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SAMD5 Gene

protein-coding   GIFtS: 40

GC06P147873
sterile alpha motif domain containing 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000017385 2
SAMDC1 3
dJ875H10.1 1, 2
Descriptions
SAM domain containing 1 2
sterile alpha motif domain containing 5 2
External Ids
HGNC: 211801
Entrez Gene: 3894322
UniProtKB: Q5TGI43
Ensembl: ENSG000002037277
Search outside databases for aliases for SAMD5 gene

Previous GC identifers: GC00U914193 GC06U900641

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.3   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24.3

SAMD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P147873:     (about GC identifiers)

Start:
147,871,756 bp from pter
End:
147,932,850 bp from pter
Size:
61,095 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAMD5_HUMAN, Q5TGI4 (See protein sequence)
Recommended Name: Sterile alpha motif domain-containing protein 5  
Size: 173 amino acids; 19231 Da

REFSEQ proteins: NP_001025231.1  

ENSEMBL proteins: 
ENSP00000356444 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for SAMD5: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for SAMD5

Assays for SAMD5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR013761 SAM_type
 IPR001660 SAM


   GeneDecks  SAMD5 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q5TGI4

ProtoNet protein and cluster: Q5TGI4

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: SAMD5_HUMAN, Q5TGI4
Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SAMD5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001030060

              Applied Biosystems Silencer® siRNAs for SAMD5

              Sigma-Aldrich siRNA for SAMD5  
                     Sigma-Aldrich shRNA for SAMD5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001030060
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001030060
                                 untagged cDNA clones in CMV expression vector (see all 2): BC018908 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001030060

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for SAMD5 (ENSP000003564443) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
SASH3ENSP000003493593STRING (score=.758)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAMD5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (SAMD5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001030060

              Sigma-Aldrich siRNA for SAMD5  
                     Sigma-Aldrich shRNA for SAMD5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001030060  

REFSEQ mRNAs for SAMD5 gene: 

NM_001030060.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001030060  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001030060
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001030060
                                 untagged cDNA clones in CMV expression vector (see all 2): BC018908 

Additional cDNA sequence: BC020896.1 

2 DOTS entries:

DT.91741375  DT.407224 

24/70 AceView cDNA sequences (see all 70 ):

BF115069 AA252168 CA942632 BU102088 BX110596 BM311407 BX099467 AA242983 
AW274555 AA452295 AA582100 CA843432 AA886794 BM717307 BX099879 BM312000 
AI435785 AI700341 AA039712 BG204892 BG204894 BC020896 BU739124 BF109382 

highest scoring ESTs for SAMD5:

AA252168 AA452295 AA039712 AA039713 AA242983 AA359571 AA453400 AA453908 AA582100 AA886794 

Unigene Cluster for SAMD5:

Sterile alpha motif domain containing 5
Hs.567973  [show with all ESTs]
Unigene Representative Sequence: NM_001030060


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000367474  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SAMD5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SAMD5

1 / 2 / 3

7 probe-sets matching SAMD5 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
56941_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA452295 0.80 1.00 0.91 1

43721_at2, 3 U95-B 1 1.00 1.00 0.35 0.56 AA252168 0.80 1.00 0.91 1

228653_at2, 3 U133-B 1 1.00 1.00 -- -- AI700341 0.60 1.00 0.82 1

242626_at2, 3 U133-B 1 0.91 1.00 -- -- BF696216 0.60 1.00 0.82 1

1569433_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

228653_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

242626_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
GeneDecks  SAMD5 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CACACTGTGA

SOURCE GeneReport for Unigene cluster: Hs.567973
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for SAMD5 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
SAMD51   -- sterile alpha motif domain containing 5 99.42(n)
98.84(a)
463054  XM_001173087.1  XP_001173087.1 
rat
(Rattus norvegicus)
Samd51   -- sterile alpha motif domain containing 5 87.86(n)
91.33(a)
365038  XM_344792.3  XP_344793.3 
mouse
(Mus musculus)
Samd51, 5 105
sterile alpha motif domain containing 51, 5 87.6(n)1
90.7(a)1
3208251  NM_177271.31  NP_796245.21 
 AI8503115  AK0456455  (see all 10)
chicken
(Gallus gallus)
SAMD51   -- sterile alpha motif domain containing 5 80.25(n)
82.22(a)
768744  XM_001231848.1  XP_001231849.1 
rainbow trout
(Oncorhynchus mykiss)
Omy.34722   -- Oncorhynchus mykiss transcribed sequences 76.56(n)  BX078108.1 
About this table        Species with no ortholog for SAMD5

ENSEMBL Gene Tree for SAMD5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/374 NCBI SNPs in SAMD5 are shown (see all 374 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 171)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs7023491,2
A,C,F,H,O147929715(+) GGACAA/GTTAGT 1 -- ut3116Minor allele frequency- G:0.18MN NA EU EA WA 1578
rs7023511,2
A,C,F,H,O147930620(-) TTCCTG/AAGAGA 1 -- ut31 ese38Minor allele frequency- A:0.40EU EA WA 776
rs7023471,2
A,C,F,H,O147929262(-) GCCACG/AGATGC 1 -- ut31 ese320Minor allele frequency- A:0.41EU EA WA NA 1868
rs7023431,2
A,C,F,H147928285(-) CCAGCA/GTCCAA 1 -- ut31 ese34Minor allele frequency- G:0.07EU EA WA 420
rs7023481,2
C,F,H,O147929583(-) TTCTTC/TCTCTA 1 -- ut31 ese3 trp312Minor allele frequency- T:0.08NS EU EA WA NA 658
rs7023501,2
C,F,H,O147930187(-) CTTGTT/GGTTGT 1 -- ut31 ese38Minor allele frequency- G:0.06MN EU EA WA NA 734
rs8445891,2
A,C,F,H147933198(-) ACATGT/CACAGA 1 -- ng314Minor allele frequency- C:0.42EU EA WA 416
rs93904771,2
A,C,F,H147930630(+) AGGATA/GAAAAA 1 -- ut314Minor allele frequency- G:0.22EU EA WA 412
rs7023411,2
A,C,F,H147927496(+) TATCAC/TGCATA 1 -- ut31 ese38Minor allele frequency- T:0.23EU EA WA 836
rs7023461,2
C,F,H,O147928911(-) AATTGC/TCCTTA 1 -- ut31 ese315Minor allele frequency- T:0.18NA EU EA WA 1398
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HapMap Linkage Disequilibrium images for SAMD5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for SAMD5 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 389432 HGNC: 21180 AceView: LOC389432 Ensembl:ENSG00000203727 euGenes: HUgn389432
ECgene: SAMD5 H-InvDB: SAMD5
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SAMD5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SAMD5-related products

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 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for SAMD5 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SAMD5 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for SAMD5

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