Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SAMD4A Gene

protein-coding   GIFtS: 52
GCID: GC14P055034

Sterile Alpha Motif Domain Containing 4A

(Previous name: sterile alpha motif domain containing 4)
(Previous symbol: SAMD4)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sterile Alpha Motif Domain Containing 4A1 2     SMAUG2
SAMD41 2 3     SMG2
SMAUG12 3 5     SMGA2
SAM Domain-Containing Protein 4A2 3     Protein Smaug Homolog 12
KIAA10533 5     hSmaug13
Smaug Homolog (Drosophila)1     Smaug 13
Sterile Alpha Motif Domain Containing 41     Sterile Alpha Motif Domain-Containing Protein 4A3

External Ids:    HGNC: 230231   Entrez Gene: 230342   Ensembl: ENSG000000205777   OMIM: 6107475   UniProtKB: Q9UPU93   

Export aliases for SAMD4A gene to outside databases

Previous GC identifers: GC14P054105 GC14P035197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SAMD4A Gene:
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a
posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which
was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 (PubMed 16221671)).(supplied by OMIM, Mar
2008)

GeneCards Summary for SAMD4A Gene:
SAMD4A (sterile alpha motif domain containing 4A) is a protein-coding gene. GO annotations related to this gene include translation repressor activity. An important paralog of this gene is SAMD4B.

UniProtKB/Swiss-Prot: SMAG1_HUMAN, Q9UPU9
Function: Acts as a translational repressor of SRE-containing messengers




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SAMD4A gene promoter:
         Max1   SRF   USF1   SRF (504 AA)   Pax-2   Pax-2a   USF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSAMD4A promoter sequence
   Search Chromatin IP Primers for SAMD4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAMD4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.2   Ensembl cytogenetic band:  14q22.2   HGNC cytogenetic band: 14q22.2

SAMD4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMD4A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P055034:  view genomic region     (about GC identifiers)

Start:
55,033,815 bp from pter      End:
55,260,033 bp from pter
Size:
226,219 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SMAG1_HUMAN, Q9UPU9 (See protein sequence)
Recommended Name: Protein Smaug homolog 1  
Size: 718 amino acids; 79415 Da
Sequence caution: Sequence=AAH57838.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAP97302.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A8MPZ5 Q0VA96 Q6PEW4
Alternative splicing: 3 isoforms:  Q9UPU9-1   Q9UPU9-2   Q9UPU9-3   

Explore the universe of human proteins at neXtProt for SAMD4A: NX_Q9UPU9

Explore proteomics data for SAMD4A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SAMD4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001155048.2  NP_001155049.1  NP_056404.4  

    ENSEMBL proteins: 
     ENSP00000452535   ENSP00000251091   ENSP00000450808   ENSP00000375919   ENSP00000350261  

    SAMD4A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SAMD4A
    OriGene Protein Over-expression Lysate for SAMD4A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SAMD4A
    GenScript Custom Purified and Recombinant Proteins Services for SAMD4A
    Novus Biologicals SAMD4A Proteins
    Novus Biologicals SAMD4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SAMD4A 

     
    antibodies-online proteins for SAMD4A (6 products) 

     
    antibodies-online peptides for SAMD4A

    SAMD4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SAMD4A
    Novus Biologicals SAMD4A Antibodies
    Search for Antibodies for SAMD4A at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SAMD4A
    antibodies-online antibodies for SAMD4A (8 products) 

    SAMD4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SAMD4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SAMD4A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SAMD4A 
    antibodies-online kits for SAMD4A (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR015327 Smaug_PHAT

    Graphical View of Domain Structure for InterPro Entry Q9UPU9

    ProtoNet protein and cluster: Q9UPU9

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: SMAG1_HUMAN, Q9UPU9
    Similarity: Belongs to the SMAUG family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with SAMD4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMAG1_HUMAN, Q9UPU9
    Function: Acts as a translational repressor of SRE-containing messengers

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030371translation repressor activity IDA16221671
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SAMD4A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SAMD4A

    miRNA
    Products:
        
    miRTarBase miRNAs that target SAMD4A:
    hsa-mir-375 (MIRT019866)

    Block miRNA regulation of human, mouse, rat SAMD4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SAMD4A (see all 141):
    hsa-miR-124* hsa-miR-411* hsa-miR-100* hsa-miR-1321 hsa-miR-574-3p hsa-miR-3074-3p hsa-miR-3921 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidSAMD4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SAMD4A
    Predesigned siRNA for gene silencing in human, mouse, rat SAMD4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SAMD4A

    Clone
    Products:
         
    OriGene clones in human, mouse for SAMD4A (see all 22)
    OriGene ORF clones in mouse, rat for SAMD4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SAMD4A (NM_001161576)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAMD4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAMD4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SAMD4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for SAMD4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SMAG1_HUMAN, Q9UPU9: Cytoplasm. Cell projection, dendrite (By similarity). Cell junction, synapse, synaptosome
    (By similarity). Note=Enriched in synaptoneurosomes (By similarity). Shuttles between the nucleus and the
    cytoplasm in a CRM1-dependent manner. Colocalizes throughout the cytoplasm in granules with polyadenylated RNAs,
    PABPC1 and STAU1. Also frequently colocalizes in cytoplasmic stress granule-like foci with ELAVL1, TIA1 and TIAL1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0030054cell junction IEA--
    GO:0030425dendrite IEA--
    GO:0045202synapse IEA--

