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Aliases for SAMD4B Gene

Aliases for SAMD4B Gene

  • Sterile Alpha Motif Domain Containing 4B 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 4B 3 4
  • SAM Domain-Containing Protein 4B 3 4
  • Smaug 2 3 4
  • Smaug2 3 4
  • Smaug Homolog B (Drosophila) 2
  • Protein Smaug Homolog 2 3
  • Smaug Homolog B 3
  • HSmaug2 4
  • SMGB 3

External Ids for SAMD4B Gene

Previous GeneCards Identifiers for SAMD4B Gene

  • GC19P044525
  • GC19P039833
  • GC19P036279

Summaries for SAMD4B Gene

GeneCards Summary for SAMD4B Gene

SAMD4B (Sterile Alpha Motif Domain Containing 4B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is SAMD4A.

UniProtKB/Swiss-Prot for SAMD4B Gene

  • Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD4B Gene

Genomics for SAMD4B Gene

Regulatory Elements for SAMD4B Gene

Enhancers for SAMD4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F039389 0.8 ENCODE 6.4 +48.4 48390 3.4 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RPS16 FBL EID2B PSMC4 ENSG00000269792 LOC105372399 ENSG00000269188 ENSG00000269172 LGALS14 ENSG00000269445
GH19F039351 0.5 ENCODE 6.2 +10.0 10004 2.4 HDGF ATF1 PKNOX1 TBL1XR1 ZNF2 RAD21 RFX5 ZNF335 ZNF366 SCRT2 RPS16 SUPT5H ZFP36 PLEKHG2 PAK4 IFNL1 EID2B SAMD4B GMFG GC19P039349
GH19F039356 0.2 ENCODE 6.1 +14.2 14239 1.2 HDGF ATF1 ARNT SIN3A FEZF1 DMAP1 YY1 SLC30A9 GATA2 ELK1 EID2B PAK4 SAMD4B RPS16 GC19P039349 RN7SL566P
GH19F039362 0.2 ENCODE 6.1 +21.1 21128 3.0 KLF1 ZSCAN18 KLF17 EBF1 ZIC2 GLIS1 ZNF747 FOS ZNF785 MED29 PAF1 EID2B PSMC4 SAMD4B RPS16 RN7SL566P GC19P039349
GH19F039334 1 FANTOM5 ENCODE 5.5 -6.0 -5975 4.3 HDGF PKNOX1 ARNT ZNF121 GLIS2 ZNF143 ZHX2 TBX21 ZNF518A MEF2D GMFG SAMD4B ENSG00000205041 CLC RINL GC19P039341 ENSG00000268262
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SAMD4B on UCSC Golden Path with GeneCards custom track

Promoters for SAMD4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346462 -396 2801 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1

Genomic Location for SAMD4B Gene

39,342,396 bp from pter
39,390,760 bp from pter
48,365 bases
Plus strand

Genomic View for SAMD4B Gene

Genes around SAMD4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD4B Gene

Proteins for SAMD4B Gene

  • Protein details for SAMD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Smaug homolog 2
    Protein Accession:
    Secondary Accessions:
    • A5Z0M6
    • Q6P194

    Protein attributes for SAMD4B Gene

    694 amino acids
    Molecular mass:
    75483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD4B Gene

Post-translational modifications for SAMD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD4B Gene

Domains & Families for SAMD4B Gene

Gene Families for SAMD4B Gene

Protein Domains for SAMD4B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the SMAUG family.
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the SMAUG family.
genes like me logo Genes that share domains with SAMD4B: view

Function for SAMD4B Gene

Molecular function for SAMD4B Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

Gene Ontology (GO) - Molecular Function for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IBA --
GO:0030371 translation repressor activity IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SAMD4B: view
genes like me logo Genes that share phenotypes with SAMD4B: view

Animal Model Products

miRNA for SAMD4B Gene

miRTarBase miRNAs that target SAMD4B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD4B Gene

