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Aliases for SAMD3 Gene

Aliases for SAMD3 Gene

  • Sterile Alpha Motif Domain Containing 3 2 3 5
  • SAM Domain-Containing Protein 3 4

External Ids for SAMD3 Gene

Previous GeneCards Identifiers for SAMD3 Gene

  • GC06M130446
  • GC06M130507
  • GC06M130465
  • GC06M128046

Summaries for SAMD3 Gene

GeneCards Summary for SAMD3 Gene

SAMD3 (Sterile Alpha Motif Domain Containing 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD3 Gene

Genomics for SAMD3 Gene

Regulatory Elements for SAMD3 Gene

Genomic Location for SAMD3 Gene

Chromosome:
6
Start:
130,133,203 bp from pter
End:
130,365,425 bp from pter
Size:
232,223 bases
Orientation:
Minus strand

Genomic View for SAMD3 Gene

Genes around SAMD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD3 Gene

Proteins for SAMD3 Gene

  • Protein details for SAMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6K7-SAMD3_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 3
    Protein Accession:
    Q8N6K7
    Secondary Accessions:
    • B4DY20
    • E1P576
    • J3KQK4
    • Q4VXD8
    • Q8NAY1
    • Q8NB96

    Protein attributes for SAMD3 Gene

    Size:
    520 amino acids
    Molecular mass:
    61237 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAMD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAMD3 Gene

Proteomics data for SAMD3 Gene at MOPED

Post-translational modifications for SAMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD3 Gene

Domains & Families for SAMD3 Gene

Gene Families for SAMD3 Gene

Protein Domains for SAMD3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6K7

UniProtKB/Swiss-Prot:

SAMD3_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD3: view

Function for SAMD3 Gene

Phenotypes for SAMD3 Gene

genes like me logo Genes that share phenotypes with SAMD3: view

Animal Model Products

miRNA for SAMD3 Gene

miRTarBase miRNAs that target SAMD3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD3 Gene

Localization for SAMD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD3 Gene COMPARTMENTS Subcellular localization image for SAMD3 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD3 Gene

Pathways & Interactions for SAMD3 Gene

SuperPathways for SAMD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAMD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD3 Gene

Drugs & Compounds for SAMD3 Gene

No Compound Related Data Available

Transcripts for SAMD3 Gene

Unigene Clusters for SAMD3 Gene

Sterile alpha motif domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for SAMD3 Gene

GeneLoc Exon Structure for
SAMD3
ECgene alternative splicing isoforms for
SAMD3

Expression for SAMD3 Gene

mRNA expression in normal human tissues for SAMD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD3 Gene

This gene is overexpressed in Whole Blood (x16.9) and Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for SAMD3 Gene

This gene is overexpressed in Plasma (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAMD3 Gene



SOURCE GeneReport for Unigene cluster for SAMD3 Gene Hs.440508

genes like me logo Genes that share expression patterns with SAMD3: view

Protein tissue co-expression partners for SAMD3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SAMD3 Gene

Orthologs for SAMD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAMD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD3 36
  • 99 (a)
OneToOne
SAMD3 35
  • 99.42 (n)
  • 99.23 (a)
cow
(Bos Taurus)
Mammalia BT.47533 36
  • 89 (a)
OneToOne
SAMD3 35
  • 90.78 (n)
  • 89.02 (a)
dog
(Canis familiaris)
Mammalia SAMD3 35
  • 86.07 (n)
  • 81.59 (a)
SAMD3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd3 16
Samd3 36
  • 82 (a)
OneToOne
Samd3 35
  • 84.5 (n)
  • 81.91 (a)
oppossum
(Monodelphis domestica)
Mammalia SAMD3 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD3 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Samd3 35
  • 84.37 (n)
  • 82.78 (a)
chicken
(Gallus gallus)
Aves SAMD3 35
  • 67.23 (n)
  • 62.58 (a)
SAMD3 36
  • 60 (a)
OneToOne
Species with no ortholog for SAMD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAMD3 Gene

ENSEMBL:
Gene Tree for SAMD3 (if available)
TreeFam:
Gene Tree for SAMD3 (if available)

Paralogs for SAMD3 Gene

No data available for Paralogs for SAMD3 Gene

Variants for SAMD3 Gene

Sequence variations from dbSNP and Humsavar for SAMD3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17852709 - 130,209,598(+) CTCTT(C/T)ATCCC reference, missense
VAR_069418 -
rs469431 -- 130,285,393(+) ATCCA(C/G)AAAAG intron-variant
rs469642 -- 130,272,819(-) tgcca(C/G)gaatc intron-variant
rs953212 -- 130,155,543(+) GGTAC(A/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD3 Gene

Variant ID Type Subtype PubMed ID
esv2677571 CNV Deletion 23128226

Variation tolerance for SAMD3 Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD3 Gene

HapMap Linkage Disequilibrium report
SAMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD3 Gene

Disorders for SAMD3 Gene

Relevant External Links for SAMD3

Genetic Association Database (GAD)
SAMD3
Human Genome Epidemiology (HuGE) Navigator
SAMD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD3

No disorders were found for SAMD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD3 Gene

Publications for SAMD3 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PMID: 23534349) Jeff J.M. … Crawford D.C. (Ann. Hum. Genet. 2013) 3
  5. Gene-environment interaction in the etiology of mathematical ability using SNP sets. (PMID: 20978832) Docherty S.J. … Plomin R. (Behav. Genet. 2011) 3

Products for SAMD3 Gene

Sources for SAMD3 Gene

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