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SAMD4A Gene

protein-coding   GIFtS: 56

GC14P054105
sterile alpha motif domain containing 4A
(Previous name: sterile alpha motif domain containing 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SAMD4)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZP434H0350 1
DKFZp434H0350 2
KIAA1053 1, 2, 3, 5
SAMD4 2, 3
SMAUG1 5
SMG 1, 2
SMGA 1, 2
Smaug 1, 2
Smaug1 2
Descriptions
smaug homolog 2
sterile alpha motif domain containing 4 1, 2
sterile alpha motif domain containing 4A 2
External Ids
HGNC: 230231
Entrez Gene: 230342
UniProtKB: Q9UPU93
Ensembl: ENSG000000205777
Search outside databases for aliases for SAMD4A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SAMD4A:
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that
functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the
Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio,
2005 [PubMed 16221671]).[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SAMD4A gene  

Entrez Gene cytogenetic band: 14q22.2   Ensembl cytogenetic band:  14q22.2   HGNC cytogenetic band: 14q22.2

SAMD4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P054105:     (about GC identifiers)

Start:
54,104,387 bp from pter
End:
54,325,595 bp from pter
Size:
221,209 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SAM4A_HUMAN, Q9UPU9 (See protein sequence)
Recommended Name: Sterile alpha motif domain-containing protein 4A  
Size: 529 amino acids; 58610 Da

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056404.2  

    ENSEMBL proteins: 
    ENSP00000251091 ENSP00000350261 ENSP00000306381 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SAMD4A)
    Human Recombinant Proteins from Abnova (SAMD4A)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019717 synaptosome IEA--
    About this table

    Antibodies for SAMD4A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SAMD4A
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SAMD4A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SAMD4A)
    Novus Biologicals Antibody for SAMD4A

    Assays for SAMD4A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR013761 SAM_type
     IPR001660 SAM


       GeneDecks  SAMD4A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UPU9

    ProtoNet protein and cluster: Q9UPU9

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: SAM4A_HUMAN, Q9UPU9
    Similarity: Contains 1 SAM (sterile alpha motif) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SAMD4A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015589

                  Applied Biosystems Silencer® siRNAs for SAMD4A

                  Sigma-Aldrich siRNA for SAMD4A  
                         Sigma-Aldrich shRNA for SAMD4A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for SAMD4A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015589
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015589
                                     untagged cDNA clones in CMV expression vector (see all 2): BC021726 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015589

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030371 translation repressor activity IDA16221671
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  SAMD4A 


    5/9 Interacting proteins for SAMD4A (Q9UPU92 ENSP000003502613) via UniProtKB, MINT, and/or STRING (see all 9 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472MINT-3976569
    SRFENSP000002653543STRING (score=.947)
    SAMSN1ENSP000003740913STRING (score=.864)
    ARENSP000003638223STRING (score=.848)
    TIAL1ENSP000003580893STRING (score=.826)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045727 positive regulation of translation IDA16221671
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SAMD4A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (SAMD4A)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015589

                  Sigma-Aldrich siRNA for SAMD4A  
                         Sigma-Aldrich shRNA for SAMD4A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015589  

    REFSEQ mRNAs for SAMD4A gene: 

    NM_015589.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015589  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015589
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015589
                                     untagged cDNA clones in CMV expression vector (see all 2): BC021726 

    Additional cDNA sequence: 

    AB028976.1 AF429970.1 AK024652.1 AK025923.1 AK074716.1 AL117523.1 BC011489.2 BC021060.1 
    BC021726.2 BC057838.1 BC121173.1 BC121174.1 BX648198.1 

    14 DOTS entries:

    DT.316734  DT.92427239  DT.97841245  DT.100787078  DT.101974729  DT.86849225  DT.95181273  DT.91915383 
    DT.120756214  DT.40119306  DT.92427240  DT.92427242  DT.91740892  DT.95181288 

    24/175 AceView cDNA sequences (see all 175 ):

    BQ213310 NM_015589 AI190545 BI829225 BM054954 AB028976 BQ440177 BM128739 
    AW955792 CD518215 BU193631 AI090923 AK024652 AA443202 F09903 AI299604 
    BC021726 AA622908 CD370605 AA411889 AI889254 AA235435 CA407556 AA377422 

    highest scoring ESTs for SAMD4A:

    AB028976 AA622908 AA682946 AA757136 AA758416 AA812909 AA992424 AI138405 AI187395 AI373580 

    Unigene Cluster for SAMD4A:

    Sterile alpha motif domain containing 4A
    Hs.98259  [show with all ESTs]
    Unigene Representative Sequence: AB028976


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4A (see all 9 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:              -     -     -     -     -     -     -     -     -                 -     -     -                             -                                 
    SP2:                                                                                -     -     -     -     -                 -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                -     -                                                                     
    SP5:                                -                                                                                                                           