    Find genes that share ontologies with SAMD4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SAMD4A
    Interactions:

        GeneGlobe Interaction Network for SAMD4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SAMD4A (Q9UPU92, 3 ENSP000003502614) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50895 I2D: score=3 STRING: ENSP00000306330
    SFNP319472, 3MINT-3976569 I2D: score=1 
    BICD1Q96G013, ENSP000002814744I2D: score=1 STRING: ENSP00000281474
    PAFAH1B1P430343I2D: score=4 
    THP071013I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017148negative regulation of translation IDA16221671
    GO:0045727positive regulation of translation IDA16221671

    Find genes that share ontologies with SAMD4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SAMD4A (SMAG1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SAMD4A gene (3 alternative transcripts): 
    NM_001161576.2  NM_001161577.1  NM_015589.5  

    Unigene Cluster for SAMD4A:

    Sterile alpha motif domain containing 4A
    Hs.98259  [show with all ESTs]
    Unigene Representative Sequence: NM_015589
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554335 ENST00000251091(uc001xbb.3 uc001xbc.3) ENST00000555112(uc001xba.3 uc001xbe.3)
    ENST00000555091 ENST00000557692 ENST00000557013(uc001xbf.2) ENST00000554587
    ENST00000555192 ENST00000556069 ENST00000553988 ENST00000555719 ENST00000392067
    ENST00000357634(uc001xbg.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SAMD4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SAMD4A (see all 141):
    hsa-miR-124* hsa-miR-411* hsa-miR-100* hsa-miR-1321 hsa-miR-574-3p hsa-miR-3074-3p hsa-miR-3921 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidSAMD4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SAMD4A
    Predesigned siRNA for gene silencing in human, mouse, rat SAMD4A
    Clone
    Products:
         
    OriGene clones in human, mouse for SAMD4A (see all 22)
    OriGene ORF clones in mouse, rat for SAMD4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SAMD4A (NM_001161576)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SAMD4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAMD4A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SAMD4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAMD4A
      QuantiTect SYBR Green Assays in human, mouse, rat SAMD4A
      QuantiFast Probe-based Assays in human, mouse, rat SAMD4A

    Additional mRNA sequence: 

    AB028976.1 AK024652.1 AK025923.1 AK074716.1 BC011489.2 BC021060.1 BC021726.2 BC121173.1 
    BC121174.1 

    10 DOTS entries:

    DT.316734  DT.97841245  DT.100787078  DT.101974729  DT.92427239  DT.120756214  DT.86849225  DT.92427240 
    DT.95181273  DT.91740892 

    Selected AceView cDNA sequences (see all 175):

    AK024652 BM054954 AW955792 AA443202 CD370605 BI829225 AB028976 CD518215 
    CA407556 AI190545 BC021726 F09903 BU634138 BQ213310 AA377422 BM128739 
    AA464602 BQ440177 BU193631 AI299604 CR618938 AA235435 BI831923 BX471435 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4A (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:              -     -     -     -     -     -     -     -     -                 -     -     -                             -                                 
    SP2:                                                                                -     -     -     -     -                 -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                -     -                                                                     
    SP5:                                -                                                                                                                           

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:        -     -                     
    SP2:        -     -                     
    SP3:              -                     
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SAMD4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SAMD4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTATATTTC
    SAMD4A Expression
    About this image


    SAMD4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Heart (Cardiovascular System)
    SAMD4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SAMD4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98259
        Custom PCR Arrays for SAMD4A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SAMD4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAMD4A
    QuantiTect SYBR Green Assays in human, mouse, rat SAMD4A
    QuantiFast Probe-based Assays in human, mouse, rat SAMD4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SAMD4A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Samd41 , 5 sterile alpha motif domain containing 41, 5 92.63(n)1
    96.34(a)1
      14 (24.41 cM)5
    744801  NM_001037221.21  NP_001032298.11 
     468828545 
    chicken
    (Gallus gallus)
    Aves SAMD4A1 sterile alpha motif domain containing 4A 84.02(n)
    87.94(a)
      423559  XM_421450.4  XP_421450.2 
    lizard
    (Anolis carolinensis)
    Reptilia SAMD4A6
    sterile alpha motif domain containing 4A
    85(a)
    1 ↔ 1
    GL343533.1(300058-450479)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.201602 Transcribed sequence with moderate similarity to protein more 78.96(n)    BX755234.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001498581 protein Smaug homolog 1-like 69.44(n)
    72.62(a)
      100149858  XM_001920663.3  XP_001920698.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta smg6
    smaug
    14(a)
    1 → many
    3L(8983417-8991089)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC190.46
    Protein ZC190.4 (ZC190.4) mRNA, complete cds
    16(a)
    1 → many
    V(8666065-8671665) WBGene00022538


