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Aliases for SAP30BP Gene

Aliases for SAP30BP Gene

  • SAP30 Binding Protein 2 3
  • HCNGP 3 4 6
  • HTRP 3 4 6
  • HTRG 3 4 6
  • Transcriptional Regulator Protein HCNGP 3 4
  • SAP30-Binding Protein 3
  • HSV-1 Binding 3

External Ids for SAP30BP Gene

Summaries for SAP30BP Gene

GeneCards Summary for SAP30BP Gene

SAP30BP (SAP30 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SAP30BP Gene

  • Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30BP Gene

Genomics for SAP30BP Gene

Genomic Location for SAP30BP Gene

Start:
75,667,116 bp from pter
End:
75,708,062 bp from pter
Size:
40,947 bases
Orientation:
Plus strand

Genomic View for SAP30BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAP30BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30BP Gene

Regulatory Elements for SAP30BP Gene

Proteins for SAP30BP Gene

  • Protein details for SAP30BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHR5-S30BP_HUMAN
    Recommended name:
    SAP30-binding protein
    Protein Accession:
    Q9UHR5
    Secondary Accessions:
    • B3KML7
    • Q8N1R5
    • Q8TDR8
    • Q96D27

    Protein attributes for SAP30BP Gene

    Size:
    308 amino acids
    Molecular mass:
    33870 Da
    Quaternary structure:
    • Interacts with SAP30.

    Alternative splice isoforms for SAP30BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAP30BP Gene

Proteomics data for SAP30BP Gene at MOPED

Post-translational modifications for SAP30BP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys144

No data available for DME Specific Peptides for SAP30BP Gene

Domains for SAP30BP Gene

Protein Domains for SAP30BP Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S30BP_HUMAN
Family:
  • Belongs to the HCNGP family.:
    • Q9UHR5
genes like me logo Genes that share domains with SAP30BP: view

No data available for Gene Families for SAP30BP Gene

Function for SAP30BP Gene

Molecular function for SAP30BP Gene

UniProtKB/Swiss-Prot Function: Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.
UniProtKB/Swiss-Prot Induction: In fibroblasts by binding of HSV1.

Gene Ontology (GO) - Molecular Function for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SAP30BP: view

Phenotypes for SAP30BP Gene

GenomeRNAi human phenotypes for SAP30BP:
genes like me logo Genes that share phenotypes with SAP30BP: view

miRNA for SAP30BP Gene

miRTarBase miRNAs that target SAP30BP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAP30BP Gene

Localization for SAP30BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30BP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP30BP Gene COMPARTMENTS Subcellular localization image for SAP30BP gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9651585
GO:0005654 nucleoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with SAP30BP: view

Pathways for SAP30BP Gene

SuperPathways for SAP30BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0010467 gene expression TAS --
GO:0010942 positive regulation of cell death IDA 15496587
genes like me logo Genes that share ontologies with SAP30BP: view

No data available for Pathways by source for SAP30BP Gene

Compounds for SAP30BP Gene

(1) Novoseek inferred chemical compound relationships for SAP30BP Gene

Compound -log(P) Hits PubMed IDs
zinc 32.3 1
genes like me logo Genes that share compounds with SAP30BP: view

Transcripts for SAP30BP Gene

Unigene Clusters for SAP30BP Gene

SAP30 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30BP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: -
SP11: - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - - - - - - - - -
SP16: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: - -
SP15: - -
SP16:

Relevant External Links for SAP30BP Gene

GeneLoc Exon Structure for
SAP30BP
ECgene alternative splicing isoforms for
SAP30BP

Expression for SAP30BP Gene

mRNA expression in normal human tissues for SAP30BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAP30BP Gene

SOURCE GeneReport for Unigene cluster for SAP30BP Gene Hs.655088

genes like me logo Genes that share expressions with SAP30BP: view

Orthologs for SAP30BP Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAP30BP 36
  • 99.68 (n)
  • 100 (a)
SAP30BP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAP30BP 36
  • 90.16 (n)
  • 95.3 (a)
SAP30BP 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP30BP 36
  • 91.02 (n)
  • 97.08 (a)
SAP30BP 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap30bp 36
  • 89.83 (n)
  • 95.78 (a)
Sap30bp 16
Sap30bp 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAP30BP 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30BP 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap30bp 36
  • 89.72 (n)
  • 96.75 (a)
chicken
(Gallus gallus)
Aves SAP30BP 36
  • 78.39 (n)
  • 89.58 (a)
SAP30BP 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAP30BP 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8637 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30bp 36
  • 75.81 (n)
  • 80.94 (a)
Str.7176 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10416 36
zebrafish
(Danio rerio)
Actinopterygii sap30bp 36
  • 69.82 (n)
  • 69.59 (a)
sap30bp 37
  • 68 (a)
OneToOne
wufb33d03 36
fruit fly
(Drosophila melanogaster)
Insecta CG2063 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y67D2.7 37
  • 19 (a)
OneToOne
Species with no ortholog for SAP30BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAP30BP Gene

ENSEMBL:
Gene Tree for SAP30BP (if available)
TreeFam:
Gene Tree for SAP30BP (if available)

Paralogs for SAP30BP Gene

Selected SIMAP similar genes for SAP30BP Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SAP30BP: view

No data available for Paralogs for SAP30BP Gene

Variants for SAP30BP Gene

Sequence variations from dbSNP and Humsavar for SAP30BP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs707706 -- 75,700,260(-) TGTGA(C/T)TTTTT intron-variant
rs707707 -- 75,673,441(-) TCCCA(C/T)ATACC intron-variant
rs820129 -- 75,672,027(+) GAGAC(A/G)ACTCA intron-variant
rs820130 -- 75,673,050(+) AATTA(A/T)AATCT intron-variant
rs820131 -- 75,673,835(-) GATGT(A/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAP30BP Gene

Variant ID Type Subtype PubMed ID
nsv516133 CNV Loss 19592680
dgv3256n71 CNV Loss 21882294
nsv470603 CNV Loss 18288195
nsv833543 CNV Loss 17160897
dgv3260n71 CNV Loss 21882294
nsv908794 CNV Loss 21882294
dgv3264n71 CNV Loss 21882294
nsv833544 CNV Loss 17160897

Relevant External Links for SAP30BP Gene

HapMap Linkage Disequilibrium report
SAP30BP

Disorders for SAP30BP Gene

Relevant External Links for SAP30BP

Genetic Association Database (GAD)
SAP30BP
Human Genome Epidemiology (HuGE) Navigator
SAP30BP
genes like me logo Genes that share disorders with SAP30BP: view

No data available for UniProtKB/Swiss-Prot for SAP30BP Gene

Publications for SAP30BP Gene

  1. HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors. (PMID: 15496587) Li J.-F. … Li Q.-H. (J. Biochem. 2004) 2 3 4 23
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 49

Products for SAP30BP Gene

Sources for SAP30BP Gene

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