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Aliases for SAP30BP Gene

Aliases for SAP30BP Gene

  • SAP30 Binding Protein 2 3 5
  • Transcriptional Regulator Protein HCNGP 3 4
  • HCNGP 3 4
  • HTRG 3 4
  • HTRP 3 4
  • SAP30-Binding Protein 3
  • HSV-1 Binding 3

External Ids for SAP30BP Gene

Previous GeneCards Identifiers for SAP30BP Gene

  • GC17P071175
  • GC17P073663
  • GC17P069087

Summaries for SAP30BP Gene

GeneCards Summary for SAP30BP Gene

SAP30BP (SAP30 Binding Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for SAP30BP Gene

  • Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.

Additional gene information for SAP30BP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30BP Gene

Genomics for SAP30BP Gene

Regulatory Elements for SAP30BP Gene

Enhancers for SAP30BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075776 2.4 ENCODE dbSUPER 20.2 +111.4 111411 4.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 UNK NUP85 SRSF2 ENSG00000267342 NT5C ENSG00000266980 MFSD11 METTL23 TRIM65 GGA3
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -575.6 -575621 11.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
GH17H076638 1.6 Ensembl ENCODE dbSUPER 19 +975.5 975542 7.8 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF766 DEK REST ZNF592 UNK SRSF2 MXRA7 METTL23 ENSG00000267342 SEPT9 CDK3 SAP30BP ENSG00000266980 H3F3B
GH17H076380 1.4 ENCODE dbSUPER 18.8 +716.9 716898 6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 UNK SRSF2 ENSG00000267342 ENSG00000266980 MFSD11 ENSG00000267546 METTL23 SEPT9 TRIM65 SAP30BP
GH17H075683 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +25.8 25763 19.7 HDGF PKNOX1 MLX ARID4B SIN3A ZBTB7B ZNF207 FOS DEK SP5 RECQL5 ENSG00000266980 ITGB4 NT5C NUP85 UNK SAP30BP SMIM5 GALK1 TRIM65
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAP30BP on UCSC Golden Path with GeneCards custom track

Promoters for SAP30BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098423 284 1601 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 FOS SP3

Genomic Locations for SAP30BP Gene

Genomic Locations for SAP30BP Gene
chr17:75,667,116-75,708,062
(GRCh38/hg38)
Size:
40,947 bases
Orientation:
Plus strand
chr17:73,663,196-73,704,142
(GRCh37/hg19)

Genomic View for SAP30BP Gene

Genes around SAP30BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP30BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP30BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30BP Gene

Proteins for SAP30BP Gene

  • Protein details for SAP30BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHR5-S30BP_HUMAN
    Recommended name:
    SAP30-binding protein
    Protein Accession:
    Q9UHR5
    Secondary Accessions:
    • B3KML7
    • Q8N1R5
    • Q8TDR8
    • Q96D27

    Protein attributes for SAP30BP Gene

    Size:
    308 amino acids
    Molecular mass:
    33870 Da
    Quaternary structure:
    • Interacts with SAP30.

    Alternative splice isoforms for SAP30BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAP30BP Gene

Post-translational modifications for SAP30BP Gene

  • Ubiquitination at isoforms=2144
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SAP30BP Gene

Domains & Families for SAP30BP Gene

Gene Families for SAP30BP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAP30BP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAP30BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHR5

UniProtKB/Swiss-Prot:

S30BP_HUMAN :
  • Belongs to the HCNGP family.
Family:
  • Belongs to the HCNGP family.
genes like me logo Genes that share domains with SAP30BP: view

Function for SAP30BP Gene

Molecular function for SAP30BP Gene

UniProtKB/Swiss-Prot Function:
Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.
UniProtKB/Swiss-Prot Induction:
In fibroblasts by binding of HSV1.

