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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SAMD7 Gene

protein-coding   GIFtS: 37
GCID: GC03P169629

sterile alpha motif domain containing 7
 Explore 1 disease affiliated with
SAMD7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SAMD7    

Aliases
for SAMD7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sterile Alpha Motif Domain Containing 71 2
SAM Domain-Containing Protein 72 3
DKFZp686E15831
Sterile Alpha Motif Domain-Containing Protein 72

External Ids:    HGNC: 253941   Entrez Gene: 3446582   Ensembl: ENSG000001870337   UniProtKB: Q7Z3H43   

Export aliases for SAMD7 gene to outside databases

Previous GC identifers: GC03P170950 GC03P171112 GC03P166999


Summaries
for SAMD7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for SAMD7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SAMD7 gene promoter:
         HOXA9B   HOXA9   ER-alpha   AML1a   Lmo2   MEF-2A   aMEF-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SAMD7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SAMD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAMD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.31

SAMD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMD7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P169629:  view genomic region     (about GC identifiers)

Start:
 169,629,360 bp from pter      End:
 169,656,963 bp from pter
Size:
 27,604 bases      Orientation:
 plus strand

Proteins
for SAMD7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SAMD7_HUMAN, Q7Z3H4 (See protein sequence)
Recommended Name: Sterile alpha motif domain-containing protein 7  
Size: 446 amino acids; 49112 Da

Explore the universe of human proteins at neXtProt for SAMD7: NX_Q7Z3H4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z3H4

    • SAMD7 Protein expression data from MOPED and PaxDb:    About this image 
    SAMD7 Protein Expression
    REFSEQ proteins: NP_872416.1  
    ENSEMBL proteins: 
     ENSP00000391299   ENSP00000334668   ENSP00000420460  

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    Protein Domains /
    Families
    for SAMD7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SAMD7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1

    Graphical View of Domain Structure for InterPro Entry Q7Z3H4

    ProtoNet protein and cluster: Q7Z3H4

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: SAMD7_HUMAN, Q7Z3H4
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for SAMD7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Phenotypes:
         3 GenomeRNAi human phenotypes for SAMD7:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SAMD7 

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    In Situ Assay
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    Pathways & Interactions
    for SAMD7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SAMD7

    Drugs & Compounds
    for SAMD7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SAMD7
    Search CenterWatch for drugs/clinical trials and news about SAMD7 

    Transcripts
    for SAMD7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SAMD7 gene: 
    NM_182610.2  

    Unigene Cluster for SAMD7:

    Sterile alpha motif domain containing 7
    Hs.439922  [show with all ESTs]
    Unigene Representative Sequence: BX648991
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428432(uc003fgd.3) ENST00000335556(uc003fge.3 uc011bpo.2)
    ENST00000487910

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    hsa-miR-548a-3p hsa-miR-548e hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: SAMD7 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SAMD7

    Additional cDNA sequence: 

    BC117339.1 BC143909.1 BX537903.1 BX648534.1 BX648989.1 BX648991.1 

    2 DOTS entries:

    DT.97762263  DT.101981753 

    9 AceView cDNA sequences:

    BX537903 BX648991 BX648989 BX648534 AL711948 NM_182610 AA059000 AA058977 
    W28179 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SAMD7    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                             
    SP2:                                                                  


    ECgene alternative splicing isoforms for SAMD7

    Expression
    for SAMD7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SAMD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SAMD7 Expression
    About this image

    SAMD7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SAMD7 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.439922
        SABiosciences Custom PCR Arrays for SAMD7
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD7

    Orthologs
    for SAMD7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SAMD7 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SAMD76
    		 Uncharacterized protein
    		 44(a)
    		 1 ↔ 1
    		 9(21444890-21450528)
    lizard
    (Anolis carolinensis)    		 Reptilia SAMD76
    		 --
    		 42(a)
    		 1 ↔ 1
    		 3(7890589-7901031)
    zebrafish
    (Danio rerio)    		 Actinopterygii samd76
    		 sterile alpha motif domain containing 7
    		 28(a)
    		 1 ↔ 1
    		 2(36947844-36963370)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Samuel6
    		 SAM-motif ubiquitously expressed punctatedly local...
    		 5(a)
    		 1 → many
    		 2L(11013221-11066997)


    ENSEMBL Gene Tree for SAMD7 (if available)
    TreeFam Gene Tree for SAMD7 (if available) 

    Paralogs
    for SAMD7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SAMD7 gene
    PHC12  PHC32  PHC22  SAMD112  

    SAMD7 for paralogs           About GeneDecksing



    Genomic Variants
    for SAMD7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/598 NCBI SNPs in SAMD7 are shown (see all 598)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1918856351,2
    		Cother169639114(+) CCAGTC/TGGATC 2 R W mis10--------
    rs67925181,2
    		C--169627754(+) acaaaA/Caaaca 1 -- us2k1 tfbs30--------
    rs76372011,2
    		C,F,A,H--169627767(+) AACAAA/CAAAAA 1 -- us2k16Minor allele frequency- C:0.36NA WA 14
    rs1998775421,2
    		--169627767(+) AACAA-/CAAAAA 1 -- us2k10--------
    rs1452912361,2
    		--169627805(+) ATAAAC/TGCTAA 1 -- us2k10--------
    rs1491626371,2
    		--169627855(+) AAAGAC/TAGTTT 1 -- us2k10--------
    rs1464352211,2
    		--169627875(+) TAGGGC/TAAAGG 1 -- us2k10--------
    rs1390138961,2
    		--169627905(+) ATAAGA/TTGAAG 1 -- us2k10--------
    rs1418840721,2
    		--169627937(+) AAAATA/GCATGT 1 -- us2k10--------
    rs1471059731,2
    		--169628089(+) ATTAGC/GCAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SAMD7 (169629360 - 169656963 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SAMD7: --

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    Disorders / Diseases
    for SAMD7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SAMD7 for disorders           About GeneDecksing

    1 disease for SAMD7:    About MalaCards
    ureteral obstruction


    Export disorders for SAMD7 gene to outside databases

    Publications
    for SAMD7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SAMD7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SAMD7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SAMD7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SAMD7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 344658 HGNC: 25394 AceView: SAMD7 Ensembl:ENSG00000187033 euGenes: HUgn344658
    ECgene: SAMD7 H-InvDB: SAMD7

    Other Databases showing SAMD7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SAMD7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SAMD7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SAMD7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SAMD7 gene:
    Search GeneIP for patents involving SAMD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SAMD7 gene

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    About This Section

     
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