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SAP30L Gene

protein-coding   GIFtS: 47

GC05P153805
SAP30-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for SAP30L

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
DKFZp667L2214 2
FLJ11526 1, 2
FLJ23595 2
FLJ36497 2
NS4ATP2 1, 2, 3
SAP30-like 2
Descriptions
HCV non-structural protein 4A-transactivated protein 2 3
Sin3 corepressor complex subunit SAP30L 3
Sin3A associated protein p30-like 2
Sin3A-associated protein p30-like protein 3
External Ids
HGNC: 256631
Entrez Gene: 796852
UniProtKB: Q9HAJ73
Ensembl: ENSG000001645767
Search outside databases for aliases for SAP30L gene

Previous GC identifer: GC05P153855

Summaries
for SAP30L

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SP30L_HUMAN, Q9HAJ7
Function: Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex
(HDAC) to the nucleolus

Genomic Location
for SAP30L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SAP30L gene  

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33.2

SAP30L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P153805:     (about GC identifiers)

Start:
 153,805,776 bp from pter
End:
 153,816,067 bp from pter
Size:
 10,292 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000005.8  NT_029289.10  

Proteins
for SAP30L

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SP30L_HUMAN, Q9HAJ7 (See protein sequence)
Recommended Name: Histone deacetylase complex subunit SAP30L  
Size: 183 amino acids; 20877 Da
Subunit: Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2.
Interacts with FEZ1
Subcellular location: Nucleus, nucleolus

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001124534.1  NP_001124535.1  NP_078908.1  


    ENSEMBL proteins: 
    ENSP00000297109 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SAP30L)
    Human Recombinant Proteins from Abnova (SAP30L)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for SAP30L: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SAP30L
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SAP30L), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SAP30L)
    Novus Biologicals Antibody for SAP30L

    Assays for SAP30L: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for SAP30L

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9HAJ7

    UniProtKB/Swiss-Prot: SP30L_HUMAN, Q9HAJ7
    Similarity: Belongs to the SAP30 family

    Gene Function
    for SAP30L

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SAP30L)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024084

                  Applied Biosystems Silencer® siRNAs for SAP30L

                  Sigma-Aldrich siRNA for SAP30L  
                         Sigma-Aldrich shRNA for SAP30L  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SAP30L
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001131062
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001131062
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001131062 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024632

    UniProtKB/Swiss-Prot: SP30L_HUMAN, Q9HAJ7
    Function: Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex
    (HDAC) to the nucleolus
    Induction: Up-regulated by TGFB1

    Pathways & Interactions
    for SAP30L

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for SAP30L (ENSP000002971093) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1ENSP000002789193STRING (score=.826)
    SIN3AENSP000003536223STRING (score=.73)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table

    Drugs & Compounds
    for SAP30L

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SAP30L

    Transcripts
    for SAP30L

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SAP30L)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024084

                  Sigma-Aldrich siRNA for SAP30L  
                         Sigma-Aldrich shRNA for SAP30L  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001131062  NM_001131063  NM_024632  

    REFSEQ mRNAs for SAP30L gene (3 alternative transcripts): 

    NM_001131062.1   NM_001131063.1   NM_024632.5   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001131062  NM_001131063  NM_024632  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001131062
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001131062
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001131062 

    Additional cDNA sequence: 

    AF085957.1 AF157116.1 AK021588.1 AK027248.1 AL833219.1 AL833381.1 AY341060.1 AY846876.1 
    BC009829.2 

    11 DOTS entries:

    DT.452424  DT.446901  DT.98131731  DT.91654711  DT.100745269  DT.109516  DT.75107727  DT.120866507 
    DT.40111921  DT.92426593  DT.95266653 

    24/163 AceView cDNA sequences (see all 163 ):

    N36358 AI823438 AI144341 BM727121 AI707824 AI130951 AI280840 BE885738 
    AA736687 AW204042 AI222754 AA693740 AI417549 AA443161 BE503089 BE503956 
    AI383405 AI436556 AI243153 AI436254 AF085957 AW470566 AA476991 AI278599 

    highest scoring ESTs for SAP30L:

    AA146974 AA235692 AA293462 AA443161 AA463372 AA476991 AA587246 AA626510 AA812197 AA897213 

    Unigene Cluster for SAP30L:

    SAP30-like
    Hs.592566  [show with all ESTs]
    Unigene Representative Sequence: NM_024632


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SAP30L (see all 6 )

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
    SP1:                    -                                                   
    SP2:              -     -                                                   
    SP3:                    -                                                   
    SP4:        -     -     -                                                   
    SP5:        -     -     -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for SAP30L

    1 Ensembl transcript including schematic representation:
    ENST00000297109  

    Expression
    for SAP30L

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SAP30L expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SAP30L

