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SAMSN1 Gene

protein-coding   GIFtS: 55
GCID: GC21M015857

SAM Domain, SH3 Domain And Nuclear Localization Signals...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
SAM Domain, SH3 Domain And Nuclear Localization Signals 11 2     Gene With Homology To KIAA0790 Protein11
HACS12 3 5     NASH12
Hematopoietic Adapter-Containing SH3 And Sterile α-Motif (SAM)
Domains 11 2
     SASH22
SAM And SH3 Domain Containing 21 2     SH3D6B2
Src Homology Domain 3 (SH3)-Containing Adapter Protein SH3 Lymphocyte
Protein 21 2
     SLy22
Hematopoietic Adaptor Containing SH3 And SAM Domains 12 3     Hematopoietic Adapter-Containing SH3 And Sterile Alpha-Motif (SAM) Domains
12
SAM Domain, SH3 Domain And Nuclear Localization Signals Protein 12 3     Nuclear Localization Signals, SAM And SH3 Domain Containing 12
SH3-SAM Adaptor Protein2 3     SAM Domain, SH3 Domain And Nuclear Localisation Signals, 12
Nuclear Localization Signals1     SAM Domain-Containing Protein SAMSN-12
SAM And SH3 Domain Containing 11     Nash13

External Ids:    HGNC: 105281   Entrez Gene: 640922   Ensembl: ENSG000001553077   OMIM: 6079785   UniProtKB: Q9NSI83   

Export aliases for SAMSN1 gene to outside databases

Previous GC identifers: GC21M012521 GC21M014779 GC21M001240


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SAMSN1 Gene:
SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM
(sterile alpha motif) domains (Claudio et al., 2001 (PubMed 11536050)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SAMSN1 Gene:
SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1) is a protein-coding gene. Diseases associated with SAMSN1 include atherosclerosis, and lung cancer. GO annotations related to this gene include phosphotyrosine binding. An important paralog of this gene is SASH3.

UniProtKB/Swiss-Prot: SAMN1_HUMAN, Q9NSI8
Function: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes
RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading
and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine
phosphorylation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAMSN1 gene promoter:
         AML1a   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAMSN1 promoter sequence

   Search Chromatin IP Primers for SAMSN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAMSN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11   Ensembl cytogenetic band:  21q11.2   HGNC cytogenetic band: 21q11
Nature(405: 311-319) cytogenetic band:   21q11
SAMSN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMSN1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M015857:   GeneLoc Nature:405,311-319
Start:
15,857,549 bp from pter       1,521,779 bp from centromere
End:
15,955,723 bp from pter 1,582,895 bp from centromere
Size:
98,175 bases 61,117 bases
Orientation:
minus strand minus strand

genomic clones: P31B5 CIT39I12


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SAMN1_HUMAN, Q9NSI8 (See protein sequence)
Recommended Name: SAM domain-containing protein SAMSN-1  
Size: 373 amino acids; 41708 Da
Subunit: Interacts with FASLG. Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with
CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly
with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1 (By similarity)
1 PDB 3D structure from and Proteopedia for SAMSN1:
2KEA (3D)    
Secondary accessions: B3KWJ3 Q8NFF7 Q9C041
Alternative splicing: 3 isoforms:  Q9NSI8-1   Q9NSI8-2   Q9NSI8-3   

Explore the universe of human proteins at neXtProt for SAMSN1: NX_Q9NSI8

Explore proteomics data for SAMSN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAMSN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243299.1  NP_001273452.1  NP_071419.3  

    ENSEMBL proteins: 
     ENSP00000383409   ENSP00000383411   ENSP00000285670  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SASH: SAM and SH3 domain containing
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 6):
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021090 rSAM/SH3_domain-containing

    Graphical View of Domain Structure for InterPro Entry Q9NSI8

    ProtoNet protein and cluster: Q9NSI8

    4 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: SAMN1_HUMAN, Q9NSI8
    Similarity: Contains 1 SAM (sterile alpha motif) domain
    Similarity: Contains 1 SH3 domain


    SAMSN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAMN1_HUMAN, Q9NSI8
    Function: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes
    RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading
    and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine
    phosphorylation (By similarity)
    Induction: Up-regulated in peripheral blood B-cells by IL4, IL13 and by CD40 stimulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IDA15381729
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    SAMSN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SAMSN1:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Samsn1):
     hematopoietic system  homeostasis/metabolism  immune system 

    SAMSN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Samsn1tm1Xyw for SAMSN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SAMSN1
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    miRTarBase miRNAs that target SAMSN1:
    hsa-mir-124-3p (MIRT022936), hsa-mir-132-3p (MIRT021787), hsa-mir-7-5p (MIRT025914)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAMN1_HUMAN, Q9NSI8: Nucleus. Cytoplasm (By similarity). Cell projection, ruffle (By similarity). Note=Shuttles
    between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005634nucleus IDA11594764
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol ----

    SAMSN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAMSN1
    Interactions:

        Search GeneGlobe Interaction Network for SAMSN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SAMSN1 (Q9NSI83 ENSP000003834114) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    SFNP319473, ENSP000003409894I2D: score=1 STRING: ENSP00000340989
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002820negative regulation of adaptive immune response ISS--
    GO:0050732negative regulation of peptidyl-tyrosine phosphorylation ISS--
    GO:0050869negative regulation of B cell activation ISS--

    SAMSN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAMSN1 (SAMN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SAMSN1 gene (3 alternative transcripts): 
    NM_001256370.1  NM_001286523.1  NM_022136.4  

    Unigene Cluster for SAMSN1:

