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Aliases for SAMD11 Gene

Aliases for SAMD11 Gene

  • Sterile Alpha Motif Domain Containing 11 2 3 5
  • SAM Domain-Containing Protein 11 3 4
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV10 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV11 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV12 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV13 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV14 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV15 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV16 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV17 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV18 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV19 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV20 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV21 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV22 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV23 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV24 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV25 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV26 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV27 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV28 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV29 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV30 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV31 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV32 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV33 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV34 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV35 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV36 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV37 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV38 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV39 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV40 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV41 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV42 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV43 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV44 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV45 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV1 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV2 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV3 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV4 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV5 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV6 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV7 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV8 3
  • Sterile Alpha Motif Domain Containing 11 Splice Variant ASV9 3
  • Sterile Alpha Motif Domain-Containing Protein 11 3
  • MRS 3

External Ids for SAMD11 Gene

Previous GeneCards Identifiers for SAMD11 Gene

  • GC01P000914
  • GC01P000850
  • GC01P000132
  • GC01P000860

Summaries for SAMD11 Gene

GeneCards Summary for SAMD11 Gene

SAMD11 (Sterile Alpha Motif Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity and PH domain binding. An important paralog of this gene is PHC1.

UniProtKB/Swiss-Prot for SAMD11 Gene

  • May play a role in photoreceptor development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD11 Gene

Genomics for SAMD11 Gene

Regulatory Elements for SAMD11 Gene

Enhancers for SAMD11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SAMD11 on UCSC Golden Path with GeneCards custom track

Promoters for SAMD11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SAMD11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SAMD11 Gene

Chromosome:
1
Start:
923,928 bp from pter
End:
944,581 bp from pter
Size:
20,654 bases
Orientation:
Plus strand

Genomic View for SAMD11 Gene

Genes around SAMD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD11 Gene

Proteins for SAMD11 Gene

  • Protein details for SAMD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NU1-SAM11_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 11
    Protein Accession:
    Q96NU1
    Secondary Accessions:
    • A2AA76
    • I7FV78
    • I7FV81
    • I7G0Z6
    • Q5SV96
    • Q5SV99
    • Q5SVA0
    • Q8N195
    • Q8TB59

    Protein attributes for SAMD11 Gene

    Size:
    681 amino acids
    Molecular mass:
    72708 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB70781.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15563.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15564.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAMD11 Gene

neXtProt entry for SAMD11 Gene

Post-translational modifications for SAMD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD11 Gene

Domains & Families for SAMD11 Gene

Gene Families for SAMD11 Gene

Protein Domains for SAMD11 Gene

Suggested Antigen Peptide Sequences for SAMD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NU1

UniProtKB/Swiss-Prot:

SAM11_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD11: view

Function for SAMD11 Gene

Molecular function for SAMD11 Gene

UniProtKB/Swiss-Prot Function:
May play a role in photoreceptor development.

Phenotypes for SAMD11 Gene

genes like me logo Genes that share phenotypes with SAMD11: view

Animal Model Products

CRISPR Products

miRNA for SAMD11 Gene

miRTarBase miRNAs that target SAMD11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD11 Gene

Localization for SAMD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD11 Gene COMPARTMENTS Subcellular localization image for SAMD11 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SAMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SAMD11: view

Pathways & Interactions for SAMD11 Gene

SuperPathways for SAMD11 Gene

No Data Available

Interacting Proteins for SAMD11 Gene

Gene Ontology (GO) - Biological Process for SAMD11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD11 Gene

Drugs & Compounds for SAMD11 Gene

No Compound Related Data Available

Transcripts for SAMD11 Gene

Unigene Clusters for SAMD11 Gene

Sterile alpha motif domain containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SAMD11 Gene

GeneLoc Exon Structure for
SAMD11
ECgene alternative splicing isoforms for
SAMD11

Expression for SAMD11 Gene

mRNA expression in normal human tissues for SAMD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD11 Gene

This gene is overexpressed in Pituitary (x6.5).

