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Aliases for SAMD12 Gene

Aliases for SAMD12 Gene

  • Sterile Alpha Motif Domain Containing 12 2 3
  • SAM Domain-Containing Protein 12 4

External Ids for SAMD12 Gene

Summaries for SAMD12 Gene

GeneCards Summary for SAMD12 Gene

SAMD12 (Sterile Alpha Motif Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is SAMD10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD12 Gene

Genomics for SAMD12 Gene

Genomic Location for SAMD12 Gene

Start:
118,189,455 bp from pter
End:
118,621,995 bp from pter
Size:
432,541 bases
Orientation:
Minus strand

Genomic View for SAMD12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAMD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD12 Gene

Regulatory Elements for SAMD12 Gene

Proteins for SAMD12 Gene

  • Protein details for SAMD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8I0-SAM12_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 12
    Protein Accession:
    Q8N8I0
    Secondary Accessions:
    • Q0P502

    Protein attributes for SAMD12 Gene

    Size:
    201 amino acids
    Molecular mass:
    22907 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD12 Gene

Proteomics data for SAMD12 Gene at MOPED

Post-translational modifications for SAMD12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD12 Gene

Domains for SAMD12 Gene

Gene Families for SAMD12 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SAMD12 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SAM12_HUMAN
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q8N8I0
genes like me logo Genes that share domains with SAMD12: view

Function for SAMD12 Gene

Gene Ontology (GO) - Molecular Function for SAMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with SAMD12: view

miRNA for SAMD12 Gene

miRTarBase miRNAs that target SAMD12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAMD12 Gene

Localization for SAMD12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD12 Gene COMPARTMENTS Subcellular localization image for SAMD12 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SAMD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with SAMD12: view

Pathways for SAMD12 Gene

SuperPathways for SAMD12 Gene

No Data Available

Interacting Proteins for SAMD12 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314173%0d%0a9606.ENSP00000356182%0d%0a9606.ENSP00000354609%0d%0a9606.ENSP00000368824%0d%0a
Selected Interacting proteins: ENSP00000314173 for SAMD12 Gene via STRING

Gene Ontology (GO) - Biological Process for SAMD12 Gene

None

No data available for Pathways by source for SAMD12 Gene

Transcripts for SAMD12 Gene

mRNA/cDNA for SAMD12 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAMD12 Gene

Sterile alpha motif domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD12 Gene

No ASD Table

Relevant External Links for SAMD12 Gene

GeneLoc Exon Structure for
SAMD12
ECgene alternative splicing isoforms for
SAMD12

Expression for SAMD12 Gene

mRNA expression in normal human tissues for SAMD12 Gene

mRNA differential expression in normal tissues according to GTEx for SAMD12 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SAMD12 Gene

SOURCE GeneReport for Unigene cluster for SAMD12 Gene Hs.359393

genes like me logo Genes that share expressions with SAMD12: view

Orthologs for SAMD12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD12 36
  • 98.93 (n)
  • 98.72 (a)
SAMD12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAMD12 36
  • 92.96 (n)
  • 95.65 (a)
SAMD12 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAMD12 36
  • 92.72 (n)
  • 95.36 (a)
SAMD12 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd12 36
  • 89.86 (n)
  • 94.41 (a)
Samd12 16
Samd12 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAMD12 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD12 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Samd12 36
  • 87.01 (n)
  • 92.21 (a)
chicken
(Gallus gallus)
Aves SAMD12 36
  • 76.25 (n)
  • 78.75 (a)
SAMD12 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAMD12 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia samd12 36
  • 67.1 (n)
  • 68.39 (a)
zebrafish
(Danio rerio)
Actinopterygii samd12 36
  • 65.09 (n)
  • 68.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta ave 37
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 20 (a)
OneToMany
Species with no ortholog for SAMD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD12 Gene

ENSEMBL:
Gene Tree for SAMD12 (if available)
TreeFam:
Gene Tree for SAMD12 (if available)

Paralogs for SAMD12 Gene

Paralogs for SAMD12 Gene

Selected SIMAP similar genes for SAMD12 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SAMD12 Gene

genes like me logo Genes that share paralogs with SAMD12: view

Variants for SAMD12 Gene

Sequence variations from dbSNP and Humsavar for SAMD12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1209 -- 118,193,795(+) AAAAA(G/T)TGCAG utr-variant-3-prime, nc-transcript-variant
rs721815 -- 118,284,047(+) TTTCA(C/T)GACAA intron-variant
rs721816 -- 118,284,183(+) TGCCC(A/C)CCTTA intron-variant
rs731563 -- 118,237,789(+) AATTC(A/C)GAAAT intron-variant
rs744079 -- 118,386,806(+) AATGA(C/T)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD12 Gene

Variant ID Type Subtype PubMed ID
nsv831441 CNV Gain 17160897
nsv821660 CNV Loss 15273396
nsv831442 CNV Loss 17160897
nsv8379 CNV Gain 18304495
esv25257 CNV Gain 19812545
nsv8381 CNV Loss 18304495
nsv6361 CNV Insertion 18451855
esv269087 CNV Insertion 20981092
esv8774 OTHER Inversion 19470904
nsv8382 CNV Gain 18304495
nsv831443 CNV Gain 17160897
nsv516067 CNV Loss 19592680
esv2661900 CNV Deletion 23128226
esv21710 CNV Gain 19812545
esv2467119 CNV Deletion 19546169
esv1943293 CNV Deletion 18987734
esv3203 CNV Deletion 18987735
esv2737481 CNV Deletion 23290073
esv1337695 CNV Deletion 17803354
esv7068 CNV Loss 19470904
nsv519793 CNV Loss 19592680
esv2499592 CNV Insertion 19546169
esv1628861 CNV Insertion 17803354
esv274277 CNV Insertion 20981092
esv267975 CNV Insertion 20981092
nsv510169 CNV Loss 20534489
nsv6362 CNV Loss 18451855
nsv891413 CNV Loss 21882294
esv2737482 CNV Deletion 23290073
esv1928288 CNV Deletion 18987734
nsv465786 CNV Loss 19166990

Relevant External Links for SAMD12 Gene

HapMap Linkage Disequilibrium report
SAMD12

Disorders for SAMD12 Gene

Relevant External Links for SAMD12

Genetic Association Database (GAD)
SAMD12
Human Genome Epidemiology (HuGE) Navigator
SAMD12
genes like me logo Genes that share disorders with SAMD12: view

No data available for UniProtKB/Swiss-Prot for SAMD12 Gene

Publications for SAMD12 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PMID: 23412934) Gourraud P.A. … Baranzini S.E. (Brain 2013) 3
  3. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D. … Mitchell G.F. (BMC Med. Genet. 2007) 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SAMD12 Gene

Sources for SAMD12 Gene

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