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Aliases for SAP30 Gene

Aliases for SAP30 Gene

  • Sin3A-Associated Protein, 30kDa 2 3
  • Sin3 Corepressor Complex Subunit SAP30 4
  • 30 KDa Sin3-Associated Polypeptide 4
  • Sin3-Associated Polypeptide P30 4

External Ids for SAP30 Gene

Previous GeneCards Identifiers for SAP30 Gene

  • GC04P175212
  • GC04P174830
  • GC04P174987
  • GC04P174666
  • GC04P174528
  • GC04P174292
  • GC04P170039

Summaries for SAP30 Gene

Entrez Gene Summary for SAP30 Gene

  • Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for SAP30 Gene

SAP30 (Sin3A-Associated Protein, 30kDa) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and RB in Cancer. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.

UniProtKB/Swiss-Prot for SAP30 Gene

  • Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Wiki entry for SAP30 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30 Gene

Genomics for SAP30 Gene

Regulatory Elements for SAP30 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAP30 Gene

Start:
173,369,969 bp from pter
End:
173,377,532 bp from pter
Size:
7,564 bases
Orientation:
Plus strand

Genomic View for SAP30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAP30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP30 Gene

Proteins for SAP30 Gene

  • Protein details for SAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75446-SAP30_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP30
    Protein Accession:
    O75446
    Secondary Accessions:
    • D3DP38

    Protein attributes for SAP30 Gene

    Size:
    220 amino acids
    Molecular mass:
    23306 Da
    Quaternary structure:
    • Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1 (By similarity). Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1.

    Three dimensional structures from OCA and Proteopedia for SAP30 Gene

neXtProt entry for SAP30 Gene

Proteomics data for SAP30 Gene at MOPED

Post-translational modifications for SAP30 Gene

  • Ubiquitination at Lys194
  • Modification sites at PhosphoSitePlus

Other Protein References for SAP30 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SAP30 Gene

Domains for SAP30 Gene

Protein Domains for SAP30 Gene

Suggested Antigen Peptide Sequences for SAP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75446

UniProtKB/Swiss-Prot:

SAP30_HUMAN :
  • O75446
Family:
  • Belongs to the SAP30 family.
genes like me logo Genes that share domains with SAP30: view

No data available for Gene Families for SAP30 Gene

Function for SAP30 Gene

Molecular function for SAP30 Gene

UniProtKB/Swiss-Prot Function: Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Ontology (GO) - Molecular Function for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 9651585
GO:0005515 protein binding IPI 12670868
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SAP30: view
genes like me logo Genes that share phenotypes with SAP30: view

Animal Model Products

CRISPR Products

miRNA for SAP30 Gene

miRTarBase miRNAs that target SAP30

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAP30

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAP30 Gene

Localization for SAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP30 Gene COMPARTMENTS Subcellular localization image for SAP30 gene
Compartment Confidence
nucleus 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 9651585
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SAP30: view

Pathways for SAP30 Gene

genes like me logo Genes that share pathways with SAP30: view

Gene Ontology (GO) - Biological Process for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 9651585
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SAP30: view

Transcripts for SAP30 Gene

mRNA/cDNA for SAP30 Gene

(46) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAP30 Gene

Sin3A-associated protein, 30kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAP30

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30 Gene

No ASD Table

Relevant External Links for SAP30 Gene

GeneLoc Exon Structure for
SAP30
ECgene alternative splicing isoforms for
SAP30

Expression for SAP30 Gene

mRNA expression in normal human tissues for SAP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAP30 Gene

SOURCE GeneReport for Unigene cluster for SAP30 Gene Hs.591715

mRNA Expression by UniProt/SwissProt for SAP30 Gene

O75446-SAP30_HUMAN
Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.
genes like me logo Genes that share expressions with SAP30: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SAP30 Gene

Orthologs for SAP30 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAP30 35
  • 99.85 (n)
  • 99.55 (a)
SAP30 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAP30 35
  • 92.12 (n)
  • 97.73 (a)
SAP30 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP30 35
  • 95.15 (n)
  • 97.73 (a)
SAP30 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap30 35
  • 88.64 (n)
  • 95.91 (a)
Sap30 16
Sap30 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAP30 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAP30 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap30 35
  • 89.85 (n)
  • 95.89 (a)
chicken
(Gallus gallus)
Aves SAP30 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAP30 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33498 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sap30 35
  • 79.91 (n)
  • 85.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sap30 36
  • 49 (a)
OneToMany
CG4756 37
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for SAP30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAP30 Gene

ENSEMBL:
Gene Tree for SAP30 (if available)
TreeFam:
Gene Tree for SAP30 (if available)

Paralogs for SAP30 Gene

Paralogs for SAP30 Gene

Selected SIMAP similar genes for SAP30 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SAP30 Gene

genes like me logo Genes that share paralogs with SAP30: view

Variants for SAP30 Gene

Sequence variations from dbSNP and Humsavar for SAP30 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12205 -- 173,377,499(+) CTAAA(G/T)TAAAT utr-variant-3-prime
rs965931 -- 173,376,532(-) ACAGA(C/T)GTAAG intron-variant
rs965932 -- 173,376,270(-) CTTGC(C/T)TTTTC intron-variant
rs1802316 -- 173,371,132(+) GGAGC(A/G)GCCAG utr-variant-5-prime
rs3052296 -- 173,375,039(+) TATAT(-/AT/ATAT)TTTAA intron-variant

Relevant External Links for SAP30 Gene

HapMap Linkage Disequilibrium report
SAP30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAP30 Gene

Disorders for SAP30 Gene

No disorders were found for SAP30 Gene.

No data available for UniProtKB/Swiss-Prot for SAP30 Gene

Publications for SAP30 Gene

  1. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PMID: 9651585) Zhang Y. … Reinberg D. (Mol. Cell 1998) 2 3 4
  2. SAP30, a component of the mSin3 corepressor complex involved in N- CoR-mediated repression by specific transcription factors. (PMID: 9702189) Laherty C.D. … Eisenman R.N. (Mol. Cell 1998) 3 4 23
  3. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. (PMID: 9150135) Zhang Y. … Reinberg D. (Cell 1997) 3 23
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. (PMID: 11000236) Krithivas A. … Hayward S.D. (J. Virol. 2000) 3 23

Products for SAP30 Gene

Sources for SAP30 Gene

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