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SAP18 Gene

protein-coding GIFtS: 63

GC13P020612

Sin3A-associated protein, 18kDa
(Previous names: sin3A-associated protein, 18kDa )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
2HOR0202 ^¹, ², ³
MGC27131 ^¹, ²
OTTHUMP00000018107 ^²
SAP18P ^²
SAP18p ^¹

Descriptions
Cell growth-inhibiting protein 38 ^³
Sin3-associated polypeptide p18 ^³
Sin3-associated polypeptide, 18 kDa ^³
Sin3A-associated protein, 18kDa ^¹, ²
cell growth inhibiting protein 38 ^²
histone deacetlyase complex subunit SAP18 ^²
sin3-associated polypeptide, p18 ^²

External Ids
HGNC: 10530¹
Entrez Gene: 10284²
UniProtKB: O00422³
Ensembl: ENSG00000150459⁷

Search outside databases for aliases for SAP18 gene

Previous GC identifers: GC13P019694 GC13P015694 GC13P020644 GC13P019512

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SAP18:

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone

acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this

gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2,

RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances

SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been

identified on chromosome 2. [provided by RefSeq]

UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422

Function: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated

transcriptional repression. When tethered to the promoter, it can direct the formation of a

repressive complex to core histone proteins

Gene Wiki entry for SAP18

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAP18 gene

Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q12.11

SAP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P020612: (about GC identifiers)

Start:	20,612,685 bp from pter
End:	20,620,977 bp from pter
Size:	8,293 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422 (See protein sequence)

Recommended Name: Histone deacetylase complex subunit SAP18

Size: 153 amino acids; 17561 Da

Subunit: Forms a complex with SIN3A and HDAC1

PDB structures from and Proteopedia :

2HDE (3D)

Secondary accessions: Q2TTR4 Q6IAW9 Q8N606 Q9UF14

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005861.2

ENSEMBL proteins:

ENSP00000371973

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SAP18)
	Human Recombinant Proteins from Abnova (SAP18)

OriGene Purified Recombinant Human Protein: SAP18

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000118	histone deacetylase complex	TAS	9150135

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Antibodies for SAP18:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SAP18
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SAP18), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SAP18)
	Novus Biologicals Antibodies for SAP18

Assays for SAP18:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O00422

ProtoNet protein and cluster: O00422

1 Blocks protein family: IPB010516 Sin3 associated polypeptide p18

UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422

Similarity: Belongs to the SAP18 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAP18)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAP18)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005870

Applied Biosystems Silencer® siRNAs for SAP18

Sigma-Aldrich siRNA for SAP18

Sigma-Aldrich shRNA for SAP18

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SAP18
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005870
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005870
untagged cDNA clone in CMV expression vector: NM_005870

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005870

UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422

Function: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated

transcriptional repression. When tethered to the promoter, it can direct the formation of a

repressive complex to core histone proteins

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003714	transcription corepressor activity	TAS	9150135
GO:0005515	protein binding	IPI	9150135 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAP18 (Your Favorite Gene powered by Ingenuity)

DNA Methylation and Transcriptional Repression Signaling

GeneDecks SAP18 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SAP18

5/52 Interacting proteins for SAP18 (ENSP00000371973³ O00422^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HDAC1	Q13547¹	STRING (score=.986) EBI-1044156, EBI-301834
ATP5L	O75964¹	EBI-1044156, EBI-1044001
C6orf211	Q9H993¹	EBI-1044156, EBI-1046033
DDOST	P39656¹	EBI-1044156, EBI-358866
EIF3E	P60228¹	EBI-1044156, EBI-347740

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	9150135

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAP18
2 PharmGKB drug compound relationships for SAP18 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAP18)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SAP18)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005870

Sigma-Aldrich siRNA for SAP18

Sigma-Aldrich shRNA for SAP18

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005870

REFSEQ mRNAs for SAP18 gene:

NM_005870.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005870

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005870
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005870
                                 untagged cDNA clone in CMV expression vector: NM_005870

Additional cDNA sequence:

AF153608.1 AK126385.1 AK311748.1 AY550970.1 BC030836.1 CR457035.1 CR590892.1 CR592416.1

CR608964.1 CR621103.1 CR622577.1 CR623915.1 CR624098.1 CR624201.1 CR625423.1 U78303.1

U96915.1

24/28 DOTS entries (see all 28 ):

