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SAMD9 Gene

protein-coding   GIFtS: 50
GCID: GC07M092728

Sterile Alpha Motif Domain Containing 9

(Previous name: chromosome 7 open reading frame 5)
(Previous symbol: C7orf5)
  See SAMD9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sterile Alpha Motif Domain Containing 91 2     Chromosome 7 Open Reading Frame 51
C7orf51 2 3     OEF22
DRIF12 3     Expressed In Aggressive Fibromatosis2
OEF12 3     Sterile Alpha Motif Domain-Containing Protein 92
SAM Domain-Containing Protein 92 3     KIAA20043
NFTC2 5     

External Ids:    HGNC: 13481   Entrez Gene: 548092   Ensembl: ENSG000002054137   OMIM: 6104565   UniProtKB: Q5K6513   

Export aliases for SAMD9 gene to outside databases

Previous GC identifers: GC07M092373 GC07M092566 GC07M087337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SAMD9 Gene:
This gene encodes a sterile alpha motif domain-containing protein. The encoded protein localizes to the cytoplasm
and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of
normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that
encode the same protein.(provided by RefSeq, Jul 2010)

GeneCards Summary for SAMD9 Gene:
SAMD9 (sterile alpha motif domain containing 9) is a protein-coding gene. Diseases associated with SAMD9 include normophosphatemic familial tumoral calcinosis, and calcinosis. An important paralog of this gene is SAMD9L.

UniProtKB/Swiss-Prot: SAMD9_HUMAN, Q5K651
Function: May play a role in the inflammatory response to tissue injury and the control of extra-osseous
calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in
coordination with RGL2

Gene Wiki entry for SAMD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAMD9 gene promoter:
         AML1a   Pax-6   HSF1 (long)   NF-AT   NF-AT4   NF-AT2   NF-AT3   HSF1short   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAMD9 promoter sequence
   Search Chromatin IP Primers for SAMD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAMD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.2   Ensembl cytogenetic band:  7q21.2   HGNC cytogenetic band: 7q21.2

SAMD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMD9 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M092728:  view genomic region     (about GC identifiers)

Start:
92,728,826 bp from pter      End:
92,747,336 bp from pter
Size:
18,511 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 92,058,134-92,076,644     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SAMD9_HUMAN, Q5K651 (See protein sequence)
Recommended Name: Sterile alpha motif domain-containing protein 9  
Size: 1589 amino acids; 184281 Da
Subunit: Interacts with RGL2
Sequence caution: Sequence=AAH65769.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAQ04689.3; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice
sites; Sequence=BAA90932.1; Type=Erroneous initiation; Sequence=BAC23101.1; Type=Erroneous initiation;
Secondary accessions: A2RU68 Q5K649 Q6P080 Q75N21 Q8IVG6 Q9NXS8

Explore the universe of human proteins at neXtProt for SAMD9: NX_Q5K651

Explore proteomics data for SAMD9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAMD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180236.1  NP_060124.2  

    ENSEMBL proteins: 
     ENSP00000369292   ENSP00000414529  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q5K651

    ProtoNet protein and cluster: Q5K651

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: SAMD9_HUMAN, Q5K651
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with SAMD9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SAMD9_HUMAN, Q5K651
    Function: May play a role in the inflammatory response to tissue injury and the control of extra-osseous
    calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in
    coordination with RGL2
    Induction: Up-regulated by TNF-alpha through p38 MAPKs and NF-kappa-B. Up-regulated by osmotic shock. Induced by
    IFNG

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SAMD9           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SAMD9

    miRNA
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    miRTarBase miRNAs that target SAMD9:
    hsa-mir-30a-5p (MIRT028548)

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    hsa-miR-298 hsa-miR-590-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SAMD9_HUMAN, Q5K651: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with SAMD9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAMD9
    Interactions:

        Search GeneGlobe Interaction Network for SAMD9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SAMD9 (Q5K6511 ENSP000003692924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEA1Q150751EBI-2814750,EBI-298113
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAMD9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SAMD9 gene (2 alternative transcripts): 
    NM_001193307.1  NM_017654.3  

    Unigene Cluster for SAMD9:

    Sterile alpha motif domain containing 9
    Hs.65641  [show with all ESTs]
    Unigene Representative Sequence: NM_017654
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379958(uc003umf.3 uc003umg.3) ENST00000446617
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SAMD9:
    hsa-miR-298 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidSAMD9 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SAMD9

    Additional mRNA sequence: 

    AB095925.2 AF445355.1 AF453311.3 AK000080.1 AK122951.1 AK125101.1 AK125131.1 AK225201.1 
    BC065769.1 BC132773.1 BC132775.1 BC150249.1 BX647072.1 

    3 DOTS entries:

    DT.100757636  DT.100785880  DT.108686 

    Selected AceView cDNA sequences (see all 90):

    AA830166 BX447355 NM_017654 BM975811 AI950623 BU509659 AK000080 CA313457 
    BM541593 CN478600 AB095925 BQ050746 CB321996 CB134607 CB123846 AW449632 
    AA745549 AK125131 BE673232 BM474521 AK125101 BX504918 BG503776 BX417126 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SAMD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SAMD9 Expression
    About this image

