SAMD9L Gene
protein-coding GIFtS : 46
GCID: GC07 M092759
sterile alpha motif domain containing 9-like (Previous name: chromosome 7 open reading frame 6 ) (Previous symbol: C7orf6 )
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Aliasesfor SAMD9L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Sterile Alpha Motif Domain Containing 9-Like 1 2 FLJ398851 C7orf61 2 3 Chromosome 7 Open Reading Frame 61 KIAA20051 3 UEF12 DRIF22 3 Sterile Alpha Motif Domain-Containing Protein 9-Like2 SAM Domain-Containing Protein 9-Like2 3 UEF3
Export aliases for SAMD9L gene to outside databases Previous GC identifers: GC07M092405 GC07M092597 GC07M087368
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Summariesfor SAMD9L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor SAMD9L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SAMD9L gene promoter: MEF-2A IRF-2 FOXO4 MEF-2 IRF-1 aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for SAMD9L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAMD9L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q21.2 Ensembl cytogenetic band: 7q21.2 HGNC cytogenetic band: 7q21.2 SAMD9L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M092759: view genomic region
(about GC identifiers )
Start:
92,759,368 bp from pter
End:
92,777,682 bp from pter
Size:
18,315 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 92,088,687-92,106,998
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Proteinsfor SAMD9L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SAM9L_HUMAN, Q8IVG5 (See
protein sequence )Recommended Name: Sterile alpha motif domain-containing protein 9-like Size : 1584 amino acids; 184533 Da
Sequence caution : Sequence=AAI27118.1; Type=Frameshift; Positions=1259; Sequence=AAI27119.1; Type=Frameshift;Positions=1516; Sequence=BAC04975.1; Type=Erroneous initiation; Sequence=BAC23102.1; Type=Erroneous initiation; Sequence=CAD38910.1; Type=Erroneous initiation;
Secondary accessions : A0JP23 A0JP24 A0PJG8 A4D1G8 D6W5Q6 Q2TV71 Q2TV75 Q2UZV8 Q8IWI4 Q8N3L9 Q8N875Alternative splicing : 2 isoforms : Q8IVG5-1 Q8IVG5-2 (No experimental confirmation available. Dubious isoform produced through aberrant splice sites)Explore the universe of human proteins at neXtProt for SAMD9L: NX_Q8IVG5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IVG5 SAMD9L Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689916.2 ENSEMBL proteins: ENSP00000326247 ENSP00000405760 ENSP00000408796 ENSP00000391699 ENSP00000391387 ENSP00000396137 ENSP00000410062 Human Recombinant Protein Products: SAMD9L Antibody Products: Assay Products for SAMD9L:
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Protein
Domains / Familiesfor SAMD9L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SAMD9L for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IVG5 ProtoNet protein and cluster: Q8IVG5
1 Blocks protein family : IPB001660 Sterile alpha motif SAM UniProtKB/Swiss-Prot: SAM9L_HUMAN, Q8IVG5 Similarity : Contains 1 SAM (sterile alpha motif) domain
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Functionfor SAMD9L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SAMD9L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SAMD9L (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SAMD9L (NM_152703 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAMD9L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SAMD9L
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD9L
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Samd9l) :
SAMD9L for phenotypes About GeneDecksing
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Pathways & Interactionsfor SAMD9L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAMD9L STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for SAMD9L (Q8IVG5 3 ENSP00000326247 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor SAMD9L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SAMD9L Search CenterWatch for drugs/clinical trials and news about SAMD9L / SAM9L
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Transcriptsfor SAMD9L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SAMD9L gene: NM_152703.2 Unigene Cluster for SAMD9L:
Sterile alpha motif domain containing 9-like Hs.489118 [show with all ESTs ] Unigene Representative Sequence: NM_152703 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000318238 (uc003umh.1 uc003umj.1 uc003umi.1 uc010lfb.1 uc003umk.1 uc010lfc.1 uc010lfd.1 )ENST00000411955 ENST00000437805 ENST00000446959 ENST00000439952 ENST00000414791 ENST00000446033 ENST00000477816 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SAMD9L (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SAMD9L (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SAMD9L (NM_152703 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SAMD9L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SAMD9L
Additional cDNA sequence: AB095926.1 AF474973.1 AK026672.1 AK097204.1 AK304307.1 AK304779.1 AL832264.1 AL834232.1 AY195582.1 AY195583.1 AY195584.1 AY195585.1 AY195586.1 AY195587.1 AY195588.1 BC029108.1 BC038974.1 BC127117.1 BC127118.1 DQ068177.1
4 DOTS entries : DT.303533 DT.95322412
