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Aliases for SAMD4A Gene

Aliases for SAMD4A Gene

  • Sterile Alpha Motif Domain Containing 4A 2 3
  • SMAUG1 3 4 6
  • SAM Domain-Containing Protein 4A 3 4
  • KIAA1053 4 6
  • SAMD4 3 4
  • Sterile Alpha Motif Domain-Containing Protein 4A 4
  • Sterile Alpha Motif Domain Containing 4 2
  • Smaug Homolog (Drosophila) 2
  • Protein Smaug Homolog 1 3
  • Smaug 1 4
  • HSmaug1 4
  • SMAUG 3
  • SMGA 3
  • SMG 3

External Ids for SAMD4A Gene

Previous Symbols for SAMD4A Gene

  • SAMD4

Summaries for SAMD4A Gene

Entrez Gene Summary for SAMD4A Gene

  • Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SAMD4A Gene

SAMD4A (Sterile Alpha Motif Domain Containing 4A) is a Protein Coding gene. GO annotations related to this gene include translation repressor activity. An important paralog of this gene is SAMD4B.

UniProtKB/Swiss-Prot for SAMD4A Gene

  • Acts as a translational repressor of SRE-containing messengers.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD4A Gene

Genomics for SAMD4A Gene

Genomic Location for SAMD4A Gene

54,567,097 bp from pter
54,793,315 bp from pter
226,219 bases
Plus strand

Genomic View for SAMD4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAMD4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD4A Gene

Regulatory Elements for SAMD4A Gene

Proteins for SAMD4A Gene

  • Protein details for SAMD4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Smaug homolog 1
    Protein Accession:
    Secondary Accessions:
    • A8MPZ5
    • Q0VA96
    • Q6PEW4

    Protein attributes for SAMD4A Gene

    718 amino acids
    Molecular mass:
    79415 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH57838.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAP97302.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SAMD4A Gene


neXtProt entry for SAMD4A Gene

Proteomics data for SAMD4A Gene at MOPED

Post-translational modifications for SAMD4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAMD4A Gene

No data available for DME Specific Peptides for SAMD4A Gene

Domains for SAMD4A Gene

Gene Families for SAMD4A Gene

  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SAMD4A Gene


  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q9UPU9
  • Belongs to the SMAUG family.:
    • Q9UPU9
genes like me logo Genes that share domains with SAMD4A: view

Function for SAMD4A Gene

Molecular function for SAMD4A Gene

UniProtKB/Swiss-Prot Function: Acts as a translational repressor of SRE-containing messengers.

Gene Ontology (GO) - Molecular Function for SAMD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0030371 translation repressor activity IDA 16221671
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SAMD4A: view

miRNA for SAMD4A Gene

miRTarBase miRNAs that target SAMD4A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAMD4A Gene

Localization for SAMD4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD4A Gene

Cytoplasm. Cell projection, dendrite. Cell junction, synapse, synaptosome. Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs, PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SAMD4A Gene COMPARTMENTS Subcellular localization image for SAMD4A gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SAMD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
GO:0043005 neuron projection --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SAMD4A: view

Pathways for SAMD4A Gene

SuperPathways for SAMD4A Gene

No Data Available

Interacting Proteins for SAMD4A Gene

Gene Ontology (GO) - Biological Process for SAMD4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017148 negative regulation of translation IDA 16221671
GO:0045727 positive regulation of translation IDA 16221671
genes like me logo Genes that share ontologies with SAMD4A: view

No data available for Pathways by source for SAMD4A Gene

Transcripts for SAMD4A Gene

Unigene Clusters for SAMD4A Gene

Sterile alpha motif domain containing 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for SAMD4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAMD4A Gene

mRNA expression in normal human tissues for SAMD4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD4A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SAMD4A Gene

SOURCE GeneReport for Unigene cluster for SAMD4A Gene Hs.98259

genes like me logo Genes that share expressions with SAMD4A: view

Orthologs for SAMD4A Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAMD4A 36
  • 99.49 (n)
  • 99.58 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SAMD4A 36
  • 94.33 (n)
  • 97.77 (a)
  • 98 (a)
(Canis familiaris)
Mammalia SAMD4A 36
  • 94.57 (n)
  • 97.49 (a)
  • 97 (a)
(Mus musculus)
Mammalia Samd4 36
  • 92.63 (n)
  • 96.34 (a)
Samd4 16
Samd4 37
  • 96 (a)
(Monodelphis domestica)
Mammalia SAMD4A 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SAMD4A 37
  • 45 (a)
(Rattus norvegicus)
Mammalia Samd4a 36
  • 91.11 (n)
  • 95.81 (a)
(Gallus gallus)
Aves SAMD4A 36
  • 84.02 (n)
  • 87.94 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia SAMD4A 37
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia samd4a 36
  • 76.39 (n)
  • 83.36 (a)
Str.20160 36
(Danio rerio)
Actinopterygii LOC100149858 36
  • 69.44 (n)
  • 72.62 (a)
samd4a 37
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta smg 37
  • 14 (a)
(Caenorhabditis elegans)
Secernentea ZC190.4 37
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7136 37
  • 49 (a)
Species with no ortholog for SAMD4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAMD4A Gene

Gene Tree for SAMD4A (if available)
Gene Tree for SAMD4A (if available)

Paralogs for SAMD4A Gene

Paralogs for SAMD4A Gene

Selected SIMAP similar genes for SAMD4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SAMD4A: view

Variants for SAMD4A Gene

Sequence variations from dbSNP and Humsavar for SAMD4A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11431 -- 54,788,955(+) GAAGA(C/T)GAGAG utr-variant-3-prime
rs709939 -- 54,782,627(+) CCCAT(C/T)GATGC intron-variant
rs734001 -- 54,766,538(-) AGGTC(C/T)CAGGG intron-variant
rs735123 -- 54,766,023(+) AGACA(C/T)GCCAT intron-variant
rs735221 -- 54,672,300(+) CAGTC(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD4A Gene

Variant ID Type Subtype PubMed ID
nsv832802 CNV Loss 17160897
esv2670707 CNV Deletion 23128226
nsv1282 CNV Insertion 18451855
nsv436788 CNV Insertion 17901297
esv2675932 CNV Deletion 23128226
esv1004703 CNV Deletion 20482838

Relevant External Links for SAMD4A Gene

HapMap Linkage Disequilibrium report

Disorders for SAMD4A Gene

Relevant External Links for SAMD4A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SAMD4A: view

No data available for UniProtKB/Swiss-Prot for SAMD4A Gene

Publications for SAMD4A Gene

  1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. (PMID: 16221671) Baez M.V. … Boccaccio G.L. (J. Biol. Chem. 2005) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation. (PMID: 22201125) Baez M.V. … Boccaccio G.L. (J. Cell Biol. 2011) 3

Products for SAMD4A Gene

Sources for SAMD4A Gene

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