    SAMD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAMD9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.65641

    UniProtKB/Swiss-Prot: SAMD9_HUMAN, Q5K651
    Tissue specificity: Widely expressed. Very low levels are detected in skeletal muscle. Not detected in brain.
    Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers. Up-regulated in fibroblasts
    from patients with normophosphatemic tumoral calcinosis (NFTC)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SAMD9 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia RGD15630911 similar to OEF2 82.13(n)
    77.24(a)
      500011  XM_575365.4  XP_575365.2 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    49(a)
    1 → many
    2(23038948-23043687)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    54(a)
    1 → many
    6(21513940-21518701)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018861561 sterile alpha motif domain-containing protein 9-like 53.37(n)
    42.31(a)
      101886156  XM_005171424.1  XP_005171481.1 


    ENSEMBL Gene Tree for SAMD9 (if available)
    TreeFam Gene Tree for SAMD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SAMD9 gene
    SAMD9L2  
    1 SIMAP similar gene for SAMD9 using alignment to 2 protein entries:     SAMD9_HUMAN (see all proteins):
    SAMD9L

    Find genes that share paralogs with SAMD9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SAMD9 (see all 503)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0315294
    Tumoral calcinosis, normophosphatemic, familial (NFTC)4--see VAR_0315292 K E mis40--------
    rs1386009711,2
    C,Funtested196037974(+) ATATTC/TGTTCA 4 K E mis12Minor allele frequency- T:0.00NA EU 5833
    rs1917250131,2
    --92065404(+) CCAGGA/CATACT 2 -- int10--------
    rs1172252151,2
    C,F--92065405(+) CAGGCA/GTACTC 2 -- int12Minor allele frequency- G:0.06NA EA 240
    rs570565921,2
    C--92746576(+) TTGTT-/GTT/  
      GTTGTT
    TTTGA
    4 -- cds10--------
    rs734046461,2
    C,F--96035010(+) ACCTGG/TGGCAG 2 -- ds50012Minor allele frequency- T:0.04WA 120
    rs744099231,2
    F--96035021(+) ACTGGG/CAAGTG 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs109530891,2
    C,F,A,H--96035092(+) TTTTAC/TATTTT 2 -- ds500122Minor allele frequency- T:0.42NS EA NA WA CSA 2348
    rs1908350021,2
    --96035148(+) ACTGCA/GTGATT 2 -- ds50010--------
    rs109530901,2
    C,F,A,H--96035193(+) CATAGG/AAGCAG 2 -- ds500111Minor allele frequency- A:0.49NS NA WA CSA EA 490

    HapMap Linkage Disequilibrium report for SAMD9 (92728826 - 92747336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SAMD9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5845CNV Loss18451855

    Human Gene Mutation Database (HGMD): SAMD9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SAMD9
    DNA2.0 Custom Variant and Variant Library Synthesis for SAMD9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610456   
    OMIM disorders: 610455  
    UniProtKB/Swiss-Prot: SAMD9_HUMAN, Q5K651
  • Tumoral calcinosis, normophosphatemic, familial (NFTC) [MIM:610455]: An uncommon, life-threatening
    disorder characterized by progressive deposition of calcified masses in cutaneous and subcutaneous tissues. Serum
    phosphate levels are normal. Clinical features include painful calcified ulcerative lesions and massive calcium
    deposition in the mid- and lower dermis, severe skin and bone infections, erythematous papular skin eruption in
    infancy, conjunctivitis, and gingivitis. NFTC shows a striking resemblance to acquired dystrophic calcinosis, in
    which tissue calcification occurs as a consequence of tissue injury/inflammation. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 4 diseases for SAMD9:    
    About MalaCards
    normophosphatemic familial tumoral calcinosis    calcinosis    familial tumoral calcinosis    fibromatosis

    1 disease from the University of Copenhagen DISEASES database for SAMD9:
    Calcinosis

    Find genes that share disorders with SAMD9           About GenesLikeMe


    Export disorders for SAMD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SAMD9 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SAMD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis. (PubMed id 21160498)1, 2 Hershkovitz D....Sprecher E. (J. Invest. Dermatol. 2011)
    2. Normophosphatemic familial tumoral calcinosis is caused by deleterious mutations in SAMD9, encoding a TNF-alpha responsive protein. (PubMed id 18094730)1, 2 Chefetz I.... Sprecher E. (J. Invest. Dermatol. 2008)
    3. Human sterile alpha motif domain 9, a novel gene identified as down- regulated in aggressive fibromatosis, is absent in the mouse. (PubMed id 17407603)1, 2 Li C.F.... Alman B.A. (BMC Genomics 2007)
    4. A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis. (PubMed id 16960814)1, 2 Topaz O.... Sprecher E. (Am. J. Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells. (PubMed id 21248034)1 Liu J....McFadden G. (J. Virol. 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54809 HGNC: 1348 AceView: SAMD9 Ensembl:ENSG00000205413 euGenes: HUgn54809
    ECgene: SAMD9 H-InvDB: SAMD9

    (According to HUGE)
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    HUGE: KIAA2004

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SAMD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SAMD9 gene:
    Search GeneIP for patents involving SAMD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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