DT.91701818 DT.121046737 24/92 AceView cDNA sequences (see all 92 ):
AI087313 BE675526 BG236517 AL832264 AW675618 AK097204 AI139687 BQ433442 AW294127 AI674920 BC029108 AA490264 BF058148 BM470525 AA988857 AA490365 AW337195 NM_152703 AA253288 BU507807 AB095926 AI457736 AA648507 BU190148 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for SAMD9L About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 SP1 :                   SP2 :       -     -         SP3 :     -   -            
ECgene alternative splicing isoforms for SAMD9L
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Expression for SAMD9L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SAMD9L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image SAMD9L expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Heart Myocardium Cardiac Fibroblasts Epicardium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
See SAMD9L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SAMD9L SOURCE GeneReport for Unigene cluster: Hs.489118 UniProtKB/Swiss-Prot: SAM9L_HUMAN, Q8IVG5 Tissue specificity : Widely expressed in adult and fetal tissues. Variable expression in tumors. Down-regulated inbreast cancer SABiosciences Custom PCR Arrays for SAMD9L Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SAMD9LBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SAMD9L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SAMD9L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SAMD9L In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD9L
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Orthologsfor SAMD9L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SAMD9L gene from 4/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for SAMD9L (if available)TreeFam Gene Tree for SAMD9L (if available)
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Paralogsfor SAMD9L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SAMD9L gene SAMD9 2 1 SIMAP similar gene for SAMD9L using alignment to 1 protein entry: SAM9L_HUMAN :SAMD9
SAMD9L for paralogs About GeneDecksing
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Genomic Variantsfor SAMD9L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SAMD9L (92759368 - 92777682 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SAMD9L: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SAMD9L
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Disorders
/ Diseasesfor SAMD9L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SAMD9L for disorders About GeneDecksing
OMIM gene information: 611170
OMIM disorders : --6 diseases for SAMD9L : About MalaCards juvenile myelomonocytic leukemia myelomonocytic leukemia calcinosis fibromatosis breast cancer leukemia 1 disease from the University of Copenhagen DISEASES database for SAMD9L :Calcinosis Export disorders for SAMD9L gene to outside databases
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Publicationsfor SAMD9L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SAMD9L gene integrated from 9 sources : (articles sorted by number of sources associating them with SAMD9L) Utopia : connect your pdf to the dynamic world of online information
Human sterile alpha motif domain 9, a novel gene identified as down- regulated in aggressive fibromatosis, is absent in the mouse. (PubMed id 17407603) 1 , 2 Li C.F.... Alman B.A. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Human chromosome 7: DNA sequence and biology. (PubMed id 12690205) 1 , 2 Scherer S.W.... Tsui L.-C. (2003) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SAMD9L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SAMD9L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SAMD9L gene
(According to HUGE )
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Specialized Databases showing SAMD9L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SAMD9L Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SAMD9L gene: Search GeneIP for patents involving SAMD9L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SAMD9L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SAMD9L OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SAMD9L OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SAMD9L Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SAMD9L OriGene 3'-UTR Clone for SAMD9L OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SAMD9L OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SAMD9L Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SAMD9L OriGene Custom Protein Services for SAMD9L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SAMD9L QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SAMD9L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAMD9L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SAMD9L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SAMD9L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SAMD9L
Search Tocris compounds for SAMD9L
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD9L
ThermoFisher Antibodies for SAMD9L
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SAMD9L
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