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Aliases for SAMD5 Gene

Aliases for SAMD5 Gene

  • Sterile Alpha Motif Domain Containing 5 2 3 5
  • SAM Domain-Containing Protein 5 3 4
  • Sterile Alpha Motif Domain-Containing Protein 5 3
  • SAM Domain Containing 1 3
  • DJ875H10.1 3
  • SAMDC1 4

External Ids for SAMD5 Gene

Previous GeneCards Identifiers for SAMD5 Gene

  • GC00U914193
  • GC06U900641
  • GC06P147873
  • GC06P145393

Summaries for SAMD5 Gene

GeneCards Summary for SAMD5 Gene

SAMD5 (Sterile Alpha Motif Domain Containing 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD5 Gene

Genomics for SAMD5 Gene

Regulatory Elements for SAMD5 Gene

Enhancers for SAMD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G147507 1.5 FANTOM5 Ensembl ENCODE 11.8 +0.7 748 4.3 HDAC1 FOXA2 RB1 ZNF2 YY1 GLIS2 GATA2 EGR1 ZSCAN5C KLF7 SAMD5 GC06M147546
GH06G147651 0.8 Ensembl ENCODE 11.2 +143.1 143051 1.2 CTCF EP300 RAD21 NR2F2 SAMD5 ENSG00000227681 GC06P147624
GH06G147558 0.6 ENCODE 14.9 +50.5 50485 1.8 CTCF CBX8 IKZF1 SMC3 EP300 RAD21 SAMD5 GC06P147565 PIR31125
GH06G147447 0.8 ENCODE 11 -60.4 -60356 1.3 HDAC1 PKNOX1 ATF1 MAX ETS1 EGR1 ZNF652 EZH2 SMAD5 L3MBTL2 SAMD5 PIR46532 LOC105378043
GH06G147620 0.6 ENCODE 12.7 +112.7 112737 0.9 PKNOX1 NR2F1 FOSL1 JUND ATF3 PBX2 FOS NR2F6 NR2C2 SAMD5 GC06P147624 GC06P147565
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAMD5 on UCSC Golden Path with GeneCards custom track

Promoters for SAMD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000323616 -148 1801 HDAC1 RB1 ZNF2 RAD21 GLIS2 GATA2 ZSCAN5C ZNF263 SP3 SMARCA4
ENSR00000204722 -1748 201 CTCF KLF1 RB1 SUZ12 ZNF76 ZNF2 RAD21 PATZ1 SMC3 PRDM10

Genomic Location for SAMD5 Gene

Chromosome:
6
Start:
147,508,648 bp from pter
End:
147,737,547 bp from pter
Size:
228,900 bases
Orientation:
Plus strand

Genomic View for SAMD5 Gene

Genes around SAMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD5 Gene

Proteins for SAMD5 Gene

  • Protein details for SAMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGI4-SAMD5_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 5
    Protein Accession:
    Q5TGI4

    Protein attributes for SAMD5 Gene

    Size:
    173 amino acids
    Molecular mass:
    19231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD5 Gene

Post-translational modifications for SAMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAMD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAMD5 Gene

Domains & Families for SAMD5 Gene

Gene Families for SAMD5 Gene

Protein Domains for SAMD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAMD5: view

No data available for UniProtKB/Swiss-Prot for SAMD5 Gene

Function for SAMD5 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD5 Gene

Localization for SAMD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD5 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SAMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SAMD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SAMD5 Gene

Pathways & Interactions for SAMD5 Gene

SuperPathways for SAMD5 Gene

No Data Available

Interacting Proteins for SAMD5 Gene

Gene Ontology (GO) - Biological Process for SAMD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD5 Gene

Drugs & Compounds for SAMD5 Gene

No Compound Related Data Available

Transcripts for SAMD5 Gene

mRNA/cDNA for SAMD5 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAMD5 Gene

Sterile alpha motif domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD5 Gene

No ASD Table

Relevant External Links for SAMD5 Gene

GeneLoc Exon Structure for
SAMD5
ECgene alternative splicing isoforms for
SAMD5

Expression for SAMD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAMD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD5 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.2), Kidney - Cortex (x5.2), and Liver (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of SAMD5 Gene:

SAMD5

SOURCE GeneReport for Unigene cluster for SAMD5 Gene:

Hs.567973
genes like me logo Genes that share expression patterns with SAMD5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD5 Gene

Orthologs for SAMD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD5 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia SAMD5 34 35
  • 92.1 (n)
rat
(Rattus norvegicus)
Mammalia Samd5 34
  • 87.86 (n)
mouse
(Mus musculus)
Mammalia Samd5 34 16 35
  • 87.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD5 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAMD5 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAMD5 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAMD5 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100148561 34
  • 59.23 (n)
SAMD5 35
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3472 34
fruit fly
(Drosophila melanogaster)
Insecta CG34377 35
  • 16 (a)
OneToMany
SKIP 35
  • 7 (a)
OneToMany
Species where no ortholog for SAMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD5 Gene

ENSEMBL:
Gene Tree for SAMD5 (if available)
TreeFam:
Gene Tree for SAMD5 (if available)

Paralogs for SAMD5 Gene

No data available for Paralogs for SAMD5 Gene

Variants for SAMD5 Gene

Sequence variations from dbSNP and Humsavar for SAMD5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000010602 -- 147,914,590(+) GCCAT(C/T)AAAGT intron-variant
rs1000015044 -- 147,907,735(+) AAGGC(C/T)TTTGT intron-variant
rs1000031332 -- 147,610,371(+) TTGGT(A/G)CAACG intron-variant
rs1000039035 -- 147,510,349(+) CTGTC(A/G)GAGTA intron-variant
rs1000040055 -- 147,947,680(+) CTTTT(C/T)TCTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SAMD5 Gene

Variant ID Type Subtype PubMed ID
esv2662219 CNV deletion 23128226
esv3611170 CNV gain 21293372
esv3611171 CNV loss 21293372
esv3611172 CNV loss 21293372
nsv604841 CNV gain 21841781
nsv819870 CNV gain 19587683

Variation tolerance for SAMD5 Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD5 Gene

Disorders for SAMD5 Gene

Relevant External Links for SAMD5

Genetic Association Database (GAD)
SAMD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD5

No disorders were found for SAMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD5 Gene

Publications for SAMD5 Gene

  1. Common genetic variation and the control of HIV-1 in humans. (PMID: 20041166) Fellay J. … Goldstein D.B. (PLoS Genet. 2009) 3 46 64
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  3. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. (PMID: 20061627) Heinzen E.L. … Goldstein D.B. (J. Alzheimers Dis. 2010) 46 64
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for SAMD5 Gene

Sources for SAMD5 Gene

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