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Aliases & Descriptions for SAP30
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Sin3 corepressor complex subunit SAP30 2, 3 | | Sin3-associated polypeptide, 30 kDa 3 | | Sin3-associated polypeptide, 30kDa 2 | | Sin3A-associated protein, 30kDa 1, 2 | | histone deacetylase complex subunit SAP30 2 |
|
| | Search outside databases for aliases for SAP30 genePrevious GC identifers: GC04P175212 GC04P174830 GC04P174987 GC04P174666 |
Summaries for SAP30(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SAP30: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq] UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histonesGene Wiki entry for SAP30 |
Genomic Location for SAP30
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAP30 gene 
Entrez Gene cytogenetic band: 4q34.1 Ensembl cytogenetic band: 4q34.1 HGNC cytogenetic band: 4q34.1SAP30 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P174528:
(about GC identifiers)
Start:
|
174,528,668 bp from pter |
End:
|
174,535,258 bp from pter |
Size:
|
6,591 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_022792.17
| Proteins for SAP30
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 (See
protein sequence)Recommended Name: Histone deacetylase complex subunit SAP30 Size: 220 amino acids; 23306 Da
Subunit: Interacts with SIN3A, SIN3B, HDAC2 and NCOR1 (By similarity). Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1
Subcellular location: Nucleus
PDB structures from and Proteopedia :2KDP (3D)
 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003855.1
ENSEMBL proteins: ENSP00000296504
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SAP30: Assays for SAP30: | Protein
Domains/ Families for SAP30(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O75446 UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446Similarity: Belongs to the SAP30 family | Gene Function for SAP30
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003864
Applied Biosystems Silencer® siRNAs for SAP30
Sigma-Aldrich siRNA for SAP30  Sigma-Aldrich shRNA for SAP30  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003864                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003864                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003864 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003864
UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for SAP30
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAP30 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for SAP30 
5/44 Interacting proteins for SAP30 (ENSP000002965043) via UniProtKB, MINT, and/or STRING (see all 44
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for SAP30(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAP30
|
Transcripts for SAP30(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003864
Sigma-Aldrich siRNA for SAP30  Sigma-Aldrich shRNA for SAP30  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003864 REFSEQ mRNAs for SAP30 gene: NM_003864.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003864               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003864                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003864                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003864  Additional cDNA sequence: AF055993.1 BC016757.1 3 DOTS entries: DT.75165308 DT.65288648 DT.92424431 24/46 AceView cDNA sequences (see all 46
):AA128116 AI138822 AW628758 AA564903 AI765148 BF726718 AI332505 AI936899 AW005627 AI025531 AI372048 AW236579 AI962241 AA746205 AI245057 CA434135 CD676900 BV167899 AI559899 AF055993 NM_003864 AA505291 BE044507 AI826705
highest scoring ESTs for SAP30:AF055993 AA026940 AA128116 AA128147 AI186178 AI283588 AI307385 AI417431 AI559899 AI634520 Unigene Cluster for SAP30: Sin3A-associated protein, 30kDa Hs.591715 [show with all ESTs]Unigene Representative Sequence: BC016757
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000296504
|
Expression for SAP30
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAP30 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAP30
1 / 2 / 3 6 probe-sets matching SAP30 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAGAAATGTT
SOURCE GeneReport for Unigene cluster: Hs.591715
Expression variation in blood from EXPOLDB for SAP30 UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney |
Orthologs for SAP30
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAP30 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for SAP30
ENSEMBL Gene Tree for SAP30 | Paralogs for SAP30(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SAP30 gene
- SAP30L2
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for SAP30(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAP30 (up to first 250kb)
|
Disorders & Mutations for SAP30
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603378
|
Medical News for SAP30(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAP30 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/35 PubMed articles for SAP30 gene (see all 35
):- SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PubMed id 9651585)2, 3, 4 Zhang Y.... Reinberg D. (1998)
- SAP30, a component of the mSin3 corepressor complex involved in N- CoR-mediated repression by specific transcription factors. (PubMed id 9702189)1, 3, 4 Laherty C.D.... Eisenman R.N. (1998)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. (PubMed id 12670868)3, 4 Wysocka J....Herr W. (2003)
- Modulation of YY1 activity by SAP30. (PubMed id 12788099)1, 3 Huang N.E....Yu W.C. (2003)
- DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PubMed id 19015240)1, 3 Viiri K.M....Lohi O. (2009)
- Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PubMed id 17897615)1, 3 Sichtig N....Steger G. (2007)
- Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. (PubMed id 11000236)1, 3 Krithivas A....Hayward S.D. (2000)
|
Search for SAP30
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAP30
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAP30
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAP30(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAP30(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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Incremental update: 13 Oct 2009
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