    SAM domain, SH3 domain and nuclear localization signals 1
    Hs.473341  [show with all ESTs]
    Unigene Representative Sequence: AF218085
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400564 ENST00000400566(uc002yju.1 uc010gky.1) ENST00000285670(uc002yjv.1)
    ENST00000463807 ENST00000493640
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      QuantiTect SYBR Green Assays in human, mouse, rat SAMSN1
      QuantiFast Probe-based Assays in human, mouse, rat SAMSN1

    Additional mRNA sequence: 

    AF218085.2 AF222927.1 AF519621.1 AK125144.1 BC020638.1 BC029112.1 

    7 DOTS entries:

    DT.310172  DT.100674977  DT.40315641  DT.92422306  DT.95265495  DT.100767140  DT.92422302 

    Selected AceView cDNA sequences (see all 81):

    CA307579 AA747998 AA741162 CD677382 BM795668 BC029112 BM714776 AF222927 
    AI635436 AA831672 AI357169 N67227 NM_022136 AI223999 BF796389 AW297416 
    AK125144 AI000065 BG534043 AW439548 BC020638 AI823872 AV756882 BG492933 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SAMSN1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:        -     -     -                 -                                   -     -               
    SP2:                    -                 -                                   -     -               
    SP3:                    -     -     -     -     -     -     -                 -     -               
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SAMSN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SAMSN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACATAAGA
    SAMSN1 Expression
    About this image


    SAMSN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SAMSN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAMSN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473341

    UniProtKB/Swiss-Prot: SAMN1_HUMAN, Q9NSI8
    Tissue specificity: Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and
    peripheral blood

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SAMSN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Samsn11 , 5 SAM domain, SH3 domain and nuclear localization signals, more1, 5 83.19(n)1
    83.57(a)1
      16 (43.36 cM)5
    677421  NM_023380.21  NP_075869.21 
     758587935 
    chicken
    (Gallus gallus)
    Aves SAMSN11 SAM domain, SH3 domain and nuclear localization signals more 72.17(n)
    71.59(a)
      418470  NM_001006256.1  NP_001006256.1 
    lizard
    (Anolis carolinensis)
    Reptilia SAMSN16
    SAM domain, SH3 domain and nuclear localization si...
    65(a)
    1 ↔ 1
    GL343230.1(1723070-1794374)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia samsn11 SAM domain, SH3 domain and nuclear localization signals more 66.75(n)
    63.54(a)
      100497069  XM_002939335.2  XP_002939381.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufq83f122 wufq83f12 71.12(n)   335755  BI842414.1 


    ENSEMBL Gene Tree for SAMSN1 (if available)
    TreeFam Gene Tree for SAMSN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAMSN1 gene
    SASH32  SASH12  
    2 SIMAP similar genes for SAMSN1 using alignment to 5 protein entries:     SAMN1_HUMAN (see all proteins):
    SASH1    SASH3

    SAMSN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SAMSN1 (see all 2527)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs622271621,2
    C,F--15857097(+) TTTCCG/ATGCAT 2 -- int16Minor allele frequency- A:0.13WA NA CSA EA 364
    rs1415300391,2
    --15857136(+) CAACCA/GTGGAA 2 -- int10--------
    rs1504449311,2
    C--15857190(+) ATCCAC/TAGGGC 2 -- int10--------
    rs1900253451,2
    --15857321(+) AGAAAC/GAAATT 2 -- int10--------
    rs755083181,2
    --15857378(+) AGGGTA/TTCAAG 2 -- int10--------
    rs1828601181,2
    --15857387(+) AGTGAA/GTCAGA 2 -- int10--------
    rs170032641,2
    C,F,H--15857425(+) ATGAGT/GTTGAG 2 -- int114Minor allele frequency- G:0.17NA NS EA WA 1334
    rs762518571,2
    C,F--15857592(+) GGTATG/ATCAAA 2 -- ut311Minor allele frequency- A:0.10WA 118
    rs1861860521,2
    C--15857796(+) ATAAGC/TATAAA 2 -- ut310--------
    rs126265931,2
    C,F,H--15857846(+) GAATCC/GTCTAT 2 -- ut31 ese324Minor allele frequency- G:0.12NS EA NA WA 2778

    HapMap Linkage Disequilibrium report for SAMSN1 (15857549 - 15955723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SAMSN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834045CNV Loss17160897
    dgv4679n71CNV Loss21882294
    nsv523557CNV Loss19592680
    nsv913407CNV Loss21882294
    dgv4678n71CNV Loss21882294
    nsv522627CNV Gain19592680
    nsv834046CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607978    OMIM disorders: --

    3 diseases for SAMSN1:    
    About MalaCards
    atherosclerosis    lung cancer    hepatitis


    SAMSN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SAMSN1
    Human Genome Epidemiology (HuGE) Navigator: SAMSN1 (1 document)

    Export disorders for SAMSN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAMSN1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SAMSN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells. (PubMed id 11536050)1, 2, 3, 9 Claudio J.O.... Stewart A.K. (Oncogene 2001)
    2. Identification of Nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells. (PubMed id 11594764)1, 2, 3 Uchida T.... Ogawa H. (Biochem. Biophys. Res. Commun. 2001)
    3. The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. (PubMed id 15381729)1, 2, 9 Zhu Y.X.... Stewart A.K. (J. Exp. Med. 2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. The immunoinhibitory adapter protein SRC homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading. (PubMed id 21296879)1 von Holleben M.... Beer-Hammer S. (J. Biol. Chem. 2011)
    10. SLy2 targets the nuclear SAP30/HDAC1 complex. (PubMed id 20478393)1 Brandt S....Beer-Hammer S. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64092 HGNC: 10528 AceView: SAMSN1 Ensembl:ENSG00000155307 euGenes: HUgn64092
    ECgene: SAMSN1 H-InvDB: SAMSN1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SAMSN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SAMSN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SAMSN1 gene:
    Search GeneIP for patents involving SAMSN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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