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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAP30 Gene

protein-coding   GIFtS: 56
GCID: GC04P174292

Sin3A-Associated Protein, 30kDa

(Previous names: sin3A-associated protein, 30kDa)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sin3A-Associated Protein, 30kDa1 2     Histone Deacetylase Complex Subunit SAP302
Sin3-Associated Polypeptide P302 3     Sin3-Associated Polypeptide, 30 KDa2
30 KDa Sin3-Associated Polypeptide2 3     Sin3-Associated Polypeptide, 30kDa2
Sin3 Corepressor Complex Subunit SAP302 3     

External Ids:    HGNC: 105321   Entrez Gene: 88192   Ensembl: ENSG000001641057   OMIM: 6033785   UniProtKB: O754463   

Export aliases for SAP30 gene to outside databases

Previous GC identifers: GC04P175212 GC04P174830 GC04P174987 GC04P174666 GC04P174528 GC04P170039


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SAP30 Gene:
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and
deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the
histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides.
This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal
histones. A pseudogene of this gene is located on chromosome 3. (provided by RefSeq, Jul 2008)

GeneCards Summary for SAP30 Gene: 
SAP30 (Sin3A-associated protein, 30kDa) is a protein-coding gene. Diseases associated with SAP30 include rift valley fever, and dermatomyositis, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Transcription Ligand-Dependent Transcription of Retinoid-Target genes. GO annotations related to this gene include transcription corepressor activity and metal ion binding. An important paralog of this gene is SAP30L.

UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446
Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific
subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core
histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones

Gene Wiki entry for SAP30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAP30 gene promoter:
         Nkx2-2   CUTL1   POU3F2   E4BP4   AP-2gamma   GATA-1   HNF-1A   S8   HNF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAP30 promoter sequence
   Search SABiosciences Chromatin IP Primers for SAP30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAP30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q34.1

SAP30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAP30 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P174292:  view genomic region     (about GC identifiers)

Start:
174,291,120 bp from pter      End:
174,298,683 bp from pter
Size:
7,564 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 (See protein sequence)
Recommended Name: Histone deacetylase complex subunit SAP30  
Size: 220 amino acids; 23306 Da
Subunit: Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1 (By similarity). Component of the
histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for SAP30:
2KDP (3D)    
Secondary accessions: D3DP38

Explore the universe of human proteins at neXtProt for SAP30: NX_O75446

Explore proteomics data for SAP30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75446

  • SAP30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SAP30 Protein Expression
    REFSEQ proteins: NP_003855.1  
    ENSEMBL proteins: 
     ENSP00000296504  

    Human Recombinant Protein Products for SAP30: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SAP30
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SAP30
    GenScript Custom Purified and Recombinant Proteins Services for SAP30
    Novus Biologicals SAP30 Proteins
    Novus Biologicals SAP30 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SAP30 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA9651585
    GO:0005634nucleus ----

    SAP30 for ontologies           About GeneDecksing



    SAP30 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SAP30
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for SAP30
    GenScript Custom Superior Antibodies Services for SAP30
    Novus Biologicals SAP30 Antibodies
    Abcam antibodies for SAP30
    Cloud-Clone Corp. Antibodies for SAP30 
    ThermoFisher Antibodies for SAP30
    LSBio Antibodies in human, mouse, rat for SAP30 

    Assay Products for SAP30: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAP30
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAP30
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAP30 
    Cloud-Clone Corp. CLIAs for SAP30


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR024145 His_deAcase_SAP30/SAP30L
     IPR025717 SAP30_zn-finger
     IPR025718 SAP30_Sin3-bd

    Graphical View of Domain Structure for InterPro Entry O75446

    ProtoNet protein and cluster: O75446

    UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446
    Similarity: Belongs to the SAP30 family


    SAP30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAP30_HUMAN, O75446
    Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific
    subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core
    histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IDA9651585
    GO:0005515protein binding IPI12670868
    GO:0046872metal ion binding IEA--
         
    SAP30 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SAP30:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SAP30 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAP30

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAP30 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAP30 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAP30
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SAP30
    SwitchGear 3'UTR luciferase reporter plasmidSAP30 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAP30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAP30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAP30
    Sirion Biotech Customized adenovirus for overexpression of SAP30

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SAP30 (see all 8)
    OriGene ORF clones in mouse, rat for SAP30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAP30 (NM_003864)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAP30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP30
    Sirion Biotech Customized lentivirus for stable overexpression of SAP30 
                         Customized lentivirus expression plasmids for stable overexpression of SAP30 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAP30
    Search LifeMap BioReagents cell lines for SAP30
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP30


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SAP30 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation0.88
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.54
    2Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    3Notch signaling pathway
    Delta-Notch Signaling Pathway0.33
    4DNA Methylation and Transcriptional Repression
    DNA Methylation and Transcriptional Repression0.30
    5Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for SAP30
        Development Notch Signaling Pathway
    Selected targets of Oct-3/4
    Transcription Sin3 and NuRD in transcription regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 R&D Systems Pathway for SAP30
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SAP30
        DNA Methylation and Transcriptional Repression

    4 GeneGo (Thomson Reuters) Pathways for SAP30
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Development Notch Signaling Pathway

    5 BioSystems Pathways for SAP30
        Delta-Notch Signaling Pathway
    Signaling events mediated by HDAC Class I
    Hedgehog signaling events mediated by Gli proteins
    Regulation of nuclear SMAD2/3 signaling
    Regulation of Telomerase



    SAP30 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAP30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for SAP30 (O754463 ENSP000002965044) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA9651585
    GO:0035914skeletal muscle cell differentiation IEA--

    SAP30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAP30

    Search CenterWatch for drugs/clinical trials and news about SAP30

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SAP30 gene: 
    NM_003864.3  

