

External Ids:    HGNC: 139381   Entrez Gene: 4012512   Ensembl: ENSG000002287277   UniProtKB: Q5SSQ63   

Export aliases for SAPCD1 gene to outside databases

Previous GC identifers: GC06P031732 GC06P031748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SAPCD1 Gene:
SAPCD1 (suppressor APC domain containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167247.2  NT_167249.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SAPCD1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAPCD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

SAPCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAPCD1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031765:  view genomic region     (about GC identifiers)

Start:
31,730,576 bp from pter      End:
31,732,628 bp from pter
Size:
2,053 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167244 3,045,524-3,047,378      Chr6+,NT_167249 3,061,586-3,063,440      Chr6+,NT_167245 3,016,355-3,018,209     
Chr6+,NT_167247 3,110,470-3,112,324      Chr6+,NT_113891.2 3,240,359-3,242,214     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SAPC1_HUMAN, Q5SSQ6 (See protein sequence)
Recommended Name: Suppressor APC domain-containing protein 1  
Size: 148 amino acids; 16650 Da
Sequence caution: Sequence=CAI18428.2; Type=Erroneous gene model prediction; Sequence=CAM24986.1; Type=Erroneous
gene model prediction; Sequence=CAM26109.1; Type=Erroneous gene model prediction;
Secondary accessions: A2ABF2 A2ABS9 Q9Y335
Alternative splicing: 2 isoforms:  Q5SSQ6-1   Q5SSQ6-2   

Explore the universe of human proteins at neXtProt for SAPCD1: NX_Q5SSQ6

Explore proteomics data for SAPCD1 at MOPED


See SAPCD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001034740.1  
ENSEMBL proteins: 
 ENSP00000408918   ENSP00000411948   ENSP00000413372  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR026831 APC_dom
 IPR026828 Suppressor_APCD_1/2

Graphical View of Domain Structure for InterPro Entry Q5SSQ6

ProtoNet protein and cluster: Q5SSQ6


Find genes that share domains with SAPCD1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAPCD1
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAPCD1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SAPCD1 About    
See pathways by source

SuperPathContained pathways About
1Ovarian Infertility Genes
Ovarian Infertility Genes


1 BioSystems Pathway for SAPCD1
    Ovarian Infertility Genes


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAPCD1
Interactions:

    Search GeneGlobe Interaction Network for SAPCD1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SAPCD1 (SAPC1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SAPCD1 gene: 
NM_001039651.1  

Unigene Cluster for SAPCD1:

Suppressor APC domain containing 1
Hs.371225  [show with all ESTs]
Unigene Representative Sequence: NM_001039651
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000433778 ENST00000415669 ENST00000494299 ENST00000425424
miRNA
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Additional mRNA sequence: 

BC137541.1 BC137542.1 

7 DOTS entries:

DT.100789190  DT.75102357  DT.100687934  DT.121408300  DT.92429769  DT.121408250  DT.92429774 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SAPCD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTATTGAAA
SAPCD1 Expression
About this image


SAPCD1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Dermis (Integumentary System)    fully expand to see all 2 entries
         Zigzag Dermal Papilla Cells Dermal Papilla
 
 Epiblast (Early Embryonic Tissues)
         Epiblast Cells Epiblast
 
 Eye (Sensory Organs)
         Retina
 
 Brain (Nervous System)
         Cerebellum
SAPCD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SAPCD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.371225
    Custom PCR Arrays for SAPCD1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAPCD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SAPCD1 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sapcd11 , 5 Ng23 protein5
suppressor APC domain containing 11
78.77(n)1
71.92(a)1
  17 (18.56 cM)5
783761  NM_023893.41  NP_076382.31 
 350259595 
lizard
(Anolis carolinensis)
Reptilia SAPCD16
suppressor APC domain containing 1
45(a)
1 ↔ 1
GL343570.1(165678-176647)


ENSEMBL Gene Tree for SAPCD1 (if available)
TreeFam Gene Tree for SAPCD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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2 SNPs for SAPCD1    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs172011511,2,4
----see VAR_0568892 mis40--------
rs69055721,2,4
----see VAR_0568902 mis40--------

HapMap Linkage Disequilibrium report for SAPCD1 (31730576 - 31732628 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SAPCD1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SAPCD1
DNA2.0 Custom Variant and Variant Library Synthesis for SAPCD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SAPCD1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with SAPCD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  2. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
  3. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). (PubMed id 8812450)1 Albertella M.R.... Campbell R.D. (Genomics 1996)
  8. Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region. (PubMed id 2477242)1 Sargent C.A.... Campbell R.D. (EMBO J. 1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 401251 HGNC: 13938 Ensembl:ENSG00000228727 euGenes: HUgn401251 ECgene: SAPCD1
H-InvDB: SAPCD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SAPCD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SAPCD1 gene:
Search GeneIP for patents involving SAPCD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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