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Aliases for SAP130 Gene

Aliases for SAP130 Gene

  • Sin3A-Associated Protein, 130kDa 2 3
  • 130 KDa Sin3-Associated Polypeptide 4
  • Sin3-Associated Polypeptide P130 4

External Ids for SAP130 Gene

Summaries for SAP130 Gene

Entrez Gene Summary for SAP130 Gene

  • SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SAP130 Gene

SAP130 (Sin3A-Associated Protein, 130kDa) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and RNA Polymerase I Promoter Opening. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity.

UniProtKB/Swiss-Prot for SAP130 Gene

  • Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Wiki entry for SAP130 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP130 Gene

Genomics for SAP130 Gene

Genomic Location for SAP130 Gene

Start:
127,941,217 bp from pter
End:
128,028,120 bp from pter
Size:
86,904 bases
Orientation:
Minus strand

Genomic View for SAP130 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAP130 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP130 Gene

Regulatory Elements for SAP130 Gene

Proteins for SAP130 Gene

  • Protein details for SAP130 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0E3-SP130_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP130
    Protein Accession:
    Q9H0E3
    Secondary Accessions:
    • B7ZLM3
    • C9K0X9
    • Q4ZFV4
    • Q53T46
    • Q8WVW4
    • Q9H9G8

    Protein attributes for SAP130 Gene

    Size:
    1048 amino acids
    Molecular mass:
    110324 Da
    Quaternary structure:
    • Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts (released by dead or dying cells) with CLEC4E (By similarity).

    Alternative splice isoforms for SAP130 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAP130 Gene

Proteomics data for SAP130 Gene at MOPED

Post-translational modifications for SAP130 Gene

Other Protein References for SAP130 Gene

No data available for DME Specific Peptides for SAP130 Gene

Domains for SAP130 Gene

Protein Domains for SAP130 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SP130_HUMAN
Domain:
  • The N-terminus may interact with a transcriptional coactivator:
    • Q9H0E3
  • The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors:
    • Q9H0E3
Family:
  • Belongs to the SAP130 family.:
    • Q9H0E3
genes like me logo Genes that share domains with SAP130: view

No data available for Gene Families for SAP130 Gene

Function for SAP130 Gene

Molecular function for SAP130 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Ontology (GO) - Molecular Function for SAP130 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SAP130: view
genes like me logo Genes that share phenotypes with SAP130: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SAP130 Gene

Localization for SAP130 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP130 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAP130 Gene COMPARTMENTS Subcellular localization image for SAP130 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SAP130 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with SAP130: view

Pathways for SAP130 Gene

genes like me logo Genes that share pathways with SAP130: view

Pathways by source for SAP130 Gene

Gene Ontology (GO) - Biological Process for SAP130 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22783022
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0010467 gene expression TAS --
GO:0040029 regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with SAP130: view

Transcripts for SAP130 Gene

Unigene Clusters for SAP130 Gene

Sin3A-associated protein, 130kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAP130 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - -
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6: -
SP7: - - - - - - - - - - - -
SP8: - - -
SP9: - -
SP10: -
SP11:

ExUns: 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SAP130 Gene

GeneLoc Exon Structure for
SAP130
ECgene alternative splicing isoforms for
SAP130

Expression for SAP130 Gene

mRNA expression in normal human tissues for SAP130 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAP130 Gene

SOURCE GeneReport for Unigene cluster for SAP130 Gene Hs.32995

mRNA Expression by UniProt/SwissProt for SAP130 Gene

Q9H0E3-SP130_HUMAN
Tissue specificity: Expressed in various cancer cell ines.
genes like me logo Genes that share expressions with SAP130: view

Orthologs for SAP130 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP130 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAP130 36
  • 99.63 (n)
  • 100 (a)
SAP130 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAP130 36
  • 90.67 (n)
  • 97.05 (a)
SAP130 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAP130 36
  • 91.72 (n)
  • 97.14 (a)
SAP130 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sap130 36
  • 88.35 (n)
  • 93.75 (a)
Sap130 16
Sap130 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAP130 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAP130 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sap130 36
  • 87.36 (n)
  • 93.41 (a)
chicken
(Gallus gallus)
Aves SAP130 36
  • 78.4 (n)
  • 88.14 (a)
SAP130 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAP130 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15283 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127690 36
  • 67.32 (n)
  • 71.46 (a)
Str.15929 36
zebrafish
(Danio rerio)
Actinopterygii sap130a 37
  • 59 (a)
OneToMany
sap130b 36
  • 64.57 (n)
  • 63.82 (a)
sap130b 37
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sap130 37
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToOne
Species with no ortholog for SAP130:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAP130 Gene

ENSEMBL:
Gene Tree for SAP130 (if available)
TreeFam:
Gene Tree for SAP130 (if available)

Paralogs for SAP130 Gene

No data available for Paralogs for SAP130 Gene

Variants for SAP130 Gene

Sequence variations from dbSNP and Humsavar for SAP130 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs751602 -- 127,984,364(-) ccaaa(A/G)cacct intron-variant
rs1079066 -- 127,983,626(+) TGACA(A/G)GCTGT intron-variant
rs1370229 -- 127,942,259(+) TGAGG(C/T)TTCCA intron-variant
rs1550174 -- 127,996,280(+) CACTT(C/T)GTTTT intron-variant
rs1898341 -- 127,963,108(+) TAGCC(A/G)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAP130 Gene

Variant ID Type Subtype PubMed ID
nsv834367 CNV Loss 17160897
nsv508865 CNV Insertion 20534489
esv2720731 CNV Deletion 23290073
esv4100 CNV Deletion 18987735
esv2720732 CNV Deletion 23290073
esv1357413 CNV Deletion 17803354
esv2720733 CNV Deletion 23290073
esv2720734 CNV Deletion 23290073
esv2720735 CNV Deletion 23290073

Relevant External Links for SAP130 Gene

HapMap Linkage Disequilibrium report
SAP130

Disorders for SAP130 Gene

Relevant External Links for SAP130

Genetic Association Database (GAD)
SAP130
Human Genome Epidemiology (HuGE) Navigator
SAP130
genes like me logo Genes that share disorders with SAP130: view

No data available for UniProtKB/Swiss-Prot for SAP130 Gene

Publications for SAP130 Gene

  1. Identification and characterization of three new components of the mSin3A corepressor complex. (PMID: 12724404) Fleischer T.C. … Ayer D.E. (Mol. Cell. Biol. 2003) 2 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PMID: 15561718) Gocke C.B. … Kang J. (J. Biol. Chem. 2005) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for SAP130 Gene

  • antibodies-online peptides for SAP130
  • antibodies-online antibodies for SAP130
  • antibodies-online kits for SAP130

Sources for SAP130 Gene

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