Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SAP30 Gene

protein-coding   GIFtS: 58
GCID: GC04P174292

Sin3A-Associated Protein, 30kDa

(Previous names: sin3A-associated protein, 30kDa)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sin3A-Associated Protein, 30kDa1 2     Histone Deacetylase Complex Subunit SAP302
Sin3-Associated Polypeptide P302 3     Sin3-Associated Polypeptide, 30 KDa2
30 KDa Sin3-Associated Polypeptide2 3     Sin3-Associated Polypeptide, 30kDa2
Sin3 Corepressor Complex Subunit SAP302 3     

External Ids:    HGNC: 105321   Entrez Gene: 88192   Ensembl: ENSG000001641057   OMIM: 6033785   UniProtKB: O754463   

Export aliases for SAP30 gene to outside databases

Previous GC identifers: GC04P175212 GC04P174830 GC04P174987 GC04P174666 GC04P174528 GC04P170039


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SAP30 Gene:
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and
deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the
histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides.
This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal
histones. A pseudogene of this gene is located on chromosome 3. (provided by RefSeq, Jul 2008)

GeneCards Summary for SAP30 Gene:
SAP30 (Sin3A-associated protein, 30kDa) is a protein-coding gene. Diseases associated with SAP30 include rift valley fever, and dermatomyositis. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.

UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446
Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific
subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core
histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones

Gene Wiki entry for SAP30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAP30 gene promoter:
         Nkx2-2   CUTL1   POU3F2   E4BP4   AP-2gamma   GATA-1   HNF-1A   S8   HNF-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAP30 promoter sequence
   Search Chromatin IP Primers for SAP30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAP30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.1   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q34.1

SAP30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAP30 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P174292:  view genomic region     (about GC identifiers)

Start:
174,291,120 bp from pter      End:
174,298,683 bp from pter
Size:
7,564 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 (See protein sequence)
Recommended Name: Histone deacetylase complex subunit SAP30  
Size: 220 amino acids; 23306 Da
Subunit: Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1 (By similarity). Component of the
histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1
1 PDB 3D structure from and Proteopedia for SAP30:
2KDP (3D)    
Secondary accessions: D3DP38

Explore the universe of human proteins at neXtProt for SAP30: NX_O75446

Explore proteomics data for SAP30 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys194
  • Modification sites at PhosphoSitePlus

  • See SAP30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003855.1  
    ENSEMBL proteins: 
     ENSP00000296504  
    Reactome Protein details: O75446

    SAP30 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SAP30
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SAP30
    GenScript Custom Purified and Recombinant Proteins Services for SAP30
    Novus Biologicals SAP30 Proteins
    Novus Biologicals SAP30 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SAP30

    SAP30 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SAP30
    Novus Biologicals SAP30 Antibodies
    Abcam antibodies for SAP30
    Cloud-Clone Corp. Antibodies for SAP30
    ThermoFisher Antibodies for SAP30
    LSBio Antibodies in human, mouse, rat for SAP30

    SAP30 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAP30
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAP30
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAP30
    Cloud-Clone Corp. CLIAs for SAP30


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR024145 His_deAcase_SAP30/SAP30L
     IPR025717 SAP30_zn-finger
     IPR025718 SAP30_Sin3-bd

    Graphical View of Domain Structure for InterPro Entry O75446

    ProtoNet protein and cluster: O75446

    UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446
    Similarity: Belongs to the SAP30 family


    SAP30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAP30_HUMAN, O75446
    Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific
    subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core
    histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003714transcription corepressor activity IDA9651585
    GO:0005515protein binding IPI12670868
    GO:0046872metal ion binding IEA--
         
    SAP30 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SAP30:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAP30
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SAP30

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAP30
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAP30

    miRNA
    Products:
        
    miRTarBase miRNAs that target SAP30:
    hsa-mir-92a-3p (MIRT049800), hsa-mir-192-5p (MIRT026771), hsa-mir-215-5p (MIRT024621)

    Block miRNA regulation of human, mouse, rat SAP30 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SAP30
    SwitchGear 3'UTR luciferase reporter plasmidSAP30 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SAP30
    Predesigned siRNA for gene silencing in human, mouse, rat SAP30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAP30

    Clone
    Products:
         
    OriGene clones in human, mouse for SAP30 (see all 7)
    OriGene ORF clones in mouse, rat for SAP30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAP30 (NM_003864)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAP30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP30

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAP30
    Browse ESI BIO Cell Lines and PureStem Progenitors for SAP30 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP30


