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Aliases for SAPCD1 Gene

Aliases for SAPCD1 Gene

  • Suppressor APC Domain Containing 1 2 3 5
  • Protein G7d 3 4
  • C6orf26 3 4
  • NG23 3 4
  • Suppressor APC Domain-Containing Protein 1 3
  • Chromosome 6 Open Reading Frame 26 2
  • G7D 4

External Ids for SAPCD1 Gene

Previous HGNC Symbols for SAPCD1 Gene

  • C6orf26

Previous GeneCards Identifiers for SAPCD1 Gene

  • GC06P031732
  • GC06P031748
  • GC06P031765
  • GC06P031767
  • GC06P031844
  • GC06P031896
  • GC06P031930
  • GC06P031965

Summaries for SAPCD1 Gene

GeneCards Summary for SAPCD1 Gene

SAPCD1 (Suppressor APC Domain Containing 1) is a Protein Coding gene.

Additional gene information for SAPCD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAPCD1 Gene

Genomics for SAPCD1 Gene

GeneHancer (GH) Regulatory Elements for SAPCD1 Gene

Promoters and enhancers for SAPCD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031762 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.8 795 1.5 HDGF CTCF KLF1 SAP130 NEUROD1 ZIC2 RAD21 TEAD3 CTBP1 POLR2A SAPCD1 SAPCD1-AS1 DDX39B SKIV2L ATF6B LY6G5B LSM2 RPL3P2 NFKBIL1 TCF19
GH06I031760 Enhancer 0.4 ENCODE 550.8 -1.8 -1800 0.2 CTCF PHF21A POLR2A SAPCD1 RNU6-850P MSH5 MSH5-SAPCD1
GH06I031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.4 -25.3 -25344 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 DDX39B LY6G5B ATF6B LSM2 CSNK2B SKIV2L GPANK1 BAG6
GH06I031861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22 +101.3 101317 4.5 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NEU1 LY6G5B LSM2 DDX39B ATF6B GPANK1 MSH5 TCF19 CSNK2B MICA
GH06I032150 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20 +390.6 390618 5.1 FEZF1 DMAP1 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 NBN NR2C1 LOC100507547 PPT2 PPT2-EGFL8 PRRT1 ATF6B MSH5 BRD2 HLA-DRB1 DDX39B SKIV2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAPCD1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SAPCD1 Gene

Genomic Locations for SAPCD1 Gene
chr6:31,762,799-31,764,851
(GRCh38/hg38)
Size:
2,053 bases
Orientation:
Plus strand
chr6:31,730,576-31,732,628
(GRCh37/hg19)

Genomic View for SAPCD1 Gene

Genes around SAPCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAPCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAPCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for SAPCD1 Gene

  • Protein details for SAPCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SSQ6-SAPC1_HUMAN
    Recommended name:
    Suppressor APC domain-containing protein 1
    Protein Accession:
    Q5SSQ6
    Secondary Accessions:
    • A2ABF2
    • A2ABS9
    • Q9Y335

    Protein attributes for SAPCD1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16650 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI18428.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM24986.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM26109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAPCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAPCD1 Gene

Post-translational modifications for SAPCD1 Gene

No Post-translational modifications

Other Protein References for SAPCD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAPCD1 Gene

Domains & Families for SAPCD1 Gene

Gene Families for SAPCD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAPCD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAPCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAPCD1: view

No data available for UniProtKB/Swiss-Prot for SAPCD1 Gene

Function for SAPCD1 Gene

Phenotypes From GWAS Catalog for SAPCD1 Gene

Phenotypes for SAPCD1 Gene

genes like me logo Genes that share phenotypes with SAPCD1: view

Animal Models for SAPCD1 Gene

MGI Knock Outs for SAPCD1:

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SAPCD1 Gene

Localization for SAPCD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAPCD1 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAPCD1 Gene

Pathways & Interactions for SAPCD1 Gene

SuperPathways for SAPCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAPCD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAPCD1 Gene

Drugs & Compounds for SAPCD1 Gene

No Compound Related Data Available

Transcripts for SAPCD1 Gene

mRNA/cDNA for SAPCD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAPCD1 Gene

Suppressor APC domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAPCD1 Gene

No ASD Table

Relevant External Links for SAPCD1 Gene

GeneLoc Exon Structure for
SAPCD1
ECgene alternative splicing isoforms for
SAPCD1

Expression for SAPCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAPCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SAPCD1 Gene:

SAPCD1

SOURCE GeneReport for Unigene cluster for SAPCD1 Gene:

Hs.371225
genes like me logo Genes that share expression patterns with SAPCD1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAPCD1 Gene

Orthologs for SAPCD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAPCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAPCD1 33 34
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia SAPCD1 33
  • 84.27 (n)
MGC151586 34
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAPCD1 33 34
  • 81.17 (n)
mouse
(Mus musculus)
Mammalia Sapcd1 33 16 34
  • 78.77 (n)
rat
(Rattus norvegicus)
Mammalia Sapcd1 33
  • 76.87 (n)
lizard
(Anolis carolinensis)
Reptilia SAPCD1 34
  • 45 (a)
OneToOne
Species where no ortholog for SAPCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAPCD1 Gene

ENSEMBL:
Gene Tree for SAPCD1 (if available)
TreeFam:
Gene Tree for SAPCD1 (if available)

Paralogs for SAPCD1 Gene

No data available for Paralogs for SAPCD1 Gene

Variants for SAPCD1 Gene

Sequence variations from dbSNP and Humsavar for SAPCD1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs6905572 benign, not specified 31,764,104(+) C/G/T coding_sequence_variant, missense_variant
rs707938 benign, not specified 31,761,582(+) A/G upstream_transcript_variant
rs1001668923 -- 31,761,838(+) T/C upstream_transcript_variant
rs1003393864 -- 31,763,425(+) T/A coding_sequence_variant, missense_variant
rs1004034887 -- 31,763,111(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SAPCD1 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
esv2763547 CNV loss 21179565
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259

Variation tolerance for SAPCD1 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAPCD1 Gene

Human Gene Mutation Database (HGMD)
SAPCD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAPCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAPCD1 Gene

Disorders for SAPCD1 Gene

Additional Disease Information for SAPCD1

No disorders were found for SAPCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAPCD1 Gene

Publications for SAPCD1 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  2. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T … Hood L (Genome research 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Biochemical and computational analysis of LNX1 interacting proteins. (PMID: 22087225) Wolting CD … McGlade CJ (PloS one 2011) 3 58

Products for SAPCD1 Gene

Sources for SAPCD1 Gene

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