Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAP18 Gene

protein-coding   GIFtS: 61
GCID: GC13P021714

Sin3A-Associated Protein, 18kDa

(Previous names: sin3A-associated protein, 18kDa)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sin3A-Associated Protein, 18kDa1 2     Cell Growth Inhibiting Protein 382
Cell Growth-Inhibiting Gene 38 Protein2 3     Cell Growth-Inhibiting Protein 382
Sin3-Associated Polypeptide P182 3     Histone Deacetlyase Complex Subunit SAP182
18 KDa Sin3-Associated Polypeptide2 3     Histone Deacetylase Complex Subunit SAP182
2HOR02022 3     Sin3-Associated Polypeptide, 18 KDa2
SAP18P2     Sin3-Associated Polypeptide, P182

External Ids:    HGNC: 105301   Entrez Gene: 102842   Ensembl: ENSG000001504597   OMIM: 6029495   UniProtKB: O004223   

Export aliases for SAP18 gene to outside databases

Previous GC identifers: GC13P019694 GC13P015694 GC13P020644 GC13P019512 GC13P020612 GC13P002516


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SAP18 Gene:
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and
deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the
histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides.
This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to
the promoter. A pseudogene has been identified on chromosome 2. (provided by RefSeq, Dec 2008)

GeneCards Summary for SAP18 Gene: 
SAP18 (Sin3A-associated protein, 18kDa) is a protein-coding gene. Diseases associated with SAP18 include rubinstein-taybi syndrome, and nevoid basal cell carcinoma syndrome, and among its related super-pathways are Transcription Ligand-Dependent Transcription of Retinoid-Target genes and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include protein binding and transcription corepressor activity.

UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422
Function: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional
repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone
proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction
on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear
and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
subsequent mRNA metabolism

Gene Wiki entry for SAP18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAP18 gene promoter:
         AhR   SRF   TBP   SRF (504 AA)   FOXD3   GATA-1   TFIID   HOXA5   COMP1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAP18 promoter sequence
   Search SABiosciences Chromatin IP Primers for SAP18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAP18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.11

SAP18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAP18 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P021714:  view genomic region     (about GC identifiers)

Start:
21,714,653 bp from pter      End:
21,723,224 bp from pter
Size:
8,572 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422 (See protein sequence)
Recommended Name: Histone deacetylase complex subunit SAP18  
Size: 153 amino acids; 17561 Da
Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3,
EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Found in a heterotrimeric complex with ACIN1, RNPS1 and
SAP18. Forms a complex with SIN3A and HDAC1
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
1 PDB 3D structure from and Proteopedia for SAP18:
2HDE (3D)    
Secondary accessions: B2R494 Q2TTR4 Q6IAW9 Q8N606 Q9UF14

Explore the universe of human proteins at neXtProt for SAP18: NX_O00422

Explore proteomics data for SAP18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00422

  • SAP18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SAP18 Protein Expression
    REFSEQ proteins: NP_005861.2  
    ENSEMBL proteins: 
     ENSP00000371973   ENSP00000475925   ENSP00000475435   ENSP00000391846   ENSP00000475358  

    Human Recombinant Protein Products for SAP18: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SAP18
    OriGene Protein Over-expression Lysate for SAP18
    OriGene MassSpec for SAP18 
    OriGene Custom Protein Services for SAP18
    GenScript Custom Purified and Recombinant Proteins Services for SAP18
    Novus Biologicals SAP18 Proteins
    Novus Biologicals SAP18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SAP18
    Cloud-Clone Corp. Proteins for SAP18 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex TAS9150135
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA--

    SAP18 for ontologies           About GeneDecksing



    SAP18 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SAP18
    GenScript Custom Superior Antibodies Services for SAP18
    Novus Biologicals SAP18 Antibodies
    Abcam antibodies for SAP18
    Cloud-Clone Corp. Antibodies for SAP18 
    Search ThermoFisher Antibodies for SAP18
    LSBio Antibodies in human, mouse, rat for SAP18 