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SAP30_HUMAN, O75446: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IDA9651585
    GO:0005634nucleus ----

    SAP30 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SAP30 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1 mediated pathway for NF KB activity modulation
    Development NOTCH1 mediated pathway for NF KB activity modulation0.50
    Transcription Sin3 and NuRD in transcription regulation0.35
    Development Notch Signaling Pathway0.50
    2Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    3Macrophage Differentiation and Growth Inhibition by METS
    DNA Methylation and Transcriptional Repression0.30
    4Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes
    5Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SAP30
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SAP30
        DNA Methylation and Transcriptional Repression

    4 GeneGo (Thomson Reuters) Pathways for SAP30
        Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Development Notch Signaling Pathway

    Selected BioSystems Pathways for SAP30 (see all 6)
        Delta-Notch Signaling Pathway
    RB in Cancer
    Regulation of nuclear SMAD2/3 signaling
    Signaling events mediated by HDAC Class I
    Regulation of Telomerase

    1 Reactome Pathway for SAP30
        NoRC negatively regulates rRNA expression



    SAP30 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAP30
    Interactions:

        GeneGlobe Interaction Network for SAP30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SAP30 (O754463 ENSP000002965044) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA9651585
    GO:0035914skeletal muscle cell differentiation IEA--

    SAP30 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAP30



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SAP30 gene: 
    NM_003864.3  

    Unigene Cluster for SAP30:

    Sin3A-associated protein, 30kDa
    Hs.591715  [show with all ESTs]
    Unigene Representative Sequence: BC016757
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504618 ENST00000296504(uc003itd.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SAP30 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SAP30
    SwitchGear 3'UTR luciferase reporter plasmidSAP30 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SAP30
    Predesigned siRNA for gene silencing in human, mouse, rat SAP30
    Clone
    Products:
         
    OriGene clones in human, mouse for SAP30 (see all 7)
    OriGene ORF clones in mouse, rat for SAP30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAP30 (NM_003864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAP30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP30
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SAP30
    OriGene qSTAR qPCR primer pairs in human, mouse for SAP30
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAP30
      QuantiTect SYBR Green Assays in human, mouse, rat SAP30
      QuantiFast Probe-based Assays in human, mouse, rat SAP30

    Additional mRNA sequence: 

    AF055993.1 BC016757.1 

    3 DOTS entries:

    DT.75165308  DT.65288648  DT.92424431 

    Selected AceView cDNA sequences (see all 46):

    AI765148 AW005627 AI936899 AA128116 AI372048 AA746205 AI332505 AA564903 
    CA434135 AI138822 AW236579 AI245057 AW628758 AI962241 AI025531 BF726718 
    BF061095 BE044507 AF055993 D57622 CD676900 BC016757 AW340532 BV167899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SAP30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAATGTT
    SAP30 Expression
    About this image


    SAP30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    SAP30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAP30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591715

    UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446
    Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and
    thymus; lowest levels in brain, placenta, lung and kidney

        Custom PCR Arrays for SAP30
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SAP30
    OriGene qSTAR qPCR primer pairs in human, mouse for SAP30
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAP30
    QuantiTect SYBR Green Assays in human, mouse, rat SAP30
    QuantiFast Probe-based Assays in human, mouse, rat SAP30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SAP30 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sap301 , 5 sin3 associated polypeptide1, 5 88.64(n)1
    95.91(a)1
      8 (29.85 cM)5
    604061  NM_021788.21  NP_068560.11 
     574827075 
    chicken
    (Gallus gallus)
    Aves SAP306
    Sin3A-associated protein, 30kDa
    85(a)
    1 ↔ 1
    4(42754695-42760373)
    lizard
    (Anolis carolinensis)
    Reptilia SAP306
    Sin3A-associated protein, 30kDa
    67(a)
    1 ↔ 1
    3(144490791-144501702)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334982 Xenopus laevis transcribed sequence with weak similarity more 79.35(n)    BJ629369.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47563 transcription co-repressor 52(a)   15A8   --


    ENSEMBL Gene Tree for SAP30 (if available)
    TreeFam Gene Tree for SAP30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SAP30 gene
    SAP30L2  
    1 SIMAP similar gene for SAP30 using alignment to 1 protein entry:     SAP30_HUMAN:
    SAP30L

    SAP30 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SAP30
    PGOHUM00000237819


