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Aliases & Descriptions for SAP130
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| 130 kDa Sin3-associated polypeptide 3 | | Sin3-associated polypeptide p130 2, 3 | | Sin3A-associated protein, 130kDa 1, 2 | | histone deacetylase complex subunit SAP130 2 | | mSin3A-associated protein 130 2 |
|
| | Search outside databases for aliases for SAP130 genePrevious GC identifers: GC02M128603 GC02M128792 |
Summaries for SAP130(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SAP130: SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM] UniProtKB/Swiss-Prot: SP130_HUMAN, Q9H0E3Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexesGene Wiki entry for SAP130 |
Genomic Location for SAP130
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAP130 gene 
Entrez Gene cytogenetic band: 2q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q14.3SAP130 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M128415:
(about GC identifiers)
Start:
|
128,415,262 bp from pter |
End:
|
128,502,164 bp from pter |
Size:
|
86,903 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022135.15
| Proteins for SAP130
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SP130_HUMAN, Q9H0E3 (See
protein sequence)Recommended Name: Histone deacetylase complex subunit SAP130 Size: 1048 amino acids; 110324 Da
Subunit: Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q4ZFV4 Q53T46 Q8WVW4 Q9H9G8Alternative splicing: 2 isoforms: Q9H0E3-1 Q9H0E3-2 Post-translational modifications:
Acetylated (Probable)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001139400.1 NP_078821.2
ENSEMBL proteins: ENSP00000259235 ENSP00000386740 ENSP00000259234 ENSP00000350333
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for SAP130: Assays for SAP130: | Protein
Domains/ Families for SAP130(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H0E3 UniProtKB/Swiss-Prot: SP130_HUMAN, Q9H0E3Domain: The N-terminus may interact with a transcriptional coactivatorDomain: The C-terminus may interact with HDAC-dependent and HDAC-independent corepressorsSimilarity: Belongs to the SAP130 family | Gene Function for SAP130
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024545
Applied Biosystems Silencer® siRNAs for SAP130
Sigma-Aldrich siRNA for SAP130  Sigma-Aldrich shRNA for SAP130  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024545                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024545                                  untagged cDNA clone in CMV expression vector: NM_024545 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024545
UniProtKB/Swiss-Prot: SP130_HUMAN, Q9H0E3Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes | Pathways & Interactions for SAP130
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for SAP130 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for SAP130 (Q9H0E32) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for SAP130(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAP130
|
Transcripts for SAP130(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024545
Sigma-Aldrich siRNA for SAP130  Sigma-Aldrich shRNA for SAP130  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024545 REFSEQ mRNAs for SAP130 gene (2 alternative transcripts): NM_001145928.1 NM_024545.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024545               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024545                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024545                                  untagged cDNA clone in CMV expression vector: NM_024545  Additional cDNA sequence: AK022823.1 AK055979.1 AK092234.1 AK315185.1 AL136833.1 AY220791.1 BC017453.1 BC117255.1 BC143898.1 CR610925.1 11 DOTS entries: DT.95272989 DT.100755412 DT.97844302 DT.40193170 DT.99947956 DT.100755418 DT.120951135 DT.92432942 DT.95272987 DT.95318104 DT.101984247 24/169 AceView cDNA sequences (see all 169
):BU855804 AA421476 BQ001004 BF507582 BM974962 BM981502 BM999957 BQ004698 BM666139 AA301138 CA951054 CA438415 AK055979 BM798273 NM_024545 CD675140 BM711051 BP353559 BQ002080 AK022823 BC017453 BU626180 BM461013 AL514244
highest scoring ESTs for SAP130:AI936906 AK055979 AL136833 AL557379 BU167898 AA233350 AA233443 AA234748 AA235147 AA251193 Unigene Cluster for SAP130: Sin3A-associated protein, 130kDa Hs.32995 [show with all ESTs]Unigene Representative Sequence: NM_001145928
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SAP130 (see all 11
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |
| SP5: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 20a | · | 20b | · | 20c | · | 20d | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SAP130
4 Ensembl transcripts including schematic representations: ENST00000259235
ENST00000409388
ENST00000259234
ENST00000357702
|
Expression for SAP130
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAP130 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAP130
1 / 2 / 3 7 probe-sets matching SAP130 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGGCCTTTT
SOURCE GeneReport for Unigene cluster: Hs.32995 UniProtKB/Swiss-Prot: SP130_HUMAN, Q9H0E3Tissue specificity: Expressed in various cancer cell ines |
Orthologs for SAP130
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAP130 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for SAP130
ENSEMBL Gene Tree for SAP130 | Paralogs for SAP130(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for SAP130(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAP130 (up to first 250kb)
|
Disorders & Mutations for SAP130
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609697
|
Medical News for SAP130(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAP130 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for SAP130 gene (see all 16
):- Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 2, 3, 4 Fleischer T.C....Ayer D.E. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2, 3, 4 Wiemann S.... Poustka A. (2001)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. (PubMed id 19088080)3 Truty M.J....Urrutia R. (2009)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)4 Imami K.... Ishihama Y. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)3 Colland F....Gauthier J.M. (2004)
|
Search for SAP130
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAP130
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAP130
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAP130(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAP130(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SAP130:

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| | | | Search Tocris compounds for SAP130 |
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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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