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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SAMD15 Gene

protein-coding GIFtS: 37
GCID: GC14P077844

sterile alpha motif domain containing 15

(Previous names: family with sequence similarity 15, member A, chromosome...)
(Previous symbols: FAM15A, C14orf174)

Search for SAMD15
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sterile Alpha Motif Domain Containing 15¹ ²		FLJ35963¹
C14orf174¹ ² ³		Chromosome 14 Open Reading Frame 174¹
FAM15A¹ ² ³		SAM Domain-Containing Protein C14orf174²
Family With Sequence Similarity 15, Member A¹ ²		Sterile Alpha Motif Domain-Containing Protein 15²
SAM Domain-Containing Protein 15² ³

External Ids:	HGNC: 18631¹	Entrez Gene: 161394²	Ensembl: ENSG00000100583⁷	UniProtKB: Q9P1V8³

Export aliases for SAMD15 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SAMD15
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SAMD15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAMD15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3

SAMD15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMD15 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P077844: view genomic region (about GC identifiers)

Start:	77,843,032 bp from pter	End:	77,857,840 bp from pter
Size:	14,809 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SAM15_HUMAN, Q9P1V8 (See protein sequence)

Recommended Name: Sterile alpha motif domain-containing protein 15

Size: 674 amino acids; 77151 Da

Secondary accessions: Q2M3P3

Alternative splicing: 2 isoforms: Q9P1V8-1 Q9P1V8-2

Explore the universe of human proteins at neXtProt for SAMD15: NX_Q9P1V8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P1V8

SAMD15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001010860.1

ENSEMBL proteins:

ENSP00000450941 ENSP00000216471

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SAMD15 for domains About GeneDecksing

3 InterPro domains/families:

IPR013761 SAM/pointed

IPR001660 SAM

IPR011510 SAM_2

Graphical View of Domain Structure for InterPro Entry Q9P1V8

ProtoNet protein and cluster: Q9P1V8

2 Blocks protein families:

IPB001660 Sterile alpha motif SAM

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: SAM15_HUMAN, Q9P1V8

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for SAMD15:

Increased cell number in G2M,

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SAMD15

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SAMD15
Search CenterWatch for drugs/clinical trials and news about SAMD15 / SAM15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SAMD15 gene:

NM_001010860.1

Unigene Cluster for SAMD15:

Sterile alpha motif domain containing 15

Hs.421961 [show with all ESTs]

Unigene Representative Sequence: AK292571

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533095 ENST00000216471(uc001xtq.1)

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Additional cDNA sequence:

AK093282.1 AK292571.1 BC104834.1 BC104836.1

2 DOTS entries:

DT.100862706 DT.40204769

15 AceView cDNA sequences:

BU101757 BM873767 CA428916 BX345044 BX088856 AA972465 AA725584 AK093282

BX348189 AL523064 CD300045 AW876659 AW855812 CD690769 AW753723

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SAMD15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGCAATTT

About this image

SAMD15 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SAMD15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAMD15

SOURCE GeneReport for Unigene cluster: Hs.421961

SABiosciences Custom PCR Arrays for SAMD15

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SAMD15 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Samd15^{1 , 5}	sterile alpha motif domain containing 15^{1, 5}	63.6(n)¹ 49.25(a)¹		12 (41.40 cM)⁵ 238333¹ XM_138106.7¹ XP_138106.7¹ 87200750⁵
chicken (Gallus gallus)	Aves	SAMD15⁶	Uncharacterized protein	47(a)	1 ↔ 1	5(41625788-41631026)
lizard (Anolis carolinensis)	Reptilia	SAMD15⁶	--	69(a)	1 ↔ 1	1(20728996-20731735)

ENSEMBL Gene Tree for SAMD15 (if available)
TreeFam Gene Tree for SAMD15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143011881^1,2		--	77841794(+)	`GCAAGA/GGACAA`	2	--	int¹ us2k¹		0	--	--	--	--
rs145121225^1,2		--	77841796(+)	`AAGGGA/GCAAGT`	2	--	us2k¹ int¹		0	--	--	--	--
rs182082870^1,2		--	77841890(+)	`GCCAAC/TGATTT`	2	--	int¹ us2k¹		0	--	--	--	--
rs4903575^1,2	C,F,A,H	--	77842048(+)	`GGATCA/GGAGTA`	2	--	int¹ us2k¹		22		NS EA NA WA CSA	2323
rs138874214^1,2		--	77842076(+)	`CCATGC/TTGGAA`	2	--	int¹ us2k¹		0	--	--	--	--
rs149493431^1,2		--	77842145(+)	`CTTACC/TGTCAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs143941597^1,2		--	77842162(+)	`TGAGAA/CGAGTA`	2	--	int¹ us2k¹		0	--	--	--	--
rs186973609^1,2		--	77842369(+)	`TCAGAC/TCTAGA`	2	--	int¹ us2k¹		0	--	--	--	--
rs148624835^1,2		--	77842381(+)	`AATTAA/CTTTAT`	2	--	int¹ us2k¹		0	--	--	--	--
rs190327764^1,2		--	77842446(+)	`AGAGCA/GTCCTT`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SAMD15 (77843032 - 77857840 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SAMD15: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SAMD15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SAMD15)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 161394	HGNC: 18631	AceView: LOC161394	Ensembl:ENSG00000100583	euGenes: HUgn161394
ECgene: SAMD15	H-InvDB: SAMD15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SAMD15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SAMD15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SAMD15 gene:
Search GeneIP for patents involving SAMD15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SAMD15 gene at Home site.

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SAMD15 Gene

sterile alpha motif domain containing 15

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for SAMD15 gene

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SAMD15 Gene

sterile alpha motif domain containing 15

Aliasesfor SAMD15 gene

Summariesfor SAMD15 gene

Genomic Viewsfor SAMD15 gene

Proteinsfor SAMD15 gene

Protein Domains /Familiesfor SAMD15 gene

Functionfor SAMD15 gene

Pathways & Interactionsfor SAMD15 gene

Drugs & Compoundsfor SAMD15 gene

Transcriptsfor SAMD15 gene

Expression for SAMD15 gene

Orthologsfor SAMD15 gene

Paralogsfor SAMD15 gene

Genomic Variantsfor SAMD15 gene

Disorders / Diseasesfor SAMD15 gene

Publicationsfor SAMD15 gene

External Searches for SAMD15 gene

Genome Databases showing SAMD15 gene

Other Databases showing SAMD15 gene

Specialized Databases showing SAMD15 gene

Intellectual Propertyfor SAMD15 gene

Productsfor SAMD15 gene

View Random Gene

Aliases
for SAMD15 gene

Summaries
for SAMD15 gene

Genomic Views
for SAMD15 gene

Proteins
for SAMD15 gene

Protein Domains /
Families
for SAMD15 gene

Function
for SAMD15 gene

Pathways & Interactions
for SAMD15 gene

Drugs & Compounds
for SAMD15 gene

Transcripts
for SAMD15 gene

Expression
for SAMD15 gene

Orthologs
for SAMD15 gene

Paralogs
for SAMD15 gene

Genomic Variants
for SAMD15 gene

Disorders / Diseases
for SAMD15 gene

Publications
for SAMD15 gene

Intellectual Property
for SAMD15 gene

Products
for SAMD15 gene