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Aliases for SAMD14 Gene

Aliases for SAMD14 Gene

  • Sterile Alpha Motif Domain Containing 14 2 3 5
  • SAM Domain-Containing Protein 14 4

External Ids for SAMD14 Gene

Previous GeneCards Identifiers for SAMD14 Gene

  • GC17M045544
  • GC17M048188
  • GC17M043557

Summaries for SAMD14 Gene

GeneCards Summary for SAMD14 Gene

SAMD14 (Sterile Alpha Motif Domain Containing 14) is a Protein Coding gene. Diseases associated with SAMD14 include Respiratory System Benign Neoplasm. An important paralog of this gene is PPP1R9A.

Additional gene information for SAMD14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD14 Gene

Genomics for SAMD14 Gene

Regulatory Elements for SAMD14 Gene

Enhancers for SAMD14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H050171 2 FANTOM5 Ensembl ENCODE dbSUPER 11 -62.6 -62640 41 DMAP1 YBX1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN SGCA ENSG00000262837 FLJ45513 TMEM92-AS1 COL1A1 TMEM92 XYLT2 ZNF652 PPP1R9B LUC7L3
GH17H050046 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +73.0 72968 21 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZBTB7B ZNF143 FOS DEK SP3 ENSG00000262837 LUC7L3 ITGA3 FAM117A FLJ45513 PDK2 ENSG00000250282 LOC105371824 COL1A1 DLX3
GH17H050144 1.8 FANTOM5 ENCODE dbSUPER 11 -20.4 -20356 11 HDGF ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 KAT7 LUC7L3 ENSG00000250282 PDK2 SAMD14 PPP1R9B PICART1 SPATA20 ENSG00000236472
GH17H049190 1.9 FANTOM5 Ensembl ENCODE 9.7 +937.1 937143 4 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A NFYC ENSG00000262837 UBE2Z FAM117A ENSG00000230532 FLJ45513 KAT7 CALCOCO2 SPOP PICART1 TAC4
GH17H050099 1.5 Ensembl ENCODE dbSUPER 11.1 +28.3 28280 3 ATF1 FOXA2 MLX ARID4B YY1 ZNF766 GLIS2 SP3 SP5 MXD4 PDK2 ENSG00000262837 ENSG00000253730 SGCA HILS1 SAMD14 PICART1 ENSG00000250282 ENSG00000275025
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAMD14 on UCSC Golden Path with GeneCards custom track

Promoters for SAMD14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095609 182 1001 ZSCAN4 BACH1 ZIC2 ZFHX2 GLIS2 ZBTB48 PATZ1 KLF8 EZH2 EGR2

Genomic Location for SAMD14 Gene

Chromosome:
17
Start:
50,110,040 bp from pter
End:
50,129,882 bp from pter
Size:
19,843 bases
Orientation:
Minus strand

Genomic View for SAMD14 Gene

Genes around SAMD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD14 Gene

Proteins for SAMD14 Gene

  • Protein details for SAMD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD0-SAM14_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 14
    Protein Accession:
    Q8IZD0
    Secondary Accessions:
    • A5D8V1
    • Q8N2X0

    Protein attributes for SAMD14 Gene

    Size:
    417 amino acids
    Molecular mass:
    45056 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAMD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAMD14 Gene

Post-translational modifications for SAMD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD14 Gene

Domains & Families for SAMD14 Gene

Gene Families for SAMD14 Gene

Protein Domains for SAMD14 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAMD14: view

No data available for UniProtKB/Swiss-Prot for SAMD14 Gene

Function for SAMD14 Gene

Phenotypes From GWAS Catalog for SAMD14 Gene

Phenotypes for SAMD14 Gene

genes like me logo Genes that share phenotypes with SAMD14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SAMD14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD14 Gene

Localization for SAMD14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD14 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD14 Gene

Pathways & Interactions for SAMD14 Gene

SuperPathways for SAMD14 Gene

No Data Available

Interacting Proteins for SAMD14 Gene

Gene Ontology (GO) - Biological Process for SAMD14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD14 Gene

Drugs & Compounds for SAMD14 Gene

No Compound Related Data Available

Transcripts for SAMD14 Gene

Unigene Clusters for SAMD14 Gene

Sterile alpha motif domain containing 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SAMD14
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD14 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6:
SP7:
SP8: -

Relevant External Links for SAMD14 Gene

GeneLoc Exon Structure for
SAMD14
ECgene alternative splicing isoforms for
SAMD14

Expression for SAMD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAMD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD14 Gene

This gene is overexpressed in Brain - Cerebellum (x7.3) and Brain - Cerebellar Hemisphere (x6.9).

Protein differential expression in normal tissues from HIPED for SAMD14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.9) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAMD14 Gene



Protein tissue co-expression partners for SAMD14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAMD14 Gene:

SAMD14

SOURCE GeneReport for Unigene cluster for SAMD14 Gene:

Hs.567769

Evidence on tissue expression from TISSUES for SAMD14 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with SAMD14: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD14 Gene

Orthologs for SAMD14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD14 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia SAMD14 33 34
  • 92.25 (n)
cow
(Bos Taurus)
Mammalia SAMD14 33 34
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Samd14 33
  • 88.49 (n)
mouse
(Mus musculus)
Mammalia Samd14 33 16 34
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SAMD14 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD14 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAMD14 33 34
  • 70.95 (n)
lizard
(Anolis carolinensis)
Reptilia SAMD14 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100537418 33
  • 53.02 (n)
SAMD14 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spn 34
  • 4 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nab-1 34
  • 11 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 10 (a)
OneToOne
Species where no ortholog for SAMD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SAMD14 Gene

ENSEMBL:
Gene Tree for SAMD14 (if available)
TreeFam:
Gene Tree for SAMD14 (if available)

Paralogs for SAMD14 Gene

Paralogs for SAMD14 Gene

(1) SIMAP similar genes for SAMD14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SAMD14: view

Variants for SAMD14 Gene

Sequence variations from dbSNP and Humsavar for SAMD14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000033875 -- 50,121,855(+) CTGGG(A/T)GACTC intron-variant
rs1000493891 -- 50,126,441(+) TGGGA(-/CTACC)CTACA intron-variant, upstream-variant-2KB
rs1000999192 -- 50,112,773(+) CCCCC(A/C/T)TGAGA utr-variant-3-prime
rs1001166593 -- 50,126,064(+) TGGGG(A/G)GAGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001265045 -- 50,129,707(+) GGGGG(A/G)GATGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SAMD14 Gene

Variant ID Type Subtype PubMed ID
esv1003562 CNV loss 20482838
nsv1071392 CNV deletion 25765185
nsv952339 CNV deletion 24416366

Variation tolerance for SAMD14 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD14 Gene

Disorders for SAMD14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAMD14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
respiratory system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SAMD14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD14
genes like me logo Genes that share disorders with SAMD14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAMD14 Gene

Publications for SAMD14 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60
  4. Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells. (PMID: 22415137) Shen Y … Goel A (Cancer biology & therapy 2012) 3 60
  5. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. (PMID: 21829388) Fehrmann RS … Franke L (PLoS genetics 2011) 3 60

Products for SAMD14 Gene

Sources for SAMD14 Gene

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