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Aliases for SAMD15 Gene

Aliases for SAMD15 Gene

  • Sterile Alpha Motif Domain Containing 15 2 3 5
  • Family With Sequence Similarity 15, Member A 2 3
  • SAM Domain-Containing Protein 15 3 4
  • C14orf174 3 4
  • FAM15A 3 4
  • Sterile Alpha Motif Domain-Containing Protein 15 3
  • SAM Domain-Containing Protein C14orf174 3
  • Chromosome 14 Open Reading Frame 174 2

External Ids for SAMD15 Gene

Previous HGNC Symbols for SAMD15 Gene

  • FAM15A
  • C14orf174

Previous GeneCards Identifiers for SAMD15 Gene

  • GC14P077844

Summaries for SAMD15 Gene

GeneCards Summary for SAMD15 Gene

SAMD15 (Sterile Alpha Motif Domain Containing 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD15 Gene

Genomics for SAMD15 Gene

Regulatory Elements for SAMD15 Gene

Enhancers for SAMD15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F077406 1 Ensembl ENCODE 33.3 +30.3 30313 2.0 CTCF HDAC1 TAL1 NR2F1 DPF2 ARID1B ZFHX2 GATA3 KLF16 SMARCA4 SAMD15 TMED8 AHSA1 VIPAS39 POMT2 GSTZ1 GC14M077403 ENSG00000280308
GH14F077378 0.2 Ensembl 22.2 +2.2 2187 0.5 ARNT MLLT1 ZBTB17 SAMD15 TMED8 GC14M077403
GH14F077375 0.9 ENCODE 22.2 -0.2 -167 2.9 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ELK1 ZNF207 NCOA1 TMED8 SAMD15 GSTZ1 LOC100422225
GH14F077382 0.7 ENCODE 20.4 +6.9 6912 1.3 HDAC1 LEF1 TAL1 CCNT2 NCOR1 GATA2 NR2F6 HES1 NR2F1 ZEB2 SAMD15 VIPAS39 TMED8 GC14M077403
GH14F077337 1 ENCODE 11.7 -38.7 -38734 1.6 CTCF JUND ZNF24 RAD21 TMED8 SAMD15 TMEM63C PIR37736 PIR54443
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SAMD15 on UCSC Golden Path with GeneCards custom track

Promoters for SAMD15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098963 211 2200 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ELK1 ZNF207 NCOA1

Genomic Location for SAMD15 Gene

77,376,689 bp from pter
77,391,497 bp from pter
14,809 bases
Plus strand

Genomic View for SAMD15 Gene

Genes around SAMD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD15 Gene

Proteins for SAMD15 Gene

  • Protein details for SAMD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sterile alpha motif domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • Q2M3P3

    Protein attributes for SAMD15 Gene

    674 amino acids
    Molecular mass:
    77151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAMD15 Gene


neXtProt entry for SAMD15 Gene

Post-translational modifications for SAMD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAMD15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAMD15 Gene

Domains & Families for SAMD15 Gene

Gene Families for SAMD15 Gene

Protein Domains for SAMD15 Gene

Suggested Antigen Peptide Sequences for SAMD15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD15: view

Function for SAMD15 Gene

genes like me logo Genes that share phenotypes with SAMD15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD15 Gene

Localization for SAMD15 Gene

Subcellular locations from

Jensen Localization Image for SAMD15 Gene COMPARTMENTS Subcellular localization image for SAMD15 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD15 Gene

Pathways & Interactions for SAMD15 Gene

SuperPathways for SAMD15 Gene

No Data Available

Interacting Proteins for SAMD15 Gene

Gene Ontology (GO) - Biological Process for SAMD15 Gene


No data available for Pathways by source and SIGNOR curated interactions for SAMD15 Gene

Transcripts for SAMD15 Gene

mRNA/cDNA for SAMD15 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAMD15 Gene

Sterile alpha motif domain containing 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD15 Gene

No ASD Table

Relevant External Links for SAMD15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAMD15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAMD15 Gene

mRNA differential expression in normal tissues according to GTEx for SAMD15 Gene

This gene is overexpressed in Testis (x17.5).

NURSA nuclear receptor signaling pathways regulating expression of SAMD15 Gene:


SOURCE GeneReport for Unigene cluster for SAMD15 Gene:

genes like me logo Genes that share expression patterns with SAMD15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SAMD15 Gene

Orthologs for SAMD15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAMD15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAMD15 34 35
  • 98.91 (n)
(Canis familiaris)
Mammalia SAMD15 34 35
  • 73.34 (n)
(Bos Taurus)
Mammalia SAMD15 34 35
  • 72.18 (n)
(Mus musculus)
Mammalia Samd15 34 16 35
  • 64.04 (n)
(Rattus norvegicus)
Mammalia Samd15 34
  • 53.91 (n)
(Monodelphis domestica)
Mammalia SAMD15 35
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia SAMD15 35
  • 31 (a)
(Gallus gallus)
Aves SAMD15 35
  • 45 (a)
(Anolis carolinensis)
Reptilia SAMD15 35
  • 69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for SAMD15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAMD15 Gene

Gene Tree for SAMD15 (if available)
Gene Tree for SAMD15 (if available)

Paralogs for SAMD15 Gene

No data available for Paralogs for SAMD15 Gene

Variants for SAMD15 Gene

Sequence variations from dbSNP and Humsavar for SAMD15 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1012468 -- 77,387,021(+) TTAGA(A/C)AACTA intron-variant
rs10133824 -- 77,378,249(+) GCAGG(A/T)CTAGA upstream-variant-2KB, reference, synonymous-codon
rs10133896 -- 77,387,463(+) AGAAA(C/T)TGCAG intron-variant
rs10138606 -- 77,376,557(+) GGGCG(A/G)CGAGG intron-variant, upstream-variant-2KB
rs10140162 -- 77,380,036(+) GGTTG(C/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD15 Gene

Variant ID Type Subtype PubMed ID
esv3635003 CNV gain 21293372
nsv1362 CNV deletion 18451855

Variation tolerance for SAMD15 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD15 Gene

Disorders for SAMD15 Gene

Relevant External Links for SAMD15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SAMD15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD15 Gene

Publications for SAMD15 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SAMD15 Gene

Sources for SAMD15 Gene

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