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SAMD3 Gene

protein-coding GIFtS: 44

GC06M130507

sterile alpha motif domain containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ34032 ^¹
FLJ34563 ^²
MGC35163 ^²
OTTHUMP00000017195 ^²
bA73O6.2 ^¹

Descriptions
sterile alpha motif domain containing 3 ^²

External Ids
HGNC: 21574¹
Entrez Gene: 154075²
UniProtKB: Q8N6K7³
Ensembl: ENSG00000164483⁷

Search outside databases for aliases for SAMD3 gene

Previous GC identifer: GC06M130446

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAMD3 gene

Entrez Gene cytogenetic band: 6q23.1 Ensembl cytogenetic band: 6q23.1 HGNC cytogenetic band: 6q23.1

SAMD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M130507: (about GC identifiers)

Start:	130,507,153 bp from pter
End:	130,728,238 bp from pter
Size:	221,086 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SAMD3_HUMAN, Q8N6K7 (See protein sequence)

Recommended Name: Sterile alpha motif domain-containing protein 3

Size: 520 amino acids; 61237 Da

Secondary accessions: Q4VXD8 Q8NAY1 Q8NB96

Alternative splicing: 2 isoforms: Q8N6K7-1 Q8N6K7-2

REFSEQ proteins (2 alternative transcripts):

NP_001017373.2 NP_689765.2

ENSEMBL proteins:

ENSP00000296977 ENSP00000357116 ENSP00000376225 ENSP00000324874

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (SAMD3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for SAMD3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for SAMD3

Assays for SAMD3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N6K7

ProtoNet protein and cluster: Q8N6K7

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: SAMD3_HUMAN, Q8N6K7

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAMD3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001017373

Applied Biosystems Silencer® siRNAs for SAMD3

Sigma-Aldrich siRNA for SAMD3

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SAMD3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001017373
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001017373
untagged cDNA clones in CMV expression vector (see all 2): NM_001017373

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001017373

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for SAMD3 (Q8N6K7²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
FANCG O15287² MINT-67343
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAMD3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAMD3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001017373

Sigma-Aldrich siRNA for SAMD3

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001017373 NM_152552

REFSEQ mRNAs for SAMD3 gene (2 alternative transcripts):

NM_001017373.2 NM_152552.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001017373 NM_152552

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001017373
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001017373
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001017373

Additional cDNA sequence:

AK091351.1 AK091882.1 AK302228.1 AK310075.1 BC029851.1 BC119757.1 BC119758.1 BC127653.1

BC127654.1 CR619249.1

8 DOTS entries:

DT.40128222 DT.95156878 DT.99946608 DT.100745072 DT.91853948 DT.99979464 DT.121375080 DT.451857

24 AceView cDNA sequences:

CR619249 BU728405 BF970519 AK091882 AX747235 BM707473 BI827294 AK091351

AX746929 BF437525 AI269610 BX431665 BC029851 AI129628 AL539181 AI002630

BG189665 NM_152552 BI461532 AL567716 BG221178 AI220609 AI499872 BG196320

highest scoring ESTs for SAMD3:

AI129628 AK091351 AK091882 AL539181 BC029851 BF970519 BI461532 CR619249 NM_152552 AI002630

Unigene Cluster for SAMD3:

Sterile alpha motif domain containing 3

Hs.440508 [show with all ESTs]

Unigene Representative Sequence: AK091351

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SAMD3

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:					-		-		-																		-
SP2:
SP3:									-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SAMD3

4 Ensembl transcripts including schematic representations:

ENST00000296977 ENST00000368134 ENST00000392430 ENST00000324172

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAMD3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAMD3

¹ / ² / ³

4 probe-sets matching SAMD3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74561_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI129628	0.60	1.00	0.82	1
236782_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI129628	0.60	1.00	0.82	1
236782_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553876_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SAMD3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTAAGTATC

SOURCE GeneReport for Unigene cluster: Hs.440508

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAMD3 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SAMD3¹	--	sterile alpha motif domain containing 3	82.25(n) 75.93(a)	484123 XM_541240.2 XP_541240.2
chimpanzee (Pan troglodytes)	SAMD3¹	--	sterile alpha motif domain containing 3	99.42(n) 99.23(a)	472123 XM_001168408.1 XP_001168408.1
cow (Bos taurus)	SAMD3¹	--	sterile alpha motif domain containing 3	91.45(n) 89.79(a)	511666 NM_001038083.1 NP_001033172.1
mouse (Mus musculus)	Samd3^{1, 5}	10⁵	sterile alpha motif domain containing 3^{1, 5}	84.37(n)¹ 81.68(a)¹	268288¹ NM_001013766.2¹ NP_001013788.1¹ AC091763⁵ AK082201⁵ (see all 9)