Protein differential expression in normal tissues from HIPED for SAMD11 Gene

This gene is overexpressed in Lung (59.9) and Retina (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAMD11 Gene



Protein tissue co-expression partners for SAMD11 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAMD11 Gene:

SAMD11

SOURCE GeneReport for Unigene cluster for SAMD11 Gene:

Hs.335293
genes like me logo Genes that share expression patterns with SAMD11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SAMD11 Gene

Orthologs for SAMD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SAMD11 34
  • 85.79 (n)
  • 84.51 (a)
SAMD11 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAMD11 34
  • 86.14 (n)
  • 86.14 (a)
SAMD11 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd11 34
  • 77.24 (n)
  • 73.73 (a)
Samd11 16
Samd11 35
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100608581 34
  • 98.78 (n)
  • 98.38 (a)
SAMD11 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102549710 34
  • 78.34 (n)
  • 77.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SAMD11 35
  • 26 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD11 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAMD11 34
  • 68.15 (n)
  • 62.06 (a)
SAMD11 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAMD11 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia samd11 34
  • 61.03 (n)
  • 60.64 (a)
Str.15654 34
zebrafish
(Danio rerio)
Actinopterygii Dr.11161 34
samd11 34
  • 61.87 (n)
  • 59.58 (a)
samd11 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Samuel 35
  • 11 (a)
OneToMany
Species where no ortholog for SAMD11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD11 Gene

ENSEMBL:
Gene Tree for SAMD11 (if available)
TreeFam:
Gene Tree for SAMD11 (if available)

Paralogs for SAMD11 Gene

Paralogs for SAMD11 Gene

Pseudogenes.org Pseudogenes for SAMD11 Gene

genes like me logo Genes that share paralogs with SAMD11: view

Variants for SAMD11 Gene

Sequence variations from dbSNP and Humsavar for SAMD11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1110051 -- 938,014(+) AGGGG(A/G)GTGGC intron-variant
rs1110052 -- 938,178(+) AATGG(G/T)TGCGG intron-variant
rs1806501 -- 928,622(+) GTTGG(C/G)GGCAG intron-variant
rs1806780 -- 936,972(+) GTCTG(C/G)GGTCC intron-variant
rs2001729 -- 932,733(-) ACAGA(C/T)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD11 Gene

Variant ID Type Subtype PubMed ID
dgv10n54 CNV gain+loss 21841781
dgv11n54 CNV loss 21841781
dgv12n54 CNV gain+loss 21841781
dgv13n54 CNV gain+loss 21841781
dgv14n54 CNV gain 21841781
dgv15n54 CNV loss 21841781
dgv16n54 CNV loss 21841781
dgv1n111 CNV duplication 26073780
dgv2n67 CNV gain 20364138
dgv3n111 CNV duplication 26073780
dgv5n100 CNV gain 25217958
dgv6n54 CNV loss 21841781
dgv7n54 CNV loss 21841781
dgv8n54 CNV loss 21841781
dgv9n54 CNV loss 21841781
esv1062785 CNV deletion 17803354
esv1732269 CNV deletion 17803354
esv2066434 CNV deletion 18987734
esv2663451 CNV deletion 23128226
esv27608 CNV gain+loss 19812545
esv2762302 CNV gain 21179565
esv2853903 CNV deletion 24192839
esv3550787 CNV deletion 23714750
esv3584987 CNV loss 21293372
esv989364 CNV loss 20482838
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074938 CNV deletion 25765185
nsv1074942 CNV deletion 25765185
nsv1142736 CNV deletion 24896259
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv509035 CNV insertion 20534489
nsv511670 CNV loss 21212237
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv544897 CNV gain+loss 21841781
nsv544898 CNV gain 21841781
nsv544904 CNV gain 21841781
nsv544919 CNV loss 21841781
nsv544924 CNV gain+loss 21841781
nsv544928 CNV gain 21841781
nsv544930 CNV loss 21841781
nsv544932 CNV loss 21841781
nsv832980 CNV gain 17160897
nsv950451 CNV deletion 24416366
nsv955441 CNV deletion 24416366

Variation tolerance for SAMD11 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SAMD11 Gene

Human Gene Mutation Database (HGMD)
SAMD11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD11 Gene

Disorders for SAMD11 Gene

Relevant External Links for SAMD11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SAMD11

No disorders were found for SAMD11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD11 Gene

Publications for SAMD11 Gene

  1. Identification and characterization of novel alternative splice variants of human SAMD11. (PMID: 23978614) Jin G. … Shen H. (Gene 2013) 3 4 65
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for SAMD11 Gene

Sources for SAMD11 Gene

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