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:        -     -                     
    SP2:        -     -                     
    SP3:              -                     
    SP4:                                    
    SP5:                                    

    About this scheme

    ECgene alternative splicing isoforms for SAMD4A

    3 Ensembl transcripts including schematic representations:
    ENST00000251091  ENST00000357634  ENST00000305831  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SAMD4A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SAMD4A

    1 / 2 / 3

    9 probe-sets matching SAMD4A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40855_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB028976 1.00 1.00 1.00 1

    215495_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL117523 0.80 1.00 0.91 1

    215120_s_at2, 3 U133-A 1 1.00 1.00 -- -- BF697247 0.20 1.00 0.72 1

    212845_at2, 3 U133-A 1 1.00 1.00 -- -- AB028976 1.00 1.00 1.00 1

    215496_at2, 3 U133-A 1 0.46 1.00 -- -- AL117523 0.80 1.00 0.91 1

    215495_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    215120_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    212845_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    215496_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    GeneDecks  SAMD4A for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCTATATTTC

    SOURCE GeneReport for Unigene cluster: Hs.98259
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for SAMD4A gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SAMD4A1   -- sterile alpha motif domain containing 4A 94.51(n)
    97.35(a)
    490700  XM_547822.2  XP_547822.2 
    chimpanzee
    (Pan troglodytes)
    SAMD4A1   -- sterile alpha motif domain containing 4A 99.44(n)
    99.44(a)
    743539  XM_001161128.1  XP_001161128.1 
    rat
    (Rattus norvegicus)
    Samd4a1   -- sterile alpha motif domain containing 4A 91.68(n)
    95.91(a)
    305826  XM_223945.4  XP_223945.3 
    mouse
    (Mus musculus)
    Samd41, 5 145
    sterile alpha motif domain containing 41, 5 92.57(n)1
    96.19(a)1
    744801  NM_001037221.11  NP_001032298.11 
     AK0062995  AK0170815  (see all 16)
    chicken
    (Gallus gallus)
    SAMD4A1   -- sterile alpha motif domain containing 4A 84.09(n)
    87.93(a)
    423559  XM_421450.2  XP_421450.2 
    About this table        Species with no ortholog for SAMD4A

    ENSEMBL Gene Tree for SAMD4A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SAMD4A gene
    SAMD4B2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1266 NCBI SNPs in SAMD4A are shown (see all 1266 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 482)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs114311,2
    A,C,F,H,O54325423(+) GAAGAT/CGAGAG 1 -- ut31 ese38Minor allele frequency- C:0.43MN EU EA WA NA 744
    rs171277921,2
    C,F,H54238664(+) TGGCTC/GACTCT 1 H/D mis1 ese37Minor allele frequency- G:0.01NA EU EA WA 510
    rs19514381,2
    A,C,F,H54312959(+) CGCTCG/ACTGCC 1 S/S syn1 ese37Minor allele frequency- A:0.02EU EA WA NA 562
    rs19514371,2
    H54312902(+) AACCCC/TGGGGG 1 P/P syn1 ese34Minor allele frequency- T:0.00EU EA WA 408
    rs9116161,2
    A,C,F,H,O54209225(+) TCTATA/GTATGT 1 -- int18Minor allele frequency- G:0.48NA EA EU WA 580
    rs19573581,2
    A,C,F,H,O54292225(+) CGTGGC/TGGAAA 1 -- int112Minor allele frequency- N:0.00EA NA EU WA 1050
    rs9116131,2
    A,C,F,H,O54303168(+) AAGCAA/CACCGG 1 -- int116Minor allele frequency- C:0.12EU EA WA NA 1474
    rs19514411,2
    A,C,F,H,O54262616(+) ACTAAA/GAGAAA 1 -- int116Minor allele frequency- G:0.09NS EU EA WA NA 1086
    rs11875861,2
    A,C,F,H,O54116939(+) ATGTCC/TTCTTG 1 -- int116Minor allele frequency- T:0.38EA NA EU WA 1474
    rs20573701,2
    A,C,F,H,O54209950(+) TGTGAC/TGGCAG 1 -- int111Minor allele frequency- T:0.41EU EA WA NA 980
    About this table

    HapMap Linkage Disequilibrium images for SAMD4A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610747

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/16 PubMed articles for SAMD4A gene (see all 16 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 23034 HGNC: 23023 AceView: SAMD4 Ensembl:ENSG00000020577 euGenes: HUgn23034
    ECgene: SAMD4A H-InvDB: SAMD4A
    (According to HUGE)
    About This Section

    HUGE: KIAA1053
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SAMD4A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for SAMD4A Antibodies for SAMD4A
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