Aliases for SAP30 Gene
External Ids for SAP30 Gene
Previous GeneCards Identifiers for SAP30 Gene
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
GeneCards Summary for SAP30 Gene
SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.
UniProtKB/Swiss-Prot for SAP30 Gene
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.