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SAP30BP Gene

protein-coding   GIFtS: 53

GC17P071175
SAP30 binding protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp586L2022 2
HCNGP 1, 2, 3
HTRG 1, 2, 3
HTRP 1, 2, 3
Descriptions
HSV-1 binding 2
SAP30 binding protein 2
Transcriptional regulator protein HCNGP 3
transcriptional regulator protein 2
External Ids
HGNC: 307851
Entrez Gene: 291152
UniProtKB: Q9UHR53
Ensembl: ENSG000001615267
Search outside databases for aliases for SAP30BP gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: S30BP_HUMAN, Q9UHR5
Function: Induces cell death. May act as a transcriptional corepressor of a gene related to cell
survival. May be involved in the regulation of beta-2-microglobulin genes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SAP30BP gene  

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

SAP30BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P071175:     (about GC identifiers)

Start:
71,174,994 bp from pter
End:
71,215,734 bp from pter
Size:
40,741 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: S30BP_HUMAN, Q9UHR5 (See protein sequence)
Recommended Name: SAP30-binding protein  
Size: 308 amino acids; 33870 Da
Subunit: Interacts with SAP30
Subcellular location: Nucleus
Secondary accessions: Q8N1R5 Q8TDR8 Q96D27
Alternative splicing: 2 isoforms:  Q9UHR5-1   Q9UHR5-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_037392.1  

    ENSEMBL proteins: 
    ENSP00000347592 ENSP00000293208 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SAP30BP)
    Human Recombinant Proteins from Abnova (SAP30BP)
                  OriGene Purified Recombinant Human Protein: SAP30BP 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA9651585
    About this table

    Antibodies for SAP30BP: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SAP30BP
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SAP30BP), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SAP30BP)
    Novus Biologicals Antibody for SAP30BP

    Assays for SAP30BP: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR012479 HCNGP


       GeneDecks  SAP30BP for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UHR5

    ProtoNet protein and cluster: Q9UHR5

    1 Blocks protein family: IPB012479 HCNGP-like

    UniProtKB/Swiss-Prot: S30BP_HUMAN, Q9UHR5
    Similarity: Belongs to the HCNGP family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SAP30BP)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013260

                  Applied Biosystems Silencer® siRNAs for SAP30BP

                  Sigma-Aldrich siRNA for SAP30BP  
                         Sigma-Aldrich shRNA for SAP30BP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SAP30BP
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_013260
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_013260
                                     untagged cDNA clone in CMV expression vector: NM_013260 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_013260

    UniProtKB/Swiss-Prot: S30BP_HUMAN, Q9UHR5
    Function: Induces cell death. May act as a transcriptional corepressor of a gene related to cell
    survival. May be involved in the regulation of beta-2-microglobulin genes
    Induction: In fibroblasts by binding of HSV1

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI9651585
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for SAP30BP (ENSP000003475923 Q9UHR51, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUF60Q9UHX11, 2STRING (score=.807) EBI-751683, EBI-1053259 MINT-68228 EBI-751683, EBI-1053259 MINT-68228
    PUF60Q9UHX11, 2STRING (score=.807) EBI-751683, EBI-1053259 MINT-68228 EBI-751683, EBI-1053259 MINT-68228
    SF3A2Q154282MINT-5206214
    PUF60Q9UHX11, 2STRING (score=.807) EBI-751683, EBI-1053259 MINT-68228 EBI-751683, EBI-1053259 MINT-68228
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006915 apoptosis IEA--
    GO:0006917 induction of apoptosis IDA9651585
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SAP30BP
    1 Novoseek chemical compound relationship for SAP30BP gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.23 1 10995766 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SAP30BP)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_013260

                  Sigma-Aldrich siRNA for SAP30BP  
                         Sigma-Aldrich shRNA for SAP30BP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_013260  

    REFSEQ mRNAs for SAP30BP gene: 

    NM_013260.6   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_013260  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_013260
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_013260
                                     untagged cDNA clone in CMV expression vector: NM_013260 

    Additional cDNA sequence: 

    AF087869.1 AF119664.1 AF450482.1 AK002202.1 AK023157.1 AK095265.1 AK098247.1 AK298060.1 
    AK310177.1 AL049465.1 AY082382.1 BC007592.1 BC011724.2 BC013409.2 BC030233.1 BC063793.1 
    BX647066.1 CR611306.1 CR618344.1 CR621811.1 

    24/26 DOTS entries (see all 26 ):

    DT.75118005  DT.446148  DT.97851801  DT.100827118  DT.40108014  DT.100031045  DT.100827117  DT.95198338 
    DT.120933951  DT.100827120  DT.120933802  DT.120933955  DT.100799003  DT.95235979  DT.120933786  DT.91764122 
    DT.95235977  DT.100759960  DT.100827109  DT.100827116  DT.120933741  DT.40257380  DT.40283007  DT.75103840 

    24/394 AceView cDNA sequences (see all 394 ):

    BG676274 BM809137 BQ575296 BM458645 AW005243 AU279772 BU733327 AK095265 
    AW071612 CA437237 BU731865 BU682923 AA350373 BG058482 BE295974 BU179689 
    BX338006 AW249882 AW024269 BM012075 BG257395 BM679609 BM807177 BQ073488 

    highest scoring ESTs for SAP30BP:

    AI074024 AI971125 AA036651 AA063582 AA074815 AA128916 AA314200 AA322293 AA350373 AA457232 

    Unigene Cluster for SAP30BP:

    SAP30 binding protein
    Hs.655088  [show with all ESTs]
    Unigene Representative Sequence: BX647066


    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for SAP30BP (see all 16 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a ·
    SP1:                          -                       -     -     -     -     -     -                 -           -     -                       -               
    SP2:                          -                 -     -     -     -     -     -     -                 -           -     -                       -               
    SP3:                          -                       -     -     -     -     -     -                 -           -     -     -     -     -     -               
    SP4:                          -                       -     -     -     -     -     -                 -           -     -                       -               
    SP5:                          -                       -     -     -     -     -     -                 -           -     -                       -               

    ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f
    SP1:  -     -                                             
    SP2:  -     -                                             
    SP3:  -     -                                             
    SP4:  -                                                   
    SP5:                                                      

    About this scheme

    ECgene alternative splicing isoforms for SAP30BP

    2 Ensembl transcripts including schematic representations:
    ENST00000355423  ENST00000293208  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SAP30BP expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SAP30BP

    1 / 2 / 3

    8 probe-sets matching SAP30BP gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    57478_at2, 3 U95-B 1 1.00 1.00 0.91 0.77 AI971125 1.00 1.00 1.00 1

    44122_at2, 3 U95-B 1 1.00 1.00 0.84 0.92 AI074024 1.00 1.00 1.00 1

    57483_g_at2, 3 U95-B 1 1.00 1.00 0.85 1.17 AI971125 1.00 1.00 1.00 1

    65279_s_at2, 3 U95-C 1 1.00 1.00 0.79 1.15 AI141475 0.80 1.00 0.91 1

    222475_at2, 3 U133-B 1 1.00 1.00 -- -- AK023157 0.80 1.00 0.91 1

    217965_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_013260 0.60 1.00 0.82 1

    222475_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217965_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SAP30BP for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTGGTCTGA

    SOURCE GeneReport for Unigene cluster: Hs.655088
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SAP30BP gene from 5/14 species (see all 14 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SAP30BP1   -- SAP30 binding protein 91.02(n)
    97.08(a)
    608519  XM_844378.1  XP_849471.1 
    chimpanzee
    (Pan troglodytes)
    SAP30BP1   -- SAP30 binding protein 99.68(n)
    100(a)
    454886  XM_001145536.1  XP_001145536.1 
    cow
    (Bos taurus)
    SAP30BP1   -- SAP30 binding protein 90.16(n)
    95.3(a)
    513544  NM_001075627.1  NP_001069095.1 
    rat
    (Rattus norvegicus)
    Sap30bp1   -- SAP30 binding protein 89.72(n)
    96.75(a)
    360662  XM_340938.3  XP_340939.1 
    mouse
    (Mus musculus)
    Sap30bp1, 5 115
    SAP30 binding protein1, 5 89.83(n)1
    95.78(a)1
    572301  NM_020483.31  NP_065229.21 
     AA0002415  AF0018955  (see all 15)
    About this table        Species with no ortholog for SAP30BP

    ENSEMBL Gene Tree for SAP30BP
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/201 NCBI SNPs in SAP30BP are shown (see all 201 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 80)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs37440001,2
    A,C,F,H71215928(+) TCCTGC/TGGGGC 1 -- ng314Minor allele frequency- T:0.40EU EA WA 420
    rs72220151,2
    C,F,H71215809(+) TCCCCC/TGTCTC 1 -- ng314Minor allele frequency- T:0.10EU EA WA 416
    --
    rs169682161,2
    F71214574(+) TGGGAC/TGCTGT 1 -- ut31 ese33Minor allele frequency- T:0.02NA 138
    --
    rs80816211,2
    A71216197(+) TGCTCA/GCCAGA 1 -- ng310--------
    rs8201291,2
    A,C,F,H,O71179702(+) GAGACG/AACTCA 1 -- int113Minor allele frequency- A:0.46MN EA NA EU WA 2588
    rs8202251,2
    A,C,F,H,O71192921(-) TCAAAG/AAAATG 1 -- int19Minor allele frequency- A:0.25EA NA MN EU WA 2052
    rs20535081,2
    A,C,F,H,O71197254(-) GGGCAT/CGGAAC 1 -- int19Minor allele frequency- C:0.42MN EU EA WA NA 800
    rs8201341,2
    A,C,F,H,O71185700(+) ATGGGG/ATCTTG 1 -- int19Minor allele frequency- A:0.25MN EU EA WA NA 810
    rs23055291,2
    A,C,F,H71213848(-) ATCCAC/TGTGCT 1 -- int112Minor allele frequency- N:0.00EA NA EU WA 2192
    rs65018301,2
    A,C,F,H71210076(+) ATGTAG/CCTGGT 1 -- int14Minor allele frequency- C:0.28EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for SAP30BP (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610218

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/19 PubMed articles for SAP30BP gene (see all 19 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 29115 HGNC: 30785 AceView: HCNGP Ensembl:ENSG00000161526 euGenes: HUgn29115
    ECgene: SAP30BP H-InvDB: SAP30BP
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SAP30BP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SAP30BP-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SAP30BP Antibodies for SAP30BP
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SAP30BP Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for SAP30BP




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for SAP30BP

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