    Assay Products for SAP18: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAP18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAP18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SAP18 
    Cloud-Clone Corp. CLIAs for SAP18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR010516 SAP18
     IPR017250 Hist_deAcase_cplx_SAP18

    Graphical View of Domain Structure for InterPro Entry O00422

    ProtoNet protein and cluster: O00422

    1 Blocks protein domain: IPB010516 Sin3 associated polypeptide p18

    UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422
    Similarity: Belongs to the SAP18 family


    SAP18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAP18_HUMAN, O00422
    Function: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional
    repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone
    proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction
    on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear
    and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
    subsequent mRNA metabolism

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS9150135
    GO:0005515protein binding IPI9150135
         
    SAP18 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SAP18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAP18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SAP18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SAP18 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAP18
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SAP18 (see all 11):
    hsa-miR-4328 hsa-miR-586 hsa-miR-578 hsa-miR-1279 hsa-miR-3158-3p hsa-miR-3154 hsa-miR-466 hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidSAP18 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAP18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAP18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAP18
    Sirion Biotech Customized adenovirus for overexpression of SAP18

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SAP18 (see all 10)
    OriGene ORF clones in mouse, rat for SAP18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAP18 (NM_005870)
    Sino Biological Human cDNA Clone for SAP18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAP18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP18
    Sirion Biotech Customized lentivirus for stable overexpression of SAP18 
                         Customized lentivirus expression plasmids for stable overexpression of SAP18 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAP18
    Search LifeMap BioReagents cell lines for SAP18
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SAP18 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00
    2Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    3Hedgehog Signaling Pathway
    Hedgehog Signaling Pathway0.32
    4DNA Methylation and Transcriptional Repression
    DNA Methylation and Transcriptional Repression0.30
    5mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SAP18
        Transcription Sin3 and NuRD in transcription regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SAP18
        DNA Methylation and Transcriptional Repression

    2 GeneGo (Thomson Reuters) Pathways for SAP18
        Transcription Sin3 and NuRD in transcription regulation
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5 BioSystems Pathways for SAP18
        Hedgehog Signaling Pathway
    Signaling events mediated by HDAC Class I
    Hedgehog signaling events mediated by Gli proteins
    Regulation of nuclear SMAD2/3 signaling
    Regulation of Telomerase



    2         Kegg Pathways  (Kegg details for SAP18):
        RNA transport
    mRNA surveillance pathway


    SAP18 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SAP18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/123 Interacting proteins for SAP18 (O004221, 2, 3 ENSP000003719734) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM39Q144982, 3, ENSP000002533634MINT-8335341 I2D: score=1 STRING: ENSP00000253363
    TADA3O755282, 3MINT-63206 I2D: score=5 
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9150135

    SAP18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SAP18

    Search CenterWatch for drugs/clinical trials and news about SAP18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SAP18 gene: 
    NM_005870.4  

    Unigene Cluster for SAP18:

    Sin3A-associated protein, 18kDa
    Hs.524899  [show with all ESTs]
    Unigene Representative Sequence: AK126385
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382533(uc001uns.3) ENST00000607003 ENST00000485646 ENST00000492245
    ENST00000450573 ENST00000467636 ENST00000471009
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SAP18
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SAP18 (see all 11):
    hsa-miR-4328 hsa-miR-586 hsa-miR-578 hsa-miR-1279 hsa-miR-3158-3p hsa-miR-3154 hsa-miR-466 hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidSAP18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SAP18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAP18
    Clone
    Products:
         
    OriGene clones in human, mouse for SAP18 (see all 10)
    OriGene ORF clones in mouse, rat for SAP18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SAP18 (NM_005870)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAP18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP18
    Sirion Biotech Customized lentivirus for stable overexpression of SAP18 
                         Customized lentivirus expression plasmids for stable overexpression of SAP18 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SAP18
    OriGene qSTAR qPCR primer pairs in human, mouse for SAP18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAP18
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAP18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAP18