DT.100858998 DT.100858990 DT.92452976 DT.100858993 DT.100039100 DT.91707316 DT.100039099 DT.120783842

DT.75174980 DT.100858987 DT.92064862 DT.102824798 DT.97790728 DT.100769059 DT.100858986 DT.100858997

DT.120784024 DT.120784125 DT.97860042 DT.100759574 DT.100858999 DT.120783902 DT.120784107 DT.86840475

24/586 AceView cDNA sequences (see all 586 ):

BI766858 AA300677 BM543417 BF791416 AW292057 BU146799 CD366272 AA906897

CD677214 BQ425837 AW137451 BE673181 CA432834 AW951925 CR592416 AW404948

CA428923 BM982745 AI364517 BM692727 CB178465 BM679975 CD364500 CA308231

highest scoring ESTs for SAP18:

AW006285 AW021542 U96915 AA025356 AA099331 AA121627 AA126817 AA165163 AA292814 AA300677

Unigene Cluster for SAP18:

Sin3A-associated protein, 18kDa

Hs.524899 [show with all ESTs]

Unigene Representative Sequence: AK126385

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SAP18

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:							-				-
SP2:							-		-		-
SP3:							-		-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SAP18

1 Ensembl transcript including schematic representation:

ENST00000382533

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAP18 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAP18

¹ / ² / ³

11 probe-sets matching SAP18 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33859_at²^{, 3}	U95-A	1	1.00	1.00	0.66	1.17	U96915	1.00	1.00	1.00	1
90038_at²^{, 3}	U95-D	1	1.00	1.00	0.65	1.35	AW006624	0.80	1.00	0.91	1
50950_at²^{, 3}	U95-C	1	1.00	1.00	0.92	0.94	AW006285	1.00	1.00	1.00	1
41277_at²^{, 3}	U95-A	2	1.00	0.97	0.95	0.74	AW021542	1.00	1.00	1.00	1
41276_at*²^{, 3}	U95-A	1	--	--	0.62	0.81	W27641	0.60	1.00	0.82	1
208740_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF593650	0.80	1.00	0.91	1
208742_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U78303	0.80	1.00	0.91	1
208741_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW274856	0.80	1.00	0.91	1
208740_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208742_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208741_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SAP18 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGACCATATT

SOURCE GeneReport for Unigene cluster: Hs.524899
Expression variation in blood from EXPOLDB for SAP18
UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAP18 gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	SAP18¹	--	Sin3A-associated protein, 18kDa	99.78(n) 99.35(a)	452467 XM_509567.2 XP_509567.2
cow (Bos taurus)	SAP18¹	--	Sin3A-associated protein, 18kDa	90.85(n) 98.69(a)	615692 NM_001035467.1 NP_001030544.1
rat (Rattus norvegicus)	Sap18¹	--	Sin3-associated polypeptide 18	90.63(n) 98.04(a)	290284 NM_001033685.1 NP_001028857.1
mouse (Mus musculus)	Sap18^{1, 5}	14 (28.50 cM)⁵	Sin3-associated polypeptide 18^{1, 5}	89.98(n)¹ 98.04(a)¹	20220¹ NM_009119.2¹ NP_033145.1¹ AK005189⁵ AK006647⁵ (see all 19)
chicken (Gallus gallus)	SAP18¹	--	Sin3A-associated protein, 18kDa	82.79(n) 98.69(a)	374206 NM_204312.1 NP_989643.1

