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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SAMD13 Gene

protein-coding GIFtS: 36
GCID: GC01P084764

sterile alpha motif domain containing 13

Search for SAMD13
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sterile Alpha Motif Domain Containing 13¹ ²
SAM Domain-Containing Protein 13² ³
RP11-376N17.1²
Dnaj-Like Protein (LOC148418)²
Sterile Alpha Motif Domain-Containing Protein 13²

External Ids:	HGNC: 24582¹	Entrez Gene: 148418²	Ensembl: ENSG00000203943⁷	UniProtKB: Q5VXD3³

Export aliases for SAMD13 gene to outside databases

Previous GC identifers: GC01P084477 GC01P084536 GC01P082874

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SAMD13 gene promoter:
POU2F1 POU2F1a HFH-1 Nkx2-5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SAMD13 promoter sequence

Search SABiosciences Chromatin IP Primers for SAMD13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SAMD13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31.1

SAMD13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SAMD13 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P084764: view genomic region (about GC identifiers)

Start:	84,764,049 bp from pter	End:	84,855,640 bp from pter
Size:	91,592 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SAM13_HUMAN, Q5VXD3 (See protein sequence)

Recommended Name: Sterile alpha motif domain-containing protein 13

Size: 122 amino acids; 13570 Da

Secondary accessions: B3KPW8 D3DT11 Q53AI4 Q5VXD2 Q5VXD4

Alternative splicing: 4 isoforms: Q5VXD3-1 Q5VXD3-2 Q5VXD3-3 Q5VXD3-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SAMD13: NX_Q5VXD3

SAMD13 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001010971.1 NP_001128135.1 NP_001128136.1

ENSEMBL proteins:

ENSP00000359707 ENSP00000359705 ENSP00000378311 ENSP00000359703 ENSP00000359702

ENSP00000359704 ENSP00000391978 ENSP00000359701

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SAMD13 for domains About GeneDecksing

3 InterPro domains/families:

IPR013761 SAM/pointed

IPR001660 SAM

IPR021129 SAM_type1

Graphical View of Domain Structure for InterPro Entry Q5VXD3

ProtoNet protein and cluster: Q5VXD3

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: SAM13_HUMAN, Q5VXD3

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SAMD13

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SAMD13

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SAMD13 (ENSP00000359707⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRSF4	ENSP00000362900⁴	STRING: ENSP00000362900
TRNAU1AP	ENSP00000362936⁴	STRING: ENSP00000362936
--	ENSP00000382723⁴	STRING: ENSP00000382723
--	ENSP00000372767⁴	STRING: ENSP00000372767

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SAMD13
Search CenterWatch for drugs/clinical trials and news about SAMD13 / SAM13

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for SAMD13 gene (3 alternative transcripts):

NM_001010971.2 NM_001134663.1 NM_001134664.1

Unigene Cluster for SAMD13:

Sterile alpha motif domain containing 13

Hs.591445 [show with all ESTs]

Unigene Representative Sequence: NM_001010971

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370673(uc001djr.3) ENST00000370671 ENST00000394834 ENST00000463429

ENST00000370669 ENST00000479082 ENST00000370668(uc010orw.2 uc010orx.2)

ENST00000370670 ENST00000454967 ENST00000370667(uc001djs.3)

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		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SAMD13:
		hsa-miR-520d-5p hsa-miR-524-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SAMD13 3' UTR sequence

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Additional cDNA sequence:

AK056937.1 AK311207.1 AY604569.1 AY604570.1 BC037973.1

6 DOTS entries:

DT.408382 DT.100016382 DT.65287831 DT.121454623 DT.99999749 DT.303134

24/41 AceView cDNA sequences (see all 41):

CK821788 CR617905 CR615899 BC037973 BX092540 AA913464 CK821789 BX281193

CD107636 AI631824 AA609154 BU680318 AA496252 AA465293 AA812514 AW262750

AI696679 BF000472 BI759190 CB047557 AA846694 BX325328 BM926925 AK056937

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SAMD13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGTGTAAT

About this image

SAMD13 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SAMD13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SAMD13

