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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAP25 Gene

protein-coding   GIFtS: 33
GCID: GC07M100171

Sin3A-Associated Protein, 25kDa

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sin3A-Associated Protein, 25kDa1 2
25 KDa Sin3-Associated Polypeptide2 3
Sin3 Corepressor Complex Subunit SAP252 3
Histone Deacetylase Complex Subunit SAP252
Sin3-Associated Polypeptide, 25kDa2
Sin3A-Binding Protein 252

External Ids:    HGNC: 419081   Entrez Gene: 1003169042   Ensembl: ENSG000002053077   UniProtKB: Q8TEE93   

Export aliases for SAP25 gene to outside databases

Previous GC identifer: GC00U923410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SAP25 Gene: 
SAP25 (Sin3A-associated protein, 25kDa) is a protein-coding gene. Diseases associated with SAP25 include retinitis.

UniProtKB/Swiss-Prot: SAP25_HUMAN, Q8TEE9
Function: Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SAP25
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SAP25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAP25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

SAP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAP25 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100171:  view genomic region     (about GC identifiers)

Start:
100,169,851 bp from pter      End:
100,171,270 bp from pter
Size:
1,420 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,529,486-99,530,905     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: SAP25_HUMAN, Q8TEE9 (See protein sequence)
Recommended Name: Histone deacetylase complex subunit SAP25  
Size: 199 amino acids; 20873 Da
Subunit: May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 (By
similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and
the cytoplasm (By similarity)
Sequence caution: Sequence=BAB85001.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Explore the universe of human proteins at neXtProt for SAP25: NX_Q8TEE9

Explore proteomics data for SAP25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEE9

  • SAP25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SAP25 Protein Expression
    REFSEQ proteins: NP_001162153.1  
    ENSEMBL proteins: 
     ENSP00000442339  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    SAP25 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8TEE9


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAP25_HUMAN, Q8TEE9
    Function: Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex
    (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SAP25 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAP25

    5/32 Interacting proteins for SAP25 (Q8TEE92, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CA8P352192, 3MINT-63687 I2D: score=1 
    MDFIQ997502, 3MINT-67726 I2D: score=1 
    RTN4Q9NQC32, 3MINT-66461 I2D: score=1 
    SIN3AQ96ST33I2D: score=3 
    BRMS1Q9HCU93I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    SAP25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAP25

    Search CenterWatch for drugs/clinical trials and news about SAP25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for SAP25 gene: 
    NM_001168682.1  

    Unigene Cluster for SAP25:

    Sin3A-associated protein, 25kDa
    Hs.633863  [show with all ESTs]
    Unigene Representative Sequence: BI518737
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000538735(uc022aip.1)
    miRNA
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    Inhib. RNA
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    6 DOTS entries:

    DT.100779312  DT.121039539  DT.95283647  DT.92434260  DT.95366153  DT.100680477 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAP25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCCAGGG
    SAP25 Expression
    About this image


    See SAP25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAP25

    SOURCE GeneReport for Unigene cluster: Hs.633863
        SABiosciences Custom PCR Arrays for SAP25
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP25

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SAP25 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sap251 , 5 sin3 associated polypeptide1, 5 67.43(n)1
    53.71(a)1
      5 (76.59 cM)5
    7518651  NM_001081962.21  NP_001075431.21 
     1376413345 


    ENSEMBL Gene Tree for SAP25 (if available)
    TreeFam Gene Tree for SAP25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAP25 gene

    SAP25 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SAP25
    PGOHUM00000248219


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/30 SNPs in SAP25 are shown (see all 30)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174596541,2
    C,F--100169413(+) AGTTCG/ATGCAA 1 -- int11Minor allele frequency- A:0.03EA 120
    rs1827180631,2
    --100169532(+) CTCCTC/TTGAGC 1 -- int10--------
    rs1490398701,2
    --100169569(+) ACTGAA/CCTCCT 1 -- int10--------
    rs1874068151,2
    --100169683(+) CAGACC/TACCCA 1 -- int10--------
    rs559765951,2
    C--100169906(+) CTGAGA/GAGGCT 1 -- ut310--------
    rs1157929101,2
    C,F--100170022(+) CAACCG/ACGGAG 2 /A /V mis11Minor allele frequency- A:0.06WA 118
    rs1922606941,2
    --100170197(+) CATCTA/GAGGAG 1 -- int10--------
    rs1848361541,2
    --100170401(+) GTGGCA/GGGCTG 1 -- int10--------
    rs1387659301,2
    C--100170497(+) GGGGCA/GCCTGC 2 A V mis10--------
    rs1162300601,2
    F--100170498(+) GGGCGC/ACTGCT 2 /A /S mis11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for SAP25 (100169851 - 100171270 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SAP25:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv7398n71CNV Loss21882294
    dgv7400n71CNV Loss21882294
    nsv888789CNV Loss21882294
    nsv888779CNV Loss21882294
    dgv7399n71CNV Loss21882294
    nsv831072CNV Loss17160897
    nsv5868CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for SAP25:    About MalaCards
    retinitis    


    SAP25 for disorders           About GeneDecksing


    Export disorders for SAP25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAP25 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SAP25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. (PubMed id 16449650)1, 2, 3 Shiio Y.... Eisenman R.N. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    5. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)1 Wistow G.... Peterson K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100316904 HGNC: 41908 Ensembl:ENSG00000205307 euGenes: HUgn100316904 ECgene: SAP25
    H-InvDB: SAP25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAP25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SAP25 gene:
    Search GeneIP for patents involving SAP25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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