About this table Species with no ortholog for SAP18

ENSEMBL Gene Tree for SAP18

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/54 NCBI SNPs in SAP18 are shown (see all 54 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 59)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs927911^1,2	A,C,F,H,O	20621281(-)	`AATTCT/CAAAAT`	1	--	ng3¹		12		NA EU EA WA	988
	rs1046530^1,2	A,C,F,H	20620190(+)	`AAGACC/GGAGGG`	1	--	ut3¹ ese³		5		MN EU EA WA	596
	rs3088071^1,2	A,C,F,H	20620557(+)	`TGAACG/AGTACG`	1	--	ut3¹		12		MN NA EU EA WA	1160
	rs7994184^1,2	A,C,F,H	20611065(+)	`aacacC/Ttgcta`	1	--	ng5¹		7		EU EA WA NA	544
	rs17062936^1,2	C,F,H	20620407(+)	`GGCCTA/GTAGGA`	1	--	ut3¹ ese³		7		NA EU EA WA	560
	rs1046537^1,2	A,C,F	20620643(+)	`AGTACT/CAGCAG`	1	--	ut3¹		4		MN NA	324
	rs17062935^1,2	F,H	20620262(+)	`GCTAGG/ATAGTG`	1	--	ut3¹		7		NA EU EA WA	552
--	rs7992986^1,2	A	20611175(+)	`tgcagC/Gctctg`	1	--	ng5¹		0	--	--	--	--
	rs12862079^1,2	H	20620532(+)	`GGCACT/CACTCT`	1	--	ut3¹ ese³		4		EU EA WA	412
	rs12865053^1,2	H	20611001(+)	`tctaaA/Ggcagg`	1	--	ng5¹		4		EU EA WA	402

About this table

HapMap Linkage Disequilibrium images for SAP18 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602949

1 PharmGKB disease relationship for SAP18 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12086872 12704389

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/20 PubMed articles for SAP18 gene (see all 20 ):

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. (PubMed id 9150135)^{1, 2, 3, 4} Zhang Y.... Reinberg D. (1997)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. (PubMed id 17002296)^{1, 3} McCallum S.A....Fairbrother W.J. (2006)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. (PubMed id 16537548)³ Joselin A.P....Schwerk C. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Nucleolar proteome dynamics. (PubMed id 15635413)³ Andersen J.S....Mann M. (2005)
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. (PubMed id 14611647)³ Paces-Fessy M....Blanchet-Tournier M.F. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10284	HGNC: 10530	AceView: SAP18	Ensembl:ENSG00000150459	euGenes: HUgn10284
ECgene: SAP18	H-InvDB: SAP18

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for SAP18	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SAP18
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SAP18:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAP18-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAP18		Antibodies for SAP18
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAP18		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SAP18)
	Antibodies (SAP18)
	Chimera RNAi (SAP18)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (SAP18)
	Antibodies (SAP18)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for SAP18

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SAP18

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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SAP18 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for SAP18

Summaries
for SAP18

Genomic Location
for SAP18

Proteins
for SAP18

Protein Domains/
Families
for SAP18

Gene Function
for SAP18

Pathways & Interactions
for SAP18

Drugs & Compounds
for SAP18

Transcripts
for SAP18

Expression
for SAP18

Orthologs
for SAP18

Paralogs
for SAP18

SNPs/Variants
for SAP18

Disorders & Mutations
for SAP18

Medical News
for SAP18

Publications
for SAP18

Search for SAP18

Genome Databases showing SAP18

Other Databases showing SAP18

Specialized Databases showing SAP18

Licensable Technologies
for SAP18

Services
for SAP18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAP18 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor SAP18

Summariesfor SAP18

Genomic Locationfor SAP18

Proteinsfor SAP18

Protein Domains/Familiesfor SAP18

Gene Functionfor SAP18

Pathways & Interactionsfor SAP18

Drugs & Compoundsfor SAP18

Transcriptsfor SAP18

Expression for SAP18

Orthologsfor SAP18

Paralogsfor SAP18

SNPs/Variantsfor SAP18

Disorders & Mutationsfor SAP18

Medical Newsfor SAP18

Publicationsfor SAP18

Search for SAP18

Genome Databases showing SAP18

Other Databases showing SAP18

Specialized Databases showing SAP18

Licensable Technologiesfor SAP18

Servicesfor SAP18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAP18

Summaries
for SAP18

Genomic Location
for SAP18

Proteins
for SAP18

Protein Domains/
Families
for SAP18

Gene Function
for SAP18

Pathways & Interactions
for SAP18

Drugs & Compounds
for SAP18

Transcripts
for SAP18

Expression
for SAP18

Orthologs
for SAP18

Paralogs
for SAP18

SNPs/Variants
for SAP18

Disorders & Mutations
for SAP18

Medical News
for SAP18

Publications
for SAP18

Licensable Technologies
for SAP18

Services
for SAP18