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SAMD14 Gene

protein-coding GIFtS: 44

GC17M045544

sterile alpha motif domain containing 14
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ36890 ^¹, ²

Descriptions
sterile alpha motif domain containing 14 ^²

External Ids
HGNC: 27312¹
Entrez Gene: 201191²
UniProtKB: Q8IZD0³
Ensembl: ENSG00000167100⁷

Search outside databases for aliases for SAMD14 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SAMD14 gene

Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33

SAMD14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M045544: (about GC identifiers)

Start:	45,543,679 bp from pter
End:	45,562,176 bp from pter
Size:	18,498 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SAM14_HUMAN, Q8IZD0 (See protein sequence)

Recommended Name: Sterile alpha motif domain-containing protein 14

Size: 417 amino acids; 45056 Da

Secondary accessions: Q8N2X0

Alternative splicing: 2 isoforms: Q8IZD0-1 Q8IZD0-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_777580.1

ENSEMBL proteins:

ENSP00000285206 ENSP00000329144

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SAMD14)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for SAMD14:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SAMD14
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SAMD14), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for SAMD14

Assays for SAMD14:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IZD0

ProtoNet protein and cluster: Q8IZD0

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: SAM14_HUMAN, Q8IZD0

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAMD14)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_174920

Applied Biosystems Silencer® siRNAs for SAMD14

Sigma-Aldrich siRNA for SAMD14

Sigma-Aldrich shRNA for SAMD14

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_174920
Myc/DDK tagged cDNA clone in CMV expression vector: NM_174920
untagged cDNA clones in CMV expression vector (see all 2): NM_174920

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_174920

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SAMD14

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SAMD14)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_174920

Sigma-Aldrich siRNA for SAMD14

Sigma-Aldrich shRNA for SAMD14

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_174920

REFSEQ mRNAs for SAMD14 gene:

NM_174920.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_174920

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_174920
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_174920
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_174920

Additional cDNA sequence:

AF035306.1 AK054843.1 AK094209.1 AK095809.1 AK225767.1 AK291482.1 AY148482.1 BC029872.1

BC047081.1 BC136485.1 BC141822.1 BC142728.1 CR592493.1

10 DOTS entries:

DT.100752224 DT.100788800 DT.120938059 DT.40112660 DT.100788798 DT.100022361 DT.91943613 DT.75168583

DT.100682988 DT.120938065

24/53 AceView cDNA sequences (see all 53 ):

CR592493 BM710994 AK054843 BQ434391 NM_174920 AA325509 AW135853 AY148482

BC029872 BI560888 AA583682 BM547145 BG338375 AK094209 BM666085 AI393094

AK095809 BM926862 Z40324 BG683960 BM973393 AF035306 BM677123 BQ068296

highest scoring ESTs for SAMD14:

AF035306 AK094209 AY148482 BM547145 BQ068296 AA322252 AA325509 AA723992 AI393094 AK095809

Unigene Cluster for SAMD14:

Sterile alpha motif domain containing 14

Hs.567769 [show with all ESTs]

Unigene Representative Sequence: AK094209

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SAMD14 (see all 8 )

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:			-		-		-				-				-						-
SP2:			-		-		-				-				-						-								-
SP3:															-						-								-
SP4:																					-								-
SP5:			-		-		-				-				-

About this scheme

ECgene alternative splicing isoforms for SAMD14

2 Ensembl transcripts including schematic representations:

ENST00000285206 ENST00000330175

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SAMD14 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SAMD14

¹ / ² / ³

7 probe-sets matching SAMD14 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37158_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	AF035306	0.80	1.00	0.91	1
213866_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL134453	0.60	1.00	0.82	1
213866_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559996_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555819_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559997_x_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--
1559995_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGAAGGGGAG

SOURCE GeneReport for Unigene cluster: Hs.567769

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SAMD14 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Samd14¹	--	sterile alpha motif domain containing 14	88.49(n) 94.96(a)	287637 NM_001024966.1 NP_001020137.1
mouse (Mus musculus)	Samd14^{1, 5}	11⁵	sterile alpha motif domain containing 14^{1, 5}	88.25(n)¹ 94.48(a)¹	217125¹ NM_146025.2¹ NP_666137.1¹ AA288660⁵ AI449632⁵ (see all 13)

