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Aliases for SAMD4B Gene

Aliases for SAMD4B Gene

  • Sterile Alpha Motif Domain Containing 4B 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 4B 3 4
  • SAM Domain-Containing Protein 4B 3 4
  • Smaug 2 3 4
  • Smaug2 3 4
  • Smaug Homolog B (Drosophila) 2
  • Smaug Homolog B 3
  • HSmaug2 4
  • SMGB 3

External Ids for SAMD4B Gene

Previous GeneCards Identifiers for SAMD4B Gene

  • GC19P044525
  • GC19P039833
  • GC19P036279

Summaries for SAMD4B Gene

GeneCards Summary for SAMD4B Gene

SAMD4B (Sterile Alpha Motif Domain Containing 4B) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is SAMD4A.

UniProtKB/Swiss-Prot for SAMD4B Gene

  • Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD4B Gene

Genomics for SAMD4B Gene

Regulatory Elements for SAMD4B Gene

Promoters for SAMD4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAMD4B on UCSC Golden Path with GeneCards custom track

Genomic Location for SAMD4B Gene

Chromosome:
19
Start:
39,342,396 bp from pter
End:
39,390,760 bp from pter
Size:
48,365 bases
Orientation:
Plus strand

Genomic View for SAMD4B Gene

Genes around SAMD4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD4B Gene

Proteins for SAMD4B Gene

  • Protein details for SAMD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PRF9-SMAG2_HUMAN
    Recommended name:
    Protein Smaug homolog 2
    Protein Accession:
    Q5PRF9
    Secondary Accessions:
    • A5Z0M6
    • Q6P194

    Protein attributes for SAMD4B Gene

    Size:
    694 amino acids
    Molecular mass:
    75483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD4B Gene

Proteomics data for SAMD4B Gene at MOPED

Post-translational modifications for SAMD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD4B Gene

Domains & Families for SAMD4B Gene

Gene Families for SAMD4B Gene

Protein Domains for SAMD4B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5PRF9

UniProtKB/Swiss-Prot:

SMAG2_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Belongs to the SMAUG family.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the SMAUG family.
genes like me logo Genes that share domains with SAMD4B: view

Function for SAMD4B Gene

Molecular function for SAMD4B Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.
genes like me logo Genes that share phenotypes with SAMD4B: view

Animal Model Products

miRNA for SAMD4B Gene

miRTarBase miRNAs that target SAMD4B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD4B Gene

Localization for SAMD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD4B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD4B Gene COMPARTMENTS Subcellular localization image for SAMD4B gene
Compartment Confidence
cytosol 4
nucleus 4
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SAMD4B Gene

Pathways & Interactions for SAMD4B Gene

SuperPathways for SAMD4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAMD4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD4B Gene

Drugs & Compounds for SAMD4B Gene

No Compound Related Data Available

Transcripts for SAMD4B Gene

Unigene Clusters for SAMD4B Gene

Sterile alpha motif domain containing 4B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for SAMD4B Gene

GeneLoc Exon Structure for
SAMD4B
ECgene alternative splicing isoforms for
SAMD4B

Expression for SAMD4B Gene

mRNA expression in normal human tissues for SAMD4B Gene

Protein differential expression in normal tissues from HIPED for SAMD4B Gene

This gene is overexpressed in Breast (16.8), Lung (14.8), and Bone marrow stromal cell (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SAMD4B Gene



SOURCE GeneReport for Unigene cluster for SAMD4B Gene Hs.707137

mRNA Expression by UniProt/SwissProt for SAMD4B Gene

Q5PRF9-SMAG2_HUMAN
Tissue specificity: Widely expressed in embryonic and adult tissues.
genes like me logo Genes that share expression patterns with SAMD4B: view

Protein tissue co-expression partners for SAMD4B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SAMD4B Gene

Orthologs for SAMD4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD4B 35
  • 99.63 (n)
  • 100 (a)
SAMD4B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAMD4B 36
  • 96 (a)
OneToOne
SAMD4B 35
  • 93.32 (n)
  • 96.4 (a)
dog
(Canis familiaris)
Mammalia SAMD4B 35
  • 94.43 (n)
  • 97.98 (a)
SAMD4B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd4b 16
Samd4b 35
  • 92.92 (n)
  • 97.67 (a)
Samd4b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAMD4B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Samd4b 35
  • 92.82 (n)
  • 97.67 (a)
lizard
(Anolis carolinensis)
Reptilia SAMD4B 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia samd4b 35
  • 69.71 (n)
  • 76.25 (a)
zebrafish
(Danio rerio)
Actinopterygii samd4b 35
  • 71.88 (n)
  • 72.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta smg 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC190.4 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7136 36
  • 49 (a)
OneToMany
Species with no ortholog for SAMD4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAMD4B Gene

ENSEMBL:
Gene Tree for SAMD4B (if available)
TreeFam:
Gene Tree for SAMD4B (if available)

Paralogs for SAMD4B Gene

Paralogs for SAMD4B Gene

genes like me logo Genes that share paralogs with SAMD4B: view

Variants for SAMD4B Gene

Sequence variations from dbSNP and Humsavar for SAMD4B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs36264 -- 39,370,874(+) GGACA(C/T)CGGGA intron-variant
rs36265 -- 39,372,241(+) GGATT(C/T)GAATG intron-variant
rs36266 -- 39,374,773(+) gaggc(A/G)gaggt intron-variant
rs917319 -- 39,365,978(+) ggcaa(A/G)tcatt intron-variant
rs685125 -- 39,359,462(+) ATATT(C/T)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD4B Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV Loss 17160897
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
nsv911681 CNV Loss 21882294
esv25791 CNV Gain 19812545
nsv2480 CNV Insertion 18451855
dgv202n21 CNV Loss 19592680
dgv3860n71 CNV Loss 21882294

Variation tolerance for SAMD4B Gene

Residual Variation Intolerance Score: 4.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD4B Gene

HapMap Linkage Disequilibrium report
SAMD4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD4B Gene

Disorders for SAMD4B Gene

Relevant External Links for SAMD4B

Genetic Association Database (GAD)
SAMD4B
Human Genome Epidemiology (HuGE) Navigator
SAMD4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD4B

No disorders were found for SAMD4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD4B Gene

Publications for SAMD4B Gene

  1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. (PMID: 16221671) Baez M.V. … Boccaccio G.L. (J. Biol. Chem. 2005) 2 3 4 67
  2. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  3. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for SAMD4B Gene

Sources for SAMD4B Gene

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