SOURCE GeneReport for Unigene cluster: Hs.591445

SABiosciences Custom PCR Arrays for SAMD13

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SAMD13 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
African clawed frog (Xenopus laevis)	Amphibia	Xl.32470²	Xenopus laevis transcribed sequence with weak similarity more	78.3(n)		BJ618989.1
zebrafish (Danio rerio)	Actinopterygii	samd13¹	sterile alpha motif domain containing 13	73.54(n) 80.41(a)		767772 NM_001168317.1 NP_001161789.1
fruit fly (Drosophila melanogaster)	Insecta	CG2662⁶	--	8(a)	1 → many	X(2592737-2594951)

ENSEMBL Gene Tree for SAMD13 (if available)
TreeFam Gene Tree for SAMD13 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SAMD13 gene

SAMD1²

13 SIMAP similar genes for SAMD13 using alignment to 3 protein entries: SAM13_HUMAN (see all proteins):

RNF113A HPH1 L3MBTL4 PHC3 PHC1 L3MBTL1

PHC2 RNF113B SAMD1 SCMH1 SFMBT2 L3MBTL3

SAMD11

SAMD13 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72714713^1,2	C	--	84764993(+)	`CTCCCC/TTCTCC`	1	--	int¹		3		NA EA	242
rs9645392^1,2	C,F	--	84764999(+)	`NNNNCC/TTATCT`	1	--	int¹ trp³		1		NA	120
rs77465459^1,2		--	84765095(+)	`TCTCTA/GAAGTT`	1	--	int¹		1		NA	120
rs187677882^1,2		--	84765137(+)	`GAAGGG/TCTTGT`	1	--	int¹		0	--	--	--	--
rs143143145^1,2	C	--	84765340(+)	`TAGTG-/TATA TATAT`	2	--	int¹ us2k¹		0	--	--	--	--
rs111746607^1,2	C	--	84768021(+)	`CTTCCT/-TTTTT`	1	--	int¹		1		CSA	2
rs112533725^1,2	C	--	84772513(+)	`CTCAAAAT/-AATAA`	3	--	int¹		1		CSA	2
rs34272806^1,2	C	--	84777832(+)	`AATTG-/TTTTTT`	1	--	int¹		1		NA	2
rs34845116^1,2	C	--	84781947(+)	`TATGC-/TTTTTG`	1	--	int¹		2		NA CSA	4
rs67849203^1,2	C	--	84816762(+)	`AATTC-/TAATAATA`	3	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SAMD13 (84764049 - 84855640 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SAMD13: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SAMD13

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SAMD13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SAMD13)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 148418	HGNC: 24582	AceView: LOC148418	Ensembl:ENSG00000203943	euGenes: HUgn148418
ECgene: SAMD13	H-InvDB: SAMD13

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SAMD13	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SAMD13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SAMD13 gene:
Search GeneIP for patents involving SAMD13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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SAMD13 Gene

sterile alpha motif domain containing 13

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SAMD13 Gene

sterile alpha motif domain containing 13

Aliasesfor SAMD13 gene

Summariesfor SAMD13 gene

Genomic Viewsfor SAMD13 gene

Proteinsfor SAMD13 gene

Protein Domains /Familiesfor SAMD13 gene

Functionfor SAMD13 gene

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Genome Databases showing SAMD13 gene

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Specialized Databases showing SAMD13 gene

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Aliases
for SAMD13 gene

Summaries
for SAMD13 gene

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for SAMD13 gene

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for SAMD13 gene

Protein Domains /
Families
for SAMD13 gene

Function
for SAMD13 gene

Pathways & Interactions
for SAMD13 gene

Drugs & Compounds
for SAMD13 gene

Transcripts
for SAMD13 gene

Expression
for SAMD13 gene

Orthologs
for SAMD13 gene

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for SAMD13 gene

Genomic Variants
for SAMD13 gene

Disorders / Diseases
for SAMD13 gene

Publications
for SAMD13 gene

Intellectual Property
for SAMD13 gene

Products
for SAMD13 gene