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Aliases for SAPCD1 Gene

Aliases for SAPCD1 Gene

  • Suppressor APC Domain Containing 1 2 3 5
  • Protein G7d 3 4
  • C6orf26 3 4
  • NG23 3 4
  • Suppressor APC Domain-Containing Protein 1 3
  • Chromosome 6 Open Reading Frame 26 2
  • G7D 4

External Ids for SAPCD1 Gene

Previous HGNC Symbols for SAPCD1 Gene

  • C6orf26

Previous GeneCards Identifiers for SAPCD1 Gene

  • GC06P031732
  • GC06P031748
  • GC06P031765
  • GC06P031767
  • GC06P031844
  • GC06P031896

Summaries for SAPCD1 Gene

GeneCards Summary for SAPCD1 Gene

SAPCD1 (Suppressor APC Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAPCD1 Gene

Genomics for SAPCD1 Gene

Regulatory Elements for SAPCD1 Gene

Enhancers for SAPCD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031733 1.9 FANTOM5 ENCODE dbSUPER 12.1 -25.3 -25345 8.5 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 LY6G5C LSM2 LY6G5B VARS ABHD16A MICA EHMT2 PRRC2A C4A CLIC1
GH06G031792 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +32.9 32896 6.7 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1 SKIV2L ATF6B LSM2 LY6G5B DDX39B BAG6 C4A VARS HLA-DRB5 RPL3P2
GH06G030777 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -980.4 -980434 10.1 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 NFYC IER3 PPP1R10 PAIP1P1 VARS2 LY6G5B GTF2H4 DHX16 NFKBIL1 DDR1 ETF1P1
GH06G032184 1.7 Ensembl ENCODE dbSUPER 10.4 +428.5 428481 13.4 MLX CREB3L1 AGO1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 HLA-DRB1 AGER RNF5 NOTCH4 STK19B ATF6B C4A EHMT2 PPT2 SAPCD1
GH06G031269 1.6 FANTOM5 ENCODE dbSUPER 10.4 -491.3 -491338 4.4 HDGF PKNOX1 ATF1 WRNIP1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF121 HLA-C PSORS1C3 PPT2 DDX39B LY6G5B TCF19 LSM2 PSORS1C2 ATF6B HCG18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAPCD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SAPCD1 Gene

Chromosome:
6
Start:
31,762,799 bp from pter
End:
31,764,851 bp from pter
Size:
2,053 bases
Orientation:
Plus strand

Genomic View for SAPCD1 Gene

Genes around SAPCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAPCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAPCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SAPCD1 Gene

  • Protein details for SAPCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SSQ6-SAPC1_HUMAN
    Recommended name:
    Suppressor APC domain-containing protein 1
    Protein Accession:
    Q5SSQ6
    Secondary Accessions:
    • A2ABF2
    • A2ABS9
    • Q9Y335

    Protein attributes for SAPCD1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16650 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI18428.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM24986.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM26109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAPCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAPCD1 Gene

Post-translational modifications for SAPCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAPCD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAPCD1 Gene

Domains & Families for SAPCD1 Gene

Protein Domains for SAPCD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAPCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAPCD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SAPCD1 Gene

Function for SAPCD1 Gene

Phenotypes for SAPCD1 Gene

genes like me logo Genes that share phenotypes with SAPCD1: view

Animal Models for SAPCD1 Gene

MGI Knock Outs for SAPCD1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SAPCD1 Gene

Localization for SAPCD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAPCD1 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAPCD1 Gene

Pathways & Interactions for SAPCD1 Gene

SuperPathways for SAPCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAPCD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAPCD1 Gene

Drugs & Compounds for SAPCD1 Gene

No Compound Related Data Available

Transcripts for SAPCD1 Gene

mRNA/cDNA for SAPCD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAPCD1 Gene

Suppressor APC domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAPCD1 Gene

No ASD Table

Relevant External Links for SAPCD1 Gene

GeneLoc Exon Structure for
SAPCD1
ECgene alternative splicing isoforms for
SAPCD1

Expression for SAPCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAPCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SAPCD1 Gene:

SAPCD1

SOURCE GeneReport for Unigene cluster for SAPCD1 Gene:

Hs.371225
genes like me logo Genes that share expression patterns with SAPCD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAPCD1 Gene

Orthologs for SAPCD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAPCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAPCD1 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia SAPCD1 34
  • 84.27 (n)
MGC151586 35
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAPCD1 34 35
  • 81.17 (n)
mouse
(Mus musculus)
Mammalia Sapcd1 34 16 35
  • 78.77 (n)
rat
(Rattus norvegicus)
Mammalia Sapcd1 34
  • 76.87 (n)
lizard
(Anolis carolinensis)
Reptilia SAPCD1 35
  • 45 (a)
OneToOne
Species where no ortholog for SAPCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAPCD1 Gene

ENSEMBL:
Gene Tree for SAPCD1 (if available)
TreeFam:
Gene Tree for SAPCD1 (if available)

Paralogs for SAPCD1 Gene

No data available for Paralogs for SAPCD1 Gene

Variants for SAPCD1 Gene

Sequence variations from dbSNP and Humsavar for SAPCD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001668923 -- 31,761,838(+) GAGGA(C/T)GGCAA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1003393864 -- 31,763,425(+) CAGGA(A/T)GCAGG nc-transcript-variant, reference, missense
rs1004034887 -- 31,763,111(+) GTCCT(A/G)CTGCT nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs1006120529 -- 31,764,975(+) TCGCT(C/T)AGGCT intron-variant, utr-variant-3-prime
rs1006483649 -- 31,763,546(+) GGGGC(A/C)CTTGG nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SAPCD1 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
esv2763547 CNV loss 21179565
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259

Variation tolerance for SAPCD1 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAPCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAPCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAPCD1 Gene

Disorders for SAPCD1 Gene

Relevant External Links for SAPCD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAPCD1

No disorders were found for SAPCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAPCD1 Gene

Publications for SAPCD1 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  2. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Biochemical and computational analysis of LNX1 interacting proteins. (PMID: 22087225) Wolting C.D. … McGlade C.J. (PLoS ONE 2011) 3 64
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 64

Products for SAPCD1 Gene

Sources for SAPCD1 Gene

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