Aliases for SAP30 Gene
External Ids for SAP30 Gene
Previous GeneCards Identifiers for SAP30 Gene
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
GeneCards Summary for SAP30 Gene
SAP30 (Sin3A-Associated Protein, 30kDa) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.
UniProtKB/Swiss-Prot for SAP30 Gene
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.