Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SAP30 Gene

Aliases for SAP30 Gene

  • Sin3A Associated Protein 30 2 3 5
  • Sin3 Corepressor Complex Subunit SAP30 4
  • 30 KDa Sin3-Associated Polypeptide 4
  • Sin3A-Associated Protein, 30kDa 2
  • Sin3-Associated Polypeptide P30 4

External Ids for SAP30 Gene

Previous GeneCards Identifiers for SAP30 Gene

  • GC04P175212
  • GC04P174830
  • GC04P174987
  • GC04P174666
  • GC04P174528
  • GC04P174292
  • GC04P170039

Summaries for SAP30 Gene

Entrez Gene Summary for SAP30 Gene

  • Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for SAP30 Gene

SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch signaling pathway (KEGG). GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.

UniProtKB/Swiss-Prot for SAP30 Gene

  • Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Wiki entry for SAP30 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30 Gene

Genomics for SAP30 Gene

Regulatory Elements for SAP30 Gene

Enhancers for SAP30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G173414 1.6 FANTOM5 Ensembl ENCODE 1.3 +46.2 46232 2.8 HDGF PKNOX1 ARNT YBX1 ZNF2 TCF12 ZNF143 ZNF207 MCM3 NCOA1 SAP30 RPL5P11 LOC101928383
GH04G173366 0.9 Ensembl ENCODE 0.7 -2.3 -2304 1.6 JUN CEBPB JUNB DPF2 TBX21 FOSL1 ARID1B JUND SCRT2 HMBOX1 HMGB2 ENSG00000248774 SCRG1 RNU6-1096P FBXO8 CEP44 SAP30 GC04P173358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAP30 on UCSC Golden Path with GeneCards custom track

Promoters for SAP30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000176229 1131 4201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for SAP30 Gene

Chromosome:
4
Start:
173,369,969 bp from pter
End:
173,377,532 bp from pter
Size:
7,564 bases
Orientation:
Plus strand

Genomic View for SAP30 Gene

Genes around SAP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30 Gene

Proteins for SAP30 Gene

  • Protein details for SAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75446-SAP30_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP30
    Protein Accession:
    O75446
    Secondary Accessions:
    • D3DP38

    Protein attributes for SAP30 Gene

    Size:
    220 amino acids
    Molecular mass:
    23306 Da
    Quaternary structure:
    • Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1 (By similarity). Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1.

    Three dimensional structures from OCA and Proteopedia for SAP30 Gene

neXtProt entry for SAP30 Gene

Post-translational modifications for SAP30 Gene

  • Ubiquitination at isoforms=194
  • Modification sites at PhosphoSitePlus

Other Protein References for SAP30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAP30 Gene

Domains & Families for SAP30 Gene

Gene Families for SAP30 Gene

Protein Domains for SAP30 Gene

Suggested Antigen Peptide Sequences for SAP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75446

UniProtKB/Swiss-Prot:

SAP30_HUMAN :
  • Belongs to the SAP30 family.
Family:
  • Belongs to the SAP30 family.
genes like me logo Genes that share domains with SAP30: view

Function for SAP30 Gene

Molecular function for SAP30 Gene

UniProtKB/Swiss-Prot Function:
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Ontology (GO) - Molecular Function for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 9651585
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 9651585
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SAP30: view
genes like me logo Genes that share phenotypes with SAP30: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30 Gene

Localization for SAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAP30 gene
Compartment Confidence
nucleus 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 9651585
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SAP30: view

Pathways & Interactions for SAP30 Gene

genes like me logo Genes that share pathways with SAP30: view

Gene Ontology (GO) - Biological Process for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 9651585
GO:0016575 histone deacetylation IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with SAP30: view

No data available for SIGNOR curated interactions for SAP30 Gene

Drugs & Compounds for SAP30 Gene

No Compound Related Data Available

Transcripts for SAP30 Gene

mRNA/cDNA for SAP30 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAP30 Gene

Sin3A-associated protein, 30kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30 Gene

No ASD Table

Relevant External Links for SAP30 Gene

GeneLoc Exon Structure for
SAP30
ECgene alternative splicing isoforms for
SAP30

Expression for SAP30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAP30 Gene

This gene is overexpressed in Breast (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAP30 Gene



Protein tissue co-expression partners for SAP30 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAP30 Gene:

SAP30

SOURCE GeneReport for Unigene cluster for SAP30 Gene:

Hs.591715

mRNA Expression by UniProt/SwissProt for SAP30 Gene:

O75446-SAP30_HUMAN
Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.

Evidence on tissue expression from TISSUES for SAP30 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with SAP30: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAP30 Gene

Orthologs for SAP30 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAP30 34 35
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia SAP30 34 35
  • 95.15 (n)
cow
(Bos Taurus)
Mammalia SAP30 34 35
  • 92.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap30 34
  • 89.85 (n)
mouse
(Mus musculus)
Mammalia Sap30 34 16 35
  • 88.64 (n)
oppossum
(Monodelphis domestica)
Mammalia SAP30 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAP30 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAP30 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30 34
  • 79.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33498 34
fruit fly
(Drosophila melanogaster)
Insecta CG4756 36
  • 52 (a)
Sap30 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for SAP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAP30 Gene

ENSEMBL:
Gene Tree for SAP30 (if available)
TreeFam:
Gene Tree for SAP30 (if available)

Paralogs for SAP30 Gene

Paralogs for SAP30 Gene

(1) SIMAP similar genes for SAP30 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SAP30 Gene

genes like me logo Genes that share paralogs with SAP30: view

Variants for SAP30 Gene

Sequence variations from dbSNP and Humsavar for SAP30 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000691525 -- 173,377,592(+) AAGAG(A/T)TCAGT downstream-variant-500B
rs1000723553 -- 173,377,901(+) CACCT(C/G)CTTCC downstream-variant-500B
rs1000872642 -- 173,372,457(+) CTCTT(C/T)AGGTG intron-variant, upstream-variant-2KB
rs1001090751 -- 173,372,706(+) AGCAA(A/T)ACTGT intron-variant, upstream-variant-2KB
rs1001211127 -- 173,372,380(+) GTAAT(C/T)AAAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SAP30 Gene

Variant ID Type Subtype PubMed ID
nsv1074240 CNV deletion 25765185

Variation tolerance for SAP30 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAP30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30 Gene

Disorders for SAP30 Gene

Relevant External Links for SAP30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAP30

No disorders were found for SAP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP30 Gene

Publications for SAP30 Gene

  1. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PMID: 9651585) Zhang Y. … Reinberg D. (Mol. Cell 1998) 2 3 4 64
  2. SAP30, a component of the mSin3 corepressor complex involved in N- CoR-mediated repression by specific transcription factors. (PMID: 9702189) Laherty C.D. … Eisenman R.N. (Mol. Cell 1998) 3 4 22 64
  3. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PMID: 19015240) Viiri K.M. … Lohi O. (Mol. Cell. Biol. 2009) 3 22 64
  4. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PMID: 17897615) Sichtig N. … Steger G. (Arch. Biochem. Biophys. 2007) 3 22 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for SAP30 Gene

Sources for SAP30 Gene

Content
Loading form....