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SAP30 (see all 173)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836992681,2
    --174290135(+) AAAAAC/TTTTTA 1 -- us2k10--------
    rs1882698631,2
    --174290197(+) AAAAAA/TAAAGT 1 -- us2k10--------
    rs1914863201,2
    --174290238(+) ATTCAC/TATGCT 1 -- us2k10--------
    rs1411380091,2
    --174290333(+) ATTGAA/GTCGAG 1 -- us2k10--------
    rs76963101,2
    C,F,H--174290352(+) TTTTGT/GTTTTT 1 -- us2k1 tfbs316Minor allele frequency- G:0.08NS EA NA WA CSA 792
    rs1380585221,2
    --174290458(+) CAGCAC/TAGCTT 1 -- us2k10--------
    rs1495071291,2
    --174290599(+) TCTGCA/GTCGAT 1 -- us2k10--------
    rs1132989661,2
    F--174290661(+) TCCCAG/CCTACT 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1831407361,2
    --174290700(+) AACTCC/GAGAGG 1 -- us2k10--------
    rs1881783001,2
    --174290726(+) CGCGCC/TACTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SAP30 (174291120 - 174298683 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SAP30: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SAP30
    DNA2.0 Custom Variant and Variant Library Synthesis for SAP30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603378    OMIM disorders: --

    5 diseases for SAP30:    
    About MalaCards
    rift valley fever    dermatomyositis    basal cell carcinoma    huntington's disease
    retinoblastoma


    SAP30 for disorders           About GeneDecksing


    Export disorders for SAP30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SAP30 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with SAP30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PubMed id 9651585)1, 2, 3 Zhang Y.... Reinberg D. (Mol. Cell 1998)
    2. SAP30, a component of the mSin3 corepressor complex involved in N- CoR-mediated repression by specific transcription factors. (PubMed id 9702189)1, 2, 9 Laherty C.D.... Eisenman R.N. (Mol. Cell 1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1, 2 Wysocka J.... Herr W. (Genes Dev. 2003)
    6. Modulation of YY1 activity by SAP30. (PubMed id 12788099)1, 9 Huang N.E....Yu W.C. (Biochem. Biophys. Res. Commun. 2003)
    7. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PubMed id 19015240)1, 9 Viiri K.M....Lohi O. (Mol. Cell. Biol. 2009)
    8. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PubMed id 17897615)1, 9 Sichtig N....Steger G. (Arch. Biochem. Biophys. 2007)
    9. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. (PubMed id 11000236)1, 9 Krithivas A....Hayward S.D. (J. Virol. 2000)
    10. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. (PubMed id 11118440)1, 9 Skowyra D.... Qin J. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8819 HGNC: 10532 AceView: SAP30 Ensembl:ENSG00000164105 euGenes: HUgn8819
    ECgene: SAP30 H-InvDB: SAP30

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SAP30 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAP30 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SAP30 gene:
    Search GeneIP for patents involving SAP30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SAP30  
     OriGene qPCR primer pairs and template standards for SAP30   OriGene Protein Over-expression Lysate for SAP30  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SAP30  
     OriGene qSTAR qPCR primer pairs in human, mouse for SAP30   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SAP30   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SAP30   OriGene Custom Protein Services for SAP30  

     
     
     Block miRNA regulation of human, mouse, rat SAP30 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SAP30
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAP30 Predesigned siRNA for gene silencing in human, mouse, rat SAP30
     QuantiFast Probe-based Assays in human, mouse, rat SAP30 QuantiTect SYBR Green Assays in human, mouse, rat SAP30
     Custom PCR Arrays for SAP30 Search Chromatin IP Primers for SAP30
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAP30  GeneGlobe Interaction Network for SAP30
     Regulatory tfbs in SAP30 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SAP30 GenScript cDNA clones with any tag delivered in your preferred vector for SAP30
     GenScript Custom Assay Services for SAP30 GenScript Custom overexpressing Cell Line Services for SAP30
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SAP30
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SAP30 antibodies
     SAP30 proteins
     SAP30 lysates
     Antibodies for SAP30
     See all of Abcam's Antibodies, Kits and Proteins for SAP30
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SAP30
     Antibodies for SAP30
     ELISAs for SAP30
     CLIAs for SAP30



     Browse ESI BIO Cell Lines and PureStem Progenitors for SAP30
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP30
     SwitchGear 3'UTR luciferase reporter plasmids for SAP30
     SwitchGear Promoter luciferase reporter plasmids for SAP30
     ThermoFisher Antibodies for SAP30
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP30
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAP30
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SAP30
     LSBio Antibodies in human, mouse, rat for SAP30
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SAP30 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4