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Aliases & Descriptions for SAMHD1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DCIP 2, 3 | | HDDC1 1, 2 | | MOP-5 1, 2, 3 | | MOP5 3 | | Mg11 1 | | OTTHUMP00000030889 2 | | SBBI88 1, 2 |
| | | Descriptions |
|---|
| Dendritic cell-derived IFNG-induced protein 2, 3 | | HD domain containing 1 2 | | Monocyte protein 5 2, 3 | | SAM domain and HD domain 1 2 | | SAM domain- and HD domain-containing protein 1 2 |
|
| | Search outside databases for aliases for SAMHD1 genePrevious GC identifers: GC20M035247 GC20M036157 GC20M036206 |
Summaries for SAMHD1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SAMH1_HUMAN, Q9Y3Z3Function: May play a role in mediating proinflammatory responses to TNF-alpha signalingGene Wiki entry for SAMHD1 |
Genomic Location for SAMHD1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAMHD1 gene 
Entrez Gene cytogenetic band: 20pter-q12 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20pter-q12SAMHD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M034954:
(about GC identifiers)
Start:
|
34,954,059 bp from pter |
End:
|
35,013,590 bp from pter |
Size:
|
59,532 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011362.9
| Proteins for SAMHD1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAMH1_HUMAN, Q9Y3Z3 (See
protein sequence)Recommended Name: SAM domain and HD domain-containing protein 1 Size: 626 amino acids; 72201 Da
PDB structures from and Proteopedia :2E8O (3D)
 
Secondary accessions: Q5JXG8 Q9H004 Q9H005 Q9H3U9Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056289.2
ENSEMBL proteins: ENSP00000362798 ENSP00000262878
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: SAMHD1 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SAMHD1: Assays for SAMHD1: | Protein
Domains/ Families for SAMHD1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y3Z3
ProtoNet protein and cluster: Q9Y3Z3 3 Blocks protein families: IPB001660 Sterile alpha motif SAM IPB006674 Metal-dependent phosphohydrolase IPB011510 Sterile alpha motif homology 2
UniProtKB/Swiss-Prot: SAMH1_HUMAN, Q9Y3Z3Similarity: Contains 1 HD domainSimilarity: Contains 1 SAM (sterile alpha motif) domain | Gene Function for SAMHD1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015474
Applied Biosystems Silencer® siRNAs for SAMHD1
Sigma-Aldrich siRNA and siRNA Panels for SAMHD1  Sigma-Aldrich shRNA for SAMHD1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015474                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015474                                  untagged cDNA clone in CMV expression vector: NM_015474 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015474
UniProtKB/Swiss-Prot: SAMH1_HUMAN, Q9Y3Z3Function: May play a role in mediating proinflammatory responses to TNF-alpha signalingInduction: By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
IEA | -- | About this table | Pathways & Interactions for SAMHD1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for SAMHD1 (ENSP000002628783) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for SAMHD1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAMHD1
|
Transcripts for SAMHD1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015474
Sigma-Aldrich siRNA and siRNA Panels for SAMHD1  Sigma-Aldrich shRNA for SAMHD1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015474 REFSEQ mRNAs for SAMHD1 gene: NM_015474.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015474               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015474                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015474                                  untagged cDNA clone in CMV expression vector: NM_015474  Additional cDNA sequence: AB013847.1 AB208944.1 AF147427.1 AF228421.1 AK027811.1 AK304187.1 AK304795.1 AK311150.1 AK315169.1 AL050267.1 BC036450.2 CR614403.1 13 DOTS entries: DT.413583 DT.99934944 DT.92429950 DT.100711750 DT.40231757 DT.95349378 DT.65284606 DT.97840638 DT.86858287 DT.92429952 DT.95209249 DT.100803378 DT.95126074 24/197 AceView cDNA sequences (see all 197
):BE501937 CR614403 AB013847 AI246486 CB215568 BP343654 BG547029 AI493181 AI224387 CA392465 AA057695 AI857756 BU621451 N22654 BX416867 AI284002 CK825622 CR612530 BF725869 BF364525 NM_015474 BI494512 BM679312 AA421603
highest scoring ESTs for SAMHD1:AL050267 AA423904 AA496236 AB013847 AF228421 AK027811 AW504769 BC036450 BG547029 BG702214 Unigene Cluster for SAMHD1: SAM domain and HD domain 1 Hs.580681 [show with all ESTs]Unigene Representative Sequence: AB208944
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SAMHD1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | |
| SP1: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SAMHD1
2 Ensembl transcripts including schematic representations: ENST00000373694
ENST00000262878
|
Expression for SAMHD1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAMHD1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAMHD1
1 / 2 / 3 6 probe-sets matching SAMHD1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGAAGCTAA
SOURCE GeneReport for Unigene cluster: Hs.580681
Expression variation in blood from EXPOLDB for SAMHD1 UniProtKB/Swiss-Prot: SAMH1_HUMAN, Q9Y3Z3Tissue specificity: Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus |
Orthologs for SAMHD1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAMHD1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for SAMHD1
ENSEMBL Gene Tree for SAMHD1 | Paralogs for SAMHD1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for SAMHD1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAMHD1 (up to first 250kb)
|
Disorders & Mutations for SAMHD1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606754
1 PharmGKB disease relationship for SAMHD1 geneAbout this table
|
Medical News for SAMHD1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAMHD1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for SAMHD1 gene (see all 12
):- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2, 3, 4 Wiemann S.... Poustka A. (2001)
- Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells. (PubMed id 11064105)2, 3, 4 Li N.... Cao X. (2000)
- Dendritic cell-derived interferon-gamma-induced protein mediates tumor necrosis factor-alpha stimulation of human lung fibroblasts. (PubMed id 18546154)3, 4 Liao W....Wong W.S. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12730115)7 Ross M.E....Downing J.R. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for SAMHD1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAMHD1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAMHD1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SAMHD1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAMHD1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SAMHD1:

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Incremental update: 13 Oct 2009
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