Phenotypes From GWAS Catalog for SAP30BP Gene

Gene Ontology (GO) - Molecular Function for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9651585
genes like me logo Genes that share ontologies with SAP30BP: view
genes like me logo Genes that share phenotypes with SAP30BP: view

Animal Model Products

CRISPR Products

miRNA for SAP30BP Gene

miRTarBase miRNAs that target SAP30BP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30BP Gene

Localization for SAP30BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30BP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAP30BP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9651585
GO:0005654 nucleoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with SAP30BP: view

Pathways & Interactions for SAP30BP Gene

genes like me logo Genes that share pathways with SAP30BP: view

Gene Ontology (GO) - Biological Process for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0010942 positive regulation of cell death IDA 15496587
genes like me logo Genes that share ontologies with SAP30BP: view

No data available for SIGNOR curated interactions for SAP30BP Gene

Drugs & Compounds for SAP30BP Gene

(1) Drugs for SAP30BP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SAP30BP: view

Transcripts for SAP30BP Gene

Unigene Clusters for SAP30BP Gene

SAP30 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30BP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: -
SP11: - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - - - - - - - - -
SP16: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: - -
SP15: - -
SP16:

Relevant External Links for SAP30BP Gene

GeneLoc Exon Structure for
SAP30BP
ECgene alternative splicing isoforms for
SAP30BP

Expression for SAP30BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAP30BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAP30BP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.5), Blymphocyte (11.2), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAP30BP Gene



Protein tissue co-expression partners for SAP30BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAP30BP Gene:

SAP30BP

SOURCE GeneReport for Unigene cluster for SAP30BP Gene:

Hs.655088

Evidence on tissue expression from TISSUES for SAP30BP Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with SAP30BP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAP30BP Gene

Orthologs for SAP30BP Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAP30BP 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia SAP30BP 33 34
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia SAP30BP 33 34
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Sap30bp 33 16 34
  • 89.83 (n)
rat
(Rattus norvegicus)
Mammalia Sap30bp 33
  • 89.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30BP 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAP30BP 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAP30BP 33 34
  • 78.39 (n)
lizard
(Anolis carolinensis)
Reptilia SAP30BP 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30bp 33
  • 75.81 (n)
Str.7176 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8637 33
zebrafish
(Danio rerio)
Actinopterygii sap30bp 33 34
  • 69.82 (n)
wufb33d03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10416 33
fruit fly
(Drosophila melanogaster)
Insecta CG2063 34
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y67D2.7 34
  • 19 (a)
OneToOne
Species where no ortholog for SAP30BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAP30BP Gene

ENSEMBL:
Gene Tree for SAP30BP (if available)
TreeFam:
Gene Tree for SAP30BP (if available)

Paralogs for SAP30BP Gene

genes like me logo Genes that share paralogs with SAP30BP: view

No data available for Paralogs for SAP30BP Gene

Variants for SAP30BP Gene

Sequence variations from dbSNP and Humsavar for SAP30BP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000008003 -- 75,708,133(+) GTCCC(C/T)CGTCT downstream-variant-500B
rs1000013488 -- 75,679,232(+) ACCTC(A/G)TGATC intron-variant
rs1000222606 -- 75,707,237(+) CCAGC(A/C)GGAGC nc-transcript-variant, utr-variant-3-prime
rs1000256498 -- 75,685,025(+) GAGGG(A/C/G)CCTTC intron-variant
rs1000278223 -- 75,667,385(+) GGAAG(A/T)AGAAT nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SAP30BP Gene

Variant ID Type Subtype PubMed ID
nsv833544 CNV loss 17160897
nsv833543 CNV loss 17160897
nsv576027 CNV gain 21841781
nsv516133 CNV loss 19592680
nsv470603 CNV loss 18288195

Variation tolerance for SAP30BP Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAP30BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAP30BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30BP Gene

Disorders for SAP30BP Gene

Relevant External Links for SAP30BP

Genetic Association Database (GAD)
SAP30BP
Human Genome Epidemiology (HuGE) Navigator
SAP30BP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAP30BP

No disorders were found for SAP30BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP30BP Gene

Publications for SAP30BP Gene

  1. HTRP--an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors. (PMID: 15496587) Li JF … Li QH (Journal of biochemistry 2004) 2 3 4 22 60
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 60

Products for SAP30BP Gene

Sources for SAP30BP Gene

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