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Aliases for SAP30L Gene

Aliases for SAP30L Gene

  • SAP30 Like 2 3
  • HCV Non-Structural Protein 4A-Transactivated Protein 2 3 4
  • Sin3 Corepressor Complex Subunit SAP30L 3 4
  • Sin3-Associated Protein P30-Like 3 4
  • NS4ATP2 3 4
  • Histone Deacetylase Complex Subunit SAP30L 3
  • Sin3A Associated Protein P30-Like 3
  • SAP30-Like 5

External Ids for SAP30L Gene

Previous GeneCards Identifiers for SAP30L Gene

  • GC05P153855
  • GC05P153805
  • GC05P148966

Summaries for SAP30L Gene

GeneCards Summary for SAP30L Gene

SAP30L (SAP30 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is SAP30.

UniProtKB/Swiss-Prot for SAP30L Gene

  • Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30L Gene

Genomics for SAP30L Gene

Regulatory Elements for SAP30L Gene

Enhancers for SAP30L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SAP30L on UCSC Golden Path with GeneCards custom track

Promoters for SAP30L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAP30L on UCSC Golden Path with GeneCards custom track

Genomic Location for SAP30L Gene

Chromosome:
5
Start:
154,445,957 bp from pter
End:
154,461,054 bp from pter
Size:
15,098 bases
Orientation:
Plus strand

Genomic View for SAP30L Gene

Genes around SAP30L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP30L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP30L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30L Gene

Proteins for SAP30L Gene

  • Protein details for SAP30L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAJ7-SP30L_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP30L
    Protein Accession:
    Q9HAJ7
    Secondary Accessions:
    • E9PAU7
    • E9PAY2

    Protein attributes for SAP30L Gene

    Size:
    183 amino acids
    Molecular mass:
    20877 Da
    Quaternary structure:
    • Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2. Interacts with FEZ1.

    Three dimensional structures from OCA and Proteopedia for SAP30L Gene

    Alternative splice isoforms for SAP30L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAP30L Gene

Post-translational modifications for SAP30L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAP30L Gene

No data available for DME Specific Peptides for SAP30L Gene

Domains & Families for SAP30L Gene

Protein Domains for SAP30L Gene

Suggested Antigen Peptide Sequences for SAP30L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAJ7

UniProtKB/Swiss-Prot:

SP30L_HUMAN :
  • Belongs to the SAP30 family.
Family:
  • Belongs to the SAP30 family.
genes like me logo Genes that share domains with SAP30L: view

No data available for Gene Families for SAP30L Gene

Function for SAP30L Gene

Molecular function for SAP30L Gene

UniProtKB/Swiss-Prot Function:
Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.
UniProtKB/Swiss-Prot Induction:
Up-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for SAP30L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SAP30L: view
genes like me logo Genes that share phenotypes with SAP30L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30L Gene

Localization for SAP30L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30L Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP30L Gene COMPARTMENTS Subcellular localization image for SAP30L gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SAP30L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SAP30L: view

Pathways & Interactions for SAP30L Gene

genes like me logo Genes that share pathways with SAP30L: view

Gene Ontology (GO) - Biological Process for SAP30L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 histone deacetylation IEA --
genes like me logo Genes that share ontologies with SAP30L: view

No data available for SIGNOR curated interactions for SAP30L Gene

Drugs & Compounds for SAP30L Gene

No Compound Related Data Available

Transcripts for SAP30L Gene

Unigene Clusters for SAP30L Gene

SAP30-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - - -
SP6:

Relevant External Links for SAP30L Gene

GeneLoc Exon Structure for
SAP30L
ECgene alternative splicing isoforms for
SAP30L

Expression for SAP30L Gene

mRNA expression in normal human tissues for SAP30L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAP30L Gene

This gene is overexpressed in Tlymphocyte (23.9), Lymph node (7.5), and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAP30L Gene



Protein tissue co-expression partners for SAP30L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAP30L Gene:

SAP30L

SOURCE GeneReport for Unigene cluster for SAP30L Gene:

Hs.592566

mRNA Expression by UniProt/SwissProt for SAP30L Gene:

Q9HAJ7-SP30L_HUMAN
Tissue specificity: Expressed in all tissues tested with highest levels in testis.
genes like me logo Genes that share expression patterns with SAP30L: view

Primer Products

No data available for mRNA differential expression in normal tissues for SAP30L Gene

Orthologs for SAP30L Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAP30L 34
  • 94.87 (n)
  • 98.9 (a)
SAP30L 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP30L 34
  • 96.89 (n)
  • 99.45 (a)
SAP30L 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap30l 34
  • 92.49 (n)
  • 96.7 (a)
Sap30l 16
Sap30l 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAP30L 34
  • 100 (n)
  • 100 (a)
SAP30L 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap30l 34
  • 91.76 (n)
  • 96.7 (a)
oppossum
(Monodelphis domestica)
Mammalia SAP30L 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30L 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAP30L 34
  • 83.55 (n)
  • 93.42 (a)
gga-mir-1778 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAP30L 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30l 34
  • 77.96 (n)
  • 90 (a)
Str.840 34
African clawed frog
(Xenopus laevis)
Amphibia flj11526-prov 34
zebrafish
(Danio rerio)
Actinopterygii sap30l 34
  • 77.72 (n)
  • 87.08 (a)
wufa26a11 34
sap30l 35
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta SAP30_ANOGA 34
  • 63.47 (n)
  • 64.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sap30 34
  • 64.02 (n)
  • 60.98 (a)
Sap30 35
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for SAP30L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAP30L Gene

ENSEMBL:
Gene Tree for SAP30L (if available)
TreeFam:
Gene Tree for SAP30L (if available)

Paralogs for SAP30L Gene

Paralogs for SAP30L Gene

(1) SIMAP similar genes for SAP30L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SAP30L Gene

genes like me logo Genes that share paralogs with SAP30L: view

Variants for SAP30L Gene

Sequence variations from dbSNP and Humsavar for SAP30L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1801600 -- 154,460,796(-) AAAAA(A/C/T)CCCCA nc-transcript-variant, utr-variant-3-prime
rs10042805 -- 154,449,401(+) tagaa(A/G)acgga intron-variant
rs2277939 -- 154,451,330(+) TTGCT(A/G)TGGAT intron-variant
rs10058057 -- 154,449,876(+) GTCTG(A/C)AAGAC intron-variant
rs3340 -- 154,452,307(-) ACGTT(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAP30L Gene

Variant ID Type Subtype PubMed ID
nsv1015362 CNV gain 25217958
nsv830520 CNV loss 17160897

Variation tolerance for SAP30L Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAP30L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAP30L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30L Gene

Disorders for SAP30L Gene

Relevant External Links for SAP30L

Genetic Association Database (GAD)
SAP30L
Human Genome Epidemiology (HuGE) Navigator
SAP30L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAP30L

No disorders were found for SAP30L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP30L Gene

Publications for SAP30L Gene

  1. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. (PMID: 16820529) Viiri K.M. … Lohi O. (Nucleic Acids Res. 2006) 2 3 4 65
  2. TGF-beta induces the expression of SAP30L, a novel nuclear protein. (PMID: 14680513) Lindfors K. … Kainulainen H. (BMC Genomics 2003) 2 3 4 65
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 65
  4. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann E.M. … Kobarg J. (J. Biol. Chem. 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for SAP30L Gene

Sources for SAP30L Gene

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