    Additional mRNA sequence: 

    AF153608.1 AK126385.1 AK311748.1 AY550970.1 BC030836.1 CR457035.1 DQ866754.1 U78303.1 
    U96915.1 

    24/28 DOTS entries (see all 28):

    DT.100858998  DT.100858990  DT.92452976  DT.100858993  DT.100039100  DT.91707316  DT.100039099  DT.75174980 
    DT.120783842  DT.100858987  DT.102824798  DT.97790728  DT.100769059  DT.100858986  DT.100858997  DT.120784024 
    DT.120784125  DT.92064862  DT.97860042  DT.100759574  DT.100858999  DT.120783902  DT.120784107  DT.86840475 

    24/586 AceView cDNA sequences (see all 586):

    H88057 CR621103 CB132779 BM982745 AA346556 AA025348 BM826754 CD677214 
    BQ212031 CB119218 BI766858 BM800150 CR625423 CA432834 BX281475 W67546 
    CD237476 BM818919 AI973131 BU784608 CA771876 BM692727 CB114702 BU146799 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SAP18    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:                    -           -                           
    SP2:                    -     -     -                           
    SP3:                    -     -     -     -                     
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for SAP18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAP18 expression in normal human tissues (normalized intensities)      SAP18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACCATATT
    SAP18 Expression
    About this image


    SAP18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See SAP18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SAP18

    SOURCE GeneReport for Unigene cluster: Hs.524899

    UniProtKB/Swiss-Prot: SAP18_HUMAN, O00422
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for SAP18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SAP18
    OriGene qSTAR qPCR primer pairs in human, mouse for SAP18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SAP18
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAP18
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAP18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SAP18 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sap181 , 5 Sin3-associated polypeptide 181, 5 90.31(n)1
    97.67(a)1
      14 (30.51 cM)5
    202201  NM_009119.31  NP_033145.21 
     577981805 
    chicken
    (Gallus gallus)
    Aves SAP181 Sin3A-associated protein, 18kDa 82.79(n)
    98.69(a)
      374206  NM_204312.1  NP_989643.1 
    lizard
    (Anolis carolinensis)
    Reptilia SAP186
    Uncharacterized protein
    95(a)
    1 ↔ 1
    3(187765115-187770004)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.86092 Xenopus laevis transcribed sequence with strong similarity more 76.77(n)    BJ071584.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059482.12   -- 75.68(n)   393693  BC059482.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bin11 , 3 negative regulation of transcription
    from Pol more3
    Bicoid interacting protein 11
    57(a)3
    58.28(n)1
    59.18(a)1
      89B123
    419651  NM_079653.21  NP_524377.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C16C10.43
    CELE_C16C10.41
    Protein C16C10.41 54(a)3
    58.13(n)1
    56(a)1
      III(4243139-4243864)3
    1755341  NM_065432.31  NP_497833.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SAP181 histone deacetylase complex subunit SAP18 55.56(n)
    54.26(a)
      819172  NM_130126.3  NP_566050.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01220001 hypothetical protein 59.6(n)
    59.32(a)
      4328127  NM_001052258.1  NP_001045723.1 


    ENSEMBL Gene Tree for SAP18 (if available)
    TreeFam Gene Tree for SAP18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAP18 gene

    SAP18 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SAP18
    PGOHUM00000237469 PGOHUM00000241036 PGOHUM00000259819 PGOHUM00000260083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 SNPs in SAP18 are shown (see all 249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391665201,2
    C--21712666(+) TCTTTG/TAGTAT 1 -- us2k10--------
    rs1135427881,2
    F--21712708(+) CATACA/CGTAAA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs786493601,2
    C,F--21712806(+) TGCTTT/CATAGT 1 -- us2k11Minor allele frequency- C:0.14WA 118
    rs1815101781,2
    --21712808(+) CTTTAC/TAGTAT 1 -- us2k10--------
    rs789339071,2
    F--21712826(+) TTGATT/GGGTAG 1 -- us2k11Minor allele frequency- G:0.08WA 118
    rs766977861,2
    F--21712839(+) TTATTG/TCTGTC 1 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1145539021,2
    F--21712874(+) GTCCTA/CCTGTT 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1431387331,2
    --21712922(+) TGAACA/GATATA 1 -- us2k10--------
    rs1474526801,2
    --21712926(+) CAATAC/TAGCTA 1 -- us2k10--------
    rs619503311,2
    C,F--21712984(+) TAGGGT/CAAGTA 1 -- us2k16Minor allele frequency- C:0.12NA CSA EA 248

