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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SAMD5 Gene

protein-coding GIFtS: 36
GCID: GC06P147873

sterile alpha motif domain containing 5

Search for SAMD5
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sterile Alpha Motif Domain Containing 5¹ ²
DJ875H10.1¹
SAM Domain-Containing Protein 5² ³
SAM Domain Containing 1²
Sterile Alpha Motif Domain-Containing Protein 5²
SAMDC1³

External Ids:	HGNC: 21180¹	Entrez Gene: 389432²	Ensembl: ENSG00000203727⁷	UniProtKB: Q5TGI4³

Export aliases for SAMD5 gene to outside databases

Previous GC identifers: GC00U914193 GC06U900641 GC06P145393

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SAMD5 gene promoter:
Olf-1 STAT5A NF-E2 p45 AREB6 POU2F1 POU2F1a Pax-4a NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SAMD5 promoter sequence

Search SABiosciences Chromatin IP Primers for SAMD5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAMD5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3 Ensembl cytogenetic band: 6q24.3 HGNC cytogenetic band: 6q24.3

SAMD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMD5 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P147873: view genomic region (about GC identifiers)

Start:	147,829,828 bp from pter	End:	148,058,683 bp from pter
Size:	228,856 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SAMD5_HUMAN, Q5TGI4 (See protein sequence)

Recommended Name: Sterile alpha motif domain-containing protein 5

Size: 173 amino acids; 19231 Da

Explore the universe of human proteins at neXtProt for SAMD5: NX_Q5TGI4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TGI4

SAMD5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001025231.1

ENSEMBL proteins:

ENSP00000356444 ENSP00000456528

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SAMD5 for domains About GeneDecksing

3 InterPro domains/families:

IPR013761 SAM/pointed

IPR001660 SAM

IPR021129 SAM_type1

Graphical View of Domain Structure for InterPro Entry Q5TGI4

ProtoNet protein and cluster: Q5TGI4

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: SAMD5_HUMAN, Q5TGI4

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SAMD5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about SAMD5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for SAMD5 gene:

NM_001030060.2

Unigene Cluster for SAMD5:

Sterile alpha motif domain containing 5

Hs.567973 [show with all ESTs]

Unigene Representative Sequence: NM_001030060

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367474(uc003qmc.2) ENST00000566741

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Additional cDNA sequence: BC020896.1

2 DOTS entries:

DT.91741375 DT.407224

24/70 AceView cDNA sequences (see all 70):

AA242983 CA942632 AA582100 BX099467 BU102088 BX110596 AA452295 AW274555

BM717307 AA252168 AA886794 CA843432 BX099879 BM311407 BF115069 BG566022

AI221792 BX642679 AI684403 BX957080 BF696216 CK821756 BG204894 BX642659

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SAMD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACTGTGA

About this image

SAMD5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SAMD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAMD5

SOURCE GeneReport for Unigene cluster: Hs.567973

SABiosciences Custom PCR Arrays for SAMD5

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SAMD5 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Samd5^{1 , 5}	sterile alpha motif domain containing 5^{1, 5}	87.6(n)¹ 90.7(a)¹		10 (3.15 cM)⁵ 320825¹ NM_177271.3¹ NP_796245.2¹ 9627259⁵
chicken (Gallus gallus)	Aves	SAMD5¹	sterile alpha motif domain containing 5	80.25(n) 82.22(a)		768744 XM_001231848.1 XP_001231849.1
lizard (Anolis carolinensis)	Reptilia	SAMD5⁶	--	60(a)	1 ↔ 1	1(208075542-208076315)
zebrafish (Danio rerio)	Actinopterygii	LOC100332473¹	sterile alpha motif domain-containing protein 5-like	64.53(n) 64.1(a)		100332473 XM_002665741.1 XP_002665787.1
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP004105¹	AGAP004105-PA	56.28(n) 50.82(a)		1273925 XM_312979.3 XP_312979.3

