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Aliases for SAP30L Gene

Aliases for SAP30L Gene

  • SAP30-Like 2 3
  • HCV Non-Structural Protein 4A-Transactivated Protein 2 3 4
  • Sin3 Corepressor Complex Subunit SAP30L 3 4
  • Sin3-Associated Protein P30-Like 3 4
  • NS4ATP2 3 4
  • Histone Deacetylase Complex Subunit SAP30L 3
  • Sin3A Associated Protein P30-Like 3

External Ids for SAP30L Gene

Previous GeneCards Identifiers for SAP30L Gene

  • GC05P153855
  • GC05P153805
  • GC05P148966

Summaries for SAP30L Gene

GeneCards Summary for SAP30L Gene

SAP30L (SAP30-Like) is a Protein Coding gene. An important paralog of this gene is SAP30.

UniProtKB/Swiss-Prot for SAP30L Gene

  • Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30L Gene

Genomics for SAP30L Gene

Regulatory Elements for SAP30L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAP30L Gene

Start:
154,445,957 bp from pter
End:
154,461,054 bp from pter
Size:
15,098 bases
Orientation:
Plus strand

Genomic View for SAP30L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAP30L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30L Gene

Proteins for SAP30L Gene

  • Protein details for SAP30L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAJ7-SP30L_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP30L
    Protein Accession:
    Q9HAJ7
    Secondary Accessions:
    • E9PAU7
    • E9PAY2

    Protein attributes for SAP30L Gene

    Size:
    183 amino acids
    Molecular mass:
    20877 Da
    Quaternary structure:
    • Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2. Interacts with FEZ1.

    Alternative splice isoforms for SAP30L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAP30L Gene

Proteomics data for SAP30L Gene at MOPED

Post-translational modifications for SAP30L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAP30L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SAP30L Gene

Domains for SAP30L Gene

Protein Domains for SAP30L Gene

Suggested Antigen Peptide Sequences for SAP30L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAJ7

UniProtKB/Swiss-Prot:

SP30L_HUMAN :
  • Q9HAJ7
Family:
  • Belongs to the SAP30 family.
genes like me logo Genes that share domains with SAP30L: view

No data available for Gene Families for SAP30L Gene

Function for SAP30L Gene

Molecular function for SAP30L Gene

UniProtKB/Swiss-Prot Function: Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.
UniProtKB/Swiss-Prot Induction: Up-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for SAP30L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SAP30L: view

Phenotypes for SAP30L Gene

genes like me logo Genes that share phenotypes with SAP30L: view

Animal Model Products

CRISPR Products

miRNA for SAP30L Gene

miRTarBase miRNAs that target SAP30L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAP30L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAP30L Gene

Localization for SAP30L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30L Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP30L Gene COMPARTMENTS Subcellular localization image for SAP30L gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SAP30L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SAP30L: view

Pathways for SAP30L Gene

SuperPathways for SAP30L Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAP30L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010467 gene expression TAS --
GO:0040029 regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with SAP30L: view

No data available for Pathways by source for SAP30L Gene

Transcripts for SAP30L Gene

Unigene Clusters for SAP30L Gene

SAP30-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAP30L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - - -
SP6:

Relevant External Links for SAP30L Gene

GeneLoc Exon Structure for
SAP30L
ECgene alternative splicing isoforms for
SAP30L

Expression for SAP30L Gene

mRNA expression in normal human tissues for SAP30L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAP30L Gene

SOURCE GeneReport for Unigene cluster for SAP30L Gene Hs.592566

mRNA Expression by UniProt/SwissProt for SAP30L Gene

Q9HAJ7-SP30L_HUMAN
Tissue specificity: Expressed in all tissues tested with highest levels in testis
genes like me logo Genes that share expressions with SAP30L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SAP30L Gene

Orthologs for SAP30L Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAP30L 35
  • 100 (n)
  • 100 (a)
SAP30L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAP30L 35
  • 94.87 (n)
  • 98.9 (a)
SAP30L 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP30L 35
  • 96.89 (n)
  • 99.45 (a)
SAP30L 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap30l 35
  • 92.49 (n)
  • 96.7 (a)
Sap30l 16
Sap30l 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAP30L 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30L 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap30l 35
  • 91.76 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves gga-mir-1778 36
  • 82 (a)
OneToOne
SAP30L 35
  • 83.55 (n)
  • 93.42 (a)
lizard
(Anolis carolinensis)
Reptilia SAP30L 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj11526-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30l 35
  • 77.96 (n)
  • 90 (a)
Str.840 35
zebrafish
(Danio rerio)
Actinopterygii sap30l 35
  • 77.72 (n)
  • 87.08 (a)
sap30l 36
  • 86 (a)
OneToOne
wufa26a11 35
African malaria mosquito
(Anopheles gambiae)
Insecta SAP30_ANOGA 35
  • 63.47 (n)
  • 64.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sap30 35
  • 64.02 (n)
  • 60.98 (a)
Sap30 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for SAP30L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAP30L Gene

ENSEMBL:
Gene Tree for SAP30L (if available)
TreeFam:
Gene Tree for SAP30L (if available)

Paralogs for SAP30L Gene

Paralogs for SAP30L Gene

Selected SIMAP similar genes for SAP30L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SAP30L Gene

genes like me logo Genes that share paralogs with SAP30L: view

Variants for SAP30L Gene

Sequence variations from dbSNP and Humsavar for SAP30L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3340 -- 154,452,307(-) ACGTT(A/G)AAGGC intron-variant
rs13491 -- 154,460,687(+) TTTCA(C/G)TTAAT utr-variant-3-prime, nc-transcript-variant
rs734200 -- 154,458,724(-) ATGTT(G/T)CCATG utr-variant-3-prime, nc-transcript-variant
rs734201 -- 154,458,815(-) TGTTG(C/T)CAACC utr-variant-3-prime, nc-transcript-variant
rs1007404 -- 154,455,818(+) AACTC(C/G)ATTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAP30L Gene

Variant ID Type Subtype PubMed ID
nsv830520 CNV Loss 17160897

Relevant External Links for SAP30L Gene

HapMap Linkage Disequilibrium report
SAP30L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30L Gene

Disorders for SAP30L Gene

Relevant External Links for SAP30L

Genetic Association Database (GAD)
SAP30L
Human Genome Epidemiology (HuGE) Navigator
SAP30L
genes like me logo Genes that share disorders with SAP30L: view

No data available for UniProtKB/Swiss-Prot for SAP30L Gene

Publications for SAP30L Gene

  1. TGF-beta induces the expression of SAP30L, a novel nuclear protein. (PMID: 14680513) Lindfors K. … Kainulainen H. (BMC Genomics 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PMID: 16484223) Assmann E.M. … Kobarg J. (J. Biol. Chem. 2006) 3 4
  4. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. (PMID: 16820529) Viiri K.M. … Lohi O. (Nucleic Acids Res. 2006) 3 4
  5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 48

Products for SAP30L Gene

Sources for SAP30L Gene

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