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Aliases for SAMD9L Gene

Aliases for SAMD9L Gene

  • Sterile Alpha Motif Domain Containing 9-Like 2 3
  • SAM Domain-Containing Protein 9-Like 3 4
  • C7orf6 3 4
  • DRIF2 3 4
  • Sterile Alpha Motif Domain-Containing Protein 9-Like 3
  • Chromosome 7 Open Reading Frame 6 2
  • KIAA2005 4
  • UEF1 3
  • UEF 4

External Ids for SAMD9L Gene

Previous HGNC Symbols for SAMD9L Gene

  • C7orf6

Previous GeneCards Identifiers for SAMD9L Gene

  • GC07M092405
  • GC07M092597
  • GC07M092759
  • GC07M087368

Summaries for SAMD9L Gene

GeneCards Summary for SAMD9L Gene

SAMD9L (Sterile Alpha Motif Domain Containing 9-Like) is a Protein Coding gene. An important paralog of this gene is SAMD9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD9L Gene

Genomics for SAMD9L Gene

Regulatory Elements for SAMD9L Gene

Genomic Location for SAMD9L Gene

93,130,055 bp from pter
93,148,376 bp from pter
18,322 bases
Minus strand

Genomic View for SAMD9L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAMD9L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD9L Gene

Proteins for SAMD9L Gene

  • Protein details for SAMD9L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sterile alpha motif domain-containing protein 9-like
    Protein Accession:
    Secondary Accessions:
    • A0JP23
    • A0JP24
    • A0PJG8
    • A4D1G8
    • D6W5Q6
    • Q2TV71
    • Q2TV75
    • Q2UZV8
    • Q8IWI4
    • Q8N3L9
    • Q8N875

    Protein attributes for SAMD9L Gene

    1584 amino acids
    Molecular mass:
    184533 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI27118.1; Type=Frameshift; Positions=1259; Evidence={ECO:0000305}; Sequence=AAI27119.1; Type=Frameshift; Positions=1516; Evidence={ECO:0000305}; Sequence=BAC04975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC23102.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38910.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SAMD9L Gene


neXtProt entry for SAMD9L Gene

Proteomics data for SAMD9L Gene at MOPED

Post-translational modifications for SAMD9L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD9L Gene

Domains for SAMD9L Gene

Gene Families for SAMD9L Gene

Protein Domains for SAMD9L Gene


Suggested Antigen Peptide Sequences for SAMD9L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD9L: view

Function for SAMD9L Gene

Gene Ontology (GO) - Molecular Function for SAMD9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SAMD9L: view

Phenotypes for SAMD9L Gene

MGI mutant phenotypes for SAMD9L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SAMD9L: view

Animal Model Products

miRNA for SAMD9L Gene

miRTarBase miRNAs that target SAMD9L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD9L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD9L Gene

Localization for SAMD9L Gene

Subcellular locations from

Jensen Localization Image for SAMD9L Gene COMPARTMENTS Subcellular localization image for SAMD9L gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SAMD9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with SAMD9L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SAMD9L Gene

Pathways for SAMD9L Gene

SuperPathways for SAMD9L Gene

No Data Available

Interacting Proteins for SAMD9L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000326247 Q8IVG5-SAM9L_HUMAN for SAMD9L Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SAMD9L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0017145 stem cell division IEA --
GO:0034058 endosomal vesicle fusion IEA --
GO:0035726 common myeloid progenitor cell proliferation IEA --
GO:0042176 regulation of protein catabolic process IEA --
genes like me logo Genes that share ontologies with SAMD9L: view

No data available for Pathways by source for SAMD9L Gene

Transcripts for SAMD9L Gene

Unigene Clusters for SAMD9L Gene

Sterile alpha motif domain containing 9-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD9L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD9L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP2: - -
SP3: - -

Relevant External Links for SAMD9L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAMD9L Gene

mRNA expression in normal human tissues for SAMD9L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD9L Gene

This gene is overexpressed in Whole Blood (4.3).

Protein differential expression in normal tissues for SAMD9L Gene

This gene is overexpressed in Lymph node (17.1), Lung (9.5), Spleen (8.3), Peripheral blood mononuclear cells (6.4), and Plasma (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAMD9L Gene

SOURCE GeneReport for Unigene cluster for SAMD9L Gene Hs.489118

mRNA Expression by UniProt/SwissProt for SAMD9L Gene

Tissue specificity: Widely expressed in adult and fetal tissues. Variable expression in tumors. Down-regulated in breast cancer.
genes like me logo Genes that share expressions with SAMD9L: view

Expression partners for SAMD9L Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SAMD9L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAMD9L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SAMD9L 35
  • 86.03 (n)
  • 79.9 (a)
  • 80 (a)
(Mus musculus)
Mammalia Samd9l 35
  • 79.69 (n)
  • 72.74 (a)
Samd9l 16
Samd9l 36
  • 72 (a)
(Pan troglodytes)
Mammalia SAMD9L 35
  • 99.49 (n)
  • 99.37 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
(Gallus gallus)
Aves SAMD9L 35
  • 62.16 (n)
  • 52.94 (a)
-- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia samd9l 35
  • 60.87 (n)
  • 53.51 (a)
(Danio rerio)
Actinopterygii si:ch211-113e8.9 36
  • 34 (a)
si:ch211-141h20.6 36
  • 37 (a)
Species with no ortholog for SAMD9L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD9L Gene

Gene Tree for SAMD9L (if available)
Gene Tree for SAMD9L (if available)

Paralogs for SAMD9L Gene

Paralogs for SAMD9L Gene

(1) SIMAP similar genes for SAMD9L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SAMD9L: view

Variants for SAMD9L Gene

Sequence variations from dbSNP and Humsavar for SAMD9L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs73710964 -- 93,134,755(+) AGTCT(C/T)GGTTT missense, reference
rs73710963 -- 93,134,059(+) ATCCA(C/T)GGGCG missense, reference
rs73710962 -- 93,132,008(+) GAGTA(A/G)TTGAC synonymous-codon, reference
rs73710961 -- 93,130,009(+) TGGGT(A/T)TGGAG downstream-variant-500B
rs73413294 -- 93,146,576(+) TAAAT(A/G)AGTAA intron-variant, upstream-variant-2KB

Relevant External Links for SAMD9L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SAMD9L Gene

Disorders for SAMD9L Gene

(1) University of Copenhagen DISEASES for SAMD9L Gene

genes like me logo Genes that share disorders with SAMD9L: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SAMD9L Gene

Publications for SAMD9L Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Human sterile alpha motif domain 9, a novel gene identified as down- regulated in aggressive fibromatosis, is absent in the mouse. (PMID: 17407603) Li C.F. … Alman B.A. (BMC Genomics 2007) 3 4
  4. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. (PMID: 23740937) Martin J.E. … Martin J. (Hum. Mol. Genet. 2013) 3
  5. SAMD9L inactivation promotes cell proliferation via facilitating G1-S transition in hepatitis B virus-associated hepatocellular carcinoma. (PMID: 25076857) Wang Q. … Han Z.G. (Int. J. Biol. Sci. 2014) 3

Products for SAMD9L Gene

Sources for SAMD9L Gene

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