ENSEMBL Gene Tree for SAMD5 (if available)
TreeFam Gene Tree for SAMD5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71566478^1,2	C,	--	147827880(+)	`TGAGTT/CTGGGG`	1	--	us2k¹		3		NA EA	242
rs116654487^1,2	F,	--	147828054(+)	`AACTCG/AGTTCC`	1	--	us2k¹		1		WA	118
rs73578571^1,2	C,	--	147828056(+)	`CTCGGT/CTCCGG`	1	--	us2k¹		2		WA	120
rs185199212^1,2		--	147828120(+)	`TCCGCA/GTTGGT`	1	--	us2k¹		0	--	--	--	--
rs35987208^1,2	C,	--	147828144(+)	`CTAAGC/GAGACA`	1	--	us2k¹		3		NA EA	242
rs77391820^1,2	C,	--	147828242(+)	`TTGGGT/GGCGCC`	1	--	us2k¹		2		CSA WA	120
rs112279316^1,2		--	147828557(+)	`GTACCT/AGCCCC`	1	--	us2k¹		1		CSA	2
rs77524386^1,2	F,	--	147828692(+)	`TGATGG/CGGAAA`	1	--	us2k¹		1		WA	118
rs183074908^1,2		--	147829320(+)	`GCGCCG/TTGGGG`	1	--	us2k¹		0	--	--	--	--
rs116980459^1,2	F,	--	147829670(+)	`CGGGCG/TGCACT`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for SAMD5 (147829828 - 148058683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SAMD5
1 CNV: 59303

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SAMD5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SAMD5)

Utopia: connect your pdf to the dynamic
world of online information

Common genetic variation and the control of HIV-1 in humans. (PubMed id 20041166)¹ Fellay J....Goldstein D.B. (2009)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 389432	HGNC: 21180	AceView: LOC389432	Ensembl:ENSG00000203727	euGenes: HUgn389432
ECgene: SAMD5	H-InvDB: SAMD5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SAMD5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SAMD5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SAMD5 gene:
Search GeneIP for patents involving SAMD5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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SAMD5 Gene

sterile alpha motif domain containing 5

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for SAMD5 gene

Summaries
for SAMD5 gene

Genomic Views
for SAMD5 gene

Proteins
for SAMD5 gene

Protein Domains /
Families
for SAMD5 gene

Function
for SAMD5 gene

Pathways & Interactions
for SAMD5 gene

Drugs & Compounds
for SAMD5 gene

Transcripts
for SAMD5 gene

Expression
for SAMD5 gene

Orthologs
for SAMD5 gene

Paralogs
for SAMD5 gene

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for SAMD5 gene

Disorders / Diseases
for SAMD5 gene

Publications
for SAMD5 gene

External Searches for SAMD5 gene

Genome Databases showing SAMD5 gene

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Export list of displayed genes

SAMD5 Gene

sterile alpha motif domain containing 5

Aliasesfor SAMD5 gene

Summariesfor SAMD5 gene

Genomic Viewsfor SAMD5 gene

Proteinsfor SAMD5 gene

Protein Domains /Familiesfor SAMD5 gene

Functionfor SAMD5 gene

Pathways & Interactionsfor SAMD5 gene

Drugs & Compoundsfor SAMD5 gene

Transcriptsfor SAMD5 gene

Expression for SAMD5 gene

Orthologsfor SAMD5 gene

Paralogsfor SAMD5 gene

Genomic Variantsfor SAMD5 gene

Disorders / Diseasesfor SAMD5 gene

Publicationsfor SAMD5 gene

External Searches for SAMD5 gene

Genome Databases showing SAMD5 gene

Other Databases showing SAMD5 gene

Specialized Databases showing SAMD5 gene

Intellectual Propertyfor SAMD5 gene

Productsfor SAMD5 gene

View Random Gene

Aliases
for SAMD5 gene

Summaries
for SAMD5 gene

Genomic Views
for SAMD5 gene

Proteins
for SAMD5 gene

Protein Domains /
Families
for SAMD5 gene

Function
for SAMD5 gene

Pathways & Interactions
for SAMD5 gene

Drugs & Compounds
for SAMD5 gene

Transcripts
for SAMD5 gene

Expression
for SAMD5 gene

Orthologs
for SAMD5 gene

Paralogs
for SAMD5 gene

Genomic Variants
for SAMD5 gene

Disorders / Diseases
for SAMD5 gene

Publications
for SAMD5 gene

Intellectual Property
for SAMD5 gene

Products
for SAMD5 gene