    ENSEMBL Gene Tree for SAMD4A (if available)
    TreeFam Gene Tree for SAMD4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SAMD4A gene
    SAMD4B2  
    2 SIMAP similar genes for SAMD4A using alignment to 4 protein entries:     SMAG1_HUMAN (see all proteins):
    DKFZp434H0350    SAMD4B

    Find genes that share paralogs with SAMD4A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SAMD4A (see all 4779)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722339931,2
    C--35231731(+) AAAAT-/ACACACACACA
    CACACACACACAC
    ACACA
    2 -- int10--------
    rs569003471,2
    C--36122066(+) TTTTT-/T/T   
       T
    /TTT
    CTTCA
    2 -- int11NA 2
    rs1892425391,2
    --55032837(+) TCCGCA/GAGCCG 2 -- us2k10--------
    rs1472112041,2
    --55032999(+) AGGGCC/TCCCGA 2 -- us2k10--------
    rs128887091,2
    --55033050(+) TACGGC/G/TCCTCG 2 -- us2k10--------
    rs1406130761,2
    --55033195(+) CCCGCC/TGGCGG 2 -- us2k10--------
    rs1162642491,2
    C,F--55033955(+) CAGCCG/TTTGGC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs45487931,2
    C,F,H--55034066(+) GGAGGG/AGGCGG 2 -- us2k116Minor allele frequency- A:0.16NS EA NA CSA WA 1966
    rs2010073091,2
    C--55034152(+) CCTCG-/CCCCCC 2 -- us2k10--------
    rs601478601,2
    C--55034377(+) TCGTTA/-TTTTT 2 -- ut512Minor allele frequency- -:0.25CSA 4

    HapMap Linkage Disequilibrium report for SAMD4A (55033815 - 55260033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SAMD4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670707CNV Deletion23128226
    esv1004703CNV Deletion20482838
    esv2675932CNV Deletion23128226
    nsv1282CNV Insertion18451855
    nsv436788CNV Insertion17901297
    nsv832802CNV Loss17160897

    Human Gene Mutation Database (HGMD): SAMD4A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SAMD4A
    DNA2.0 Custom Variant and Variant Library Synthesis for SAMD4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610747    OMIM disorders: --


    Find genes that share disorders with SAMD4A           About GenesLikeMe

    Genetic Association Database (GAD): SAMD4A
    Human Genome Epidemiology (HuGE) Navigator: SAMD4A (4 documents)

    Export disorders for SAMD4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SAMD4A gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SAMD4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. (PubMed id 16221671)1, 2, 3 Baez M.V. and Boccaccio G.L. (J. Biol. Chem. 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    5. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PubMed id 24023788)1 Ong B.A....Hakonarson H. (PLoS ONE 2013)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation. (PubMed id 22201125)1 Baez M.V....Boccaccio G.L. (J. Cell Biol. 2011)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23034 HGNC: 23023 AceView: SAMD4 Ensembl:ENSG00000020577 euGenes: HUgn23034
    ECgene: SAMD4A H-InvDB: SAMD4A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1053

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SAMD4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SAMD4A gene:
    Search GeneIP for patents involving SAMD4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SAMD4A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SAMD4A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SAMD4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for SAMD4A   OriGene Purified Protein for SAMD4A  
     OriGene ORF clones in mouse, rat for SAMD4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SAMD4A   OriGene Custom Protein Services for SAMD4A  

     
     
     Block miRNA regulation of human, mouse, rat SAMD4A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SAMD4A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SAMD4A Predesigned siRNA for gene silencing in human, mouse, rat SAMD4A
     QuantiFast Probe-based Assays in human, mouse, rat SAMD4A QuantiTect SYBR Green Assays in human, mouse, rat SAMD4A
     Custom PCR Arrays for SAMD4A Search Chromatin IP Primers for SAMD4A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SAMD4A  GeneGlobe Interaction Network for SAMD4A
     Regulatory tfbs in SAMD4A promoter
     GenScript Custom Purified and Recombinant Proteins Services for SAMD4A GenScript cDNA clones with any tag delivered in your preferred vector for SAMD4A
     GenScript Custom Assay Services for SAMD4A GenScript Custom overexpressing Cell Line Services for SAMD4A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SAMD4A (SMAG1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SAMD4A antibodies
     SAMD4A proteins
     SAMD4A lysates
     Search for Antibodies for SAMD4A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SAMD4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SAMD4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SAMD4A
     SwitchGear 3'UTR luciferase reporter plasmids for SAMD4A
     SwitchGear Promoter luciferase reporter plasmids for SAMD4A
     Search ThermoFisher Antibodies for SAMD4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SAMD4A
     Browse compounds at ApexBio
     Search Addgene for plasmids for SAMD4A
      Search eBioscience for proteins for SAMD4A
      Search eBioscience for elisas for SAMD4A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SAMD4A
     antibodies-online antibodies for SAMD4A (8 products)
     antibodies-online kits for SAMD4A (6 products)
     antibodies-online peptides for SAMD4A
     antibodies-online proteins for SAMD4A (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SAMD4A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4