Aliases for SAP130 Gene
External Ids for SAP130 Gene
Previous GeneCards Identifiers for SAP130 Gene
SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SAP130 Gene
SAP130 (Sin3A Associated Protein 130) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription coactivator activity and histone acetyltransferase activity.
UniProtKB/Swiss-Prot for SAP130 Gene
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.