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Aliases for SAMD4B Gene

Aliases for SAMD4B Gene

  • Sterile Alpha Motif Domain Containing 4B 2 3
  • Sterile Alpha Motif Domain-Containing Protein 4B 3 4
  • SAM Domain-Containing Protein 4B 3 4
  • Smaug 2 3 4
  • Smaug2 3 4
  • Smaug Homolog B (Drosophila) 2
  • Protein Smaug Homolog 2 3
  • Smaug Homolog B 3
  • HSmaug2 4
  • SMGB 3

External Ids for SAMD4B Gene

Previous GeneCards Identifiers for SAMD4B Gene

  • GC19P044525
  • GC19P039833
  • GC19P036279

Summaries for SAMD4B Gene

GeneCards Summary for SAMD4B Gene

SAMD4B (Sterile Alpha Motif Domain Containing 4B) is a Protein Coding gene. An important paralog of this gene is SAMD4A.

UniProtKB/Swiss-Prot for SAMD4B Gene

  • Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD4B Gene

Genomics for SAMD4B Gene

Regulatory Elements for SAMD4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAMD4B Gene

Start:
39,342,396 bp from pter
End:
39,385,710 bp from pter
Size:
43,315 bases
Orientation:
Plus strand

Genomic View for SAMD4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAMD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD4B Gene

Proteins for SAMD4B Gene

  • Protein details for SAMD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PRF9-SMAG2_HUMAN
    Recommended name:
    Protein Smaug homolog 2
    Protein Accession:
    Q5PRF9
    Secondary Accessions:
    • A5Z0M6
    • Q6P194

    Protein attributes for SAMD4B Gene

    Size:
    694 amino acids
    Molecular mass:
    75483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD4B Gene

Proteomics data for SAMD4B Gene at MOPED

Post-translational modifications for SAMD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD4B Gene

Domains for SAMD4B Gene

Gene Families for SAMD4B Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SAMD4B Gene

Graphical View of Domain Structure for InterPro Entry

Q5PRF9

UniProtKB/Swiss-Prot:

SMAG2_HUMAN :
  • Q5PRF9
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SMAUG family.
genes like me logo Genes that share domains with SAMD4B: view

Function for SAMD4B Gene

Molecular function for SAMD4B Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

Gene Ontology (GO) - Molecular Function for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SAMD4B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAMD4B Gene

Localization for SAMD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD4B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD4B Gene COMPARTMENTS Subcellular localization image for SAMD4B gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SAMD4B: view

Pathways for SAMD4B Gene

SuperPathways for SAMD4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SAMD4B: view

No data available for Pathways by source for SAMD4B Gene

Transcripts for SAMD4B Gene

Unigene Clusters for SAMD4B Gene

Sterile alpha motif domain containing 4B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for SAMD4B Gene

GeneLoc Exon Structure for
SAMD4B
ECgene alternative splicing isoforms for
SAMD4B

Expression for SAMD4B Gene

mRNA expression in normal human tissues for SAMD4B Gene

Protein differential expression in normal tissues for SAMD4B Gene

This gene is overexpressed in Breast (16.8), Lung (14.8), and Bone marrow stromal cell (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAMD4B Gene

SOURCE GeneReport for Unigene cluster for SAMD4B Gene Hs.707137

mRNA Expression by UniProt/SwissProt for SAMD4B Gene

Q5PRF9-SMAG2_HUMAN
Tissue specificity: Widely expressed in embryonic and adult tissues.
genes like me logo Genes that share expressions with SAMD4B: view

Expression partners for SAMD4B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SAMD4B Gene

Orthologs for SAMD4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAMD4B 35
  • 93.32 (n)
  • 96.4 (a)
SAMD4B 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAMD4B 35
  • 94.43 (n)
  • 97.98 (a)
SAMD4B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd4b 35
  • 92.92 (n)
  • 97.67 (a)
Samd4b 16
Samd4b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SAMD4B 35
  • 99.63 (n)
  • 100 (a)
SAMD4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Samd4b 35
  • 92.82 (n)
  • 97.67 (a)
oppossum
(Monodelphis domestica)
Mammalia SAMD4B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia SAMD4B 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia samd4b 35
  • 69.71 (n)
  • 76.25 (a)
zebrafish
(Danio rerio)
Actinopterygii samd4b 35
  • 71.88 (n)
  • 72.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta smg 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC190.4 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7136 36
  • 49 (a)
OneToMany
Species with no ortholog for SAMD4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAMD4B Gene

ENSEMBL:
Gene Tree for SAMD4B (if available)
TreeFam:
Gene Tree for SAMD4B (if available)

Paralogs for SAMD4B Gene

Paralogs for SAMD4B Gene

Selected SIMAP similar genes for SAMD4B Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SAMD4B: view

Variants for SAMD4B Gene

Sequence variations from dbSNP and Humsavar for SAMD4B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs30453 -- 39,354,904(-) caggg(A/C)aactc intron-variant, upstream-variant-2KB
rs30454 -- 39,353,536(-) CTACA(C/T)AGTAA intron-variant, upstream-variant-2KB
rs30455 -- 39,352,983(-) TCCCT(C/T)GGGAG intron-variant, upstream-variant-2KB
rs30456 -- 39,350,061(-) TATAT(A/T)ACATA intron-variant
rs30457 -- 39,349,909(-) TGCAA(C/G)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD4B Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV Loss 17160897
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
nsv911681 CNV Loss 21882294
esv25791 CNV Gain 19812545
nsv2480 CNV Insertion 18451855
dgv202n21 CNV Loss 19592680
dgv3860n71 CNV Loss 21882294

Relevant External Links for SAMD4B Gene

HapMap Linkage Disequilibrium report
SAMD4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD4B Gene

Disorders for SAMD4B Gene

Relevant External Links for SAMD4B

Genetic Association Database (GAD)
SAMD4B
Human Genome Epidemiology (HuGE) Navigator
SAMD4B

No disorders were found for SAMD4B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SAMD4B Gene

Publications for SAMD4B Gene

  1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. (PMID: 16221671) Baez M.V. … Boccaccio G.L. (J. Biol. Chem. 2005) 2 3 4
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21- mediated transcriptional activity. (PMID: 20510020) Luo N. … Wu X. (BMB Rep. 2010) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SAMD4B Gene

Sources for SAMD4B Gene

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