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Aliases for SAMD11 Gene

Aliases for SAMD11 Gene

  • Sterile Alpha Motif Domain Containing 11 2 3
  • SAM Domain-Containing Protein 11 4

External Ids for SAMD11 Gene

Previous GeneCards Identifiers for SAMD11 Gene

  • GC01P000914
  • GC01P000850
  • GC01P000132
  • GC01P000860

Summaries for SAMD11 Gene

GeneCards Summary for SAMD11 Gene

SAMD11 (Sterile Alpha Motif Domain Containing 11) is a Protein Coding gene. GO annotations related to this gene include protein self-association and SAM domain binding. An important paralog of this gene is SAMD7.

UniProtKB/Swiss-Prot for SAMD11 Gene

  • May play a role in photoreceptor development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD11 Gene

Genomics for SAMD11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SAMD11 Gene

Start:
924,880 bp from pter
End:
944,581 bp from pter
Size:
19,702 bases
Orientation:
Plus strand

Genomic View for SAMD11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SAMD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD11 Gene

No data available for Regulatory Elements for SAMD11 Gene

Proteins for SAMD11 Gene

  • Protein details for SAMD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NU1-SAM11_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 11
    Protein Accession:
    Q96NU1
    Secondary Accessions:
    • A2AA76
    • I7FV78
    • I7FV81
    • I7G0Z6
    • Q5SV96
    • Q5SV99
    • Q5SVA0
    • Q8N195
    • Q8TB59

    Protein attributes for SAMD11 Gene

    Size:
    681 amino acids
    Molecular mass:
    72708 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB70781.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15563.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15564.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SAMD11 Gene

neXtProt entry for SAMD11 Gene

Proteomics data for SAMD11 Gene at MOPED

Post-translational modifications for SAMD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD11 Gene

Domains for SAMD11 Gene

Gene Families for SAMD11 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for SAMD11 Gene

Suggested Antigen Peptide Sequences for SAMD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NU1

UniProtKB/Swiss-Prot:

SAM11_HUMAN :
  • Q96NU1
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with SAMD11: view

Function for SAMD11 Gene

Molecular function for SAMD11 Gene

UniProtKB/Swiss-Prot Function: May play a role in photoreceptor development.

Gene Ontology (GO) - Molecular Function for SAMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity --
GO:0005515 protein binding --
GO:0032093 SAM domain binding IEA --
GO:0042731 PH domain binding IEA --
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with SAMD11: view

Animal Model Products

CRISPR Products

miRNA for SAMD11 Gene

miRTarBase miRNAs that target SAMD11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SAMD11 Gene

Localization for SAMD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SAMD11 Gene COMPARTMENTS Subcellular localization image for SAMD11 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SAMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SAMD11: view

Pathways for SAMD11 Gene

SuperPathways for SAMD11 Gene

No Data Available

Interacting Proteins for SAMD11 Gene

Gene Ontology (GO) - Biological Process for SAMD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SAMD11: view

No data available for Pathways by source for SAMD11 Gene

Transcripts for SAMD11 Gene

Unigene Clusters for SAMD11 Gene

Sterile alpha motif domain containing 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SAMD11
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SAMD11 Gene

GeneLoc Exon Structure for
SAMD11
ECgene alternative splicing isoforms for
SAMD11

Expression for SAMD11 Gene

mRNA expression in normal human tissues for SAMD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD11 Gene

This gene is overexpressed in Pituitary (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SAMD11 Gene

SOURCE GeneReport for Unigene cluster for SAMD11 Gene Hs.335293

genes like me logo Genes that share expressions with SAMD11: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SAMD11 Gene

Orthologs for SAMD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100608581 35
  • 98.78 (n)
  • 98.38 (a)
SAMD11 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAMD11 35
  • 85.79 (n)
  • 84.51 (a)
SAMD11 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SAMD11 35
  • 86.14 (n)
  • 86.14 (a)
SAMD11 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Samd11 35
  • 77.24 (n)
  • 73.73 (a)
Samd11 16
Samd11 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SAMD11 36
  • 26 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD11 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102549710 35
  • 78.34 (n)
  • 77.02 (a)
chicken
(Gallus gallus)
Aves SAMD11 35
  • 68.15 (n)
  • 62.06 (a)
SAMD11 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAMD11 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia samd11 35
  • 61.03 (n)
  • 60.64 (a)
Str.15654 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11161 35
samd11 35
  • 61.87 (n)
  • 59.58 (a)
samd11 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Samuel 36
  • 11 (a)
OneToMany
Species with no ortholog for SAMD11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD11 Gene

ENSEMBL:
Gene Tree for SAMD11 (if available)
TreeFam:
Gene Tree for SAMD11 (if available)

Paralogs for SAMD11 Gene

Paralogs for SAMD11 Gene

Pseudogenes.org Pseudogenes for SAMD11 Gene

genes like me logo Genes that share paralogs with SAMD11: view

Variants for SAMD11 Gene

Sequence variations from dbSNP and Humsavar for SAMD11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1110051 -- 938,014(+) AGGGG(A/G)GTGGC intron-variant
rs1110052 -- 938,178(+) AATGG(G/T)TGCGG intron-variant
rs1806501 -- 928,622(+) GTTGG(C/G)GGCAG intron-variant
rs1806780 -- 936,972(+) GTCTG(C/G)GGTCC intron-variant
rs2001729 -- 932,733(-) ACAGA(C/T)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD11 Gene

Variant ID Type Subtype PubMed ID
dgv3e1 CNV Complex 17122850
essv4734 CNV CNV 17122850
nsv10161 CNV Gain+Loss 18304495
essv2408 CNV CNV 17122850
nsv517709 CNV Gain+Loss 19592680
nsv832980 CNV Gain 17160897
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv509035 CNV Insertion 20534489
dgv8n71 CNV Loss 21882294
nsv871883 CNV Gain+Loss 21882294
dgv9n71 CNV Loss 21882294
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
nsv511670 CNV Loss 21212237
esv27608 CNV Gain+Loss 19812545
esv2721694 CNV Deletion 23290073
esv989364 CNV Loss 20482838
esv1732269 CNV Deletion 17803354
esv1062785 CNV Deletion 17803354
esv2722805 CNV Deletion 23290073
esv2066434 CNV Deletion 18987734
esv2723916 CNV Deletion 23290073
esv2663451 CNV Deletion 23128226

Relevant External Links for SAMD11 Gene

HapMap Linkage Disequilibrium report
SAMD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD11 Gene

Disorders for SAMD11 Gene

No disorders were found for SAMD11 Gene.

No data available for UniProtKB/Swiss-Prot for SAMD11 Gene

Publications for SAMD11 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Identification and characterization of novel alternative splice variants of human SAMD11. (PMID: 23978614) Jin G. … Shen H. (Gene 2013) 3 4

Products for SAMD11 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SAMD11
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SAMD11
  • Block miRNA regulation of SAMD11 using miScript Target Protectors

Sources for SAMD11 Gene

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