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Aliases for SAP30BP Gene

Aliases for SAP30BP Gene

  • SAP30 Binding Protein 2 3 5
  • Transcriptional Regulator Protein HCNGP 3 4
  • HCNGP 3 4
  • HTRG 3 4
  • HTRP 3 4
  • SAP30-Binding Protein 3
  • HSV-1 Binding 3

External Ids for SAP30BP Gene

Previous GeneCards Identifiers for SAP30BP Gene

  • GC17P071175
  • GC17P073663
  • GC17P069087

Summaries for SAP30BP Gene

GeneCards Summary for SAP30BP Gene

SAP30BP (SAP30 Binding Protein) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Gene Expression.

UniProtKB/Swiss-Prot for SAP30BP Gene

  • Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30BP Gene

Genomics for SAP30BP Gene

Regulatory Elements for SAP30BP Gene

Enhancers for SAP30BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SAP30BP on UCSC Golden Path with GeneCards custom track

Promoters for SAP30BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SAP30BP Gene

Chromosome:
17
Start:
75,667,116 bp from pter
End:
75,708,062 bp from pter
Size:
40,947 bases
Orientation:
Plus strand

Genomic View for SAP30BP Gene

Genes around SAP30BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP30BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP30BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30BP Gene

Proteins for SAP30BP Gene

  • Protein details for SAP30BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHR5-S30BP_HUMAN
    Recommended name:
    SAP30-binding protein
    Protein Accession:
    Q9UHR5
    Secondary Accessions:
    • B3KML7
    • Q8N1R5
    • Q8TDR8
    • Q96D27

    Protein attributes for SAP30BP Gene

    Size:
    308 amino acids
    Molecular mass:
    33870 Da
    Quaternary structure:
    • Interacts with SAP30.

    Alternative splice isoforms for SAP30BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAP30BP Gene

Post-translational modifications for SAP30BP Gene

  • Ubiquitination at Lys 144
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SAP30BP Gene

Domains & Families for SAP30BP Gene

Protein Domains for SAP30BP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAP30BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHR5

UniProtKB/Swiss-Prot:

S30BP_HUMAN :
  • Belongs to the HCNGP family.
Family:
  • Belongs to the HCNGP family.
genes like me logo Genes that share domains with SAP30BP: view

No data available for Gene Families for SAP30BP Gene

Function for SAP30BP Gene

Molecular function for SAP30BP Gene

UniProtKB/Swiss-Prot Function:
Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.
UniProtKB/Swiss-Prot Induction:
In fibroblasts by binding of HSV1.

Gene Ontology (GO) - Molecular Function for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9651585
genes like me logo Genes that share ontologies with SAP30BP: view
genes like me logo Genes that share phenotypes with SAP30BP: view

Animal Model Products

CRISPR Products

miRNA for SAP30BP Gene

miRTarBase miRNAs that target SAP30BP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30BP Gene

Localization for SAP30BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30BP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP30BP Gene COMPARTMENTS Subcellular localization image for SAP30BP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9651585
GO:0005654 nucleoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with SAP30BP: view

Pathways & Interactions for SAP30BP Gene

genes like me logo Genes that share pathways with SAP30BP: view

Gene Ontology (GO) - Biological Process for SAP30BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0010942 positive regulation of cell death IDA 15496587
genes like me logo Genes that share ontologies with SAP30BP: view

No data available for SIGNOR curated interactions for SAP30BP Gene

Drugs & Compounds for SAP30BP Gene

(1) Drugs for SAP30BP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SAP30BP: view

Transcripts for SAP30BP Gene

Unigene Clusters for SAP30BP Gene

SAP30 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30BP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: -
SP11: - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - - - - - - - - -
SP16: -

ExUns: 13b ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e · 16f
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14: - -
SP15: - -
SP16:

Relevant External Links for SAP30BP Gene

GeneLoc Exon Structure for
SAP30BP
ECgene alternative splicing isoforms for
SAP30BP

Expression for SAP30BP Gene

mRNA expression in normal human tissues for SAP30BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAP30BP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.5), Blymphocyte (11.2), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAP30BP Gene



Protein tissue co-expression partners for SAP30BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAP30BP Gene:

SAP30BP

SOURCE GeneReport for Unigene cluster for SAP30BP Gene:

Hs.655088
genes like me logo Genes that share expression patterns with SAP30BP: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SAP30BP Gene

Orthologs for SAP30BP Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30BP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAP30BP 34
  • 90.16 (n)
  • 95.3 (a)
SAP30BP 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP30BP 34
  • 91.02 (n)
  • 97.08 (a)
SAP30BP 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap30bp 34
  • 89.83 (n)
  • 95.78 (a)
Sap30bp 16
Sap30bp 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAP30BP 34
  • 99.68 (n)
  • 100 (a)
SAP30BP 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap30bp 34
  • 89.72 (n)
  • 96.75 (a)
oppossum
(Monodelphis domestica)
Mammalia SAP30BP 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30BP 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAP30BP 34
  • 78.39 (n)
  • 89.58 (a)
SAP30BP 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAP30BP 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30bp 34
  • 75.81 (n)
  • 80.94 (a)
Str.7176 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8637 34
zebrafish
(Danio rerio)
Actinopterygii sap30bp 34
  • 69.82 (n)
  • 69.59 (a)
wufb33d03 34
sap30bp 35
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10416 34
fruit fly
(Drosophila melanogaster)
Insecta CG2063 35
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y67D2.7 35
  • 19 (a)
OneToOne
Species where no ortholog for SAP30BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAP30BP Gene

ENSEMBL:
Gene Tree for SAP30BP (if available)
TreeFam:
Gene Tree for SAP30BP (if available)

Paralogs for SAP30BP Gene

genes like me logo Genes that share paralogs with SAP30BP: view

No data available for Paralogs for SAP30BP Gene

Variants for SAP30BP Gene

Sequence variations from dbSNP and Humsavar for SAP30BP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs707706 -- 75,700,260(-) TGTGA(C/T)TTTTT intron-variant
rs707707 -- 75,673,441(-) TCCCA(C/T)ATACC intron-variant
rs1046554 -- 75,708,015(+) AACCA(A/G)AGGTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1063092 -- 75,707,895(+) CCGGC(A/C)CCTCT nc-transcript-variant, utr-variant-3-prime
rs1063093 -- 75,707,913(+) ATTCC(A/C)CTTAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SAP30BP Gene

Variant ID Type Subtype PubMed ID
nsv470603 CNV loss 18288195
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv833543 CNV loss 17160897
nsv833544 CNV loss 17160897

Variation tolerance for SAP30BP Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAP30BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAP30BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30BP Gene

Disorders for SAP30BP Gene

Relevant External Links for SAP30BP

Genetic Association Database (GAD)
SAP30BP
Human Genome Epidemiology (HuGE) Navigator
SAP30BP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAP30BP

No disorders were found for SAP30BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP30BP Gene

Publications for SAP30BP Gene

  1. HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors. (PMID: 15496587) Li J.-F. … Li Q.-H. (J. Biochem. 2004) 2 3 4 22 65
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 65

Products for SAP30BP Gene

Sources for SAP30BP Gene

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