SAP30 Gene
protein-coding GIFtS : 53 GCID: GC04 P174292
Sin3A-associated protein, 30kDa sin3A-associated protein, 30kDa )
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Aliasesfor SAP30 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sin3A-Associated Protein, 30kDa 1 2 Histone Deacetylase Complex Subunit SAP302 Sin3-Associated Polypeptide P302 3 Sin3-Associated Polypeptide, 30 KDa2 30 KDa Sin3-Associated Polypeptide2 3 Sin3-Associated Polypeptide, 30kDa2 Sin3 Corepressor Complex Subunit SAP302 3
Export aliases for SAP30 gene to outside databases Previous GC identifers: GC04P175212 GC04P174830 GC04P174987 GC04P174666 GC04P174528 GC04P170039
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Summariesfor SAP30 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SAP30 : Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 Function : Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset ofN-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones Gene Wiki entry for SAP30
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Genomic Viewsfor SAP30 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SAP30 gene promoter:Nkx2-2 CUTL1 POU3F2 E4BP4 AP-2gamma GATA-1 HNF-1A S8 HNF-1 RSRFC4 Other transcription factors Search SABiosciences Chromatin IP Primers for SAP30 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q34.1 Ensembl cytogenetic band: 4q34.1 HGNC cytogenetic band: 4q34.1 SAP30 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P174292: view genomic region
(about GC identifiers )
Start: 174,291,120 bp from pter End:
174,298,683 bp from pter
Size: 7,564 bases Orientation:
plus strand
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Proteinsfor SAP30 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 See
protein sequence )Recommended Name: Size : 220 amino acids; 23306 DaSubunit : Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1 (By similarity). Component of the histonedeacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1
Subcellular location : Nucleus1 PDB 3D structure from :2KDP (3D) Secondary accessions : D3DP38Explore the universe of human proteins at neXtProt for SAP30: NX_O75446 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75446 SAP30 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_003855.1 ENSEMBL proteins: ENSP00000296504 Human Recombinant Protein Products for SAP30: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing SAP30 Antibody Products: Assay Products for SAP30:
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Protein
Domains /for SAP30 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O75446 ProtoNet protein and cluster: O75446
UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 Similarity : Belongs to the SAP30 family
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Functionfor SAP30 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: SAP30_HUMAN, O75446 Function : Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset ofN-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for SAP30 :Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SAP30 (NM_003864 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAP30 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SAP30
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Pathways & Interactionsfor SAP30 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/11 super-pathways (see all 11 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription_Sin3 and NuRD in transcription regulation 2 Development_Notch Signaling Pathway 3 Development NOTCH1-mediated pathway for NF-KB activity modulation 4 HIV Infection 5 Selected targets of Oct-3/4
Pathway sources See GeneCards unified pathways Show all pathways 5 1 4 5 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAP30 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/99 Interacting proteins for SAP30 (O75446 3 ENSP00000296504 4 via UniProtKB, MINT, STRING , and/or I2D (see all 99 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IEA -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IDA 9651585
About GeneDecksing
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Drugs & Compoundsfor SAP30 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SAP30 SAP30
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Transcriptsfor SAP30 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SAP30 gene: NM_003864.3 Unigene Cluster for SAP30:
Sin3A-associated protein, 30kDa Hs.591715 [show with all ESTs ] Unigene Representative Sequence: BC016757 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000504618 ENST00000296504 (uc003itd.3 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SAP30 (NM_003864 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAP30 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SAP30
Additional cDNA sequence: AF055993.1 BC016757.1
3 DOTS entries : DT.75165308 DT.65288648
DT.92424431 24/46 AceView cDNA sequences (see all 46 ):
AW236579 AI138822 AI765148 AI936899 AA564903 BF726718 AI025531 AA746205 AI962241 AA128116 CA434135 AI372048 AI245057 AI332505 AW628758 AW005627 AI559899 BF061095 BV167899 AW340532 CD676900 BC016757 AA505291 AF055993 GeneLoc Exon Structure
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Expression for SAP30 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SAP30 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAGAAATGTTAbout this image SAP30 expression in embryonic tissues and stem cells About this table
See SAP30 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SAP30 SOURCE GeneReport for Unigene cluster: Hs.591715 UniProtKB/Swiss-Prot: SAP30_HUMAN, O75446 Tissue specificity : Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus;lowest levels in brain, placenta, lung and kidney SABiosciences Custom PCR Arrays for SAP30 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor SAP30 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for SAP30 gene from 4/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves SAP301
Sin3A-associated protein, 30kDa
78.5(n) 80.84(a)
422562 XM_420522.3 XP_420522.3
lizard Reptilia SAP306
--
80(a)
1 ↔ 1
3(144493130-144561916)
African clawed frog Amphibia Xl.334982
Xenopus laevis transcribed sequence with weak similarity more
79.35(n)
BJ629369.1
fruit fly Insecta CG47563
transcription co-repressor
52(a)
15A8 --
ENSEMBL Gene Tree for SAP30 (if available)TreeFam Gene Tree for SAP30 (if available)
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Paralogsfor SAP30 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SAP30 gene SAP30L 2 1 SIMAP similar gene for SAP30 using alignment to 1 protein entry: SAP30_HUMAN :SAP30L About GeneDecksing 1 Pseudogenes.org Pseudogene for SAP30 PGOHUM00000237819
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Genomic Variantsfor SAP30 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 4 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for SAP30 (174291120 - 174298683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SAP30: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor SAP30 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 603378
OMIM disorders : --6 : About MalaCards rift valley fever basal cell carcinoma dermatomyositis huntington's disease retinoblastoma carcinoma Export disorders for SAP30 gene to outside databases
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Publicationsfor SAP30 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SAP30 gene, integrated from 9 sources (see all 54 ):(articles sorted by number of sources associating them with SAP30) Utopia : connect your pdf to the dynamic
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PubMed id 9651585) 1 , 2 , 3(1998) SAP30, a component of the mSin3 corepressor complex involved in N- CoR-mediated repression by specific transcription factors. (PubMed id 9702189) 1 , 2 , 9(1998) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868) 1 , 2 (2003) Modulation of YY1 activity by SAP30. (PubMed id 12788099) 1 , 9(2003) DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PubMed id 19015240) 1 , 9(2009) Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PubMed id 17897615) 1 , 9(2007) Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. (PubMed id 11000236) 1 , 9(2000) Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. (PubMed id 11118440) 1 , 9(2001)
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External Searches for SAP30 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SAP30 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SAP30 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SAP30 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SAP30 gene: SAP30 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SAP30 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SAP30 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for SAP30 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SAP30 OriGene 3'-UTR Clone for SAP30 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SAP30 OriGene Custom Protein Services for SAP30 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAP30 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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SAP30 Proteins, Antibodies, CLIAs, and ELISAs
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Aliases for SAP30
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Expression by the Database of Embryonic development, Stem cell research, and
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Anatomical Compartment 
Negative
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In-situ hybridization