About this table Species with no ortholog for SAMD3

ENSEMBL Gene Tree for SAMD3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/518 NCBI SNPs in SAMD3 are shown (see all 518 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 186)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4895867^1,2	A,C,F,H	130586202(+)	`AATTCC/TCGTTA`	1	--	ng3¹		7		EU EA WA NA	558
--	rs6903714^1,2	A,C,F,H	130587003(+)	`gctgtT/Cgatgt`	1	--	ng3¹		8		EU EA WA	838
	rs4897379^1,2	A,C,F,H	130586454(+)	`AGGGGA/CTGCAA`	1	--	ng3¹ trp³		7		EU EA WA NA	562
	rs2326951^1,2	A,C,F,H	130578698(-)	`TCTTGC/TTAACG`	2	--	ng3¹ int¹		11		EU EA WA NA	920
	rs6924118^1,2	A,H	130586970(+)	`cccagG/Ccaaat`	1	--	ng3¹		3		EU EA	290
	rs11965136^1,2	C	130579092(+)	`GTGGGA/GTGGAG`	2	--	ng3¹ int¹		0	--	--	--	--
	rs9388777^1,2	H	130585860(+)	`CGTTTG/TCACCT`	1	--	ng3¹		4		EU EA WA	418
	rs12665779^1,2	H	130579462(+)	`AGAAAA/GCAAGT`	2	--	ng3¹ int¹		4		EU EA WA	416
--	rs9492496^1,2	A	130579123(+)	`AAAACA/GTTTTA`	2	--	int¹ ng3¹		0	--	--	--	--
	rs12665786^1,2	H	130579506(+)	`TGTTCA/GCAAAC`	2	--	int¹ ng3¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for SAMD3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for SAMD3 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)³ Gudbjartsson D.F....Stefansson K. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)⁴ Mungall A.J.... Beck S. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 154075	HGNC: 21574	AceView: SAMD3	Ensembl:ENSG00000164483	euGenes: HUgn154075
ECgene: SAMD3	H-InvDB: SAMD3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SAMD3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SAMD3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAMD3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAMD3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for SAMD3

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SAMD3 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for SAMD3

Summaries
for SAMD3

Genomic Location
for SAMD3

Proteins
for SAMD3

Protein Domains/
Families
for SAMD3

Gene Function
for SAMD3

Pathways & Interactions
for SAMD3

Drugs & Compounds
for SAMD3

Transcripts
for SAMD3

Expression
for SAMD3

Orthologs
for SAMD3

Paralogs
for SAMD3

SNPs/Variants
for SAMD3

Disorders & Mutations
for SAMD3

Medical News
for SAMD3

Publications
for SAMD3

Search for SAMD3

Genome Databases showing SAMD3

Other Databases showing SAMD3

Specialized Databases showing SAMD3

Licensable Technologies
for SAMD3

Services
for SAMD3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAMD3 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor SAMD3

Summariesfor SAMD3

Genomic Locationfor SAMD3

Proteinsfor SAMD3

Protein Domains/Familiesfor SAMD3

Gene Functionfor SAMD3

Pathways & Interactionsfor SAMD3

Drugs & Compoundsfor SAMD3

Transcriptsfor SAMD3

Expression for SAMD3

Orthologsfor SAMD3

Paralogsfor SAMD3

SNPs/Variantsfor SAMD3

Disorders & Mutationsfor SAMD3

Medical Newsfor SAMD3

Publicationsfor SAMD3

Search for SAMD3

Genome Databases showing SAMD3

Other Databases showing SAMD3

Specialized Databases showing SAMD3

Licensable Technologiesfor SAMD3

Servicesfor SAMD3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAMD3

Summaries
for SAMD3

Genomic Location
for SAMD3

Proteins
for SAMD3

Protein Domains/
Families
for SAMD3

Gene Function
for SAMD3

Pathways & Interactions
for SAMD3

Drugs & Compounds
for SAMD3

Transcripts
for SAMD3

Expression
for SAMD3

Orthologs
for SAMD3

Paralogs
for SAMD3

SNPs/Variants
for SAMD3

Disorders & Mutations
for SAMD3

Medical News
for SAMD3

Publications
for SAMD3

Licensable Technologies
for SAMD3

Services
for SAMD3