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Aliases for SAMD14 Gene

Aliases for SAMD14 Gene

  • Sterile Alpha Motif Domain Containing 14 2 3 5
  • SAM Domain-Containing Protein 14 4

External Ids for SAMD14 Gene

Previous GeneCards Identifiers for SAMD14 Gene

  • GC17M045544
  • GC17M048188
  • GC17M043557

Summaries for SAMD14 Gene

GeneCards Summary for SAMD14 Gene

SAMD14 (Sterile Alpha Motif Domain Containing 14) is a Protein Coding gene. Diseases associated with SAMD14 include Respiratory System Benign Neoplasm. An important paralog of this gene is PPP1R9A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD14 Gene

Genomics for SAMD14 Gene

Regulatory Elements for SAMD14 Gene

Enhancers for SAMD14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G050171 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11 -62.6 -62640 42.0 CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 SGCA ENSG00000262837 CACNA1G-AS1 MYCBPAP LOC105371824 FLJ45513 NXPH3 TMEM92-AS1 COL1A1 TMEM92
GH17G050046 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +73.0 72968 21.3 HDGF FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZBTB7B ZNF143 FOS DEK PDK2 ENSG00000250282 ITGA3 COL1A1 ENSG00000262837 DLX3 ENSG00000248172 SAMD14 PICART1 ENSG00000261959
GH17G050144 1.8 FANTOM5 ENCODE dbSUPER 11 -20.4 -20356 11.6 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ZNF610 GLIS1 ENSG00000250282 PDK2 SAMD14 PPP1R9B PICART1 SPATA20 ENSG00000236472
GH17G050099 1.5 Ensembl ENCODE dbSUPER 11.1 +28.3 28280 3.6 ATF1 FOXA2 MLX ARID4B E2F7 YY1 ZNF766 GLIS2 FOS ZNF263 PDK2 ENSG00000262837 ENSG00000253730 SGCA HILS1 SAMD14 PICART1 ENSG00000250282 ENSG00000275025
GH17G050139 1.5 Ensembl ENCODE dbSUPER 10.9 -11.3 -11264 3.3 HDGF WRNIP1 ARID4B SIN3A ZNF2 CBX5 ZNF143 KLF13 ZNF263 SP3 SAMD14 ENSG00000236472 PPP1R9B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SAMD14 on UCSC Golden Path with GeneCards custom track

Promoters for SAMD14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095609 182 1001 AGO1 ZSCAN4 SIN3A ZNF48 GLIS2 PCBP1 EGR2 GATAD2B ZNF398 KLF16

Genomic Location for SAMD14 Gene

Chromosome:
17
Start:
50,110,040 bp from pter
End:
50,129,882 bp from pter
Size:
19,843 bases
Orientation:
Minus strand

Genomic View for SAMD14 Gene

Genes around SAMD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD14 Gene

Proteins for SAMD14 Gene

  • Protein details for SAMD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD0-SAM14_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 14
    Protein Accession:
    Q8IZD0
    Secondary Accessions:
    • A5D8V1
    • Q8N2X0

    Protein attributes for SAMD14 Gene

    Size:
    417 amino acids
    Molecular mass:
    45056 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAMD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAMD14 Gene

Post-translational modifications for SAMD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD14 Gene

Domains & Families for SAMD14 Gene

Gene Families for SAMD14 Gene

Protein Domains for SAMD14 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD14 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAMD14: view

No data available for UniProtKB/Swiss-Prot for SAMD14 Gene

Function for SAMD14 Gene

Phenotypes for SAMD14 Gene

genes like me logo Genes that share phenotypes with SAMD14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD14 Gene

Localization for SAMD14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD14 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD14 Gene

Pathways & Interactions for SAMD14 Gene

SuperPathways for SAMD14 Gene

No Data Available

Interacting Proteins for SAMD14 Gene

Gene Ontology (GO) - Biological Process for SAMD14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD14 Gene

Drugs & Compounds for SAMD14 Gene

No Compound Related Data Available

Transcripts for SAMD14 Gene

Unigene Clusters for SAMD14 Gene

Sterile alpha motif domain containing 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD14 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6:
SP7:
SP8: -

Relevant External Links for SAMD14 Gene

GeneLoc Exon Structure for
SAMD14
ECgene alternative splicing isoforms for
SAMD14

Expression for SAMD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAMD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD14 Gene

This gene is overexpressed in Brain - Cerebellum (x7.3) and Brain - Cerebellar Hemisphere (x6.9).

Protein differential expression in normal tissues from HIPED for SAMD14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.9) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAMD14 Gene



Protein tissue co-expression partners for SAMD14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAMD14 Gene:

SAMD14

SOURCE GeneReport for Unigene cluster for SAMD14 Gene:

Hs.567769

Evidence on tissue expression from TISSUES for SAMD14 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with SAMD14: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD14 Gene

Orthologs for SAMD14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD14 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia SAMD14 34 35
  • 92.25 (n)
cow
(Bos Taurus)
Mammalia SAMD14 34 35
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Samd14 34
  • 88.49 (n)
mouse
(Mus musculus)
Mammalia Samd14 34 16 35
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia SAMD14 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD14 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAMD14 34 35
  • 70.95 (n)
lizard
(Anolis carolinensis)
Reptilia SAMD14 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100537418 34
  • 53.02 (n)
SAMD14 35
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spn 35
  • 4 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nab-1 35
  • 11 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 10 (a)
OneToOne
Species where no ortholog for SAMD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SAMD14 Gene

ENSEMBL:
Gene Tree for SAMD14 (if available)
TreeFam:
Gene Tree for SAMD14 (if available)

Paralogs for SAMD14 Gene

Paralogs for SAMD14 Gene

(1) SIMAP similar genes for SAMD14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SAMD14: view

Variants for SAMD14 Gene

Sequence variations from dbSNP and Humsavar for SAMD14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000033875 -- 50,121,855(+) CTGGG(A/T)GACTC intron-variant
rs1000493891 -- 50,126,441(+) TGGGA(-/CTACC)CTACA intron-variant, upstream-variant-2KB
rs1000999192 -- 50,112,773(+) CCCCC(A/C/T)TGAGA utr-variant-3-prime
rs1001166593 -- 50,126,064(+) TGGGG(A/G)GAGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001265045 -- 50,129,707(+) GGGGG(A/G)GATGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SAMD14 Gene

Variant ID Type Subtype PubMed ID
esv1003562 CNV loss 20482838
nsv1071392 CNV deletion 25765185
nsv952339 CNV deletion 24416366

Variation tolerance for SAMD14 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD14 Gene

Disorders for SAMD14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAMD14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
respiratory system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SAMD14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD14
genes like me logo Genes that share disorders with SAMD14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAMD14 Gene

Publications for SAMD14 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3 64
  4. Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells. (PMID: 22415137) Shen Y. … Goel A. (Cancer Biol. Ther. 2012) 3 64
  5. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA. (PMID: 21829388) Fehrmann R.S. … Franke L. (PLoS Genet. 2011) 3 64

Products for SAMD14 Gene

Sources for SAMD14 Gene

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