    HapMap Linkage Disequilibrium report for SAP18 (21714653 - 21723224 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SAP18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1278877CNV Deletion17803354
    nsv899878CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SAP18
    DNA2.0 Custom Variant and Variant Library Synthesis for SAP18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602949    OMIM disorders: --

    4 diseases for SAP18:    About MalaCards
    rubinstein-taybi syndrome    nevoid basal cell carcinoma syndrome    pallister-hall syndrome    basal cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for SAP18:
    Pallister-Hall syndrome

    SAP18 for disorders           About GeneDecksing


    Export disorders for SAP18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAP18 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with SAP18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. (PubMed id 9150135)1, 2, 3, 9 Zhang Y.... Reinberg D. (1997)
    2. Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. (PubMed id 16314458)1, 2 Tange T.O.... Moore M.J. (2005)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. (PubMed id 17002296)1, 9 McCallum S.A....Fairbrother W.J. (2006)
    6. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10284 HGNC: 10530 AceView: SAP18 Ensembl:ENSG00000150459 euGenes: HUgn10284
    ECgene: SAP18 Kegg: 10284 H-InvDB: SAP18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAP18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAP18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SAP18 gene:
    Search GeneIP for patents involving SAP18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SAP18  
     OriGene qPCR primer pairs and template standards for SAP18   OriGene Protein Over-expression Lysate for SAP18  
     OriGene MassSpec something-or-other for SAP18   OriGene clones in human, mouse for SAP18  
     OriGene qSTAR qPCR primer pairs in human, mouse for SAP18   OriGene Purified Protein for SAP18  
     OriGene ORF clones in mouse, rat for SAP18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SAP18   OriGene Custom Protein Services for SAP18  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAP18
     QIAGEN SeqTarget long-range PCR primers for resequencing SAP18
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAP18
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SAP18
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAP18
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SAP18
     GenScript Custom Purified and Recombinant Proteins Services for SAP18 GenScript cDNA clones with any tag delivered in your preferred vector for SAP18
     GenScript Custom Assay Services for SAP18 GenScript Custom Superior Antibodies Services for SAP18
     GenScript Custom overexpressing Cell Line Services for SAP18 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SAP18 promoter
     Search Chromatin IP Primers for SAP18
     RT2 qPCR Primer Assay in human, mouse, rat SAP18
     GNC Network for SAP18
     SABiosciences PCR Arrays including human, mouse, rat SAP18
     Search Tocris compounds for SAP18
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SAP18
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SAP18 antibodies
     SAP18 proteins
     SAP18 lysates
     Antibodies for SAP18
     See all of Abcam's Antibodies, Kits and Proteins for SAP18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SAP18




     Proteins for SAP18
     Antibodies for SAP18
     ELISAs for SAP18
     CLIAs for SAP18
     Search LifeMap BioReagents cell lines for SAP18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAP18
     SwitchGear 3'UTR luciferase reporter plasmids for SAP18
     SwitchGear Promoter luciferase reporter plasmids for SAP18
     Search ThermoFisher Antibodies for SAP18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAP18
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SAP18
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SAP18
    Customized:
     lentivirus for stable overexpression of SAP18
     lentivirus expression plasmids for stable overexpression of SAP18
     adenovirus for overexpression of SAP18
     LSBio Antibodies in human, mouse, rat for SAP18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SAP18 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4