    Unigene Cluster for SAP30:

    Sin3A-associated protein, 30kDa
    Hs.591715  [show with all ESTs]
    Unigene Representative Sequence: BC016757
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504618 ENST00000296504(uc003itd.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAP30
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SAP30
    SwitchGear 3'UTR luciferase reporter plasmidSAP30 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAP30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAP30
    Clone
    Products:
         
    OriGene clones in human, mouse for SAP30 (see all 8)
    OriGene ORF clones in mouse, rat for SAP30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAP30 (NM_003864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAP30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP30
    Sirion Biotech Customized lentivirus for stable overexpression of SAP30 
                         Customized lentivirus expression plasmids for stable overexpression of SAP30 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SAP30
    OriGene qSTAR qPCR primer pairs in human, mouse for SAP30
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAP30
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAP30
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAP30

    Additional mRNA sequence: 

    AF055993.1 BC016757.1 

    3 DOTS entries:

    DT.75165308  DT.65288648  DT.92424431 

    24/46 AceView cDNA sequences (see all 46):

    BF726718 AI936899 AI025531 CA434135 AW628758 AI332505 AI372048 AI962241 
    AA128116 AA564903 AW005627 AW236579 AI138822 AI245057 AA746205 AI765148 
    AA505291 AI559899 AW340532 BC016757 BF061095 BV167899 AF055993 NM_003864 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAP30 expression in normal human tissues (normalized intensities)      SAP30 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAATGTT
    SAP30 Expression
    About this image


    SAP30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Sox17-GFP genetically modified stem cells
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer

    See SAP30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAP30

    SOURCE GeneReport for Unigene cluster: Hs.591715

    UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446
    Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and
    thymus; lowest levels in brain, placenta, lung and kidney

        SABiosciences Custom PCR Arrays for SAP30
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAP30
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAP30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SAP30 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sap301 , 5 sin3 associated polypeptide1, 5 88.64(n)1
    95.91(a)1
      8 (29.85 cM)5
    604061  NM_021788.21  NP_068560.11 
     574827075 
    chicken
    (Gallus gallus)
    Aves SAP301 Sin3A-associated protein, 30kDa 78.5(n)
    80.84(a)
      422562  XM_420522.3  XP_420522.3 
    lizard
    (Anolis carolinensis)
    Reptilia SAP306
    Sin3A-associated protein, 30kDa
    69(a)
    1 ↔ 1
    3(144490791-144501702)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334982 Xenopus laevis transcribed sequence with weak similarity more 79.35(n)    BJ629369.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47563 transcription co-repressor 52(a)   15A8   --


    ENSEMBL Gene Tree for SAP30 (if available)
    TreeFam Gene Tree for SAP30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAP30 gene
    SAP30L2  
    1 SIMAP similar gene for SAP30 using alignment to 1 protein entry:     SAP30_HUMAN:
    SAP30L

    SAP30 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SAP30
    PGOHUM00000237819


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/173 SNPs in SAP30 are shown (see all 173)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836992681,2
    --174290135(+) AAAAAC/TTTTTA 1 -- us2k10--------
    rs1882698631,2
    --174290197(+) AAAAAA/TAAAGT 1 -- us2k10--------
    rs1914863201,2
    --174290238(+) ATTCAC/TATGCT 1 -- us2k10--------
    rs1411380091,2
    --174290333(+) ATTGAA/GTCGAG 1 -- us2k10--------
    rs76963101,2
    C,F,H--174290352(+) TTTTGT/GTTTTT 1 -- us2k1 tfbs316Minor allele frequency- G:0.08NS EA NA WA CSA 792
    rs1380585221,2
    --174290458(+) CAGCAC/TAGCTT 1 -- us2k10--------
    rs1495071291,2
    --174290599(+) TCTGCA/GTCGAT 1 -- us2k10--------
    rs1132989661,2
    F--174290661(+) TCCCAG/CCTACT 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1831407361,2
    --174290700(+) AACTCC/GAGAGG 1 -- us2k10--------
    rs1881783001,2
    --174290726(+) CGCGCC/TACTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SAP30 (174291120 - 174298683 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SAP30: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SAP30
    DNA2.0 Custom Variant and Variant Library Synthesis for SAP30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603378    OMIM disorders: --

    5 diseases for SAP30:    About MalaCards
    rift valley fever    dermatomyositis    basal cell carcinoma    huntington's disease
    retinoblastoma


    SAP30 for disorders           About GeneDecksing


    Export disorders for SAP30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAP30 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with SAP30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PubMed id 9651585)1, 2, 3 Zhang Y.... Reinberg D. (1998)
    2. SAP30, a component of the mSin3 corepressor complex involved in N- CoR-mediated repression by specific transcription factors. (PubMed id 9702189)1, 2, 9 Laherty C.D.... Eisenman R.N. (1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1, 2 Wysocka J.... Herr W. (2003)
    6. Modulation of YY1 activity by SAP30. (PubMed id 12788099)1, 9 Huang N.E....Yu W.C. (2003)
    7. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PubMed id 19015240)1, 9 Viiri K.M....Lohi O. (2009)
    8. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PubMed id 17897615)1, 9 Sichtig N....Steger G. (2007)
    9. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. (PubMed id 11000236)1, 9 Krithivas A....Hayward S.D. (2000)
    10. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. (PubMed id 11118440)1, 9 Skowyra D.... Qin J. (2001)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8819 HGNC: 10532 AceView: SAP30 Ensembl:ENSG00000164105 euGenes: HUgn8819
    ECgene: SAP30 H-InvDB: SAP30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAP30 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAP30 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SAP30 gene:
    Search GeneIP for patents involving SAP30

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