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Aliases for SAMD9L Gene

Aliases for SAMD9L Gene

  • Sterile Alpha Motif Domain Containing 9 Like 2 3
  • Sterile Alpha Motif Domain Containing 9-Like 2 3 5
  • SAM Domain-Containing Protein 9-Like 3 4
  • C7orf6 3 4
  • DRIF2 3 4
  • Chromosome 7 Open Reading Frame 6 2
  • KIAA2005 4
  • UEF1 3
  • UEF 4

External Ids for SAMD9L Gene

Previous HGNC Symbols for SAMD9L Gene

  • C7orf6

Previous GeneCards Identifiers for SAMD9L Gene

  • GC07M092405
  • GC07M092597
  • GC07M092759
  • GC07M087368

Summaries for SAMD9L Gene

GeneCards Summary for SAMD9L Gene

SAMD9L (Sterile Alpha Motif Domain Containing 9 Like) is a Protein Coding gene. Diseases associated with SAMD9L include leukemia, acute myelomonocytic, somatic, somatic. An important paralog of this gene is SAMD9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD9L Gene

Genomics for SAMD9L Gene

Regulatory Elements for SAMD9L Gene

Promoters for SAMD9L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAMD9L on UCSC Golden Path with GeneCards custom track

Genomic Location for SAMD9L Gene

Chromosome:
7
Start:
93,130,054 bp from pter
End:
93,148,393 bp from pter
Size:
18,340 bases
Orientation:
Minus strand

Genomic View for SAMD9L Gene

Genes around SAMD9L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD9L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD9L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD9L Gene

Proteins for SAMD9L Gene

  • Protein details for SAMD9L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVG5-SAM9L_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 9-like
    Protein Accession:
    Q8IVG5
    Secondary Accessions:
    • A0JP23
    • A0JP24
    • A0PJG8
    • A4D1G8
    • D6W5Q6
    • Q2TV71
    • Q2TV75
    • Q2UZV8
    • Q8IWI4
    • Q8N3L9
    • Q8N875

    Protein attributes for SAMD9L Gene

    Size:
    1584 amino acids
    Molecular mass:
    184533 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI27118.1; Type=Frameshift; Positions=1259; Evidence={ECO:0000305}; Sequence=AAI27119.1; Type=Frameshift; Positions=1516; Evidence={ECO:0000305}; Sequence=BAC04975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC23102.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38910.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SAMD9L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAMD9L Gene

Proteomics data for SAMD9L Gene at MOPED

Post-translational modifications for SAMD9L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD9L Gene

Domains & Families for SAMD9L Gene

Gene Families for SAMD9L Gene

Protein Domains for SAMD9L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD9L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVG5

UniProtKB/Swiss-Prot:

SAM9L_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD9L: view

Function for SAMD9L Gene

genes like me logo Genes that share phenotypes with SAMD9L: view

Animal Models for SAMD9L Gene

MGI Knock Outs for SAMD9L:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SAMD9L Gene

Localization for SAMD9L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD9L Gene COMPARTMENTS Subcellular localization image for SAMD9L gene
Compartment Confidence
cytosol 3
endosome 2
nucleus 2
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD9L Gene

Pathways & Interactions for SAMD9L Gene

SuperPathways for SAMD9L Gene

No Data Available

Interacting Proteins for SAMD9L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326247%0d%0a9606.ENSP00000317955%0d%0a
Selected Interacting proteins: Q8IVG5-SAM9L_HUMAN ENSP00000326247 for SAMD9L Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SAMD9L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD9L Gene

Drugs & Compounds for SAMD9L Gene

No Compound Related Data Available

Transcripts for SAMD9L Gene

Unigene Clusters for SAMD9L Gene

Sterile alpha motif domain containing 9-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD9L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: - -
SP3: - -

Relevant External Links for SAMD9L Gene

GeneLoc Exon Structure for
SAMD9L
ECgene alternative splicing isoforms for
SAMD9L

Expression for SAMD9L Gene

mRNA expression in normal human tissues for SAMD9L Gene

mRNA differential expression in normal tissues according to GTEx for SAMD9L Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for SAMD9L Gene

This gene is overexpressed in Lymph node (17.1), Lung (9.5), Spleen (8.3), Peripheral blood mononuclear cells (6.4), and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAMD9L Gene



SOURCE GeneReport for Unigene cluster for SAMD9L Gene Hs.489118

mRNA Expression by UniProt/SwissProt for SAMD9L Gene

Q8IVG5-SAM9L_HUMAN
Tissue specificity: Widely expressed in adult and fetal tissues. Variable expression in tumors. Down-regulated in breast cancer.
genes like me logo Genes that share expression patterns with SAMD9L: view

Protein tissue co-expression partners for SAMD9L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SAMD9L Gene

Orthologs for SAMD9L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAMD9L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD9L 36
  • 99 (a)
OneToOne
SAMD9L 35
  • 99.49 (n)
  • 99.37 (a)
dog
(Canis familiaris)
Mammalia SAMD9L 35
  • 86.03 (n)
  • 79.9 (a)
SAMD9L 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd9l 16
Samd9l 36
  • 72 (a)
OneToOne
Samd9l 35
  • 79.69 (n)
  • 72.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SAMD9L 35
  • 62.16 (n)
  • 52.94 (a)
-- 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia samd9l 35
  • 60.87 (n)
  • 53.51 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113e8.9 36
  • 34 (a)
ManyToMany
si:ch211-141h20.6 36
  • 37 (a)
ManyToMany
Species with no ortholog for SAMD9L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD9L Gene

ENSEMBL:
Gene Tree for SAMD9L (if available)
TreeFam:
Gene Tree for SAMD9L (if available)

Paralogs for SAMD9L Gene

Paralogs for SAMD9L Gene

(1) SIMAP similar genes for SAMD9L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SAMD9L: view

Variants for SAMD9L Gene

Sequence variations from dbSNP and Humsavar for SAMD9L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10488532 - 93,135,176(+) CATTA(C/T)ATTGA reference, missense
rs2073793 - 93,135,106(+) CCACA(A/G)ACCTT reference, missense
rs17165111 - 93,132,562(+) TGTTC(C/G/T)CATCC reference, missense
rs10282508 - 93,131,425(+) CTTCA(G/T)TTTTT reference, missense
rs4267 -- 93,130,149(+) TTCCA(A/G)GCTCT utr-variant-3-prime

Variation tolerance for SAMD9L Gene

Residual Variation Intolerance Score: 6.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.15; 69.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD9L Gene

HapMap Linkage Disequilibrium report
SAMD9L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAMD9L Gene

Disorders for SAMD9L Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAMD9L Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myelomonocytic, somatic, somatic
  • leukemia, juvenile myelomonocytic, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SAMD9L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD9L
genes like me logo Genes that share disorders with SAMD9L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAMD9L Gene

Publications for SAMD9L Gene

  1. Human sterile alpha motif domain 9, a novel gene identified as down- regulated in aggressive fibromatosis, is absent in the mouse. (PMID: 17407603) Li C.F. … Alman B.A. (BMC Genomics 2007) 3 4 67
  2. SAMD9L inactivation promotes cell proliferation via facilitating G1-S transition in hepatitis B virus-associated hepatocellular carcinoma. (PMID: 25076857) Wang Q. … Han Z.G. (Int. J. Biol. Sci. 2014) 3
  3. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. (PMID: 23740937) Martin J.E. … Martin J. (Hum. Mol. Genet. 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3

Products for SAMD9L Gene

Sources for SAMD9L Gene

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