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Aliases & Descriptions for SAMD4A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZP434H0350 1 | | DKFZp434H0350 2 | | KIAA1053 1, 2, 3, 5 | | SAMD4 2, 3 | | SMAUG1 5 | | SMG 1, 2 | | SMGA 1, 2 | | Smaug 1, 2 | | Smaug1 2 |
| | | Descriptions |
|---|
| smaug homolog 2 | | sterile alpha motif domain containing 4 1, 2 | | sterile alpha motif domain containing 4A 2 |
|
| | Search outside databases for aliases for SAMD4A gene |
Summaries for SAMD4A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SAMD4A: Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM]
|
Genomic Location for SAMD4A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SAMD4A gene 
Entrez Gene cytogenetic band: 14q22.2 Ensembl cytogenetic band: 14q22.2 HGNC cytogenetic band: 14q22.2SAMD4A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P054105:
(about GC identifiers)
Start:
|
54,104,387 bp from pter |
End:
|
54,325,595 bp from pter |
Size:
|
221,209 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000014.7 NT_026437.11
| Proteins for SAMD4A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SAM4A_HUMAN, Q9UPU9 (See
protein sequence)Recommended Name: Sterile alpha motif domain-containing protein 4A Size: 529 amino acids; 58610 DaPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056404.2
ENSEMBL proteins: ENSP00000251091 ENSP00000350261 ENSP00000306381
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019717 | synaptosome |
IEA | -- | About this table
Antibodies for SAMD4A: Assays for SAMD4A: | Protein
Domains/ Families for SAMD4A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UPU9
ProtoNet protein and cluster: Q9UPU9 1 Blocks protein family: IPB001660 Sterile alpha motif SAM
UniProtKB/Swiss-Prot: SAM4A_HUMAN, Q9UPU9Similarity: Contains 1 SAM (sterile alpha motif) domain | Gene Function for SAMD4A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015589
Applied Biosystems Silencer® siRNAs for SAMD4A
Sigma-Aldrich siRNA for SAMD4A  Sigma-Aldrich shRNA for SAMD4A  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015589                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015589                                  untagged cDNA clones in CMV expression vector (see all 2): BC021726 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015589
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030371 | translation repressor activity |
IDA | 16221671 | About this table | Pathways & Interactions for SAMD4A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for SAMD4A 
5/9 Interacting proteins for SAMD4A (Q9UPU92 ENSP000003502613) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045727 | positive regulation of translation |
IDA | 16221671 | About this table
|
Drugs & Compounds for SAMD4A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SAMD4A
|
Transcripts for SAMD4A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015589
Sigma-Aldrich siRNA for SAMD4A  Sigma-Aldrich shRNA for SAMD4A  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015589 REFSEQ mRNAs for SAMD4A gene: NM_015589.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015589               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015589                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015589                                  untagged cDNA clones in CMV expression vector (see all 2): BC021726  Additional cDNA sequence: AB028976.1 AF429970.1 AK024652.1 AK025923.1 AK074716.1 AL117523.1 BC011489.2 BC021060.1 BC021726.2 BC057838.1 BC121173.1 BC121174.1 BX648198.1 14 DOTS entries: DT.316734 DT.92427239 DT.97841245 DT.100787078 DT.101974729 DT.86849225 DT.95181273 DT.91915383 DT.120756214 DT.40119306 DT.92427240 DT.92427242 DT.91740892 DT.95181288 24/175 AceView cDNA sequences (see all 175
):BQ213310 NM_015589 AI190545 BI829225 BM054954 AB028976 BQ440177 BM128739 AW955792 CD518215 BU193631 AI090923 AK024652 AA443202 F09903 AI299604 BC021726 AA622908 CD370605 AA411889 AI889254 AA235435 CA407556 AA377422
highest scoring ESTs for SAMD4A:AB028976 AA622908 AA682946 AA757136 AA758416 AA812909 AA992424 AI138405 AI187395 AI373580 Unigene Cluster for SAMD4A: Sterile alpha motif domain containing 4A Hs.98259 [show with all ESTs]Unigene Representative Sequence: AB028976
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4A (see all 9
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | |
| SP1: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | |
| SP1: | |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SAMD4A
3 Ensembl transcripts including schematic representations: ENST00000251091
ENST00000357634
ENST00000305831
|
Expression for SAMD4A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SAMD4A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SAMD4A
1 / 2 / 3 9 probe-sets matching SAMD4A gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTATATTTC
SOURCE GeneReport for Unigene cluster: Hs.98259
|
Orthologs for SAMD4A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SAMD4A gene from 5/7 species (see all 7
)
About this table Species with no ortholog for SAMD4A
ENSEMBL Gene Tree for SAMD4A | Paralogs for SAMD4A(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SAMD4A gene
- SAMD4B2
|
SNPs/Variants for SAMD4A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SAMD4A (up to first 250kb)
|
Disorders & Mutations for SAMD4A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610747
|
Medical News for SAMD4A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SAMD4A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for SAMD4A gene (see all 16
): |
Search for SAMD4A
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SAMD4A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SAMD4A
(According to HUGE)
About This Section
| |
Specialized Databases showing SAMD4A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SAMD4A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for SAMD4A:

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| | | | Search Tocris compounds for SAMD4A |
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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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