Aliases for SAP30L Gene
External Ids for SAP30L Gene
Previous GeneCards Identifiers for SAP30L Gene
GeneCards Summary for SAP30L Gene
UniProtKB/Swiss-Prot for SAP30L Gene
Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676).
Isoform 2: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.
Isoform 3: Functions as transcription repressor; its activity is marginally lower than that of isoform 1.