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Aliases for SAP25 Gene

Aliases for SAP25 Gene

  • Sin3A-Associated Protein, 25kDa 2 3
  • Sin3 Corepressor Complex Subunit SAP25 4
  • 25 KDa Sin3-Associated Polypeptide 4

External Ids for SAP25 Gene

Previous GeneCards Identifiers for SAP25 Gene

  • GC00U923410
  • GC07M100171

Summaries for SAP25 Gene

GeneCards Summary for SAP25 Gene

SAP25 (Sin3A-Associated Protein, 25kDa) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SAP25 Gene

  • Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP25 Gene

Genomics for SAP25 Gene

Genomic Location for SAP25 Gene

Chromosome:
7
Start:
100,572,226 bp from pter
End:
100,573,864 bp from pter
Size:
1,639 bases
Orientation:
Minus strand

Genomic View for SAP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP25 Gene

No data available for Regulatory Elements for SAP25 Gene

Proteins for SAP25 Gene

  • Protein details for SAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEE9-SAP25_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP25
    Protein Accession:
    Q8TEE9

    Protein attributes for SAP25 Gene

    Size:
    199 amino acids
    Molecular mass:
    20873 Da
    Quaternary structure:
    • May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 (By similarity).
    SequenceCaution:
    • Sequence=BAB85001.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for SAP25 Gene

Proteomics data for SAP25 Gene at MOPED

Post-translational modifications for SAP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAP25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAP25 Gene

Domains & Families for SAP25 Gene

Protein Domains for SAP25 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAP25: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SAP25 Gene

Function for SAP25 Gene

Molecular function for SAP25 Gene

UniProtKB/Swiss-Prot Function:
Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAP25 Gene

Localization for SAP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP25 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP25 Gene COMPARTMENTS Subcellular localization image for SAP25 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SAP25: view

Pathways & Interactions for SAP25 Gene

SuperPathways for SAP25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SAP25: view

No data available for Pathways by source and SIGNOR curated interactions for SAP25 Gene

Drugs & Compounds for SAP25 Gene

No Compound Related Data Available

Transcripts for SAP25 Gene

mRNA/cDNA for SAP25 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAP25 Gene

Sin3A-associated protein, 25kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAP25 Gene

No ASD Table

Relevant External Links for SAP25 Gene

GeneLoc Exon Structure for
SAP25
ECgene alternative splicing isoforms for
SAP25

Expression for SAP25 Gene

mRNA expression in normal human tissues for SAP25 Gene

mRNA differential expression in normal tissues according to GTEx for SAP25 Gene

This gene is overexpressed in Whole Blood (x9.6) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for SAP25 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAP25 Gene



SOURCE GeneReport for Unigene cluster for SAP25 Gene Hs.633863

genes like me logo Genes that share expression patterns with SAP25: view

Protein tissue co-expression partners for SAP25 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SAP25 Gene

Orthologs for SAP25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SAP25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAP25 35
  • 77.44 (n)
  • 68.72 (a)
SAP25 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP25 35
  • 79.63 (n)
  • 79.01 (a)
SAP25 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap25 35
  • 69.93 (n)
  • 58.17 (a)
Sap25 16
Sap25 36
  • 35 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAP25 35
  • 99.5 (n)
  • 100 (a)
SAP25 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap25 35
  • 70.3 (n)
  • 59.62 (a)
Species with no ortholog for SAP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAP25 Gene

ENSEMBL:
Gene Tree for SAP25 (if available)
TreeFam:
Gene Tree for SAP25 (if available)

Paralogs for SAP25 Gene

Pseudogenes.org Pseudogenes for SAP25 Gene

genes like me logo Genes that share paralogs with SAP25: view

No data available for Paralogs for SAP25 Gene

Variants for SAP25 Gene

Sequence variations from dbSNP and Humsavar for SAP25 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12113269 -- 100,571,727(+) AACCA(C/G)CGAGA downstream-variant-500B
rs34397882 -- 100,571,861(+) CATGG(-/G)ACCGG downstream-variant-500B
rs55976595 -- 100,572,283(+) CTGAG(A/G)AGGCT utr-variant-3-prime
rs73156207 -- 100,573,289(+) GGGCC(C/T)GTCCT intron-variant
rs115792910 -- 100,572,399(+) CAACC(A/G)CGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SAP25 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
dgv7400n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888789 CNV Loss 21882294
nsv5868 CNV Loss 18451855

Variation tolerance for SAP25 Gene

Gene Damage Index Score: 0.73; 15.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAP25 Gene

HapMap Linkage Disequilibrium report
SAP25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP25 Gene

Disorders for SAP25 Gene

Relevant External Links for SAP25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAP25
genes like me logo Genes that share disorders with SAP25: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP25 Gene

Publications for SAP25 Gene

  1. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. (PMID: 16449650) Shiio Y. … Eisenman R.N. (Mol. Cell. Biol. 2006) 2 67
  2. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G. … Peterson K. (Mol. Vis. 2002) 67

Products for SAP25 Gene

Sources for SAP25 Gene

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