    1 / 2 / 3

    9 probe-sets matching SAP30L gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		56307_at2, 3 U95-B 1 1.00 1.00 0.36 1.50 AI862477 0.20 0.33 0.27 2

    		44153_at2, 3 U95-B 1 1.00 1.00 0.50 0.45 AI417549 0.40 0.50 0.45 1
    71085_at2 U95-E 1 1.00 1.00 0.56 1.10 -- -- -- -- --

    		225509_at2, 3 U133-B 1 1.00 1.00 -- -- AI862477 0.20 0.33 0.27 2

    		232135_at2, 3 U133-B 1 1.00 1.00 -- -- BF112166 0.40 0.67 0.55 1

    		219129_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024632 0.60 1.00 0.82 1

    		225509_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		232135_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		219129_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SAP30L for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGCAATATC

    SOURCE GeneReport for Unigene cluster: Hs.592566

    UniProtKB/Swiss-Prot: SP30L_HUMAN, Q9HAJ7
    Tissue specificity: Expressed in all tissues tested with highest levels in testis

    Orthologs
    for SAP30L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SAP30L gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 SAP30L1   -- SAP30-like 95.29(n)
    98.24(a)    		 612111  XM_849837.1  XP_854930.1 
    chimpanzee
    (Pan troglodytes)    		 SAP30L1   -- SAP30-like 100(n)
    100(a)    		 462208  XM_518049.2  XP_518049.2 
    cow
    (Bos taurus)    		 SAP30L1   -- SAP30-like 95.24(n)
    99.45(a)    		 533462  XM_612877.3  XP_612877.3 
    rat
    (Rattus norvegicus)    		 Sap30l1   -- SAP30-like 92.12(n)
    97.25(a)    		 360531  XM_340803.3  XP_340804.3 
    mouse
    (Mus musculus)    		 Sap30l1, 5 115
    		 SAP30-like1, 5 92.86(n)1
    97.25(a)1    		 507241  NM_001081168.11  NP_001074637.11 
     AF0069985  AK0102345  (see all 13)
    About this table        Species with no ortholog for SAP30L

    ENSEMBL Gene Tree for SAP30L

    Paralogs
    for SAP30L

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SAP30L gene
    SAP302  

    SNPs/Variants
    for SAP30L

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/66 NCBI SNPs in SAP30L are shown (see all 66 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 35)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs23514821,2
    		C,F,H,O153818101(+) AAATCC/TGTTCT 3 -- ut318Minor allele frequency- T:0.35EU EA WA NA 2052
    rs7342001,2
    		A,C,F,O153818477(-) ATGTTT/GCCATG 3 -- ut312Minor allele frequency- G:0.25MN EA 1494
    rs134911,2
    		C,F,H153820440(+) TTTCAC/GTTAAT 3 -- ut318Minor allele frequency- G:0.01MN NA EU EA WA 714
    rs171161651,2
    		C,F,H153817596(+) GTGTTT/CAGAGA 3 -- ut3112Minor allele frequency- C:0.15NA EU EA WA 1052
    --
    rs68842661,2
    		C,F,H153820665(+) AACTTC/TGTAAT 3 -- ut317Minor allele frequency- T:0.29EU EA WA NA 560
    rs37340861,2
    		F,H153805358(+) ATCCTC/TTTTAG 1 -- ng515Minor allele frequency- T:0.07EA EU WA 1912
    --
    rs9725961,2
    		A,C153804390(-) GCCTAC/TCAGAG 1 -- ng510--------
    rs9719221,2
    		C,F153805379(-) AGGAGC/GGGCAT 1 -- ng51 trp31Minor allele frequency- G:0.25MN 184
    rs171161691,2
    		F,H153817675(+) TGCAGG/ATTAAG 3 -- ut317Minor allele frequency- A:0.06NA EU EA WA 562
    --
    rs68753581,2
    		H153815803(+) AAAGGA/GATGAA 3 -- ut314Minor allele frequency- G:0.00EU EA WA 414
    About this table

    HapMap Linkage Disequilibrium images for SAP30L (up to first 250kb)

    Disorders & Mutations
    for SAP30L

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 610398

    Medical News
    for SAP30L

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SAP30L

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/11 PubMed articles for SAP30L gene (see all 11 ):

    Search for SAP30L

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SAP30L

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 79685 HGNC: 25663 AceView: SAP30L Ensembl:ENSG00000164576 euGenes: HUgn79685
    ECgene: SAP30L H-InvDB: SAP30L

    Other Databases showing SAP30L

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SAP30L

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for SAP30L

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SAP30L

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SAP30L:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SAP30L-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SAP30L Antibodies for SAP30L
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SAP30L Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (SAP30L)
     Antibodies (SAP30L)
     Search OriGene for SAP30L
     Search Tocris compounds for SAP30L




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for SAP30L

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