Localization for SAMD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD4B Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for SAMD4B Gene COMPARTMENTS Subcellular localization image for SAMD4B gene
Compartment Confidence
cytosol 4
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA --
genes like me logo Genes that share ontologies with SAMD4B: view

Pathways & Interactions for SAMD4B Gene

SuperPathways for SAMD4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0017148 negative regulation of translation IBA --
GO:0043488 regulation of mRNA stability IBA --
genes like me logo Genes that share ontologies with SAMD4B: view

No data available for Pathways by source and SIGNOR curated interactions for SAMD4B Gene

Transcripts for SAMD4B Gene

Unigene Clusters for SAMD4B Gene

Sterile alpha motif domain containing 4B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: - -
SP4: -

Relevant External Links for SAMD4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAMD4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAMD4B Gene

Protein differential expression in normal tissues from HIPED for SAMD4B Gene

This gene is overexpressed in Breast (16.8), Lung (14.8), and Bone marrow stromal cell (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAMD4B Gene

Protein tissue co-expression partners for SAMD4B Gene

NURSA nuclear receptor signaling pathways regulating expression of SAMD4B Gene:


SOURCE GeneReport for Unigene cluster for SAMD4B Gene:


mRNA Expression by UniProt/SwissProt for SAMD4B Gene:

Tissue specificity: Widely expressed in embryonic and adult tissues.
genes like me logo Genes that share expression patterns with SAMD4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SAMD4B Gene

Orthologs for SAMD4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAMD4B 34 35
  • 99.63 (n)
(Canis familiaris)
Mammalia SAMD4B 34 35
  • 94.43 (n)
(Bos Taurus)
Mammalia SAMD4B 34 35
  • 93.32 (n)
(Mus musculus)
Mammalia Samd4b 34 16 35
  • 92.92 (n)
(Rattus norvegicus)
Mammalia Samd4b 34
  • 92.82 (n)
(Monodelphis domestica)
Mammalia SAMD4B 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
(Anolis carolinensis)
Reptilia SAMD4B 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia samd4b 34
  • 69.71 (n)
(Danio rerio)
Actinopterygii samd4b 34
  • 71.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta smg 35
  • 12 (a)
(Caenorhabditis elegans)
Secernentea ZC190.4 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7136 35
  • 49 (a)
Species where no ortholog for SAMD4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAMD4B Gene

Gene Tree for SAMD4B (if available)
Gene Tree for SAMD4B (if available)

Paralogs for SAMD4B Gene

Paralogs for SAMD4B Gene

genes like me logo Genes that share paralogs with SAMD4B: view

Variants for SAMD4B Gene

Sequence variations from dbSNP and Humsavar for SAMD4B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10153522 -- 39,361,918(+) ccaga(C/T)tccgt intron-variant
rs10403438 -- 39,374,616(+) gtggg(C/T)ggatc intron-variant
rs10405369 -- 39,369,328(+) ggagg(A/G)gtgaa intron-variant
rs10412658 -- 39,384,911(+) AAAAA(A/C)CAAAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10422570 -- 39,373,596(+) TGAGC(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD4B Gene

Variant ID Type Subtype PubMed ID
dgv202n21 CNV loss 19592680
esv25791 CNV gain 19812545
esv3583388 CNV loss 25503493
nsv1126522 CNV deletion 24896259
nsv2480 CNV insertion 18451855
nsv833830 CNV loss 17160897

Variation tolerance for SAMD4B Gene

Residual Variation Intolerance Score: 4.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD4B Gene

Disorders for SAMD4B Gene

Relevant External Links for SAMD4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SAMD4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD4B Gene

Publications for SAMD4B Gene

  1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. (PMID: 16221671) Baez M.V. … Boccaccio G.L. (J. Biol. Chem. 2005) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21- mediated transcriptional activity. (PMID: 20510020) Luo N. … Wu X. (BMB Rep. 2010) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SAMD4B Gene

Sources for SAMD4B Gene

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