About this table Species with no ortholog for SAMD14

ENSEMBL Gene Tree for SAMD14

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SAMD14 gene

PPP1R9A² PPP1R9B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/102 NCBI SNPs in SAMD14 are shown (see all 102 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs847682^1,2	A,C,F,H	45563273(-)	`TCTTCA/GGTGTC`	1	--	ng3¹		8		EU EA WA NA	782
	rs847689^1,2	A,C,F	45544952(-)	`GGGAGC/GCTGGG`	1	--	ng5¹		4		MN EA NA	236
	rs2239952^1,2	A,C,F	45544917(-)	`CCATCA/GTGGGG`	1	--	ng5¹ ese³		1		EA	1304
	rs11868719^1,2	C	45563454(+)	`CAATGC/TAGGGA`	1	--	ng3¹		0	--	--	--	--
--	rs847681^1,2	C	45563692(-)	`catgtA/Gatcca`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs8078588^1,2	A,C,F,H	45554584(+)	`ATATGG/ATCGCC`	1	--	int¹		12		EU EA WA	1258
	rs12453869^1,2	A,C,F,H	45560070(+)	`TCTCCG/AAGAAC`	1	--	int¹		8		EU EA WA	838
	rs739500^1,2	A,C,F,H	45550817(-)	`TCTGTA/GCTCCC`	1	--	int¹		7		NA EA EU WA	662
	rs9896401^1,2	A,C,F,H	45552809(+)	`gattaT/Ctacaa`	1	--	int¹		12		EU EA WA	1258
	rs739499^1,2	A,C,F	45550913(-)	`ATCACC/ACGGCG`	1	--	int¹		3		NA EA	245

About this table

HapMap Linkage Disequilibrium images for SAMD14 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for SAMD14 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)^{2, 3} Andersson B....Gibbs R.A. (1996)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)³ Yu W....Gibbs R.A. (1997)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 201191	HGNC: 27312	AceView: LOC201191	Ensembl:ENSG00000167100	euGenes: HUgn201191
ECgene: SAMD14	H-InvDB: SAMD14

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for SAMD14
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SAMD14:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SAMD14-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SAMD14		Antibodies for SAMD14
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SAMD14		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for SAMD14

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SAMD14 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for SAMD14

Summaries
for SAMD14

Genomic Location
for SAMD14

Proteins
for SAMD14

Protein Domains/
Families
for SAMD14

Gene Function
for SAMD14

Pathways & Interactions
for SAMD14

Drugs & Compounds
for SAMD14

Transcripts
for SAMD14

Expression
for SAMD14

Orthologs
for SAMD14

Paralogs
for SAMD14

SNPs/Variants
for SAMD14

Disorders & Mutations
for SAMD14

Medical News
for SAMD14

Publications
for SAMD14

Search for SAMD14

Genome Databases showing SAMD14

Other Databases showing SAMD14

Specialized Databases showing SAMD14

Licensable Technologies
for SAMD14

Services
for SAMD14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SAMD14 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor SAMD14

Summariesfor SAMD14

Genomic Locationfor SAMD14

Proteinsfor SAMD14

Protein Domains/Familiesfor SAMD14

Gene Functionfor SAMD14

Pathways & Interactionsfor SAMD14

Drugs & Compoundsfor SAMD14

Transcriptsfor SAMD14

Expression for SAMD14

Orthologsfor SAMD14

Paralogsfor SAMD14

SNPs/Variantsfor SAMD14

Disorders & Mutationsfor SAMD14

Medical Newsfor SAMD14

Publicationsfor SAMD14

Search for SAMD14

Genome Databases showing SAMD14

Other Databases showing SAMD14

Specialized Databases showing SAMD14

Licensable Technologiesfor SAMD14

Servicesfor SAMD14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SAMD14

Summaries
for SAMD14

Genomic Location
for SAMD14

Proteins
for SAMD14

Protein Domains/
Families
for SAMD14

Gene Function
for SAMD14

Pathways & Interactions
for SAMD14

Drugs & Compounds
for SAMD14

Transcripts
for SAMD14

Expression
for SAMD14

Orthologs
for SAMD14

Paralogs
for SAMD14

SNPs/Variants
for SAMD14

Disorders & Mutations
for SAMD14

Medical News
for SAMD14

Publications
for SAMD14

Licensable Technologies
for SAMD14

Services
for SAMD14